Context-dependent control of alternative splicing by RNA-binding proteins

Development and Applications of CRISPR-Cas9 for Genome Engineering

Hsu, P. D., Lander, E. S., & Zhang, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.010 · Cited by 5,762

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873

Mechanisms of Alternative Pre-Messenger RNA Splicing

Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665

Expansion of the eukaryotic proteome by alternative splicing

Nilsen, T. W., & Graveley, B. R. (2010) · Nature · doi:10.1038/nature08909 · Cited by 2,270

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132

Frequent pathway mutations of splicing machinery in myelodysplasia

Yoshida, K., Sanada, M., Shiraishi, Y., Nowak, D., Nagata, Y., Yamamoto, R., Sato, Y., Sato-Otsubo, A., Kon, A., Nagasaki, M., et al. (2011) · Nature · doi:10.1038/nature10496 · Cited by 2,029

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.017 · Cited by 2,012

A compendium of RNA-binding motifs for decoding gene regulation

Ray, D., Kazan, H., Cook, K. B., Weirauch, M. T., Najafabadi, H. S., Li, X., Gueroussov, S., Albu, M., Zheng, H., Yang, A., et al. (2013) · Nature · doi:10.1038/nature12311 · Cited by 1,480

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

Kim, H. J., Kim, N. C., Wang, Y., Scarborough, E. A., Moore, J., Diaz, Z., MacLea, K. S., Freibaum, B. D., Li, S., Molliex, A., et al. (2013) · Nature · doi:10.1038/nature11922 · Cited by 1,478

Design of a GFP reporter for splicing analysis in mammalian cellsPreprint

Menezes, A. T., Nagasse, H. Y., & Coltri, P. P. (2020) · doi:10.21203/rs.3.rs-20486/v2

Análise da regulação do splicing de microRNAs do cluster miR-17-92.

da Silva, G. H. G. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2021.tde-15122022-154218

NIBAN2 promotes osteogenic differentiation and antagonizes osteoporosis by regulating RUNX2 alternative splicingPreprint

Zhang, S., Yang, Z., Wei, R., Zhang, Y., Chen, Z., Lv, X., Deng, Z., Huang, Z., Xie, Y., & Cai, L. (2023) · Research Square · doi:10.21203/rs.3.rs-2395653/v1

The Musashi RNA Binding Proteins Are Regulators of Alternative Splicing and Protein Expression in Photoreceptor Cells

Matalkah, F. K. (2022) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.11594

Pre-RNA Splicing Analysis: From Basic Science To Applied Research

Coltri, P. P. (2022) · Journal of Visualized Experiments · doi:10.3791/64630

DNA/RNA structure and processing in vitro and in cells: from probing to prediction

Korsakova, A. (2022) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/164272

Data from In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target

Vujovic, A., de Rooij, L. P. M. H., Chahi, A. K., Chen, H. T., Yee, B. A., Loganathan, S. K., Liu, L., Chan, D. C. H., Tajik, A., Tsao, E., et al. (2023) · doi:10.1158/2643-3230.c.6572000

Analysis of Expression of RNA Helicases and Cofactors in Human Tissues and Cancer

Rathje, K. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9872

JoVE Video Dataset

Coltri, P. P. (2023) · doi:10.3791/64630-v

Integration of aberrant alternative splicing events and RNA binding proteins revealed their potential regulation in diabetic foot ulcersPreprint

Wang, M., Hao, Q., Ma, R., Qin, H.-S., & luo, A. (2023) · Research Square · doi:10.21203/rs.3.rs-3042595/v1

Reclassification of Splicing Gene Variants in Hereditary Cancer: Cases Report and Literature Review

Bouzarelou, D., Αγιαννιτόπουλος, Κ., Tsaousis, G., Papadopoulou, E., & Nasioulas, G. (2023) · In Vivo · doi:10.21873/invivo.13227

Análise funcional do polimorfismo c.303+373G>A do gene CRBE1, envolvido com a melanogênese, em melanoma cutâneo

Silva, J. K. (2019) · doi:10.47749/t/unicamp.2019.1163331

Alteración de los patrones de splicing en genes de susceptibilidad a cáncer de mama: análisis funcional mediante minigenes híbridos.

Sanoguera‐Miralles, L. (2024) · doi:10.35376/10324/66867

Study of prognostic splicing factors in cancer using machine learning approaches

Yang, M., Liu, J., Kim, P., & Zhou, X. (2024) · Human Molecular Genetics · doi:10.1093/hmg/ddae047

Additional file 1 of Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders

Gillentine, M. A., Wang, T., Hoekzema, K., Rosenfeld, J. A., Liu, P., Guo, H., Kim, C. N., Vries, B. B. A. D., Vissers, L. E. L. M., Nordenskjöld, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14450781

Additional file 1 of Identification of cell-type specific alternative transcripts in the multicellular alga Volvox carteri

Balasubramanian, R. N., Gao, M., & Umen, J. (2023) · Figshare · doi:10.6084/m9.figshare.24465066

Additional file 1 of RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins

Zhang, J., Liu, J. J., Lee, D., Feng, J.-J., Lochovsky, L., Lou, S., Rutenberg-Schoenberg, M., & Gerstein, M. (2020) · Figshare · doi:10.6084/m9.figshare.12737169

The polyadenosine RNA binding protein Nab2 regulates alternative splicing and intron retention during Drosophila melanogaster brain developmentPreprint

Kelly, S. M., Paschack, A., Mishra, G., Ahn, J., Smith, E., Haynes, K., Shelmidine, K., Lee, K., Yazhbin, A., & Ji, Y. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.17.594635

Age-dependent regulation of ELP1 exon 20 splicing in Familial Dysautonomia by RNA Polymerase II kinetics and chromatin structure

Riccardi, F., Romano, G., Licastro, D., & Pagani, F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298965

Translational study on the role of genetic and prenatal risk factors in neurodevelopmental psychiatric disorders

Yotova, A. Y. (2024) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.85791

PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal traffickingPreprint

Forman, T. E., Sajek, M. P., Larson, E. D., Mukherjee, N., & Fantauzzo, K. A. (2024) · eLife · doi:10.7554/elife.98531.1

Reviewer #1 (Public Review): PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

(2024) · eLife · doi:10.7554/elife.98531.1.sa1

eLife Assessment: PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

Mishina, Y. M. (2024) · eLife · doi:10.7554/elife.98531.1.sa2

Reviewer #2 (Public Review): PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

(2024) · eLife · doi:10.7554/elife.98531.1.sa0

RNA Binding Protein Khdrbs1 Regulates Hematopoietic Stem and Progenitor Cell Emergence via SplicingPreprint

Karp, I., & Bowman, T. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.01.621494

PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal traffickingPreprint

Forman, T. E., Sajek, M. P., Larson, E. D., Mukherjee, N., & Fantauzzo, K. A. (2024) · eLife · doi:10.7554/elife.98531.2

Reviewer #2 (Public review): PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

(2024) · eLife · doi:10.7554/elife.98531.2.sa1

Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicingPreprint

de Castro, K. L. P., Abril, J. M., Liao, K., Hao, H., Donohue, J. P., Russell, W. K., & Fagg, W. S. (2024) · eLife · doi:10.7554/elife.103167

An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicingPreprint

de Castro, K. L. P., Abril, J. M., Liao, K., Hao, H., Donohue, J. P., Russell, W. K., & Fagg, W. S. (2024) · eLife · doi:10.7554/elife.103167.1

2-Desaza-annomontine impedes angiogenesis by inhibiting CDC2-like-kinases and β-catenin activity

Zech, T. (2024) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.87954

eLife Assessment: PDGFRα signaling regulates Srsf3 transcript binding to affect PI3K signaling and endosomal trafficking

Mishina, Y. M. (2024) · eLife · doi:10.7554/elife.98531.3.sa0

CIRCULAR RNAS: NEW AND EXCITING BIOMARKERS IN THE PROGNOSIS OF CARDIOVASCULAR DISEASES

Ghiasi, M., Zarandi, P. K., & Dayani, A. (2024) · Studies in Medical Sciences · doi:10.61186/umj.35.7.586

Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity

Vijayakumar, A., Vasudevan, S., John, S., Ozbun, M. A., Bartee, E., & Palanisamy, V. (2025) · Immunometabolism · doi:10.1097/in9.0000000000000054

eLife Assessment: Generative modeling for RNA splicing predictions and design

Koo, P. K. (2025) · eLife · doi:10.7554/elife.106043.1.sa3

Transcriptome sequencing analysis identified an alternative splicing regulatory network mediated by RNA-binding proteins in asthma

Zhang, J., Wang, M., Yu, D., Qu, C. F., Zhang, J., & Lao, H. (2025) · Journal of Asthma · doi:10.1080/02770903.2025.2526365

Alternative splicing as a novel pathogenic mechanism in chronic kidney disease

Qiu, J., Wang, R., Li, L., Wu, P. J., Zhang, H., Gong, S., Ren, X., Tao, Y., & Fang, X. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111972

An in vivo parallelized reporter assay to uncover tissue-specific splicing regulatory sequences in a multicellular animal

Bhatnagar, S., Ho, J., Sadek, N. H., Singh, I., Zoberman, M., Koterniak, B., Liu, Y., Fusca, D. D., Cutter, A. D., Moses, A. M., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag451

Functional study of RNA alternative splicing in zebrafish adaptation to low temperaturePreprint

Li, J., Li, W., Lu, H., Zhao, Y., Zhu, Z., & Chen, L. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5415151

Circular RNAs in Organ Fibrosis

Ranjan, P., Dutta, R. K., & Verma, S. K. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-981-96-9428-0_19

Multi-Transcripts and Expressions of Trypsin Inhibitor and α-Amylase Inhibitor Genes of Sengon (Falcataria falcata) Against Xystrocera festiva Stem Borer Infestation

Siregar, U. J., Shabrina, H., Nurianti, E., Dwiyuni, F., Lestari, A. I., Sihombing, J. K., Larosa, B., Anita, V. P. D., & Matra, D. D. (2025) · Plants · doi:10.3390/plants14172750

Molecular Basis of UG‐Rich Element Recognition by ESRP2 RRM3

Kumari, P., Yadav, P., & Bhavesh, N. S. (2025) · Magnetic Resonance in Chemistry · doi:10.1002/mrc.70034

Functional study of RNA alternative splicing in zebrafish adaptation to low temperaturePreprint

Li, J., Li, W., Lu, H., Zhao, Y., Zhu, Z., & Chen, L. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5448255

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sitesPreprint

Akinyi, M. V., Yao, W., Zeman, J., Hipp, C., Bartsch, D., Heaven, L., Roux, C. A. L., Starner, A. C., Yuan, F., Bartels, M. D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.04.674271

Unraveling the impact of VHL exon 2 mutations in erythrocytosis or von Hippel-Lindau disease identified RNA-binding proteins involved in VHL splicing

Karaghiannis, V., Schmitt, L., Chesnel, F., Gautier, E., Leduc, M., Gall, M. L., Idriss, S., Couvé, S., Barlier, A., Sarrabay, G., et al. (2025) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2025.09.002

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant CancersPreprint

Boddu, P. C., Roy, R., Hütter, S., Baumgartner, F., Li, W., Todisco, G., Ficara, F., Porta, M. G. D., Liu, Y., Haferlach, T., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.08.679601

Monitoring rapid degradation of NANOG reveals UTP15 maintains pluripotency by regulating nascent transcripts

Deng, M., He, D., Wang, X., Yuan, Y., Wang, L., Hou, Y., Zhu, Q., Zhou, C., Mai, Z., Zhang, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67018-7

Competition for the conserved branch point sequence influences physiological outcomes in pre-mRNA splicingPreprint

de Castro, K. L. P., Abril, J. M., Liao, K., Hao, H., Donohue, J. P., Russell, W. K., & Fagg, W. S. (2025) · eLife · doi:10.7554/elife.103167.2

RNA secondary structures modulate hnRNPH1-mediated alternative splicing of cold-shock protein RBM3Preprint

Shen, S., McFarlane, L., Ruepp, M., Lin, J. Q., & Khuperkar, D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.18.694734

Additional file 1 of Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing

Zhang, Q., Zhang, J., Ye, J., Li, X., Liu, H., Ma, X., Wang, C., He, K., Zhang, W., Yuan, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16664627

Additional file 2 of Combining full-length gene assay and SpliceAI to interpret the splicing impact of all possible SPINK1 coding variants

Wu, H., Lin, J., Tang, X.-Y., Marenne, G., Zou, W.-B., Schutz, S., Masson, E., Génin, E., Fichou, Y., Gac, G. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26685999

Additional file 2 of Identification of cell-type specific alternative transcripts in the multicellular alga Volvox carteri

Balasubramanian, R. N., Gao, M., & Umen, J. (2024) · Figshare · doi:10.6084/m9.figshare.24465336

Additional file 2 of Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders

Gillentine, M. A., Wang, T., Hoekzema, K., Rosenfeld, J., Liu, P., Guo, H., Kim, C. N., Vries, B. B. A. D., Vissers, L. E. L. M., Nordenskjöld, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14450784

Additional file 2 of RADAR: annotation and prioritization of variants in the post-transcriptional regulome of RNA-binding proteins

Zhang, J., Liu, J. J., Lee, D., Feng, J.-J., Lochovsky, L., Lou, S., Rutenberg-Schoenberg, M., & Gerstein, M. (2020) · Figshare · doi:10.6084/m9.figshare.12737172

Additional file 1 of FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells

Jia, T., Jacquet, T., Dalonneau, F., Coudert, P., Vaganay, E., Exbrayat-Heritier, C., Vollaire, J., Josserand, V., Ruggiero, F., Coll, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16442231

Additional file 3 of Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders

Gillentine, M. A., Wang, T., Hoekzema, K., Rosenfeld, J., Liu, P., Guo, H., Kim, C. N., Vries, B. B. A. D., Vissers, L. E. L. M., Nordenskjöld, M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14450793

Additional file 3 of Combining full-length gene assay and SpliceAI to interpret the splicing impact of all possible SPINK1 coding variants

Wu, H., Lin, J., Tang, X., Marenne, G., Zou, W.-B., Schutz, S., Masson, E., Génin, E., Fichou, Y., Gac, G. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26686002

Additional file 2 of FGF-2 promotes angiogenesis through a SRSF1/SRSF3/SRPK1-dependent axis that controls VEGFR1 splicing in endothelial cells

Jia, T., Jacquet, T., Dalonneau, F., Coudert, P., Vaganay, E., Exbrayat-Heritier, C., Vollaire, J., Josserand, V., Ruggiero, F., Coll, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16442234

Additional file 1 of Enhanced Integrated Gradients: improving interpretability of deep learning models using splicing codes as a case study

Jha, A., K. Aicher, J., R. Gazzara, M., Singh, D., & Barash, Y. (2020) · Figshare · doi:10.6084/m9.figshare.12519467

Additional file 3 of RBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Du, X., Qin, W., Yang, C., Dai, L., San, M., Xia, Y., Zhou, S., Wang, M., Wu, S., Zhang, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26708906

Additional file 2 of RBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Du, X., Qin, W., Yang, C., Dai, L., San, M., Xia, Y., Zhou, S., Wang, M., Wu, S., Zhang, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26708903

Additional file 1 of Combining full-length gene assay and SpliceAI to interpret the splicing impact of all possible SPINK1 coding variants

Wu, H., Lin, J., Tang, X., Marenne, G., Zou, W.-B., Schutz, S., Masson, E., Génin, E., Fichou, Y., Gac, G. L., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26685996

Additional file 1 of RBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Du, X., Qin, W., Yang, C., Dai, L., San, M., Xia, Y., Zhou, S., Wang, M., Wu, S., Zhang, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26708900

Additional file 2 of Enhanced Integrated Gradients: improving interpretability of deep learning models using splicing codes as a case study

Jha, A., K. Aicher, J., R. Gazzara, M., Singh, D., & Barash, Y. (2020) · Figshare · doi:10.6084/m9.figshare.12519470

Regulation of Exon Recognition by Serine-Arginine Rich Splicing Factors and Heterogeneous Ribonucleoproteins in Higher Eukaryotes

Kataoka, N. (2025) · Nucleic acids and molecular biology · doi:10.1007/978-3-032-03300-0_3

Conserved differential expression of DDX helicase and CPEB genes in skeletal muscles potentially influences neuromuscular junctions during aging: a computational analysis

Nishanth, M. J., & Jha, S. (2026) · Biogerontology · doi:10.1007/s10522-025-10382-0

Primate lineage specification requires suppression of Alu hypereditingPreprint

Park, E. J., Cui, Y., Levin-Ferreyra, F., Soriano, V. L., Wu, H., Lupión-Garcia, N., Sands, C. M., Pessina, P., Guerra, M. C., Botas, J., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.14.699349

dirCLIP profiles variant-specific RNA-protein interactions via nanopore long-read sequencingPreprint

Bahrudeen, M. N. M., Scaravilli, M., Zahir, Z., Woodward, K., Ahola, T., Ratnadiwakara, M., Kaslin, J., Loughlin, F. E., Shirokikh, N. E., & Änkö, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.22.701028

PTBP1 supports mouse spermatogenesis by facilitating cytoskeletal organization through the mTORC2–PKCα pathway in Sertoli cells

Ozawa, M., Taguchi, J., Mori, H., Kikuchi, M., Muratani, M., Yamamoto, T., Yamada, Y., Yoshida, N., & Ikawa, M. (2026) · Communications Biology · doi:10.1038/s42003-026-09636-5

CTAS: a network control theory-based approach to identify key regulatory TFs of AS events during epithelial–mesenchymal transition

Yan, G., He, Y., Zhao, P., Ching, W., & Qiu, Y. (2026) · Briefings in Bioinformatics · doi:10.1093/bib/bbag042

Pan-cell-type prediction of splicing patterns from sequence and splicing factor expressionPreprint

Vetsigian, K., Lancaster, J., Ieremie, I., Radens, C. M., Smyth, P., & Young, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.18.706660

PRIME-BSPre: a genome-wide protein-RNA binding sites prediction method based on templates

Wei, X., Duan, Y., Li, D., Liu, X., Xie, J., & Liu, S. (2026) · BMC Genomics · doi:10.1186/s12864-026-12657-3

Integrative Analysis of Alternative Splicing Regulation Reveals Genetic and RBP-Mediated Mechanisms in Endometriosis Pathogenesis

Wang, Z., Yan, H., Zhu, L., Ni, S., Qian, L., Yu, M., & Yu, J. (2026) · Reproductive Sciences · doi:10.1007/s43032-026-02064-0

Integrative transcriptomic analysis reveals alternative splicing programs in sepsis-induced myocardial injury across dual mouse models

Zhou, S., Liu, D., Zong, H., Nie, K., Yan, S., Chen, Y., Jiang, J., Sun, M., & Peng, H. (2026) · Inflammation Research · doi:10.1007/s00011-026-02201-0

Interpretable machine learning enables de novo mapping of cell type-specific RNA splicing regulation from scRNA-seq data

Yang, X., & Xiang, X. (2026) · Nature Communications · doi:10.1038/s41467-026-77627-5

A novel strategy for the treatment of Obesity using the small molecule ABX300, a modulator of the LMNA gene splicing

Herrera, C. L. (2015) · theses.fr (ABES) · doi:10.70675/d09d7e9cz079fz4faaz985aza9cd4fc18f18

Le saut d’exon thérapeutique pour le traitement des dysferlinopathies

Malcher, J. (2018) · theses.fr (ABES) · doi:10.70675/0e15f50dzf72az4420za9b0zda56bec1c40b

Identification and characterization of the RIG-I helicase partners involved in the balance proliferation / cell differentiation. Characterization of G-quadruplex resolving by the helicase Pif1 in Bacteroides sp 3_1_23.

naves, C. A. (2018) · theses.fr (ABES) · doi:10.70675/3d6c8af3z77e3z44f6z93bbzcf07eab6dcc5

Alteration of alternative splicing in the pathogenesis of liver disease

Wang, H. (2017) · theses.fr (ABES) · doi:10.70675/bbd0da03z44bcz4adczaedazc17212ba6ebe

When splicing is not all or none: GT>GC 5′ splice-site variants as a model for intermediate effects and challenges in variant classification

Lin, J., Wu, H., Tang, X., Masson, E., Stenson, P. D., Phillips, A. D., Cooper, D. N., Férec, C., Liao, Z., Zou, W., et al. (2026) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2026.100602

Développement de stratégies de criblage de mutations d'épissage dans des gènes de prédisposition au cancer.

Tubeuf, H. (2019) · theses.fr (ABES) · doi:10.70675/e62a0ca5z7722z4c72z9d57z726ae2bc0e42

Biais de composition nucléotidique des gènes et épissage alternatif

Lemaire, S. (2019) · theses.fr (ABES) · doi:10.70675/f23d8d55z764cz4603za028zf9f54d767039

New Mechanism of Action of Rapalogs : Transcriptional Regulation of TRIB3 and Alteration of Pre-mRNA Splicing

Stefanovska, B. (2019) · theses.fr (ABES) · doi:10.70675/31fe0043zbb1az45d6z84e3ze78ee83670a0

Regulation of alternative splicing and polyadenylation by genotoxic anti-cancer agents

Tanaka, I. (2019) · theses.fr (ABES) · doi:10.70675/8177333az76a6z4204z808az958753142caf

Epigenetic regulation of transcription from genes-containing heterochromatin

Idir, Y. (2019) · theses.fr (ABES) · doi:10.70675/44dfd2d8za3f1z4d2azb17az7b325385be3b

Études d'association génome entier guidées par des réseaux

Climente-González, H. (2020) · theses.fr (ABES) · doi:10.70675/12a8ecbfzb2f9z440aza09ezfe0661eb4ebb

Study of the splicing factor CWC27 and its link to genetic diseases and EJC assembly

Busetto, V. (2019) · theses.fr (ABES) · doi:10.70675/310a7718za787z417cz884czc1decc1f56f2

Modulation of hippo pathway by alternative splicing

Srivastava, D. (2019) · theses.fr (ABES) · doi:10.70675/39639c36z8ae3z4f14z9907zaaead2a13436

De la variabilité génétique à l’expression phénotypique des groupes sanguins : exemple du système Rh

Raud, L. (2020) · theses.fr (ABES) · doi:10.70675/36ac5d0dz7837z4d9fz9220z7df321ac1ad9

The role of histone modifications in the regulation of alternative splicing during epithelial-to-mesenchymal transition

Segelle, A. (2020) · theses.fr (ABES) · doi:10.70675/40e530e9z2e50z46e1zac0aze57debc0a189

Caractérisation fonctionnelle de variations splicéogéniques à l'origine d'anomalies d'épissage en phase dans des gènes de prédisposition aux cancers : implications en génétique médicale

Meulemans, L. (2021) · theses.fr (ABES) · doi:10.70675/ed895fcez2ba8z4741z8f61zd703806944d6

Rôle du complexe de jonction exon-exon (EJC) dans l'épissage de l'ARN pré-messager du gène DMD et dans la différenciation myogénique.

da Cunha, D. (2022) · theses.fr (ABES) · doi:10.70675/3bcf211aza961z4896z8bb7z53103834e0fc

Contribution au diagnostic de l’albinisme : étude de variants d'épissage, recherche de variants régulateurs et étude du spectre génotypique au Mali

Diallo, M. (2024) · theses.fr (ABES) · doi:10.70675/73b90693z3546z49fez8cb5z95d7f450b40c

Modeling Chronic Myelomonocytic Leukemia with the Aim of Identifying Novel Therapeutic Targets

Alawieh, D. (2025) · theses.fr (ABES) · doi:10.70675/c7daf13fz397fz4894zbafezd95092b27414

Detection of a sequence feature for recursive splicingPreprint

Wang, B., Yang, K., Barash, Y., Choi, P. S., Mount, S. M., & Larson, D. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.13.717821

Evaluating splicing factor and kinase network crosstalk through global phosphoproteomicsPreprint

Crowl, S., Singh, S., Zhang, T., & Naegle, K. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.16.718710

PABPC1 Modulates Immunoglobulin pre-mRNA Alternative PolyadenylationPreprint

Miller, Z. D., Dearborn, J., Barrantes-Reynolds, R., Paculová, H., Honson, D. D., Sha, J., Deng, W., Kirch, T., Dowell, W., Languon, S., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.23.720383

TAR syndrome causal gene RBM8A is critical for embryonic bone development and proper Hedgehog signalingPreprint

Mao, Y., Mott, J., Pei, Z., Sun, J., Lee, C., Puri, T., Sachs, Z. M., Vargas, A. A., Blaha, N., Tong, M. M. B., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9543669/v1

RNA splicing regulation and tumor: A focus on the multifunctional SRSF family as a therapeutic target

Ren, X., Shan, W., Salman, M., Ren, J., Gao, X., & Liu, X. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118060

Modeling context-dependent RNA splicing by deep learning

Chen, C., & Han, L. (2026) · Nature Computational Science · doi:10.1038/s43588-026-00987-x

Author response: Generative modeling for RNA splicing prediction and design

Wu, D., Maus, N., Jha, A., Yang, K., Wales-McGrath, B. D., Jewell, S., Tangiyan, A., Choi, P. S., Gardner, J. R., & Barash, Y. (2026) · eLife · doi:10.7554/elife.106043.3.sa3

Understanding splicing regulation through RNA splicing maps

Witten, J. T., & Ule, J. (2011) · Trends in Genetics · doi:10.1016/j.tig.2010.12.001 · Cited by 289

Experimental strategies for studying RNA-binding proteins and their complexes in alternative mRNA splicing

Srivastava, D., Ramakrishnan, L. S., Shadija, Y., Sandeep, G., & Misra, A. (2026) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2026.07.031

Mechanism of an alternative splicing switch mediated by cell-specific and general splicing regulatorsPreprint

Yang, Y. A., Lee, G. C., Nakagaki-Silva, E. E., Huang, Y., Peacey, M., Partridge, R., Gooding, C., & Smith, C. W. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.23.525191 · Cited by 1

Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing

Horn, T., Gosliga, A. R., Li, C., Enculescu, M., & Legewie, S. (2023) · npj Systems Biology and Applications · doi:10.1038/s41540-022-00264-3 · Cited by 26

Regulation of alternative splicing in Drosophila by 56 RNA binding proteinsPreprint

Brooks, A. N., Duff, M. O., May, G. E., Yang, L. C., Bolisetty, M. T., Landolin, J. M., Wan, K., Sandler, J. E., Booth, B. W., Celniker, S., et al. (2015) · Genome Research · doi:10.1101/gr.192518.115 · Cited by 84