Cited by 3,039Epigenetics and DNA MethylationGenomics and Chromatin DynamicsGenetic Syndromes and Imprinting

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DNA methylation landscapes: provocative insights from epigenomics

Suzuki, Miho M., Bird, Adrian·2008·Nature Reviews Genetics

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Abstract

The genomes of many animals, plants and fungi are tagged by methylation of DNA cytosine. To understand the biological significance of this epigenetic mark it is essential to know where in the genome it is located. New techniques are making it easier to map DNA methylation patterns on a large scale and the results have already provided surprises. In particular, the conventional view that DNA methylation functions predominantly to irreversibly silence transcription is being challenged. Not only is promoter methylation often highly dynamic during development, but many organisms also seem to target DNA methylation specifically to the bodies of active genes.

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Authors: Suzuki, M. M., & Bird, A.
Affiliations: Wellcome Centre for Cell Biology (GB)
Corresponding author: Suzuki, Miho M.
ORCID: Suzuki, Miho M.
Bird, Adrian
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 9
Issue: 6
Pages: 465-476
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg2341
OpenAlex: W2114970231
Cited by: 3,039
References: 108
Citations by year: 2026: 61 · 2025: 89 · 2024: 120 · 2023: 128 · 2022: 167 · 2021: 236 · 2020: 184 · 2019: 163 · 2018: 173 · 2017: 201 · 2016: 195 · 2015: 195 · 2014: 224 · 2013: 214 · 2012: 198
FWCI: 12.51
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Keywords: DNA methylation, gene body, promoter methylation, gene silencing, gene expression regulation, epigenomics, cytosine methylation, development (biology), genome-wide methylation mapping
MeSH terms: Animals, Humans, Transcription, Genetic, Genome, DNA Methylation, Genomics, Epigenesis, Genetic

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DNA methylation landscapes: provocative insights from epigenomics

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