High-throughput functional genomics using CRISPR-Cas9

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Items 101–200 of 1,000

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2. Epigenetics in Insects: Genome Regulation and the Generation of Phenotypic Diversity
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3. Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens
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4. Applications in image-based profiling of perturbations
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5. Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease
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6. The genetics of alcohol dependence and alcohol-related liver disease
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7. Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
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8. Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system
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9. Structural basis for specific single-stranded RNA recognition by designer pentatricopeptide repeat proteins
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10. Advances in Engineering the Fly Genome with the CRISPR-Cas System
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11. CRISPR/Cas 9 genome editing and its applications in organoids
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12. Generation of a Collection of Mutant Tomato Lines Using Pooled CRISPR Libraries
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13. Evolution of RNA- and DNA-guided antivirus defense systems in prokaryotes and eukaryotes: common ancestry vs convergence
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14. Dual gene activation and knockout screen reveals directional dependencies in genetic networks
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15. CRISPRs for Optimal Targeting: Delivery of CRISPR Components as DNA, RNA, and Protein into Cultured Cells and Single-Cell Embryos
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16. CRISPR-Cas Biology and Its Application to Infectious Diseases
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17. Role of Biofuels in Energy Transition, Green Economy and Carbon Neutrality
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18. Progress and promise in understanding the genetic basis of common diseases
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19. Delivery of CRISPR/Cas9 for therapeutic genome editing
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20. ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanisms
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21. Immunity to CRISPR Cas9 and Cas12a therapeutics
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22. Building a Genetic Manipulation Tool Box for Orchid Biology: Identification of Constitutive Promoters and Application of CRISPR/Cas9 in the Orchid, Dendrobium officinale
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23. CRISPR/Cas9 technology as a potent molecular tool for gene therapy
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24. A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
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25. The Crosstalk Between Hippo-YAP Pathway and Innate Immunity
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26. The Caenorhabditis elegans Transgenic Toolbox
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27. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
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28. Surface-Engineered Viral Vectors for Selective and Cell Type-Specific Gene Delivery
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29. High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening
    Rodrigo A. Gier, Krista A. Budinich, Niklaus H. Evitt, Zhendong Cao, Elizabeth Freilich, Qingzhou Chen, Jun Qi, Yemin Lan, Rahul M. Kohli, Junwei Shi · 2020 · Nature Communications
30. Computational Tools and Resources for CRISPR/Cas Genome Editing
    Chao Li, Wen Chu, Rafaqat A. Gill, Shifei Sang, Yuqin Shi, Xuezhi Hu, Yuting Yang, Qamar U. Zaman, Baohong Zhang · 2022 · Genomics Proteomics & Bioinformatics
31. CRISPR/Cas9‐mediated genome editing: From basic research to translational medicine
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32. CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens
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33. Emerging Avenues for Utilization of Exotic Germplasm
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34. Multiplexed Gene Editing and Protein Overexpression Using a Tobacco mosaic virus Viral Vector
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35. A practical view of fine-mapping and gene prioritization in the post-genome-wide association era
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36. CRISPR/dCas-mediated transcriptional and epigenetic regulation in plants
    Changtian Pan, Simon Sretenovic, Yiping Qi · 2021 · Current Opinion in Plant Biology
37. CRISPR screens uncover protective effect of PSTK as a regulator of chemotherapy-induced ferroptosis in hepatocellular carcinoma
    Yiran Chen, Li Li, Jie Lan, Yang Cui, Xiaosong Rao, Jing Zhao, Tao Xing, Gaoda Ju, Guangtao Song, Jizhong Lou et al. · 2022 · Molecular Cancer
38. Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
    Feng Tian, Yuyan Cheng, Songlin Zhou, Qianbin Wang, Aboozar Monavarfeshani, Kun Gao, Weiqian Jiang, Riki Kawaguchi, Qing Wang, Mingjun Tang et al. · 2022 · Neuron
39. Engineering cell signaling using tunable CRISPR–Cpf1-based transcription factors
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40. Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression
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41. Tahoe-100M : A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling
    Jesse M. Zhang, Airol A. Ubas, Richard de Borja, Valentine Svensson, Nicole Thomas, Neha Thakar, Ian K. Lai, Aidan F. Winters, Umair Khan, Matthew G. Jones et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
42. Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning
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43. Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
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44. Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
    Alexander Muir, Laura V. Danai, Matthew G. Vander Heiden · 2018 · Disease Models & Mechanisms
45. Genome-wide CRISPR-Cas9 Interrogation of Splicing Networks Reveals a Mechanism for Recognition of Autism-Misregulated Neuronal Microexons
    Thomas Gonatopoulos-Pournatzis, Mingkun Wu, Ulrich Braunschweig, Jonathan F. Roth, Hong Ryul Han, Andrew J. Best, Bushra Raj, Michael Aregger, Dave O’Hanlon, Jonathan D. Ellis et al. · 2018 · Molecular Cell
46. Cancer CRISPR Screens In Vivo
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47. Leveraging preclinical models for the development of Alzheimer disease therapeutics
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48. Antioxidant Defense Systems in Plants: Mechanisms, Regulation, and Biotechnological Strategies for Enhanced Oxidative Stress Tolerance
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49. Precision Control of CRISPR-Cas9 Using Small Molecules and Light
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50. A new age in functional genomics using CRISPR/Cas9 in arrayed library screening
    Alexander Agrotis, Robin Ketteler · 2015 · Frontiers in Genetics
51. Genetics of neurodegenerative diseases: an overview
    Lasse Pihlstrøm, Sarah Wiethoff, Henry Houlden · 2017 · Handbook of clinical neurology
52. Advances and perspectives on the use of CRISPR/Cas9 systems in plant genomics research
    Degao Liu, Rongbin Hu, Kaitlin J. Palla, Gerald A. Tuskan, Xiaohan Yang · 2016 · Current Opinion in Plant Biology
53. The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes
    Nicolas Mérienne, Gabriel Vachey, Lucie de Longprez, Cécile Meunier, Virginie Zimmer, Guillaume Perriard, Mathieu Canales, Amandine Mathias, Lucas Herrgott, Tim Beltraminelli et al. · 2017 · Cell Reports
54. Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer
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55. Genomic tools for behavioural ecologists to understand repeatable individual differences in behaviour
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56. CRISPR/Cas approach: A new way of looking at plant-abiotic interactions
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57. Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications
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58. Neurobiology of cannabinoid receptor signaling
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59. Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer
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60. Prediction of CRISPR sgRNA Activity Using a Deep Convolutional Neural Network
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61. Single-Cell and Single-Molecule Analysis of Gene Expression Regulation
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62. RNA i‐based targeted gene knockdown in the model oleaginous microalgae Nannochloropsis oceanica
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63. New CRISPR Mutagenesis Strategies Reveal Variation in Repair Mechanisms among Fungi
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64. Advancements and Obstacles of CRISPR-Cas9 Technology in Translational Research
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65. CRISPR/Cas9 for Human Genome Engineering and Disease Research
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66. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci
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67. Optochemische Steuerung biologischer Vorgänge in Zellen und Tieren
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68. A glance at genome editing with CRISPR–Cas9 technology
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69. Integrin αvβ5 Internalizes Zika Virus during Neural Stem Cells Infection and Provides a Promising Target for Antiviral Therapy
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70. Enabling functional genomics with genome engineering
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71. Advances and challenges in genetic engineering of microalgae
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72. Resources for the design of CRISPR gene editing experiments
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73. Modular one-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis
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74. Good guide, bad guide: spacer sequence-dependent cleavage efficiency of Cas12a
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75. CRISPR screens in plants: approaches, guidelines, and future prospects
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76. Cas9-edited immune checkpoint blockade PD-1 DNA polyaptamer hydrogel for cancer immunotherapy
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77. Functional variomics and network perturbation: connecting genotype to phenotype in cancer
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78. Functional Genomics via CRISPR–Cas
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79. CRISPR/Cas9 – An evolving biological tool kit for cancer biology and oncology
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80. Self-cleaving ribozymes enable the production of guide RNAs from unlimited choices of promoters for CRISPR/Cas9 mediated genome editing
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81. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila
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82. CRISPR screening of porcine sgRNA library identifies host factors associated with Japanese encephalitis virus replication
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83. Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni
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84. Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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85. Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma
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86. CRISPR/Cas9 Landscape: Current State and Future Perspectives
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87. Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease
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88. PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer
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89. Multi-omics approaches for understanding gene-environment interactions in noncommunicable diseases: techniques, translation, and equity issues
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90. A ‘suicide’ CRISPR-Cas9 system to promote gene deletion and restoration by electroporation in Cryptococcus neoformans
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91. A High-Resolution Genome-Wide CRISPR/Cas9 Viability Screen Reveals Structural Features and Contextual Diversity of the Human Cell-Essential Proteome
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92. Cell-Based Assay Design for High-Content Screening of Drug Candidates
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93. Improved sgRNA design in bacteria via genome-wide activity profiling
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94. Immunoliposomes for cancer therapy.
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95. Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers
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96. Transcriptional regulation with CRISPR-Cas9: principles, advances, and applications
    Didovyk, Andriy, Borek, Bartłomiej, Tsimring, Lev, Hasty, Jeff · 2016 · Current Opinion in Biotechnology
97. Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations
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98. Highly parallel genome variant engineering with CRISPR–Cas9
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99. CRISPR library designer (CLD): software for multispecies design of single guide RNA libraries
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100. CRISPR/Cas9: Transcending the Reality of Genome Editing
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