Histone methylation: a dynamic mark in health, disease and inheritance

Chromatin modifications and their function

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Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

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A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

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Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

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Integrating Proteomics and Targeted Metabolomics to Understand Global Changes in Histone Modifications

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Identification of SUV39H2 as a potential oncogene in lung adenocarcinoma

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Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer

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The current status of blood epigenetic biomarkers for dementia

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Epigenetic, Metabolic, and Immune Crosstalk in Germinal-Center-Derived B-Cell Lymphomas: Unveiling New Vulnerabilities for Rational Combination Therapies

Serganova, I. S., Chakraborty, S., Yamshon, S., Isshiki, Y., Bucktrout, R., Melnick, A. M., Béguelin, W., & Zappasodi, R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.805195 · Cited by 30

Epigenetic biomarkers in aging and longevity: Current and future application

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Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions

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The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Plasmodium falciparum Gametocyte Development and Transmission

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Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance

Liu, Q., Borcherding, N. C., Shao, P., Maina, P. K., Zhang, W., & Qi, H. H. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2019.102612 · Cited by 30

The Mitochondrial Protein VDAC1 at the Crossroads of Cancer Cell Metabolism: The Epigenetic Link

Amsalem, Z., Arif, T., Shteinfer‐Kuzmine, A., Caspi, V. C., & Shoshan‐Barmatz, V. (2020) · Cancers · doi:10.3390/cancers12041031 · Cited by 30

Cell geometry and the cytoskeleton impact the nucleo-cytoplasmic localisation of the SMYD3 methyltransferase

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Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

Wan, C., Zhang, F., Yao, H., Li, H., & Tuan, R. S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.626708 · Cited by 31

Histone methyltransferase Smyd2 contributes to blood‐brain barrier breakdown in stroke

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The Role of Epigenetic Modifications in Late Complications in Type 1 Diabetes

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The function of histone methylation and acetylation regulators in GBM pathophysiology

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Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis

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Emerging roles for histone modifications in DNA excision repair

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Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase

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Epigenetic Modifications and Neurodegenerative Disorders: A Biochemical Perspective

Zhang, X., Zhang, J., Wang, Y., Wang, M., Tang, M., Lin, Y.-H., & Liu, Q. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00701 · Cited by 28

A bacteriocyte symbiont determines whitefly sex ratio by regulating mitochondrial function

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Epigenetics of Fear, Anxiety and Stress – Focus on Histone Modifications

Ell, M. A., Schiele, M. A., Iovino, N., & Domschke, K. (2023) · Current Neuropharmacology · doi:10.2174/1570159x21666230322154158 · Cited by 29

EED regulates epithelial–mesenchymal transition of cancer cells induced by TGF-β

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A positive role for polycomb in transcriptional regulation via H4K20me1

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Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer

Nishikawaji, T., Akiyama, Y., Shimada, S., Kojima, K., Kawano, T., Eishi, Y., Yuasa, Y., & Tanaka, S. (2016) · Oncotarget · doi:10.18632/oncotarget.11625 · Cited by 29

Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer

Yang, J., Harris, A. L., & Davidoff, A. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010240 · Cited by 30

Integrated Genomic and Proteomic Analyses Reveal Novel Mechanisms of the Methyltransferase SETD2 in Renal Cell Carcinoma Development

Li, L., Miao, W., Huang, M., Williams, P. B., & Wang, Y. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000957 · Cited by 28

The Histone Demethylase JMJD1C Regulates CAMKK2-AMPK Signaling to Participate in Cardiac Hypertrophy

Shuang, Y., Li, Y., Zhao, H., Wang, Q., & Chen, P. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00539 · Cited by 28

Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth

Chen, J., Li, C., Lai, Y.-S., & Hung, W. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01112-z · Cited by 28

Epigenetic enzymes: A role in aging and prospects for pharmacological targeting

PASYUKOVA, E. G., Symonenko, A. V., Rybina, O. Y., & Vaiserman, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101312 · Cited by 28

HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

Kim, H., Ding, Y., Zhang, G., Yan, Y., Conte, D., Dong, M., & Mello, C. C. (2021) · eLife · doi:10.7554/elife.63299 · Cited by 27

Metabolo-epigenetics: the interplay of metabolism and epigenetics during early germ cells development†

Verdikt, R., & Allard, P. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab118 · Cited by 25

Epigenetic regulation of inflammatory factors in adipose tissue

Jung, B. C., & Kang, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159019 · Cited by 28

Drug discovery of histone lysine demethylases (KDMs) inhibitors (progress from 2018 to present)

He, X., Zhang, H., Zhang, Y., Ye, Y., Wang, S., Bai, R., Xie, T., & Ye, X. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114143 · Cited by 28

Epi‐miRNAs : Modern mediators of methylation status in human cancers

Papadimitriou, M., Panoutsopoulou, K., Pilala, K., Scorilas, A., & Avgeris, M. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1735 · Cited by 29

Role of histone modification in the occurrence and development of osteoporosis

Sun, P., Huang, T., Huang, C., Wang, Y., & Tang, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.964103 · Cited by 27

Epigenetic regulation of autophagy by histone-modifying enzymes under nutrient stress

Yu, Y. S., Kim, H.-K., Kim, K. I., & Baek, S. H. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01154-9 · Cited by 31

Neuroepigenetics of ageing and neurodegeneration-associated dementia: An updated review

Mir, F. A., Amanullah, A., Jain, B. P., Hyderi, Z., & Gautam, A. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102067 · Cited by 30

Histone methyltransferase activity affects metabolism in human cells independently of transcriptional regulation

Perez, M. F., & Sarkies, P. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002354 · Cited by 31

Epigenetics and Ocular Diseases: From Basic Biology to Clinical Study

Yan, B., Yao, J., Tao, Z.-F., & Jiang, Q. L. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24522 · Cited by 28

The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1

Mariani, L. L., Lussi, Y., Vandamme, J., Riveiro, A. R., & Salcini, A. E. (2016) · Development · doi:10.1242/dev.132985 · Cited by 26

Adverse effects of bisphenol A and its analogues on male fertility: An epigenetic perspective

Deng, X., Liang, S., Tang, Y., Li, Y., Xu, R., Lu, L., Wang, Q., Zhang, X., & Liu, Y. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.123393 · Cited by 27

Transgenerational Effects of Arsenic Exposure on Learning and Memory in Rats: Crosstalk between Arsenic Methylation, Hippocampal Metabolism, and Histone Modifications

Hua, W., Han, X., Li, F., Lu, L., Sun, Y., Hassanian‐Moghaddam, H., Tian, M., Lu, Y.-Y., & Huang, Q. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c07989 · Cited by 27

Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins

Piao, L., Nakakido, M., Suzuki, T., Dohmae, N., Nakamura, Y., & Hamamoto, R. (2016) · Oncotarget · doi:10.18632/oncotarget.8072 · Cited by 27

Analysis of the role of mutations in the KMT 2D histone lysine methyltransferase in bladder cancer

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Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation

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Epigenetic Regulation of Spermatogonial Stem Cell Homeostasis: From DNA Methylation to Histone Modification

Zhou, S., Feng, S., Qin, W., Wang, X., Tang, Y., & Yuan, S. (2020) · Stem Cell Reviews and Reports · doi:10.1007/s12015-020-10044-3 · Cited by 29

Epigenetic regulation in Alzheimer’s disease: is it a potential therapeutic target?

Coppedè, F. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1916469 · Cited by 30

DIA proteomics analysis through serum profiles reveals the significant proteins as candidate biomarkers in women with PCOS

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Dynamic changes of histone methylation in mammalian oocytes and early embryos

Bilmez, Y., Talibova, G., & Öztürk, S. (2021) · Histochemistry and Cell Biology · doi:10.1007/s00418-021-02036-2 · Cited by 27

Epigenetic Mechanisms as Emerging Therapeutic Targets and Microfluidic Chips Application in Pulmonary Arterial Hypertension

Ho, L., Hossen, M. N., Nguyen, T. B., Vo, A., & Ahsan, F. (2022) · Biomedicines · doi:10.3390/biomedicines10010170 · Cited by 27

The role of epigenetic modification in postoperative cognitive dysfunction

Wu, W.-F., Lin, J.-T., Qiu, Y.-K., Dong, W., Wan, J., Li, S., Zheng, H., & Wu, Y.-Q. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101983 · Cited by 28

Physicochemical modifications of histones and their impact on epigenomics

Andreoli, F., & Río, A. D. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.05.005 · Cited by 29

Histone lysine demethylases in Drosophila melanogaster

Holowatyj, A., Yang, Z.-Q., & Pile, L. A. (2015) · Fly · doi:10.1080/19336934.2015.1074787 · Cited by 27

Human germline and pan-cancer variomes and their distinct functional profiles

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Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells

Li, F., Ortega, J., Gu, L., & Li, G. (2015) · DNA repair · doi:10.1016/j.dnarep.2015.11.021 · Cited by 27

Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors

Milite, C., Feoli, A., Viviano, M., Rescigno, D., Mai, A., Castellano, S., & Sbardella, G. (2016) · ChemMedChem · doi:10.1002/cmdc.201600272 · Cited by 27

Analysis of mRNA abundance for histone variants, histone- and DNA-modifiers in bovine in vivo and in vitro oocytes and embryos

Duan, J. E., Zhu, L., Dong, H., Zheng, X., Jiang, Z., Chen, J., & Tian, X. (2019) · Scientific Reports · doi:10.1038/s41598-018-38083-4 · Cited by 30

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

Samec, M., Líšková, A., Koklesová, L., Mešťanová, V., Franekova, M., Kassayová, M., Bojková, B., Uramova, S., Žúbor, P., Janíková, K., et al. (2019) · Biomolecules · doi:10.3390/biom9120829 · Cited by 27

Integration of epigenetic regulatory mechanisms in heart failure

Sopić, M., Robinson, E. L., Emanueli, C., Srivastava, P. K., Angione, C., Gaetano, C., Condorelli, G., Martelli, F., Pedrazzini, T., Devaux, Y., et al. (2023) · Basic Research in Cardiology · doi:10.1007/s00395-023-00986-3 · Cited by 28

The pharmacoepigenetic paradigm in cancer treatment

Ocaña-Paredes, B., Rivera-Orellana, S., Ramírez-Sánchez, D., Montalvo-Guerrero, J., Freire, M. P., Espinoza-Ferrao, S., Altamirano-Colina, A., Echeverría-Espinoza, P., Ramos-Medina, M. J., Echeverría‐Garcés, G., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1381168 · Cited by 28

Translation of Epigenetics in Cell-Free DNA Liquid Biopsy Technology and Precision Oncology

Tan, W. Y., Nagabhyrava, S., Ang-Olson, O., Das, P., Ladel, L., Sailo, B., He, L., Sharma, A. R., & Ahuja, N. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46070390 · Cited by 28

The Drosophila Huntington's disease gene ortholog dhtt influences chromatin regulation during development

Dietz, K. N., Stefano, L. D., Maher, R. C., Zhu, H., MacDonald, M. E., Gusella, J. F., & Walker, J. A. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu446 · Cited by 28

Low activity of LSD1 elicits a pro-inflammatory gene expression profile in riboflavin-deficient human T Lymphoma Jurkat cells

Liu, D., & Zempleni, J. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0422-6 · Cited by 25

Genome-Wide Epigenetic Studies in Human Disease: A Primer on -Omic Technologies

Yan, H., Tian, S., Slager, S. L., Sun, Z., & Ördög, T. (2015) · American Journal of Epidemiology · doi:10.1093/aje/kwv187 · Cited by 26

Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies

Fratta, E., Montico, B., Rizzo, A., Colizzi, F., Sigalotti, L., & Dolcetti, R. (2016) · Oncotarget · doi:10.18632/oncotarget.10033 · Cited by 26

Epigenetics in Social Insects

Glastad, K. M., Chau, L. M., & Goodisman, M. A. D. (2015) · Advances in insect physiology · doi:10.1016/bs.aiip.2014.12.007 · Cited by 26

Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation

Jeon, J., McGinty, R. K., Muir, T. W., Kim, J., & Kim, J. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky920 · Cited by 29

JMJD2A sensitizes gastric cancer to chemotherapy by cooperating with CCDC8

Nakagawa, T., Sato, Y., Tanahashi, T., Mitsui, Y., Kida, Y., Fujino, Y., Hirata, M., Kitamura, S., Miyamoto, H., Okamoto, K., et al. (2019) · Gastric Cancer · doi:10.1007/s10120-019-01024-9 · Cited by 26

Increase in hippocampal histone H3K9me3 is negatively correlated with memory in old male mice

Kushwaha, A., & Thakur, M. K. (2019) · Biogerontology · doi:10.1007/s10522-019-09850-1 · Cited by 28

Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells in vitro

Al‐Ghabkari, A., & Narendran, A. (2021) · Cancer Biology & Therapy · doi:10.1080/15384047.2021.1902913 · Cited by 26

A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain

Balan, S., Iwayama, Y., Ohnishi, T., Fukuda, M., Shirai, A., Yamada, A., Weirich, S., Schuhmacher, M. K., Dileep, K. V., Endo, T., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01199-7 · Cited by 25

Cocultivation of Anaerobic Fungi with Rumen Bacteria Establishes an Antagonistic Relationship

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Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

Leonen, C. J. A., Shimada, M., Weller, C. E., Nakadai, T., Hsu, P., Tyson, E. L., Mishra, A., Shelton, P. M., Sadilek, M., Hawkins, R. D., et al. (2021) · eLife · doi:10.7554/elife.67952 · Cited by 26

The JMJD Family Histone Demethylases in Crosstalk Between Inflammation and Cancer

Yang, J., Hu, Y., Zhang, B., Liang, X., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.881396 · Cited by 26

G9a/GLP inhibition during ex vivo lymphocyte expansion increases in vivo cytotoxicity of engineered T cells against hepatocellular carcinoma

Lam, M. S. Y., Reales‐Calderón, J. A., Ow, J. R., Aw, J., Tan, D., Vijayakumar, R., Ceccarello, E., Tabaglio, T., Lim, Y. T., Chien, W. L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36160-5 · Cited by 26

Roles of histone methyl‐modifying enzymes in development and progression of cancer

Suzuki, T., Terashima, M., Tange, S., & Ishimura, A. (2013) · Cancer Science · doi:10.1111/cas.12169 · Cited by 26

Genome-Wide Epigenetics

Capell, B. C., & Berger, S. L. (2013) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.173 · Cited by 31

Utx loss causes myeloid transformation

Zheng, L., Xu, L., Xu, Q., Yu, L., Zhao, D., Chen, P., Wang, W., Wang, Y., Han, G., & Chen, C. D. (2018) · Leukemia · doi:10.1038/s41375-018-0011-6 · Cited by 26

The Histone Demethylase Enzymes KDM3A and KDM4B Co-Operatively Regulate Chromatin Transactions of the Estrogen Receptor in Breast Cancer

Jones, D., Wilson, L., Thomas, H., Gaughan, L., & Wade, M. (2019) · Cancers · doi:10.3390/cancers11081122 · Cited by 23

A chromatin scaffold for DNA damage recognition: how histone methyltransferases prime nucleosomes for repair of ultraviolet light-induced lesions

Gsell, C., Richly, H., Coin, F., & Naegeli, H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1229 · Cited by 26

Development and Structural Evaluation of N‐Alkylated trans‐2‐Phenylcyclopropylamine‐Based LSD1 Inhibitors

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Alzheimer’s Disease: the Potential of Epigenetic Treatments and Current Clinical Candidates

Coneys, R., & Wood, I. C. (2020) · Neurodegenerative Disease Management · doi:10.2217/nmt-2019-0034 · Cited by 26

Natural variation in the histone demethylase, KDM4C, influences expression levels of specific genes including those that affect cell growthPreprint

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Mutant IDH : A Targetable Driver of Leukemic Phenotypes Linking Metabolism, Epigenetics and Transcriptional Regulation

Garrett-Bakelman, F. E., & Melnick, A. M. (2016) · Epigenomics · doi:10.2217/epi-2016-0008 · Cited by 25

Pathogenesis and biomarkers of colorectal cancer by epigenetic alteration

Oh, C. K., & Cho, Y. (2024) · Intestinal Research · doi:10.5217/ir.2023.00115 · Cited by 24

Epigenetic biomarkers in Alzheimer's disease: Diagnostic and prognostic relevance

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From the editors

(2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2159

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