Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
Open accessAbstract
Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.
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Common variant SNP effects have been estimated to explain large proportions of the phenotypic heritability for a wide range of diseases: BIP and SCZ; T1DM, T2DM, Crohn's disease, rheumatoid arthritis, celiac disease, and coronary artery disease; and continuous traits (height, intelligence, and body mass).
“Common variant SNP effects have been estimated to explain large proportions of the phenotypic heritability for a wide range of diseases: BIP and SCZ; 69,130 T1DM, T2DM, Crohn’s disease, rheumatoid arthritis, celiac disease, and coronary artery disease; 70,77 and continuous traits (height, intelligence, and body mass). 70,131,132”
From Genetic architectures of psychiatric disorders: the emerging picture and its implications (2012) · cites this paper as [131]
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Cites
GCTA: a tool for genome-wide complex trait analysis
Yang, J., Lee, S. H., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.011 · Cited by 8,279 · see citing works
Self-citationCommon polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
Common SNPs explain a large proportion of the heritability for human height
Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446 · see citing works
Self-citationVariance component model to account for sample structure in genome-wide association studies
Kang, H. M., Sul, J. H., Service, S. K., Zaitlen, N. A., Kong, S.-Y., Freimer, N. B., Sabatti, C., & Eskin, E. (2010) · Nature Genetics · doi:10.1038/ng.548 · Cited by 2,817 · see citing works
Self, S. G., & Liang, K. (1987) · Journal of the American Statistical Association · doi:10.1080/01621459.1987.10478472 · Cited by 2,657 · see citing works
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356 · see citing works
Self-citationChristakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290 · see citing works
Lichtenstein, P., Yip, B. H., Björk, C., Pawitan, Y., Cannon, T. D., Sullivan, P. F., & Hultman, C. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60072-6 · Cited by 2,125 · see citing works
Self-citationHundreds of variants clustered in genomic loci and biological pathways affect human height
Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Willer, C. J., Jackson, A. U., Vedantam, S., Raychaudhuri, S., et al. (2010) · Nature · doi:10.1038/nature09410 · Cited by 1,945 · see citing works
Self-citationGenome-wide association study identifies five new schizophrenia loci
The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011) · Nature Genetics · doi:10.1038/ng.940 · Cited by 1,919 · see citing works
Common variants on chromosome 6p22.1 are associated with schizophrenia
Shi, J., Levinson, D. F., Duan, J., Sanders, A. R., Zheng, Y., Pe’er, I., Dudbridge, F., Holmans, P., Whittemore, A. S., Mowry, B. J., et al. (2009) · Nature · doi:10.1038/nature08192 · Cited by 1,154 · see citing works
Uncovering the roles of rare variants in common disease through whole-genome sequencing
Cirulli, E. T., & Goldstein, D. B. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2779 · Cited by 1,136 · see citing works
Estimating Missing Heritability for Disease from Genome-wide Association Studies
Lee, S. H., Wray, N. R., Goddard, M. E., & Visscher, P. M. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.02.002 · Cited by 1,064 · see citing works
Self-citationGenetic Heterogeneity in Human Disease
McClellan, J., & King, M.-C. (2010) · Cell · doi:10.1016/j.cell.2010.03.032 · Cited by 981 · see citing works
Genome partitioning of genetic variation for complex traits using common SNPs
Yang, J., Manolio, T. A., Pasquale, L. R., Boerwinkle, E., Caporaso, N., Cunningham, J. M., de Andrade, M., Feenstra, B., Feingold, E., Hayes, M. G., et al. (2011) · Nature Genetics · doi:10.1038/ng.823 · Cited by 890 · see citing works
Self-citationSex differences in schizophrenia
Abel, K. M., Drake, R., & Goldstein, J. M. (2010) · International Review of Psychiatry · doi:10.3109/09540261.2010.515205 · Cited by 762 · see citing works
Reconciling the analysis of IBD and IBS in complex trait studies
Powell, J. E., Visscher, P. M., & Goddard, M. E. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2865 · Cited by 391 · see citing works
Self-citationMoskvina, V, Craddock, N., Holmans, P., Nikolov, I., Pahwa, J. S., Green, E., Wellcome Trust Case Control Consortium, Owen, M. J., & O'Donovan, M. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.133 · Cited by 363 · see citing works
Schizophrenia: a common disease caused by multiple rare alleles
McClellan, J. M., Susser, E., & King, M.-C. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.025585 · Cited by 296 · see citing works
Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results
Wray, N. R., Purcell, S. M., & Visscher, P. M. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000579 · Cited by 176 · see citing works
Self-citationYang, Q., Wu, H., Guo, C., & Fox, C. S. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20497 · Cited by 142 · see citing works
Visscher, P. M., Goddard, M. E., Derks, E. M., & Wray, N. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.65 · Cited by 138 · see citing works
Self-citationRaychaudhuri, S., Korn, J. M., McCarroll, S. A., The International Schizophrenia Consortium, Altshuler, D., Sklar, P., Purcell, S., & Daly, M. J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001097 · Cited by 131 · see citing works
Phenotypic and genetic complexity of psychosis
Craddock, N. J., O’Donovan, M. C., & Owen, M. J. (2007) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.033761 · Cited by 103 · see citing works
Wray, N. R. (2005) · Twin Research and Human Genetics · doi:10.1375/1832427053738827 · Cited by 100 · see citing works
Self-citationYang, J., Wray, N. R., & Visscher, P. M. (2009) · Genetic Epidemiology · doi:10.1002/gepi.20456 · Cited by 99 · see citing works
Self-citationWray, N. R. (2005) · Twin Research and Human Genetics · doi:10.1375/twin.8.2.87 · Cited by 96 · see citing works
Self-citationInvited commentary on Mental health of looked after children
Vostanis, P. (2003) · Advances in Psychiatric Treatment · doi:10.1192/apt.9.4.256 · Cited by 83 · see citing works
Lee, S., & van der Werf, J. H. J. (2005) · Genetics Selection Evolution · doi:10.1186/1297-9686-38-1-25 · Cited by 65 · see citing works
Self-citationGenomic Analysis of Mental Illness: A Changing Landscape
McClellan, J., & King, M.-C. (2010) · JAMA · doi:10.1001/jama.2010.869 · Cited by 63 · see citing works
Cardno, A. G., & Gottesman, I. I. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(200021)97:1
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ReproGen Consortium, Finucane, H. K., Schizophrenia Working Group of the Psychiatric Genomics Consortium, The RACI Consortium, Bulik-Sullivan, B., Gusev, A., Trynka, G., Reshef, Y., Loh, P.-R., Anttila, V., et al. (2015) · Nature Genetics · doi:10.1038/ng.3404 · Cited by 2,604 · see citing works
Self-citationGenetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Cross-Disorder Group of the Psychiatric Genomics Consortium (2013) · Nature Genetics · doi:10.1038/ng.2711 · Cited by 2,263 · see citing works
Power and predictive accuracy of polygenic risk scores
Dudbridge, F. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003348 · Cited by 1,509 · see citing works
“These results are similar to a recent estimate using mixed modelling of the same data [27].”
ResultGenome-wide association analysis identifies 13 new risk loci for schizophrenia
Multicenter Genetic Studies of Schizophrenia Consortium, Ripke, S., Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2, O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., Bergen, S. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2742 · Cited by 1,496 · see citing works
Self-citationA polygenic burden of rare disruptive mutations in schizophrenia
Purcell, S. M., Moran, J. L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O’Dushlaine, C., Chambert, K., Bergen, S. E., Kähler, A., et al. (2014) · Nature · doi:10.1038/nature12975 · Cited by 1,385 · see citing works
Self-citationGenetic architectures of psychiatric disorders: the emerging picture and its implications
Sullivan, P. F., Daly, M. J., & O'Donovan, M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3240 · Cited by 1,177 · see citing works
Self-citationAdvancing the understanding of autism disease mechanisms through genetics
de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827 · see citing works
Zheng, J., Erzurumluoglu, A. M., Elsworth, B. L., Kemp, J. P., Howe, L., Haycock, P. C., Hemani, G., Tansey, K., Laurin, C., Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, et al. (2017) · Bioinformatics · doi:10.1093/bioinformatics/btw613 · Cited by 869 · see citing works
Lee, S. H., Yang, J., Goddard, M. E., Visscher, P. M., & Wray, N. R. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts474 · Cited by 635 · see citing works
Self-citationSearching for missing heritability: Designing rare variant association studies
Zuk, O., Schaffner, S. F., Samocha, K., Do, R., Hechter, E., Kathiresan, S., Daly, M. J., Neale, B. M., Sunyaev, S. R., & Lander, E. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322563111 · Cited by 635 · see citing works
Partitioning Heritability of Regulatory and Cell-Type-Specific Variants across 11 Common Diseases
Gusev, A., Lee, S. H., Trynka, G., Finucane, H., Vilhjálmsson, B. J., Xu, H., Zang, C., Ripke, S., Bulik-Sullivan, B., Stahl, E., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.10.004 · Cited by 544 · see citing works
Self-citationSchizophrenia Working Group of the Psychiatric Genomics Consortium, Loh, P.-R., Bhatia, G., Gusev, A., Finucane, H. K., Bulik-Sullivan, B. K., Pollack, S. J., de Candia, T. R., Lee, S. H., Wray, N. R., et al. (2015) · Nature Genetics · doi:10.1038/ng.3431 · Cited by 449 · see citing works
Self-citationGazal, S., Finucane, H. K., Furlotte, N. A., Loh, P.-R., Palamara, P. F., Liu, X., Schoech, A., Bulik-Sullivan, B., Neale, B. M., Gusev, A., et al. (2017) · Nature Genetics · doi:10.1038/ng.3954 · Cited by 525 · see citing works
Sequence Kernel Association Tests for the Combined Effect of Rare and Common Variants
Ionita-Laza, I., Lee, S., Makarov, V., Buxbaum, J. D., & Lin, X. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.04.015 · Cited by 433 · see citing works
Self-citationCommon genetic variants, acting additively, are a major source of risk for autism
Klei, L., Sanders, S. J., Murtha, M. T., Hus, V., Lowe, J. K., Willsey, A. J., Moreno-De-Luca, D., Yu, T. W., Fombonne, E., Geschwind, D., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-9 · Cited by 418 · see citing works
Measuring missing heritability: Inferring the contribution of common variants
Golan, D., Lander, E. S., & Rosset, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419064111 · Cited by 288 · see citing works
The heritability of human disease: estimation, uses and abuses.
Tenesa, A., & Haley, C. S. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3377 · Cited by 283 · see citing works
Haplotype Reference Consortium, Evans, L. M., Tahmasbi, R., Vrieze, S. I., Abecasis, G. R., Das, S., Gazal, S., Bjelland, D. W., de Candia, T. R., Goddard, M. E., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0108-x · Cited by 239 · see citing works
Self-citationGenetics and epigenetics of eating disorders
Bulik, C., Yilmaz, Z., & HArdaway, A. (2015) · Advances in Genomics and Genetics · doi:10.2147/agg.s55776 · Cited by 278 · see citing works
Meda, S. A., Ruaño, G., Windemuth, A., O’Neil, K., Berwise, C., Dunn, S. M., Boccaccio, L. E., Narayanan, B., Kocherla, M., Sprooten, E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313093111 · Cited by 242 · see citing works
Doherty, J. L., & Owen, M. J. (2014) · Genome Medicine · doi:10.1186/gm546 · Cited by 228 · see citing works
Lee, S. H., Harold, D., Nyholt, D. R., ANZGene Consortium, International Endogene Consortium, the Genetic and Environmental Risk for Alzheimer's disease (GERAD1) Consortium, Goddard, M. E., Zondervan, K. T., Williams, J., Montgomery, G. W., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/dds491 · Cited by 217 · see citing works
Self-citationHowrigan, D. P., Rose, S. A., Samocha, K. E., Fromer, M., Cerrato, F., Chen, W. J., Churchhouse, C., Chambert, K., Chandler, S. D., Daly, M. J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0564-3 · Cited by 168 · see citing works
GROUP investigators, Børglum, A. D., Demontis, D., Grove, J., Pallesen, J., Hollegaard, M. V., Pedersen, C. B., Hedemand, A., Mattheisen, M., Uitterlinden, A., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.2 · Cited by 186 · see citing works
Schoech, A. P., Jordan, D. M., Loh, P.-R., Gazal, S., O’Connor, L. J., Balick, D. J., Palamara, P. F., Finucane, H. K., Sunyaev, S. R., & Price, A. L. (2019) · Nature Communications · doi:10.1038/s41467-019-08424-6 · Cited by 157 · see citing works
GROUP Investigators, Rees, E., Han, J., Morgan, J., Carrera, N., Escott-Price, V., Pocklington, A. J., Duffield, M., Hall, L. S., Legge, S. E., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-019-0565-2 · Cited by 129 · see citing works
Common alleles contribute to schizophrenia in CNV carriers
Tansey, K. E., Rees, E., Linden, D. E., Ripke, S., Chambert, K. D., Moran, J. L., McCarroll, S. A., Holmans, P., Kirov, G., Walters, J., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.143 · Cited by 132 · see citing works
Self-citationLimitations of GCTA as a solution to the missing heritability problem.
Krishna Kumar, S., Feldman, M. W., Rehkopf, D. H., & Tuljapurkar, S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520109113 · Cited by 128 · see citing works
Common DNA Markers Can Account for More Than Half of the Genetic Influence on Cognitive Abilities
Plomin, R., Haworth, C. M. A., Meaburn, E. L., Price, T. S., Wellcome Trust Case Control Consortium 2, & Davis, O. S. P. (2013) · Psychological Science · doi:10.1177/0956797612457952 · Cited by 138 · see citing works
“GCTA has been used to estimate heritability as captured by genotyping arrays for height (Yang et al., 2010), weight (Yang, Manolio, et al., 2011), psychiatric and other medical disorders (Lee et al., 2012; Lee et al., 2011; Lubke et al., 2012), and personality (Vinkhuyzen, Pedersen, et al., 2012).”
MethodSpine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine
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Risk of psychiatric illness from advanced paternal age is not predominantly from de novo mutations
Gratten, J., Wray, N. R., Peyrot, W. J., McGrath, J. J., Visscher, P. M., & Goddard, M. E. (2016) · Nature Genetics · doi:10.1038/ng.3577 · Cited by 118 · see citing works
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Lencz, T., Guha, S., Liu, C., Rosenfeld, J., Mukherjee, S., DeRosse, P., John, M., Cheng, L., Zhang, C., Badner, J. A., et al. (2013) · Nature Communications · doi:10.1038/ncomms3739 · Cited by 111 · see citing works
Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture
Hou, K., Burch, K. S., Majumdar, A., Shi, H., Mancuso, N., Wu, Y., Sankararaman, S., & Pasaniuc, B. (2019) · Nature Genetics · doi:10.1038/s41588-019-0465-0 · Cited by 91 · see citing works
Study, D. (. D. I. S. A. C., Liu, J., Zhou, Y., Liu, S., Song, X., Yang, X.-Z., Fan, Y., Chen, W., Akdemir, Z. C., Yan, Z., et al. (2018) · Human Genetics · doi:10.1007/s00439-018-1910-3 · Cited by 77 · see citing works
Modeling psychiatric disorders with patient-derived iPSCs
Wen, Z., Christian, K. M., Song, H., & Ming, G.-L. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.11.003 · Cited by 84 · see citing works
Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease
Gratten, J., Visscher, P. M., Mowry, B. J., & Wray, N. R. (2013) · Nature Genetics · doi:10.1038/ng.2555 · Cited by 77 · see citing works
Self-citationHeritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies
Zhao, B., Ibrahim, J. G., Li, Y., Li, T., Wang, Y., Shan, Y., Zhu, Z., Zhou, F., Zhang, J., Huang, C., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy157 · Cited by 58 · see citing works
Efficient variance components analysis across millions of genomes
Pazokitoroudi, A., Wu, Y., Burch, K. S., Hou, K., Zhou, A., Pasaniuc, B., & Sankararaman, S. (2020) · Nature Communications · doi:10.1038/s41467-020-17576-9 · Cited by 55 · see citing works
Fanelli, G., & Serretti, A. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.007 · Cited by 52 · see citing works
Genome-wide association studies of suicidal behaviors: a review
Sokolowski, M., Wasserman, J., & Wasserman, D. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.08.006 · Cited by 48 · see citing works
Gene expression alterations in bipolar disorder postmortem brains
Chen, H., Wang, N., Zhao, X., Ross, C. A., O’Shea, K. S., & McInnis, M. G. (2013) · Bipolar Disorders · doi:10.1111/bdi.12039 · Cited by 46 · see citing works
Morris, D. W., Pearson, R. D., Cormican, P., Kenny, E. M., O'Dushlaine, C. T., Perreault, L.-P. L., Giannoulatou, E., Tropea, D., Maher, B. S., Wormley, B., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu025 · Cited by 42 · see citing works
Self-citationEvolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders
Schadt, E. E., Buchanan, S., Brennand, K. J., & Merchant, K. M. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00252 · Cited by 39 · see citing works
Rajkumar, A. P., Christensen, J. H., Mattheisen, M., Jacobsen, I., Bache, I., Pallesen, J., Grove, J., Qvist, P., McQuillin, A., Gurling, H. M., et al. (2015) · Bipolar Disorders · doi:10.1111/bdi.12239 · Cited by 24 · see citing works
Enrichment of schizophrenia heritability in both neuronal and glia cell regulatory elements
Tansey, K. E., & Hill, M. J. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0053-y · Cited by 21 · see citing works
Suárez-Rama, J. J., Arrojo, M., Sobrino, B., Amigo, J., Brenlla, J., Agra, S., Paz, E., Brión, M., Carracedo, Á., Páramo, M., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.04.013 · Cited by 18 · see citing works
- Authors
- The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), Lee, S. H., The International Schizophrenia Consortium (ISC), The Molecular Genetics of Schizophrenia Collaboration (MGS), DeCandia, T. R., Ripke, S., Yang, J., Sullivan, P. F., Goddard, M. E., Keller, M. C., Visscher, P. M., & Wray, N. R.
- Affiliations
- The University of Queensland (AU)
- University of Colorado Boulder (US)
- Broad Institute (US)
- University of North Carolina at Chapel Hill (US)
- The University of Melbourne (AU)
- Corresponding author
- Wray, Naomi R
- ORCID
- Venue
- Nature Genetics
- Published
- 2012-02-19
- Volume
- 44
- Issue
- 3
- Pages
- 247-250
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC3327879
- OpenAlex
- W2113381731
- Cited by
- 579
- References
- 31
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 6 · 2023: 17 · 2022: 23 · 2021: 20 · 2020: 26 · 2019: 32 · 2018: 48 · 2017: 45 · 2016: 62 · 2015: 83 · 2014: 83 · 2013: 82 · 2012: 35
- FWCI
- 53.66
- Type
- journal article
- Language
- en
- Update notices
- erratum (2012-06-27)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Lirias (submittedVersion, other-oa)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- RUNE (Research UNE) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (480- 05-003)
- National Institutes of Health (6u54rr020278-06, n01mh90001-21-0-0)
- National Institute of Mental Health (K23MH001760, R01MH077139, P30MH074543, U01MH046276, P50MH066392, R01MH061884, U01MH085520, R01MH059566, R01MH052618, U01MH046318, R01MH059571, R01MH058693, R01MH060879, R01MH059565, N01 MH090001, R01MH081800, R01MH085542, R01MH060870, U01MH046289, U01MH079469, K01MH085812, R01MH061675, R01MH078075, R01MH085548, R01MH059586, R01MH071681, R01MH059588, R01MH067257, U01MH079470, MH085812, R01MH074027, R01MH079800, R01MH084098, R01MH059587, R01MH080403)
- National Center for Research Resources (U54-RR020278, M01RR018535)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- schizophrenia, genetic susceptibility, polygenic architecture, heritability, genetic variance explained, chromosome length, imputed SNPs
- MeSH terms
- Analysis of Variance, Central Nervous System, Chromosomes, Human, Computer Simulation, Female, Humans, Male, Models, Genetic, Schizophrenia, Genetic Variation, Likelihood Functions, Linear Models, Genetic Predisposition to Disease, Multifactorial Inheritance, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Molecular Sequence Annotation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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