Context-dependent control of alternative splicing by RNA-binding proteins

Development and Applications of CRISPR-Cas9 for Genome Engineering

Hsu, P. D., Lander, E. S., & Zhang, F. (2014) · Cell · doi:10.1016/j.cell.2014.05.010 · Cited by 5,762

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873

Mechanisms of Alternative Pre-Messenger RNA Splicing

Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704

The Spliceosome: Design Principles of a Dynamic RNP Machine

Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665

Expansion of the eukaryotic proteome by alternative splicing

Nilsen, T. W., & Graveley, B. R. (2010) · Nature · doi:10.1038/nature08909 · Cited by 2,270

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

Castello, A., Fischer, B., Eichelbaum, K., Horos, R., Beckmann, B. M., Strein, C., Davey, N. E., Humphreys, D. T., Preiss, T., Steinmetz, L. M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.031 · Cited by 2,132

Frequent pathway mutations of splicing machinery in myelodysplasia

Yoshida, K., Sanada, M., Shiraishi, Y., Nowak, D., Nagata, Y., Yamamoto, R., Sato, Y., Sato-Otsubo, A., Kon, A., Nagasaki, M., et al. (2011) · Nature · doi:10.1038/nature10496 · Cited by 2,029

Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels

Kato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.017 · Cited by 2,012

A compendium of RNA-binding motifs for decoding gene regulation

Ray, D., Kazan, H., Cook, K. B., Weirauch, M. T., Najafabadi, H. S., Li, X., Gueroussov, S., Albu, M., Zheng, H., Yang, A., et al. (2013) · Nature · doi:10.1038/nature12311 · Cited by 1,480

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

Kim, H. J., Kim, N. C., Wang, Y., Scarborough, E. A., Moore, J., Diaz, Z., MacLea, K. S., Freibaum, B. D., Li, S., Molliex, A., et al. (2013) · Nature · doi:10.1038/nature11922 · Cited by 1,478

Identification of survival-associated alternative splicing events and signatures in adrenocortical carcinoma based on TCGA SpliceSeq data

Xu, N., Ke, Z., Lin, X., Lin, F., Chen, S., Wu, Y., Chen, Y., Wei, Y., & Zheng, Q. (2020) · Aging · doi:10.18632/aging.102924 · Cited by 18

Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly

Shenasa, H., Movassat, M., Forouzmand, E., & Hertel, K. J. (2020) · RNA · doi:10.1261/rna.075135.120 · Cited by 19

Systems Virology and Human Cytomegalovirus: Using High Throughput Approaches to Identify Novel Host-Virus Interactions During Lytic Infection

Lee, C.-H., & Grey, F. E. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00280 · Cited by 18

RNA binding proteins: Linking mechanotransduction and tumor metastasis

Zhang, Y., & Li, Z. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.09.020 · Cited by 19

Splice and Dice: Intronic microRNAs, Splicing and Cancer

Wong, A. C. H., & Rasko, J. E. J. (2021) · Biomedicines · doi:10.3390/biomedicines9091268 · Cited by 18

Exploring the Diverse Functional and Regulatory Consequences of Alternative Splicing in Development and Disease

Titus, M. B., Chang, A. W., & Olesnicky, E. C. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.775395 · Cited by 18

Functional Impact and Regulation of Alternative Splicing in Mouse Heart Development and Disease

Martí‐Gómez, C., Larrasa-Alonso, J., López-Olañeta, M. M., Villalba‐Orero, M., García‐Pavía, P., Sánchez‐Cabo, F., & Lara‐Pezzi, E. (2022) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-022-10244-x · Cited by 18

Exon junction complex-associated multi-adapter RNPS1 nucleates splicing regulatory complexes to maintain transcriptome surveillance

Schlautmann, L. P., Lackmann, J., Altmüller, J., Dieterich, C., Boehm, V., & Gehring, N. H. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac428 · Cited by 18

Splicing alterations contributing to cancer hallmarks in the liver: central role of dedifferentiation and genome instability

Jiménez, M., Arechederra, M., Avila, M. A., & Berasain, C. (2018) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2018.10.11 · Cited by 19

Splicing Factor SRSF5 Deletion Disrupts Alternative Splicing and Causes Noncompaction of Ventricular Myocardium

Zhang, X., Wang, Z., Xu, Q., Chen, Y., Liu, W., Zhong, T., Li, H., Quan, C., Zhang, L., & Cui, C. (2021) · iScience · doi:10.1016/j.isci.2021.103097 · Cited by 17

A UHM–ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing

Galardi, J. W., Bela, V. N., Jeffery, N. N., He, X., Glasser, E., Loerch, S., Jenkins, J. L., Pulvino, M. J., Boutz, P. L., & Kielkopf, C. L. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102224 · Cited by 17

Alternative splicing in bladder cancer: potential strategies for cancer diagnosis, prognosis, and treatment

Montero‐Hidalgo, A. J., Pérez‐Gómez, J. M., Martínez‐Fuentes, A. J., Gómez‐Gómez, E., Gahete, M. D., Jiménez‐Vacas, J. M., & Luque, R. M. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1760 · Cited by 17

mTOR Contributes to the Proteome Diversity through Transcriptome-Wide Alternative Splicing

Cheng, S. L. A., Fahmi, N. A., Park, M., Chang, J.-W., Sun, J., Thao, K., Yeh, H.-S., Zhang, W., & Yong, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012416 · Cited by 17

Alternative splicing decouples local from global PRC2 activity

Arecco, N., Mocavini, I., Blanco, E., Ballaré, C., Libman, E., Bonnal, S., Irimia, M., & Croce, L. D. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.02.011 · Cited by 17

RNA molecules display distinctive organization at nuclear speckles

Paul, S., Arias, M. A., Wen, L., Liao, S. E., Zhang, J., Wang, X., Regev, O., & Fei, J. (2024) · iScience · doi:10.1016/j.isci.2024.109603 · Cited by 19

Characterization of cis-acting elements that control oscillating alternative splicing

Goldammer, G., Neumann, A., Strauch, M., Müller-McNicoll, M., Heyd, F., & Preußner, M. (2018) · RNA Biology · doi:10.1080/15476286.2018.1502587 · Cited by 17

TfR1 Extensively Regulates the Expression of Genes Associated with Ion Transport and Immunity

Huang, N. J., Zhan, L., Cheng, Y., Wang, X., Wei, Y., Wang, Q., & Li, W. (2020) · Current Medical Science · doi:10.1007/s11596-020-2208-y · Cited by 17

ATP5A1 Participates in Transcriptional and Posttranscriptional Regulation of Cancer-Associated Genes by Modulating Their Expression and Alternative Splicing Profiles in HeLa Cells

Yisa Song, B., Wang, F., Wei, Y., Chen, D., & Deng, B. G. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211039126 · Cited by 17

From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform

Tian, N., Li, J., Shi, J., & Sui, G. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030191 · Cited by 17

Discovering the Interactions between Circular RNAs and RNA-binding Proteins from CLIP-seq Data using circScanPreprint

Li, B., Zhang, X., Liu, S., Liu, S., Sun, W., Lin, Q., Luo, Y.-X., Zhou, K., Zhang, C.-M., Tan, Y.-Y., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/115980 · Cited by 17

cDeepbind: A context sensitive deep learning model of RNA-protein bindingPreprint

Gandhi, S., Lee, L. J., Delong, A., Duvenaud, D., & Frey, B. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/345140 · Cited by 17

Interplay between coding and exonic splicing regulatory sequencesPreprint

Fontrodona, N., Aubé, F., Claude, J., Polvèche, H., Lemaire, S., Tranchevent, L.-C., Modolo, L., Mortreux, F., Bourgeois, C. F., & Auboeuf, D. (2019) · Genome Research · doi:10.1101/gr.241315.118 · Cited by 17

Integration of CLIP experiments of RNA-binding proteins: a novel approach to predict context-dependent splicing factors from transcriptomic data

Carazo, F., Gimeno, M., Ferrer-Bonsoms, J. A., & Rubio, Á. (2019) · BMC Genomics · doi:10.1186/s12864-019-5900-1 · Cited by 16

In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target

Vujovic, A., de Rooij, L. P. M. H., Chahi, A. K., Chen, H. T., Yee, B. A., Loganathan, S. K., Liu, L., Chan, D. C. H., Tajik, A., Tsao, E., et al. (2023) · Blood Cancer Discovery · doi:10.1158/2643-3230.bcd-22-0086 · Cited by 17

Regulating PCCA gene expression by modulation of pseudoexon splicing patterns to rescue enzyme activity in propionic acidemia

Petersen, U. S. S., Dembić, M., Martínez‐Pizarro, A., Richard, E., Holm, L. L., Havelund, J. F., Doktor, T. K., Larsen, M. R., Færgeman, N. J., Desviat, L. R., et al. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102101 · Cited by 16

RBM22 regulates RNA polymerase II 5′ pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Du, X., Qin, W., Yang, C., Dai, L., San, M., Xia, Y., Zhou, S., Wang, M., Wu, S., Zhang, S., et al. (2024) · Genome biology · doi:10.1186/s13059-024-03242-6 · Cited by 17

Faulty RNA splicing: consequences and therapeutic opportunities in brain and muscle disorders

Pagliarini, V., Rosa, P. L., & Sette, C. (2017) · Human Genetics · doi:10.1007/s00439-017-1802-y · Cited by 16

Insights into the roles of lncRNAs in skeletal and dental diseases

Li, Y., Zhang, J., Pan, J., Xu, F., Duan, P., Yin, X., Xu, Y., Wang, X., & Zou, S. (2018) · Cell & Bioscience · doi:10.1186/s13578-018-0208-4 · Cited by 16

Differential Alternative Splicing Genes and Isoform Regulation Networks of Rapeseed (Brassica napus L.) Infected with Sclerotinia sclerotiorum

Ma, J., Xu, W., Xu, F., Lin, A., Sun, W., Jiang, H., Lu, K., Li, J., & Wei, L. (2020) · Genes · doi:10.3390/genes11070784 · Cited by 16

Principles and Practical Considerations for the Analysis of Disease-Associated Alternative Splicing Events Using the Gateway Cloning-Based Minigene Vectors pDESTsplice and pSpliceExpress

Putscher, E., Hecker, M., Fitzner, B., Lorenz, P., & Zettl, U. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105154 · Cited by 16

PacBio and Illumina RNA Sequencing Identify Alternative Splicing Events in Response to Cold Stress in Two Poplar Species

Yang, J., Lv, W., Shao, L., Fu, Y., Liu, H., Yang, C., Chen, A., Xie, X., Wang, Z., & Li, C. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.737004 · Cited by 16

Non-canonical function of an Hif-1α splice variant contributes to the sustained flight of locusts

Ding, D., Zhang, J., Du, B., Wang, X., Hou, L., Guo, S., Chen, B., & Kang, L. (2022) · eLife · doi:10.7554/elife.74554 · Cited by 16

Alternative Splicing Outcomes Across an RNA-Binding Protein Concentration Gradient

Ellis, J. A., Hale, M. A., Cleary, J. D., Wang, E. T., & Berglund, J. A. (2023) · Journal of Molecular Biology · doi:10.1016/j.jmb.2023.168156 · Cited by 16

The discovery, function, and regulation of epithelial splicing regulatory proteins (ESRP) 1 and 2

Derham, J. M., & Kalsotra, A. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221124 · Cited by 16

Dynamic U2AF cycling defines two phases of cotranscriptional pre-mRNA splicing

Shao, C., Hao, Y., Jiang, L., Wang, D., Wang, R., Li, Y., Wang, H., Ge, Y., Bai, R., Du, X., et al. (2025) · Science · doi:10.1126/science.adj9141 · Cited by 15

Characterizing isoform switching events in esophageal adenocarcinoma

Zhang, Y., Weh, K. M., Howard, C. L., Riethoven, J.-J. M., Clarke, J., Lagisetty, K. H., Lin, J., Reddy, R. M., Chang, A. C., Beer, D. G., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.08.018 · Cited by 15

The Role of RNA-Binding Proteins in Hematological Malignancies

Aguilar-Garrido, P., Otero, Á., Navarro-Aguadero, M. Á., Velasco‐Estevez, M., & Gallardo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179552 · Cited by 15

Sex-specific splicing occurs genome-wide during early Drosophila embryogenesis

Ray, M., Conard, A. M., Urban, J. A., Aguilera, J., Huang, A., Mahableshwarkar, P., Vaidyanathan, S., & Larschan, E. (2023) · eLife · doi:10.7554/elife.87865 · Cited by 15

Differential hnRNP D isoform incorporation may confer plasticity to the ESSV-mediated repressive state across HIV-1 exon 3

Hillebrand, F., Peter, J. O., Brillen, A.-L., Otte, M., Schaal, H., & Erkelenz, S. (2016) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2016.12.001 · Cited by 15

Defective Ribonucleoproteins, Mistakes in RNA Processing, and Diseases

Mihailovic, M. K., Chen, A., Gonzalez‐Rivera, J. C., & Contreras, L. M. (2017) · Biochemistry · doi:10.1021/acs.biochem.6b01134 · Cited by 15

Splicing activator RNPS1 suppresses errors in pre-mRNA splicing: A key factor for mRNA quality control

Fukumura, K., Inoue, K., & Mayeda, A. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.120 · Cited by 15

Emerging properties of nuclear RNP biogenesis and export

Oeffinger, M., & Montpetit, B. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.04.007 · Cited by 16

Identification of prognosis‐related alternative splicing events in kidney renal clear cell carcinoma

Zuo, Y., Zhang, L. N., Tang, W., & Tang, W. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14651 · Cited by 15

Analysis of the Impact of Known SPINK1 Missense Variants on Pre-mRNA Splicing and/or mRNA Stability in a Full-Length Gene Assay

Wu, H., Boulling, A., Cooper, D. N., Li, Z., Liao, Z., Férec, C., & Chen, J. (2017) · Genes · doi:10.3390/genes8100263 · Cited by 15

Blocking the 5′ splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch

Cheatham, A. M., Davis, S. E., Khatua, A. K., & Popik, W. (2018) · Scientific Reports · doi:10.1038/s41598-018-27104-x · Cited by 15

Alternative splicing in human cancer cells is modulated by the amiloride derivative 3,5‐diamino‐6‐chloro‐N‐(N‐(2,6‐dichlorobenzoyl)carbamimidoyl)pyrazine‐2‐carboxide

Lee, C., Chang, W., Chang, Y., Yang, J., Chang, C., Hsu, K., Chen, Y., Liu, T., Chen, Y., Lin, S., et al. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12524 · Cited by 15

Functions of the Muscleblind-like protein family and their role in disease

Zhou, H., Xu, J., & Pan, L. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02102-5 · Cited by 14

Titration of SF3B1 Activity Reveals Distinct Effects on the Transcriptome and Cell Physiology

Guisbert, K. S. K., Mossiah, I., & Guisbert, E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249641 · Cited by 14

HNRNPU's multi‐tasking is essential for proper cortical development

Sapir, T., & Reiner, O. (2023) · BioEssays · doi:10.1002/bies.202300039 · Cited by 14

The Regulatory Network of hnRNPs Underlying Regulating PKM Alternative Splicing in Tumor Progression

Li, Y., Zhang, S., Li, Y., Liu, J., Li, Q., Zang, W., & Pan, Y. (2024) · Biomolecules · doi:10.3390/biom14050566 · Cited by 14

Relevance and regulation of alternative splicing in plant secondary metabolism: current understanding and future directions

Xu, Z., Xiao, Y., Guo, J., Lv, Z., & Chen, W. (2024) · Horticulture Research · doi:10.1093/hr/uhae173 · Cited by 14

PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators

Wang, Y., Chembazhi, U. V., Yee, D., Chen, S., Ji, J., Wang, Y., Nguyen, K. L., Lin, P.-C. P., Ratti, A., Hess, R. A., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae862 · Cited by 14

Proteomic study identifies Aurora-A–mediated regulation of alternative splicing through multiple splicing factors

Damodaran, A. P., Gavard, O., Gagné, J., Rogalska, M. E., Behera, A. K., Mancini, E., Bertolin, G., Courthéoux, T., Kumari, B., Cailloce, J., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.108000 · Cited by 14

Condensation of ZFP207 and U1 snRNP promotes spliceosome assembly

Zhou, Y., Tong, C., Shi, Z., Zhang, Y., Xiong, X., Shen, X., Li, X., & Yin, Y. (2025) · Nature Structural & Molecular Biology · doi:10.1038/s41594-025-01501-z · Cited by 15

Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells

Liu, L., Liu, K., Yan, Y., Chu, Z., Tang, Y., & Tang, C. (2018) · BioMed Research International · doi:10.1155/2018/7849294 · Cited by 14

Modeling and Predicting the Activities of Trans-Acting Splicing Factors with Machine Learning

Mao, M., Hu, Y., Yang, Y., Qian, Y., Wei, H. Y., Fan, W., Yang, Y. A., Li, X., & Wang, Z. (2018) · Cell Systems · doi:10.1016/j.cels.2018.09.002 · Cited by 14

acorde unravels functionally interpretable networks of isoform co-usage from single cell data

Arzalluz-Luque, Á., Salguero, P., Tarazona, S., & Conesa, A. (2022) · Nature Communications · doi:10.1038/s41467-022-29497-w · Cited by 15

Cooperative engagement and subsequent selective displacement of SR proteins define the pre-mRNA 3D structural scaffold for early spliceosome assembly

Saha, K., & Ghosh, G. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac636 · Cited by 14

The transcription factor c-Jun inhibits RBM39 to reprogram pre-mRNA splicing during genotoxic stress

Lemaitre, F., Chakrama, F. Z., O’Grady, T. M., Peulen, O., Rademaker, G., Deward, A., Chabot, B., Piette, J. G., Colige, A., Lambert, C. A., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac1130 · Cited by 15

YBX1 regulates the survival of chronic myeloid leukemia stem cells by modulating m6A-mediated YWHAZ stability

Chai, J., Wang, Q., Qiu, Q., Han, G., Chen, Y., Li, W., & Zhang, H. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00762-w · Cited by 14

Binding of SRSF4 to a novel enhancer modulates splicing of exon 6 of Fas pre-mRNA

Jang, H. N., Liu, Y., Choi, N., Oh, J., Ha, J., Zheng, X., & Shen, H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.123 · Cited by 15

The Alternative Splicing Landscape of Brassica napus Infected with Leptosphaeria maculans

Ma, J., Wei, L., Lin, A., Zhang, C., Sun, W., Yang, B., Lu, K., & Li, J. (2019) · Genes · doi:10.3390/genes10040296 · Cited by 14

Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation

Nakamura, S., Kahyo, T., Tao, H., Shibata, K., Kurabe, N., Yamada, H., Shinmura, K., Ohnishi, K., & Sugimura, H. (2015) · Scientific Reports · doi:10.1038/srep13474 · Cited by 14

RBM4 modulates the proliferation and expression of inflammatory factors via the alternative splicing of regulatory factors in HeLa cells

Wang, W.-Y., Quan, W., Yang, F., Wei, Y., Chen, J., Yu, H., Xie, J., Zhang, Y., & Li, Z. (2019) · Molecular Genetics and Genomics · doi:10.1007/s00438-019-01606-3 · Cited by 14

All differential on the splicing front: Host alternative splicing alters the landscape of virus-host conflict

Mann, J. T., Riley, B. A., & Baker, S. F. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.01.013 · Cited by 14

WVDL: Weighted Voting Deep Learning Model for Predicting RNA-Protein Binding Sites

Pan, Z., Zhou, S., Liu, T., Liu, C., Zang, M., & Wang, Q. (2023) · IEEE Transactions on Computational Biology and Bioinformatics · doi:10.1109/tcbb.2023.3252276 · Cited by 13

Combining full-length gene assay and SpliceAI to interpret the splicing impact of all possible SPINK1 coding variants

Wu, H., Lin, J., Tang, X., Marenne, G., Zou, W., Schutz, S., Masson, E., Génin, E., Fichou, Y., Gac, G. L., et al. (2024) · Human Genomics · doi:10.1186/s40246-024-00586-9 · Cited by 13

RNA-Binding Protein-Mediated Alternative Splicing Regulates Abiotic Stress Responses in Plants

Guo, Y., Shang, X., Ma, L., & Cao, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910548 · Cited by 13

Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer’s disease

Wang, F., Li, Y., Shen, H., Martínez-Feduchi, P., Ji, X., Teng, P., Krishnakumar, S., Hu, J., Chen, L., Feng, Y., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01404-6 · Cited by 13

NUMB alternative splicing and isoform-specific functions in development and disease

Dho, S. E., Othman, K., Zhang, Y., & McGlade, C. J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108215 · Cited by 13

Identification of NIBAN2‐Regulated RUNX2 Alternative Splicing Presents Novel Strategies for Antagonizing Osteoporosis

Zhang, S., Yang, Z., Xie, Y., Zhang, Y., Chen, Z., Lv, X., Deng, Z., Huang, Z., Cai, L., & Wei, R. (2025) · Advanced Science · doi:10.1002/advs.202416536 · Cited by 13

Post‐Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs

Lancaster, C. L., Moberg, K. H., & Corbett, A. H. (2025) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.70007 · Cited by 14

The Crumbs_C isoform ofDrosophilashows tissue- and stage-specific expression and prevents light-dependent retinal degeneration

Spannl, S., Kumichel, A., Hebbar, S., Kapp, K., González‐Gaitán, M., Winkler, S., Blawid, R., Jessberger, G., & Knust, E. (2017) · Biology Open · doi:10.1242/bio.020040 · Cited by 13

Toward a clinical diagnostic pipeline for SPINK1 intronic variants

Tang, X., Lin, J., Zou, W., Masson, E., Boulling, A., Deng, S., Cooper, D. N., Liao, Z., Férec, C., Li, Z., et al. (2019) · Human Genomics · doi:10.1186/s40246-019-0193-7 · Cited by 13

Systemic Analysis of RNA Alternative Splicing Signals Related to the Prognosis for Head and Neck Squamous Cell Carcinoma

Li, Z., Chen, X., Wei, M., Liu, G., Tian, Y., Zhang, X., Zhu, G., Chen, C., Liu, J., Wang, T., et al. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00087 · Cited by 13

Biological functions and prognostic value of RNA Binding Proteins in clear cell Renal Cell Carcinoma

Zhu, Z., He, A., Lin, L., Xu, C., Cai, T., & Lin, J. (2020) · Journal of Cancer · doi:10.7150/jca.49175 · Cited by 13

Toxicological effects of tris(1,3-dichloro-2-propyl) phosphate in oyster Crassostrea gigas using proteomic and phosphoproteomic analyses

Yin, C., Sun, Z., Ji, C., Li, F., & Wu, H. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.128824 · Cited by 13

Context-Dependent Function of Long Noncoding RNA PURPL in Transcriptome Regulation during p53 Activation

Hartford, C. C. R., Shrestha, R. L., Pongor, L. S., Zhao, Y., Chen, X., Fromont, C., Chaudhary, R., Li, X. L., Pasterczyk, K. R., Kumar, R. S., et al. (2022) · Molecular and Cellular Biology · doi:10.1128/mcb.00289-22 · Cited by 13

Post-Transcriptional Modification by Alternative Splicing and Pathogenic Splicing Variants in Cardiovascular Development and Congenital Heart Defects

Mehta, Z., & Touma, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021555 · Cited by 13

Alternative Splicing in the Regulatory Circuit of Plant Temperature Response

Xue, R., Mo, R., Cui, D., Cheng, W., Wang, H., Qin, J., & Liu, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043878 · Cited by 13

A novel splicing variant of DJ-1 in Parkinson's disease induces mitochondrial dysfunction

Cho, N., Joo, J., Choi, S., Kang, B.-G., Lee, A., Youn, S.-Y., Park, S., Kim, E. M., Masliah, E., Ko, Y., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14039 · Cited by 13

Dissecting the expression relationships between RNA-binding proteins and their cognate targets in eukaryotic post-transcriptional regulatory networks

Nishtala, S., Neelamraju, Y., & Janga, S. C. (2016) · Scientific Reports · doi:10.1038/srep25711 · Cited by 14

Haplotype-specific MAPT exon 3 expression regulated by common intronic polymorphisms associated with Parkinsonian disorders

Lai, M. C., Bechy, A.-L., Denk, F., Collins, E., Gavriliouk, M., Zaugg, J. B., Ryan, B. J., Wade‐Martins, R., & Caffrey, T. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0224-6 · Cited by 15

Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ

Iida, K., Hagiwara, M., & Takeuchi, A. (2020) · iScience · doi:10.1016/j.isci.2020.101325 · Cited by 13

The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response

Liao, K., Chuo, V., Fagg, W. S., Modahl, C. M., Widen, S. G., & García-Blanco, M. A. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab732 · Cited by 13

Comprehensive transcript-level analysis reveals transcriptional reprogramming during the progression of Alzheimer’s disease

Wu, H., Wang, J., Hu, X., Zhuang, C., Zhou, J., Wu, P., Li, S., & Zhao, R. C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1191680 · Cited by 12

M6A RNA methylation in biliary tract cancer: the function roles and potential therapeutic implications

Bai, X., Huang, J., Jin, Y., Chen, J., Zhou, S., Dong, L., Han, X., & He, X. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01849-z · Cited by 12

Role of alternative splicing in fish immunity

Wang, Y., Xu, X., Zhang, A., Yang, S., & Li, H. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109601 · Cited by 12

Uncovering the dynamics and consequences of RNA isoform changes during neuronal differentiation

Ulićević, J., Shao, Z., Jasnovidova, O., Bressin, A., Gajos, M., Ng, A. H. M., Annaldasula, S., Meierhofer, D., Church, G. M., Busskamp, V., et al. (2024) · Molecular Systems Biology · doi:10.1038/s44320-024-00039-4 · Cited by 12

Splicing dysregulation: hallmark and therapeutic opportunity in pancreatic cancer

Naro, C., Ruta, V., & Sette, C. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.11.007 · Cited by 12

The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation

Reane, D. V., Cerqua, C., Sacconi, S., Salviati, L., Trevisson, E., & Raffaello, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052517 · Cited by 12

RNA-Binding Proteins and Alternative Splicing Genes Are Coregulated in Human Retinal Endothelial Cells Treated with High Glucose

Zhao, H., Kong, H., Wang, B., Wu, S., Chen, T., & Cui, Y. T. (2022) · Journal of Diabetes Research · doi:10.1155/2022/7680513 · Cited by 13

PQBP1 regulates striatum development through balancing striatal progenitor proliferation and differentiation

Liu, W., Xie, H., Liu, X., Xu, S., Cheng, S., Wang, Z., Xie, T., Zhang, Z. C., & Han, J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112277 · Cited by 12

Both sides of the same coin: Rac1 splicing regulation by EGF signaling

Fu, X. (2017) · Cell Research · doi:10.1038/cr.2017.19 · Cited by 12

An emerging model organism Caenorhabditis elegans for alternative pre‐ mRNA processing in vivo

Wani, S., & Kuroyanagi, H. (2017) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1428 · Cited by 12

Temperature‐controlled Rhythmic Gene Expression in Endothermic Mammals: All Diurnal Rhythms are Equal, but Some are Circadian

Preußner, M., & Heyd, F. (2018) · BioEssays · doi:10.1002/bies.201700216 · Cited by 13

Global Profiling of Dynamic Alternative Splicing Modulation in Arabidopsis Root upon Ralstonia solanacearum Infection

Qin, N., Zhang, R., Zhang, M., Niu, Y., Fu, S., Wang, Y., Wang, D., Chen, Y., Zhao, C., Chen, Q., et al. (2020) · Genes · doi:10.3390/genes11091078 · Cited by 12

RBM14 Modulates Tubulin Acetylation and Regulates Spindle Morphology During Meiotic Maturation in Mouse Oocytes

Qin, H., Qu, Y., Yuan, Y.-F., Li, Y., & Qiao, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.635728 · Cited by 12

Commentary: FUS affects circular RNA expression in murine embryonic stem cell-derived motor neurons

Verheijen, B. M., & Pasterkamp, R. J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00412 · Cited by 13

SRSF2 safeguards efficient transcription of DNA damage and repair genes

Wagner, R. E., Arnetzl, L., Britto‐Borges, T., Heit-Mondrzyk, A., Bakr, A., Sollier, E., Gkatza, N. A., Panten, J., Delaunay, S., Sohn, D., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114869 · Cited by 11

Understanding splicing regulation through RNA splicing maps

Witten, J. T., & Ule, J. (2011) · Trends in Genetics · doi:10.1016/j.tig.2010.12.001 · Cited by 289

Experimental strategies for studying RNA-binding proteins and their complexes in alternative mRNA splicing

Srivastava, D., Ramakrishnan, L. S., Shadija, Y., Sandeep, G., & Misra, A. (2026) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2026.07.031

Mechanism of an alternative splicing switch mediated by cell-specific and general splicing regulatorsPreprint

Yang, Y. A., Lee, G. C., Nakagaki-Silva, E. E., Huang, Y., Peacey, M., Partridge, R., Gooding, C., & Smith, C. W. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.23.525191 · Cited by 1

Position-dependent effects of RNA-binding proteins in the context of co-transcriptional splicing

Horn, T., Gosliga, A. R., Li, C., Enculescu, M., & Legewie, S. (2023) · npj Systems Biology and Applications · doi:10.1038/s41540-022-00264-3 · Cited by 26

Regulation of alternative splicing in Drosophila by 56 RNA binding proteinsPreprint

Brooks, A. N., Duff, M. O., May, G. E., Yang, L. C., Bolisetty, M. T., Landolin, J. M., Wan, K., Sandler, J. E., Booth, B. W., Celniker, S., et al. (2015) · Genome Research · doi:10.1101/gr.192518.115 · Cited by 84