Cited by 3,039Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.

DNA methylation landscapes: provocative insights from epigenomics

Suzuki, Miho M., Bird, Adrian·2008·Nature Reviews Genetics

Open this paper in CoChat — free account

Abstract

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome it is located. New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises. In particular, the conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged. Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes.

Integrity signals

Registry

Crossref · 10.1038/nrg2341

Cites

108 of 108 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Self-citation
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
Okano, M., Bell, D. W., Haber, D. A., & Li, E. (1999) · Cell · doi:10.1016/s0092-8674(00)81656-6 · Cited by 6,143
The Epigenomics of Cancer
Jones, P. A., & Baylin, S. B. (2007) · Cell · doi:10.1016/j.cell.2007.01.029 · Cited by 4,515
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
CpG-rich islands and the function of DNA methylation
Bird, A. P. (1986) · Nature · doi:10.1038/321209a0 · Cited by 3,777
Self-citation
Epigenetic differences arise during the lifetime of monozygotic twins
Fraga, M. F., Ballestar, E., Paz, M. F., Ropero, S., Setien, F., Ballestar, M. L., Heine-Suñer, D., Cigudosa, J. C., Urioste, M., Benitez, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500398102 · Cited by 3,602
CpG Islands in vertebrate genomes
Gardiner‐Garden, M., & Frommer, M. (1987) · Journal of Molecular Biology · doi:10.1016/0022-2836(87)90689-9 · Cited by 3,417
A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
Frommer, M., McDonald, L. E., Millar, D. S., Collis, C. M., Watt, F., Grigg, G. W., Molloy, P. L., & Paul, C. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1827 · Cited by 3,238
Perceptions of epigenetics
Bird, A. (2007) · Nature · doi:10.1038/nature05913 · Cited by 3,011
Self-citation
DNA methylation and human disease
Robertson, K. D. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1655 · Cited by 2,864

Show all 108 references

Sorted by citations

Items 201–300 of 1,007

Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease
Blanch, M., Mosquera, J. L., Ansoleaga, B., Ferrer, I., & Barrachina, M. (2016) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.10.004 · Cited by 192
Vascular Smooth Muscle Progenitor Cells
Majesky, M. W., Dong, X. R., Regan, J. N., & Hoglund, V. J. (2011) · Circulation Research · doi:10.1161/circresaha.110.223800 · Cited by 196
m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer
Zhao, Y., Zhao, Q., Kaboli, P. J., Shen, J., Li, M., Wu, X., Yin, J., Zhang, H., Wu, Y., Lin, L., et al. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.06.007 · Cited by 185
Dynamics and Context-Dependent Roles of DNA Methylation
Ambrosi, C. M., Manzo, M., & Baubec, T. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.02.008 · Cited by 201
Epigenetics and its implications for ecotoxicology
Vandegehuchte, M., & Janssen, C. (2011) · Ecotoxicology · doi:10.1007/s10646-011-0634-0 · Cited by 199
Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders
Dudley, K. J., Li, X., Kobor, M. S., Kippin, T. E., & Bredy, T. W. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.016 · Cited by 180
DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation
Hutnick, L. K., Golshani, P., Namihira, M., Xue, Z., Matynia, A., Yang, X. W., Silva, A. J., Schweizer, F. E., & Fan, G. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp222 · Cited by 181
RNA m6A regulates transcription via DNA demethylation and chromatin accessibility
Deng, S., Zhang, J., Su, J., Zuo, Z., Zeng, L., Liu, K., Zheng, Y., Huang, X., Bai, R., Zhuang, L., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01173-1 · Cited by 187
DNA methylation and gene expression
Siegfried, Z., & Simon, I. (2009) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.64 · Cited by 186
DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter
Han, H., Cortez, C. C., Yang, X., Nichols, P. W., Jones, P. A., & Liang, G. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr356 · Cited by 195
Epigenetic mechanisms of major depression: Targeting neuronal plasticity
Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181
Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research
Shenker, N. S., & Flanagan, J. M. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.550 · Cited by 183
Synthesis and Biochemical Evaluation of Δ 2 -Isoxazoline Derivatives as DNA Methyltransferase 1 Inhibitors
Castellano, S., Kuck, D., Viviano, M., Yoo, J., López-Vallejo, F., Conti, P., Tamborini, L., Pinto, A., Medina‐Franco, J. L., & Sbardella, G. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm2010404 · Cited by 183
DNA–bare gold affinity interactions: mechanism and applications in biosensing
Koo, K. M., Sina, A. A. I., Carrascosa, L. G., Shiddiky, M. J. A., & Trau, M. (2015) · Analytical Methods · doi:10.1039/c5ay01479d · Cited by 178
DNA manipulation, sorting, and mapping in nanofluidic systems
Levy, S. L., & Craighead, H. G. (2010) · Chemical Society Reviews · doi:10.1039/b820266b · Cited by 180
Zinc Finger Protein ZFP57 Requires Its Co-factor to Recruit DNA Methyltransferases and Maintains DNA Methylation Imprint in Embryonic Stem Cells via Its Transcriptional Repression Domain
Zuo, X., Sheng, J., Lau, H.-T., McDonald, C. M., Andrade, M., Cullen, D. E., Bell, F. T., Iacovino, M., Kyba, M., Xu, G., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322644 · Cited by 189
Epstein-Barr Virus Latency in B Cells Leads to Epigenetic Repression and CpG Methylation of the Tumour Suppressor Gene Bim
Paschos, K., Smith, P. R., Anderton, E., Middeldorp, J. M., White, R. E., & Allday, M. J. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000492 · Cited by 175
Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation
Tsagaratou, A., Äijö, T., Lio, C. J., Yue, X., Huang, Y., Jacobsen, S. E., Lähdesmäki, H. J., & Rao, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412327111 · Cited by 186
Evolution of bird genomes—a transposon's‐eye view
Kapusta, A., & Suh, A. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13295 · Cited by 178
NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs
Haute, L. V., Lee, S.-Y., McCann, B. J., Powell, C. A., Bansal, D., Vasiliauskaitė, L., Garone, C., Shin, S., Kim, J., Frye, M., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz559 · Cited by 181
Vasa genes: Emerging roles in the germ line and in multipotent cells
Gustafson, E. A., & Wessel, G. M. (2010) · BioEssays · doi:10.1002/bies.201000001 · Cited by 173
Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
Sina, A. A. I., Carrascosa, L. G., Liang, Z., Grewal, Y. S., Wardiana, A., Shiddiky, M. J. A., Gardiner, R. A., Samaratunga, H., Gandhi, M. K., Scott, R. J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07214-w · Cited by 169
Function and Evolution of DNA Methylation in Nasonia vitripennis
Wang, X., Wheeler, D., Avery, A., Rago, A., Choi, J.-H., Colbourne, J. K., Clark, A. G., & Werren, J. H. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003872 · Cited by 172
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Slieker, R. C., van Iterson, M., Luijk, R., Beekman, M., Zhernakova, D. V., Moed, M. H., Mei, H., van Galen, M., Deelen, P., Bonder, M. J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1053-6 · Cited by 171
Bioinformatics approaches for genomics and post genomics applications of next-generation sequencing
Horner, D. S., Pavesi, G., Castrignanò, T., Meo, P. D. D., Liuni, S., Sammeth, M., Picardi, E., & Pesole, G. (2009) · Briefings in Bioinformatics · doi:10.1093/bib/bbp046 · Cited by 183
RETRACTED: METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing
Chen, X., Xu, M., Xu, X., Zeng, K., Liu, X., Sun, L., Pan, B., He, B., Pan, Y., Sun, H., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.11.016 · Cited by 171
Retracted
Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers
Jin, J., Xie, Y., Zhang, J.-S., Wang, J., Dai, S.-J., He, W., Li, S.-Y., Ashby, C. R., Chen, Z., & He, Q. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100929 · Cited by 185
Epigenetic aberrations during oncogenesis
Hatziapostolou, M., & Iliopoulos, D. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0624-z · Cited by 173
Genome-wide association between DNA methylation and alternative splicing in an invertebrate
Flores, K., Wolschin, F., Corneveaux, J. J., Allen, A. N., Huentelman, M. J., & Amdam, G. V. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-480 · Cited by 174
High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors
Cattoglio, C., Pellin, D., Rizzi, E., Maruggi, G., Corti, G., Miselli, F., Sartori, D., Guffanti, A., Serio, C. D., Ambrosi, A., et al. (2010) · Blood · doi:10.1182/blood-2010-05-283523 · Cited by 175
Molecular aspects of steroidogenic factor 1 (SF-1)
Høivik, E. A., Lewis, A. E., Aumo, L., & Bakke, M. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.003 · Cited by 166
DNA Methylation and Cancer
Taberlay, P. C., & Jones, P. A. (2010) · Springer eBooks · doi:10.1007/978-3-7643-8989-5_1 · Cited by 174
Personalized treatment strategies in glioblastoma: MGMT promoter methylation status
Thon, N., Kreth, S., & Kreth, F. W. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s50208 · Cited by 180
Evolution of DNA Methylome Diversity in Eukaryotes
de Mendoza, A., Lister, R., & Bogdanović, O. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.11.003 · Cited by 170
Epigenome Mapping in Normal and Disease States
Maunakea, A. K., Chepelev, I., & Zhao, K. (2010) · Circulation Research · doi:10.1161/circresaha.110.222463 · Cited by 165
Epigenetics in Insects: Genome Regulation and the Generation of Phenotypic Diversity
Glastad, K. M., Hunt, B. G., & Goodisman, M. A. D. (2018) · Annual Review of Entomology · doi:10.1146/annurev-ento-011118-111914 · Cited by 176
Epigenetics: poly(ADP‐ribosyl)ation of PARP‐1 regulates genomic methylation patterns
Caiafa, P., Guastafierro, T., & Zampieri, M. (2008) · The FASEB Journal · doi:10.1096/fj.08-123265 · Cited by 176
Association mapping in plants in the post-GWAS genomics era
Gupta, P. K., Kulwal, P. L., & Jaiswal, V. (2019) · Advances in genetics · doi:10.1016/bs.adgen.2018.12.001 · Cited by 167
Impact of DNA methylation on 3D genome structure
Buitrago, D., Labrador, M., Arcon, J. P., Lema, R., Flores, O., Esteve‐Codina, A., Blanc, J. M., Villegas, N., Bellido, D., Gut, M. O., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23142-8 · Cited by 173
Genomics of DNA cytosine methylation in Escherichia coli reveals its role in stationary phase transcription
Kahramanoglou, C., Prieto, A. I., Khedkar, S., Haase, B., Gupta, A., Beneš, V., Fraser, G. M., Luscombe, N. M., & Seshasayee, A. S. N. (2012) · Nature Communications · doi:10.1038/ncomms1878 · Cited by 156
Evolution of DNA Methylation Patterns in the Brassicaceae is Driven by Differences in Genome Organization
Seymour, D. K., Koenig, D., Hagmann, J., Becker, C., & Weigel, D. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004785 · Cited by 162
DNA Methylation Impacts Gene Expression and Ensures Hypoxic Survival of Mycobacterium tuberculosis
Shell, S. S., Prestwich, E. G., Baek, S.-H., Shah-Rohlfs, R., Sassetti, C. M., Dedon, P. C., & Fortune, S. M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003419 · Cited by 168
epiGBS: reference-free reduced representation bisulfite sequencing
van Gurp, T. P., Wagemaker, C. A. M., Wouters, B., Vergeer, P., Ouborg, J., & Verhoeven, K. J. F. (2016) · Nature Methods · doi:10.1038/nmeth.3763 · Cited by 164
Maternal nutritional status, C1metabolism and offspring DNA methylation: a review of current evidence in human subjects
Dominguez-Salas, P., Cox, S. E., Prentice, A. M., Hennig, B. J., & Moore, S. E. (2012) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111003338 · Cited by 163
Epigenetic Signaling in Psychiatric Disorders
Peña, C. J., Bagot, R. C., Labonté, B., & Nestler, E. J. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.03.016 · Cited by 163
Probing DNA shape and methylation state on a genomic scale with DNase I
Lazarovici, A., Zhou, T., Shafer, A., Dantas Machado, A. C., Riley, T. R., Sandstrom, R., Sabo, P. J., Lu, Y., Rohs, R., Stamatoyannopoulos, J. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216822110 · Cited by 162
DNA Methylation Analysis of Chromosome 21 Gene Promoters at Single Base Pair and Single Allele Resolution
Zhang, Y., Rohde, C., Tierling, S., Jurkowski, T. P., Bock, C., Santacruz, D., Ragozin, S., Reinhardt, R., Groth, M., Walter, J., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000438 · Cited by 166
Functions of DNA Methylation and Hydroxymethylation in Mammalian Development
Guibert, S., & Weber, M. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416027-9.00002-4 · Cited by 173
5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes
Mellén, M., Ayata, P., & Heintz, N. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708044114 · Cited by 151
Divergent Whole-Genome Methylation Maps of Human and Chimpanzee Brains Reveal Epigenetic Basis of Human Regulatory Evolution
Zeng, J., Konopka, G., Hunt, B. G., Preuss, T. M., Geschwind, D. H., & Yi, S. V. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.07.024 · Cited by 167
DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update
Anglim, P. P., Alonzo, T. A., & Laird‐Offringa, I. A. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-81 · Cited by 160
The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention
Schiele, M. A., Gottschalk, M. G., & Domschke, K. (2020) · Clinical Psychology Review · doi:10.1016/j.cpr.2020.101830 · Cited by 156
Altered CpG methylation in sporadic Alzheimer's disease is associated with APP and MAPT dysregulation
Iwata, A., Nagata, K., Hatsuta, H., Takuma, H., Bundo, M., Iwamoto, K., Tamaoka, A., Murayama, S., Saido, T. C., & Tsuji, S. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt451 · Cited by 158
DNA Methylation and Histone H1 Jointly Repress Transposable Elements and Aberrant Intragenic Transcripts
Choi, J., Lyons, D. B., Kim, M. Y., Moore, J. D., & Zilberman, D. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.10.011 · Cited by 159
Epigenetics in Alzheimer’s Disease: Perspective of DNA Methylation
Qazi, T. J., Quan, Z., Mir, A., & Qing, H. (2018) · Molecular Neurobiology · doi:10.1007/s12035-016-0357-6 · Cited by 153
DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer
Toiyama, Y., Okugawa, Y., & Goel, A. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.001 · Cited by 159
HIV Latency: Should We Shock or Lock?
Darcis, G., Driessche, B. V., & Lint, C. M. V. (2017) · Trends in Immunology · doi:10.1016/j.it.2016.12.003 · Cited by 152
Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methodsPreprint
Stevens, M. W., Cheng, J. B., Li, D., Xie, M., Hong, C., Maire, C. L., Ligon, K. L., Hirst, M., Marra, M. A., Costello, J., et al. (2013) · Genome Research · doi:10.1101/gr.152231.112 · Cited by 160
Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease
Pietrzak, M., Rempala, G., Nelson, P. T., Zheng, J.-J., & Hetman, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022585 · Cited by 155
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers
Oda, M., Glass, J. L., Thompson, R. F., Mo, Y., Olivier, E. N., Figueroa, M. E., Selzer, R. R., Richmond, T., Zhang, X., Dannenberg, L. O., et al. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp260 · Cited by 154
Self-citation
Impact of Methylation on the Physical Properties of DNA
Pérez, A., Castellazzi, C. L., Battistini, F., Collinet, K., Flores, O., Deniz, Ö., Ruiz, M. L., Torrents, D., Eritja, R., Soler‐López, M., et al. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2012.03.056 · Cited by 158
Epigenetic control of gene expression: Potential implications for cancer treatment
Perri, F., Longo, F., Giuliano, M., Sabbatino, F., Favia, G., Ionna, F., Addeo, R., Scarpati, G. D. V., Lorenzo, G. D., & Pisconti, S. (2017) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2017.01.020 · Cited by 154
Parallel Epigenomic and Transcriptomic Responses to Viral Infection in Honey Bees (Apis mellifera)
Galbraith, D. A., Yang, X., Niño, E. L., Yi, S. V., & Grozinger, C. M. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004713 · Cited by 157
Is There a Relationship between DNA Methylation and Phenotypic Plasticity in Invertebrates?
Roberts, S., & Gavery, M. R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2011.00116 · Cited by 157
Mutual regulation of microRNAs and DNA methylation in human cancers
Wang, S., Wu, W., & Claret, F. X. (2017) · Epigenetics · doi:10.1080/15592294.2016.1273308 · Cited by 153
Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms
Tonna, S. J., El‐Osta, A., Cooper, M. E., & Tikellis, C. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.55 · Cited by 151
Epigenetic regulation and cancer (Review)
CHEN, Q. W., Zhu, X., Li, Y., & Meng, Z. (2013) · Oncology Reports · doi:10.3892/or.2013.2913 · Cited by 150
CYP81A68 confers metabolic resistance to ALS and ACCase-inhibiting herbicides and its epigenetic regulation in Echinochloa crus-galli
Pan, L., Guo, Q., Wang, J., Shi, L., Yang, X., Zhou, Y., Yu, Q. P., & Bai, L. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128225 · Cited by 150
Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries
Nguyen, U. T. T., Bittova, L., Müller, M. M., Fierz, B., David, Y., Houck-Loomis, B. R., Feng, V., Dann, G. P., & Muir, T. W. (2014) · Nature Methods · doi:10.1038/nmeth.3022 · Cited by 149
Ecological Epigenetics: Beyond MS-AFLP
Schrey, A. W., Álvarez, M., Foust, C. M., Kilvitis, H. J., Lee, J. D., Liebl, A. L., Martin, L. B., Richards, C. L., & Robertson, M. (2013) · Integrative and Comparative Biology · doi:10.1093/icb/ict012 · Cited by 148
Methylation of DNA in Cancer
Watanabe, Y., & Maekawa, M. (2010) · Advances in clinical chemistry · doi:10.1016/s0065-2423(10)52006-7 · Cited by 145
DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia
Milani, L. A., Lundmark, A., Kiialainen, A., Nordlund, J., Flægstad, T., Forestier, E., Heyman, M. M., Jónmundsson, G., Kanerva, J. A., Schmiegelow, K., et al. (2009) · Blood · doi:10.1182/blood-2009-04-214668 · Cited by 146
Lysine Demethylases Inhibitors
Suzuki, T., & Miyata, N. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm201048w · Cited by 146
Evolutionary Transition of Promoter and Gene Body DNA Methylation across Invertebrate–Vertebrate Boundary
Keller, T. E., Han, P., & Yi, S. V. (2015) · Molecular Biology and Evolution · doi:10.1093/molbev/msv345 · Cited by 148
MethSMRT: an integrative database for DNA N6-methyladenine and N4-methylcytosine generated by single-molecular real-time sequencing
Ye, P., Luan, Y., Chen, K., Liu, Y., Xiao, C., & Xie, Z. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw950 · Cited by 149
DNA methylation and transcriptional noise
Huh, I., Zeng, J., Park, T., & Yi, S. V. (2013) · Epigenetics & Chromatin · doi:10.1186/1756-8935-6-9 · Cited by 147
A comprehensive epigenome atlas reveals DNA methylation regulating skeletal muscle development
Yang, Y., Fan, X., Yan, J., Chen, M., Zhu, M., Tang, Y., Liu, S., & Tang, Z. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa1203 · Cited by 146
Tissue- and Expression Level–Specific Chromatin Looping at Maizeb1Epialleles
Louwers, M., Bader, R., Haring, M., DRIEL, R. V., de Laat, W. L., & Stam, M. E. (2009) · The Plant Cell · doi:10.1105/tpc.108.064329 · Cited by 151
Increased 5-Methylcytosine and Decreased 5-Hydroxymethylcytosine Levels are Associated with Reduced Striatal A2AR Levels in Huntington’s Disease
Villar-Menéndez, I., Blanch, M., Tyebji, S., Pereira‐Veiga, T., Albasanz, J. L., Martı́n, M., Ferrer, I., Pérez‐Navarro, E., & Barrachina, M. (2013) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8219-0 · Cited by 144
Mechanism and Stem‐Cell Activity of 5‐Carboxycytosine Decarboxylation Determined by Isotope Tracing
Schießer, S., Hackner, B., Pfaffeneder, T., Müller, M., Hagemeier, C., Truß, M., & Carell, T. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201202583 · Cited by 143
Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans
Sun, Y. V., Smith, A. K., Conneely, K. N., Chang, Q., Li, W., Zagel, A. L., Smith, J. A., Almli, L. M., Binder, E. B., Klengel, T., et al. (2013) · Human Genetics · doi:10.1007/s00439-013-1311-6 · Cited by 144
Ethnic and population differences in the genetic predisposition to human obesity
Stryjecki, C., Alyass, A., & Meyre, D. (2017) · Obesity Reviews · doi:10.1111/obr.12604 · Cited by 147
Epigenetic flexibility in metabolic regulation: disease cause and prevention
Kirchner, H., Osler, M. E., Krook, A., & Zierath, J. R. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.11.008 · Cited by 143
An epigenetic hypothesis of aging-related cognitive dysfunction
Penner (2010) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2010.00009 · Cited by 144
Hypermethylation of Tumor Suppressor Genes Involved in Critical Regulatory Pathways for Developing a Blood-Based Test in Breast Cancer
Radpour, R., Barekati, Z., Kohler, C., Lv, Q., Bürki, N., Diesch, C., Bitzer, J., Zheng, H. Y., Schmid, S. M., & Zhong, X. Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016080 · Cited by 142
NRL-Regulated Transcriptome Dynamics of Developing Rod Photoreceptors
Kim, J.-W., Yang, H., Brooks, M. J., Zelinger, L., Karakülah, G., Gotoh, N., Boleda, A., Gieser, L. M., Giuste, F., Whitaker, D. T., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.074 · Cited by 144
Molecular Complexes at Euchromatin, Heterochromatin and Centromeric Chromatin
Morrison, O., & Thakur, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136922 · Cited by 193
Genome-wide and single-base resolution DNA methylomes of the Pacific oyster Crassostrea gigas provide insight into the evolution of invertebrate CpG methylation
Wang, X., Li, Q., Lian, J., Li, L., Jin, L., Cai, H., Xu, F., Qi, H., Zhang, L., Wu, F., et al. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1119 · Cited by 145
Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans
Fryer, A. A., Emes, R. D., ISMAIL, K. M. K., Haworth, K. E., Mein, C. A., Carroll, W. D., & Farrell, W. E. (2011) · Epigenetics · doi:10.4161/epi.6.1.13392 · Cited by 140
Snf2-family proteins: chromatin remodellers for any occasion
Ryan, D., & Owen‐Hughes, T. (2011) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2011.07.022 · Cited by 148
Neurobiology of early life adversity: A systematic review of meta-analyses towards an integrative account of its neurobiological trajectories to mental disorders
Hakamata, Y., Suzuki, Y., Kobashikawa, H., & Hori, H. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100994 · Cited by 159
Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition
Hauke, J., Rießland, M., Lunke, S., Eyüpoglu, I. Y., Blümcke, I., El‐Osta, A., Wirth, B., & Hahnen, E. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn357 · Cited by 143
Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date
Mould, D. P., McGonagle, A. E., Wiseman, D. H., Williams, E. L., & Jordan, A. M. (2014) · Medicinal Research Reviews · doi:10.1002/med.21334 · Cited by 138
RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation
Jiang, L., Wang, J., Wang, K., Wang, H., Wu, Q., Yang, C., Yu, Y., Ni, P., Zhong, Y., Song, Z., et al. (2021) · Blood · doi:10.1182/blood.2020008986 · Cited by 138
A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics
Su, Z., Shu, L., Khor, T. O., Lee, J. H., Fuentes, F., & Kong, A. T. (2012) · Topics in current chemistry · doi:10.1007/128_2012_340 · Cited by 139
Genome-scale methylation analysis of Parkinson's disease patients' brains reveals DNA hypomethylation and increased mRNA expression of cytochrome P450 2E1
Kaut, O., Schmitt, I., & Wüllner, U. (2012) · Neurogenetics · doi:10.1007/s10048-011-0308-3 · Cited by 138
Epigenetic Regulations in Neuropsychiatric Disorders
Kuehner, J. N., Bruggeman, E. C., Wen, Z., & Yao, B. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00268 · Cited by 144
Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
Flanagan, J. M., Muñoz-Alegre, M., Henderson, S. R., Tang, T., Sun, P., Johnson, N., Fletcher, O., dos‐Santos‐Silva, I., Peto, J., Boshoff, C., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp033 · Cited by 137
Structure and function of active chromatin and DNase I hypersensitive sites
Cockerill, P. N. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08128.x · Cited by 135
Epigenetics and Evolution
Mendizabal, I., Keller, T. E., Zeng, J., & Yi, S. V. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu040 · Cited by 139

Authors: Suzuki, M. M., & Bird, A.
Affiliations: Wellcome Centre for Cell Biology (GB)
Corresponding author: Suzuki, Miho M.
ORCID: Suzuki, Miho M.
Bird, Adrian
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 9
Issue: 6
Pages: 465-476
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2341
OpenAlex: W2114970231
Cited by: 3,039
References: 108
Citations by year: 2026: 61 · 2025: 89 · 2024: 120 · 2023: 128 · 2022: 167 · 2021: 236 · 2020: 184 · 2019: 163 · 2018: 173 · 2017: 201 · 2016: 195 · 2015: 195 · 2014: 224 · 2013: 214 · 2012: 198
FWCI: 12.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: DNA methylation, gene body, promoter methylation, gene silencing, gene expression regulation, epigenomics, cytosine methylation, development (biology), genome-wide methylation mapping
MeSH terms: Animals, Humans, Transcription, Genetic, Genome, DNA Methylation, Genomics, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

DNA methylation landscapes: provocative insights from epigenomics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks