Cited by 2,241Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related gene regulation

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Histone methylation: a dynamic mark in health, disease and inheritance

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Greer, Eric L., Shi, Yang·2012·Nature Reviews Genetics

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Abstract

Organisms require an appropriate balance of stability and reversibility in gene expression programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation is integral to this dynamic control. Post-translational modification of histones by methylation is an important and widespread type of chromatin modification that is known to influence biological processes in the context of development and cellular responses. To evaluate how histone methylation contributes to stable or reversible control, we provide a broad overview of how histone methylation is regulated and leads to biological outcomes. The importance of appropriately maintaining or reprogramming histone methylation is illustrated by its links to disease and ageing and possibly to transmission of traits across generations.

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Authors: Greer, E. L., & Shi, Y.
Affiliations: Boston Children's Hospital (US)
Corresponding author: Shi, Yang
ORCID: Greer, Eric L.
Shi, Yang
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2012-04-03
Volume: 13
Issue: 5
Pages: 343-357
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg3173
PMC: PMC4073795
OpenAlex: W2009858080
Cited by: 2,241
References: 277
Citations by year: 2026: 95 · 2025: 195 · 2024: 173 · 2023: 175 · 2022: 175 · 2021: 167 · 2020: 178 · 2019: 165 · 2018: 164 · 2017: 157 · 2016: 158 · 2015: 149 · 2014: 147 · 2013: 104 · 2012: 38
FWCI: 12.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
U.S. Public Health Service (NCI118487)
National Cancer Institute (R01CA118487)
National Institute of General Medical Sciences (GM058012, R01GM071004, R01GM058012, GM071004)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Keywords: histone methylation, epigenetic regulation, chromatin modification, gene expression regulation, cell identity, development (biology), disease, aging, heredity (biology), transgenerational epigenetic inheritance, histone demethylation
MeSH terms: Histone Methyltransferases, Animals, Caenorhabditis, Drosophila, Female, Histones, Humans, Male, Methylation, Neoplasms, Histone-Lysine N-Methyltransferase, Protein Processing, Post-Translational, Epigenesis, Genetic, Mice, Rats, Histone Demethylases

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Histone methylation: a dynamic mark in health, disease and inheritance

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