Histone methylation: a dynamic mark in health, disease and inheritance

Chromatin modifications and their function

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Regulation of chromatin by histone modifications

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

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Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

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Epigenetic modifications: Critical participants of the PD‑L1 regulatory mechanism in solid tumors (Review)

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Structural and Functional Landscape of FAD-Dependent Histone Lysine Demethylases for New Drug Discovery

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Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery

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Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation

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Histone modifications and mRNA expression in the inner cell mass and trophectoderm of bovine blastocysts

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Dynamic behavior of the post‐SET loop region of NSD1: Implications for histone binding and drug development

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Epigenetics of pheochromocytoma and paraganglioma

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Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease

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The complex CBX7-PRMT1 has a critical role in regulating E-cadherin gene expression and cell migration

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Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury

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Dynamic regulators of ferroptosis: Post-translational modifications in ferroptotic cell death

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Review of Environmental Impact on the Epigenetic Regulation of Atopic Diseases

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SUMO modification system facilitates the exchange of histone variant H2A.Z-2 at DNA damage sites

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H3K9me3, H3K36me3, and H4K20me3 Expression Correlates with Patient Outcome in Esophageal Squamous Cell Carcinoma as Epigenetic Markers

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Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner

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Early Life Stress- and Drug-Induced Histone Modifications Within the Ventral Tegmental Area

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A novel EZH2/NXPH4/CDKN2A axis is involved in regulating the proliferation and migration of non-small cell lung cancer cells

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Genetic intersection between dystonia and neurodevelopmental disorders: Insights from genomic sequencing

Dzinovic, I., Winkelmann, J., & Zech, M. (2022) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2022.08.019 · Cited by 24

Recent advances of LSD1/KDM1A inhibitors for disease therapy

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The Role of Histone Modifications in the Pathogenesis of Diabetic Kidney Disease

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Persister cell plasticity in tumour drug resistance

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Epigenetic methylations and their connections with metabolism

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Mechanisms underlying the tissue-specific and regulated activity of the Gnrhr promoter in mammals

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Oncogene LSD1 is epigenetically suppressed by miR-137 overexpression in human non-small cell lung cancer

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Chromatin state dynamics during NK cell activation

Li, Y., Wang, J., Yin, J., Liu, X., Yu, M., Li, T., Yan, H., & Wang, X. (2017) · Oncotarget · doi:10.18632/oncotarget.16688 · Cited by 24

Opposite Effects of SET7/9 on Apoptosis of Human Acute Myeloid Leukemia Cells and Lung Cancer Cells

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An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2

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New discoveries of mdig in the epigenetic regulation of cancers

Zhang, Q., Thakur, C., Shi, J., Sun, J., Fu, Y. S., Stemmer, P. M., & Chen, F. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.013 · Cited by 24

Structural heterogeneity of the mammalian polycomb repressor complex in immune regulation

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Phenotypic plasticity as a facilitator of microbial evolution

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Epigenetic remodelling under hypoxia

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Pulmonary Hypertension: Molecular Mechanisms and Clinical Studies

Adu‐Amankwaah, J., You, Q., Liu, X., Jiang, J., Yang, D., Liu, K., Yuan, J., Wang, Y., Hu, Q., & Tan, R. (2025) · MedComm · doi:10.1002/mco2.70134 · Cited by 24

Epigenetic regulation by DNA methylation, histone modifications and chromatin remodeling complexes in controlling spermatogenesis and their dysfunction with male infertility

Cui, Y., Deng, J., Zhang, Y., Du, L., Jiang, F., Li, C., Chen, W., Zhang, H., & He, Z. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05831-5 · Cited by 28

A regulatory circuitry comprising TP53, miR-29 family, and SETDB1 in non-small cell lung cancer

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Molecular mechanisms regulating lifespan and environmental stress responses

Kishimoto, S., Uno, M., & Nishida, E. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0080-y · Cited by 23

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase

Brewitz, L., Tumber, A., Thalhammer, A., Salah, E., Christensen, K. E., & Schofield, C. J. (2020) · ChemMedChem · doi:10.1002/cmdc.202000147 · Cited by 22

Recent advancements in understanding the role of epigenetics in the auditory system

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Controlling the Controllers: Regulation of Histone Methylation by Phosphosignalling

Separovich, R. J., Pang, C. N. I., & Wilkins, M. R. (2020) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.08.004 · Cited by 23

Epigenetic Regulators of White Adipocyte Browning

Nanduri, R. (2021) · Epigenomes · doi:10.3390/epigenomes5010003 · Cited by 23

Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active

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Epigenetic Regulatory Dynamics in Models of Methamphetamine-Use Disorder

Jayanthi, S., McCoy, M. T., & Cadet, J. L. (2021) · Genes · doi:10.3390/genes12101614 · Cited by 22

Chromatin Structure and Dynamics: Focus on Neuronal Differentiation and Pathological Implication

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8-Hydroxyquinoline-modified ruthenium( ii ) polypyridyl complexes for JMJD inhibition and photodynamic antitumor therapy

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Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors

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Genetically Encoded Molecular Biosensors To Image Histone Methylation in Living Animals

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Impaired removal of H3K4 methylation affects cell fate determination and gene transcription

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KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer

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Integrative genomic and transcriptomic analysis for pinpointing recurrent alterations of plant homeodomain genes and their clinical significance in breast cancer

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SPION ‐mediated miR‐141 promotes the differentiation of Hu AESC s into dopaminergic neuron‐like cells via suppressing lnc RNA ‐ HOTAIR

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Quantitative analysis of global protein lysine methylation by mass spectrometry

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VEPAD - Predicting the effect of variants associated with Alzheimer's disease using machine learning

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Epigenetic Alterations and Biomarkers for Immune Checkpoint Inhibitors–Current Standards and Future Perspectives in Malignant Pleural Mesothelioma Treatment

Yoshikawa, Y., Kuribayashi, K., Minami, T., Ohmuraya, M., & Kijima, T. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.554570 · Cited by 23

Ketogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki syndrome

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Oxidative stress-mediated epigenetic remodeling, metastatic progression and cell signaling in cancer

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EZH2-mediated macrophage-to-myofibroblast transition contributes to calcium oxalate crystal-induced kidney fibrosis

Xia, Y., Ye, Z., Li, B., Yan, X., Yuan, T., Li, L., Song, B., Yu, W., Rao, T., Ning, J., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07735-3 · Cited by 22

Repressive histone methylation: A case study in deterministic versus stochastic gene regulation

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Highly Efficient Extraction of Cellular Nucleic Acid Associated Proteins in Vitro with Magnetic Oxidized Carbon Nanotubes

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Epigenetic Regulation of Circadian Clocks and Its Involvement in Drug Addiction

Saad, L., Zwiller, J., Kalsbeek, A., & Anglard, P. (2021) · Genes · doi:10.3390/genes12081263 · Cited by 24

KDM3A-mediated SP1 activates PFKFB4 transcription to promote aerobic glycolysis in osteosarcoma and augment tumor development

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JmjC Family of Histone Demethylases Form Nuclear Condensates

Vicioso‐Mantis, M., Aguirre, S., & Martínez‐Balbás, M. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147664 · Cited by 22

PHF20 is crucial for epigenetic control of starvation-induced autophagy through enhancer activation

Park, S. W., Kim, J., Oh, S., Lee, J., Cha, J., Lee, H. S., Kim, K. I., Park, D., & Baek, S. H. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac584 · Cited by 22

Role of Histone Deacetylases in T-Cell Development and Function

Pieniawska, M., & Iżykowska, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147828 · Cited by 24

Epigenetics of neural differentiation: Spotlight on enhancers

Giacoman-Lozano, M., Meléndez-Ramírez, C., Martínez-Ledesma, E., Durán, R. C., & Velasco, I. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1001701 · Cited by 23

The Role of Epigenetics in the Development and Progression of Multiple Myeloma

Ismail, N. H., Mussa, A., Zakaria, N. A., Al-Khreisat, M. J., Zahidin, M. A., Ramli, N. N., Mohammad, S. N. N. A., Hassan, R., Mohd Noor, N. H., Iberahim, S., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10112767 · Cited by 22

The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis

Guo, P., Hoang, N., Sanchez, J. C., Zhang, E. H., Rajawasam, K., Trinidad, K., Sun, H., & Zhang, H. (2022) · Nature Communications · doi:10.1038/s41467-022-34348-9 · Cited by 22

EZH2 Promotes Cholangiocarcinoma Development and Progression through Histone Methylation and microRNA-Mediated Down-Regulation of Tumor Suppressor Genes

Zhang, J., Chen, W., Ma, W., Han, C., Song, K., Kwon, H., & Wu, T. (2022) · American Journal Of Pathology · doi:10.1016/j.ajpath.2022.08.008 · Cited by 22

Epigenetics in Pancreatic Ductal Adenocarcinoma: Impact on Biology and Utilization in Diagnostics and Treatment

Elrakaybi, A., Ruess, D. A., Lübbert, M., Quante, M., & Becker, H. (2022) · Cancers · doi:10.3390/cancers14235926 · Cited by 22

Tackling triple negative breast cancer with HDAC inhibitors: 6 is the isoform!

Guadagni, A., Barone, S., Alfano, A. I., Pelliccia, S., Bello, I., Panza, E., Summa, V., & Brindisi, M. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116884 · Cited by 22

A course‐based undergraduate research experience investigating p300 bromodomain mutations

Shanle, E. K., Tsun, I. K., & Strahl, B. D. (2015) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.20927 · Cited by 21

An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury

Gupta, R. K., Saha, P., Sen, T., & Sen, N. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.02.015 · Cited by 22

Epigenetics of cutaneous T-cell lymphoma: biomarkers and therapeutic potentials

Lai, P., & Wang, Y. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0216 · Cited by 25

Dynamic multilayered control of m 6 A RNA demethylase activity

Jaafar, C., & Aguiar, R. C. T. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2317847121 · Cited by 24

Epigenetic marvels: exploring the landscape of colorectal cancer treatment through cutting-edge epigenetic-based drug strategies

Tahghighi, A., Seyedhashemi, E., Mohammadi, J., Moradi, A., Esmaeili, A., Pornour, M., Jafarifar, K., & Ganji, S. M. (2025) · Clinical Epigenetics · doi:10.1186/s13148-025-01844-w · Cited by 21

Chemical proteomics approaches to examine novel histone posttranslational modifications

Li, X., & Li, X. D. (2014) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2014.10.015 · Cited by 21

Structure–Activity Relationship Studies on (R)‐PFI‐2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7

Lenstra, D. C., Damen, E., Leenders, R. G. G., Blaauw, R. H., Rutjes, F. P. J. T., Wegert, A., & Mecinović, J. (2018) · ChemMedChem · doi:10.1002/cmdc.201800242 · Cited by 21

An Ethnic Comparison of Arginine Dimethylation and Cardiometabolic Factors in Healthy Black and White Youth: The ASOS and African-PREDICT Studies

Bollenbach, A., Schutte, A. E., Kruger, R., & Tsikas, D. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030844 · Cited by 21

Epigenetic regulation of cancer stem cell and tumorigenesis

Zhu, K., Xie, V. K., & Huang, S. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.05.001 · Cited by 21

Prognostic Value of EZH2 in Non‐Small‐Cell Lung Cancers: A Meta‐Analysis and Bioinformatics Analysis

Fan, K., Zhang, C., Qi, Y., Dai, X., Birling, Y., Tan, Z., & Cao, F. (2020) · BioMed Research International · doi:10.1155/2020/2380124 · Cited by 21

The Effects of Interferons on Allogeneic T Cell Response in GVHD: The Multifaced Biology and Epigenetic Regulations

Zhao, C., Zhang, Y., & Zheng, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.717540 · Cited by 21

“Reading” a new chapter in protozoan parasite transcriptional regulation

Fleck, K., Nitz, M., & Jeffers, V. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1010056 · Cited by 21

Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries

Bilmez, Y., Talibova, G., & Öztürk, S. (2022) · Histochemistry and Cell Biology · doi:10.1007/s00418-022-02102-3 · Cited by 21

Histone Modifications in Acute Kidney Injury

Wang, J., Shen, F., Liu, F., & Zhuang, S. (2022) · Kidney Diseases · doi:10.1159/000527799 · Cited by 23

Hypoxia induces transgenerational epigenetic inheritance of small RNAs

Wang, S. Y., Kim, K., O’Brown, Z. K., Levan, A., Dodson, A. E., Kennedy, S. G., Chernoff, C., & Greer, E. L. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111800 · Cited by 21

Alzheimer’s disease is an inherent, natural part of human brain aging: an integrated perspective

Ferrer, I. (2022) · Free Neuropathology · doi:10.17879/freeneuropathology-2022-3806 · Cited by 25

Targeting epigenetic and post-translational modifications regulating pyroptosis for the treatment of inflammatory diseases

Ri-Wen, Yang, Y., Zhang, T., Liu, C., & Yang, N. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107182 · Cited by 25

Interplay between epigenetics, senescence and cellular redox metabolism in cancer and its therapeutic implications

Balamurli, G., Liew, A. Q. X., Tee, W., & Pervaiz, S. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103441 · Cited by 23

Roles of small molecules in somatic cell reprogramming

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Cross-Species Functional Genomic Analysis Identifies Resistance Genes of the Histone Deacetylase Inhibitor Valproic Acid

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Traceless Semisynthesis of a Set of Histone 3 Species Bearing Specific Lysine Methylation Marks

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