Cited by 1,872MicroRNA in disease regulationRNA Interference and Gene DeliveryRNA Research and Splicing

The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.

Towards a molecular understanding of microRNA-mediated gene silencing

Jonas, Stefanie, Izaurralde, Elisa·2015·Nature Reviews Genetics

Open this paper in CoChat — free account

Abstract

MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post-transcriptional silencing of complementary mRNA targets. Silencing is accomplished through a combination of translational repression and mRNA destabilization, with the latter contributing to most of the steady-state repression in animal cell cultures. Degradation of the mRNA target is initiated by deadenylation, which is followed by decapping and 5'-to-3' exonucleolytic decay. Recent work has enhanced our understanding of the mechanisms of silencing, making it possible to describe in molecular terms a continuum of direct interactions from miRNA target recognition to mRNA deadenylation, decapping and 5'-to-3' degradation. Furthermore, an intricate interplay between translational repression and mRNA degradation is emerging.

Integrity signals

Registry

Crossref · 10.1038/nrg3965

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Widespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429
The mechanism of eukaryotic translation initiation and principles of its regulation
Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2838 · Cited by 2,759
Gene silencing by microRNAs: contributions of translational repression and mRNA decay
Huntzinger, E., & Izaurralde, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2936 · Cited by 2,339
Self-citation
A brain-specific microRNA regulates dendritic spine development
Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786
Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,647
Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells
Pillai, R. S., Bhattacharyya, S. N., Artus-Revel, C. G., Zoller, T., Cougot, N., Basyuk, E. I., Bertrand, É., & Filipowicz, W. (2005) · Science · doi:10.1126/science.1115079 · Cited by 1,489

Flagged first, then by citations

Show all 116 references

Sorted by citations

Items 801–900 of 1,002

MicroRNA-200a-3p Is a Positive Regulator in Cardiac Hypertrophy Through Directly Targeting WDR1 as Well as Modulating PTEN/PI3K/AKT/CREB/WDR1 Signaling
Yang, X., Chen, G., & Chen, Z. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000732 · Cited by 21
Blood-based Biomarkers of Alzheimer’s Disease: The Long and Winding Road
Manzine, P. R., Vatanabe, I. P., Peron, R., Grigoli, M. M., Pedroso, R. V., Nascimento, C. M. C., & Cominetti, M. R. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200114105515 · Cited by 22
MicroRNAs as sentinels and protagonists of carotid artery thromboembolism
Raju, S., Fish, J. E., & Howe, K. L. (2020) · Clinical Science · doi:10.1042/cs20190651 · Cited by 22
High-Throughput Fluorescence-Based Screen Identifies the Neuronal MicroRNA miR-124 as a Positive Regulator of Alphavirus Infection
López, P., Girardi, E., Mounce, B. C., Weiss, A., Chane-Woon-Ming, B., Messmer, M., Kaukinen, P., Kopp, A., Bortolamiol-Bécet, D., Fendri, A., et al. (2020) · Journal of Virology · doi:10.1128/jvi.02145-19 · Cited by 21
tRNA Fragments Populations Analysis in Mutants Affecting tRNAs Processing and tRNA Methylation
Molla‐Herman, A., Angelova, M. T., Ginestet, M., Carré, C., Antoniewski, C., & Huynh, J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.518949 · Cited by 21
The role of RNA-binding and ribosomal proteins as specific RNA translation regulators in cellular differentiation and carcinogenesis
Ceci, M., Fazi, F., & Romano, N. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.166046 · Cited by 21
A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease
Luo, J., Xie, M., Hou, Y., Ma, W., Jin, Y., Chen, J., Li, C., Zhao, K., Chen, N., Xu, L., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114582 · Cited by 21
MicroRNA Expression Changes in Kidney Transplant: Diagnostic Efficacy of miR-150-5p as Potential Rejection Biomarker, Pilot Study
Alfaro, R., Legáz, I., Jiménez-Coll, V., band, J. E. K. E., Martínez‐Banaclocha, H., Galián, J. A., Parrado, A., Mrowiec, A., Botella, C., Moya‐Quiles, M. R., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132748 · Cited by 21
microRNAs stimulate translation initiation mediated by HCV-like IRESes
Mengardi, C., Limousin, T., Ricci, E. P., Soto‐Rifo, R., Décimo, D., & Ohlmann, T. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1345 · Cited by 21
MiR34a Regulates Neuronal MHC Class I Molecules and Promotes Primary Hippocampal Neuron Dendritic Growth and Branching
Hu, Y., Pei, W., Hu, Y., Li, P., Sun, C., Du, J., Zhang, Y., Miao, F., Zhang, A., Shen, Y., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.573208 · Cited by 18
microRNA-9 selectively targets LMX1A to promote gastric cancer cell progression
Zhang, X., Qian, Y., Fan, L., Bei, S., Li, M., & Feng, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.101 · Cited by 20
microRNA-4532 inhibition protects human lens epithelial cells from ultra-violet-induced oxidative injury via activating SIRT6-Nrf2 signaling
Sun, G., Huang, D. F., Li, K., & Jiang, Q. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.026 · Cited by 20
The Role of Dynamic miRISC During Neuronal Development
Nawalpuri, B., Ravindran, S., & Muddashetty, R. S. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00008 · Cited by 19
Integrated Transcriptome and Proteome Analyses Reveal the Regulatory Role of miR-146a in Human Limbal Epithelium via Notch Signaling
Poe, A. J., Kulkarni, M. M., Leszczynska, A., Tang, J., Shah, R., Jami‐Alahmadi, Y., Wang, J., Kramerov, A. A., Wohlschlegel, J. A., Punj, V., et al. (2020) · Cells · doi:10.3390/cells9102175 · Cited by 20
Exosome-Derived Noncoding RNAs as a Promising Treatment of Bone Regeneration
Yin, B., Ma, Q., Song, C., Zhao, L., Yu, F., Wang, C., Shi, Y., & Ye, L. (2021) · Stem Cells International · doi:10.1155/2021/6696894 · Cited by 20
Synthetic RNA-based post-transcriptional expression control methods and genetic circuits
Pardi, M. L., Wu, J., Kawasaki, S., & Saito, H. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114196 · Cited by 20
MicroRNAs and Progesterone Receptor Signaling in Endometriosis Pathophysiology
Nothnick, W. B. (2022) · Cells · doi:10.3390/cells11071096 · Cited by 22
enrichMiR predicts functionally relevant microRNAs based on target collections
Soutschek, M., Germade, T., Germain, P., & Schratt, G. M. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac395 · Cited by 20
[Retracted] The Correlation of PM2.5 Exposure with Acute Attack and Steroid Sensitivity in Asthma
Luo, J., Liu, H., Hua, S., & Song, L. (2022) · BioMed Research International · doi:10.1155/2022/2756147 · Cited by 20
Retracted
Study on the Mechanism of miR-125b-5p Affecting Melanocyte Biological Behavior and Melanogenesis in Vitiligo through Regulation of MITF
Wang, X., Wu, Y., Du, P., Xu, L., Chen, Y., Li, J., Pan, X., & Wang, Z. (2022) · Disease Markers · doi:10.1155/2022/6832680 · Cited by 20
Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities
Rungratanawanich, W., Ballway, J. W., Wang, X., Won, K., Hardwick, J. P., & Song, B. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108547 · Cited by 22
MicroRNA Biogenesis, Gene Regulation Mechanisms, and Availability in Foods
Mello, A. S. D., Ferguson, B. S., Shebs, E. L., & Giotto, F. M. (2024) · Non-Coding RNA · doi:10.3390/ncrna10050052 · Cited by 24
Attenuation of miR-34a protects cardiomyocytes against hypoxic stress through maintenance of glycolysis
Zhang, Y., Liu, G., & Gao, X. (2017) · Bioscience Reports · doi:10.1042/bsr20170925 · Cited by 20
Differentially expressed microRNAs associated with changes of transcript levels in detoxification pathways and DDT-resistance in the Drosophila melanogaster strain 91-R
Seong, K. M., Coates, B. S., Kim, D.-H., Hansen, A. K., & Pittendrigh, B. R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196518 · Cited by 20
Opposing roles of miR‐294 and MBNL1/2 in shaping the gene regulatory network of embryonic stem cells
Wu, D., Gu, K., Yu, J., Fu, X., Wang, X., Guo, W., Liao, L., Zhu, H. M., Zhang, X., Hui, J., et al. (2018) · EMBO Reports · doi:10.15252/embr.201745657 · Cited by 20
miR‑339‑5p negatively regulates loureirin A‑induced hair follicle stem cell differentiation by targeting DLX5
Li, X., Wu, Y., Xie, F., Zhang, F., Zhang, S., Zhou, J., Chen, D., & Liu, A. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9110 · Cited by 21
Targeting ninjurin 2 by miR-764 regulates hydrogen peroxide (H2O2)-induced neuronal cell death
Ding, J., Yinzhu, L., Jinjing, P., Liang, L., & Zhang, G. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.184 · Cited by 20
A potential therapeutic target for regulating osteoporosis via suppression of osteoclast differentiation
Sun, Q., Zhang, B., Zhu, W., Wei, W., Ma, J., & Tay, F. R. (2019) · Journal of Dentistry · doi:10.1016/j.jdent.2019.01.015 · Cited by 20
Asymmetric polymerase chain reaction and loop-mediated isothermal amplification (AP-LAMP) for ultrasensitive detection of microRNAs
Wang, R., Lan, L., Liu, L., & Cheng, L. (2019) · Chinese Chemical Letters · doi:10.1016/j.cclet.2019.05.003 · Cited by 20
Subacute exposure of PM2.5 induces airway inflammation through inflammatory cell infiltration and cytokine expression in rats
Li, Y., Sun, B., Shi, Y., Jiang, J., Du, Z., Chen, R., Duan, J., & Sun, Z. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126423 · Cited by 20
Hsa-miR-494-3p attenuates gene HtrA3 transcription to increase inflammatory response in hypoxia/reoxygenation HK2 Cells
Gong, Q., Shen, Z., Sheng, Z., Jiang, S. W., & Ge, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-81113-x · Cited by 20
Cytotoxic Effect of Progesterone, Tamoxifen and Their Combination in Experimental Cell Models of Human Adrenocortical Cancer
Rossini, E., Tamburello, M., Abate, A., Beretta, S., Fragni, M., Cominelli, M., Cosentini, D., Hantel, C., Bono, F., Grisanti, S., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.669426 · Cited by 20
Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing
Johnson, S. T., Chu, Y., Liu, J., & Corey, D. R. (2021) · RNA · doi:10.1261/rna.078709.121 · Cited by 20
MiR-301a-5p/SCIN promotes gastric cancer progression via regulating STAT3 and NF-κB signaling
Huang, Y., Du, X., Chen, X., Chen, C., Wang, H., Yang, Y., & Teng, L. (2021) · Journal of Cancer · doi:10.7150/jca.59747 · Cited by 20
Phosphoglycerate kinase 1 silencing by a novel microRNA microRNA-4523 protects human osteoblasts from dexamethasone through activation of Nrf2 signaling cascade
Liang, J., Zhou, Z., Lin, B., Tan, H., Hu, J., & Tan, M.-S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04250-1 · Cited by 20
Circulating cell‐free micro RNA s in cutaneous melanoma staging and recurrence or survival prognosis
Polini, B., Carpi, S., Romanini, A., Breschi, M. C., Nieri, P., & Podestà, A. (2018) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12755 · Cited by 19
microRNA-628 inhibits the proliferation of acute myeloid leukemia cells by directly targeting IGF-1R
Chen, L., Jiang, X. J., Chen, H., Han, Q., Liu, C., & Sun, M. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s192137 · Cited by 19
Retracted
MicroRNA Modulation by Dietary Supplements in Obesity
Filardi, T., Sabato, C., Lubrano, C., Santangelo, C., Morano, S., Lenzi, A., Migliaccio, S., Ferretti, E., & Catanzaro, G. (2020) · Biomedicines · doi:10.3390/biomedicines8120545 · Cited by 19
Identification of Bovine miRNAs with the Potential to Affect Human Gene Expression
Myrzabekova, M., Labeit, S., Niyazova, R., Akimniyazova, A., & At, I. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.705350 · Cited by 22
Cerebrospinal Fluid biomarkers in pediatric brain tumors: A systematic review
Lehner, K., Jiang, K., Rincón-Torroella, J., Perera, R. J., & Bettegowda, C. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100852 · Cited by 20
Dissection of theCaenorhabditis elegans Microprocessor
Nguyễn, T. L., Nguyen, T. D., Ngo, M. K., & Nguyen, T. A. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkac1170 · Cited by 19
Epigenetic modifications as therapeutic targets in atherosclerosis: a focus on DNA methylation and non-coding RNAs
Sum, H., & Brewer, A. C. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1183181 · Cited by 20
Noncanonical processing by animal Microprocessor
Nguyễn, T. L., Nguyen, T. D., Ngo, M. K., Le, T. N.-Y., & Nguyen, T. A. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.05.004 · Cited by 19
Structure and function of molecular machines involved in deadenylation-dependent 5′-3′ mRNA degradation
Zhao, Q., Pavanello, L., Bartlam, M. G., & Winkler, G. S. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1233842 · Cited by 19
microRNA-608 inhibits human hepatocellular carcinoma cell proliferation via targeting the BET family protein BRD4
He, L., Meng, D., Zhang, S., Zhang, Y., Deng, Z., & Kong, L. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.108 · Cited by 19
Venom gland transcriptomics and microRNA profiling of juvenile and adult yellow-bellied sea snake, Hydrophis platurus, from Playa del Coco (Guanacaste, Costa Rica)
Durbán, J., Sasa, M., & Calvete, J. J. (2018) · Toxicon · doi:10.1016/j.toxicon.2018.08.016 · Cited by 19
Curcumin improves perfusion recovery in experimental peripheral arterial disease by upregulating microRNA‑93 expression
Zhang, J., Wang, Q., Rao, G., Qiu, J., & He, R.-H. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.7000 · Cited by 19
Epigenetic regulators of the revascularization response to chronic arterial occlusion
Heuslein, J. L., Gorick, C. M., & Price, R. J. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz001 · Cited by 20
RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement
Abu‐Baker, A., Kharma, N. N., Perreault, J., Grant, A., Shekarabi, M., Maios, C., Dona, M., Néri, C., Dion, P. A., Parker, J. A., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.02.003 · Cited by 19
A novel method for stabilizing microRNA mimics
Nogimori, T., Furutachi, K., Ogami, K., Hosoda, N., & Hoshino, S.-I. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.075 · Cited by 19
Aire-dependent genes undergo Clp1-mediated 3’UTR shortening associated with higher transcript stability in the thymus
Guyon, C., Jmari, N., Padonou, F., Li, Y.-C., Ucar, O., Fujikado, N., Coulpier, F., Blanchet, C., Root, D. E., & Giraud, M. (2020) · eLife · doi:10.7554/elife.52985 · Cited by 21
RNAi-mediated control of CRISPR functions
Huang, X., Chen, Z., & Liu, Y. (2020) · Theranostics · doi:10.7150/thno.44880 · Cited by 19
MiR-145 functions as a tumor suppressor in Papillary Thyroid Cancer by inhibiting RAB5C
Zhang, W., Ji, W., Li, T., Liu, T., & Zhao, X. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.44723 · Cited by 19
Micro-RNA networks in T-cell prolymphocytic leukemia reflect T-cell activation and shape DNA damage response and survival pathways
Braun, T., Glaß, M., Wahnschaffe, L., Otte, M., Mayer, P., Franitza, M., Altmüller, J., Hallek, M. J., Hüttelmaier, S., Schrader, A., et al. (2020) · Haematologica · doi:10.3324/haematol.2020.267500 · Cited by 19
From t RNA to mi RNA : RNA ‐folding contributes to correct entry into noncoding RNA pathways
Hasler, D., & Meister, G. (2016) · FEBS Letters · doi:10.1002/1873-3468.12294 · Cited by 19
Cooperative enhancement of translation by two adjacent microRNA-122/Argonaute 2 complexes binding to the 5′ untranslated region of hepatitis C virus RNA
Nieder-Röhrmann, A., Dünnes, N., Gerresheim, G. K., Shalamova, L. A., Herchenröther, A., & Niepmann, M. (2016) · Journal of General Virology · doi:10.1099/jgv.0.000697 · Cited by 19
MicroRNA-142-3p inhibits high-glucose-induced endothelial-to-mesenchymal transition through targeting TGF-β1/Smad pathway in primary human aortic endothelial cells.
Zhu, G., Li, R., Zeng, Y., Zhou, T., Xiong, F., & Zhu, M. (2018) · PubMed Central · Cited by 19
Understanding the Neuroepigenetic Constituents of Suicide Brain
Roy, B., & Dwivedi, Y. (2018) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2018.01.007 · Cited by 17
Dissecting miRNA gene repression on single cell level with an advanced fluorescent reporter system
Lemus-Diaz, N., Böker, K. O., Rodriguez-Polo, I., Mitter, M., Preis, J., Arlt, M., & Gruber, J. (2017) · Scientific Reports · doi:10.1038/srep45197 · Cited by 18
The power of microRNA regulation—insights into immunity and metabolism
Oliveto, S., Manfrini, N., & Biffo, S. (2025) · FEBS Letters · doi:10.1002/1873-3468.70039 · Cited by 21
Human disease-associated single nucleotide polymorphism changes the orientation of DROSHA on pri-mir-146a
Le, C. T., Nguyễn, T. L., Nguyen, T. D., & Nguyen, T. A. (2020) · RNA · doi:10.1261/rna.077487.120 · Cited by 18
Roles of Noncoding RNAs in the Initiation and Progression of Myocardial Ischemia-Reperfusion Injury
Bai, X., Niu, R., Liu, J., Pan, X.-D., Wang, F., Yang, W., Wang, L.-Q., & Sun, L. (2021) · Epigenomics · doi:10.2217/epi-2020-0359 · Cited by 18
The emerging role of microRNAs in fish ovary: A mini review
Alvi, S. M., Zayed, Y., Malik, R., & Peng, C. (2021) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2021.113850 · Cited by 18
MiR-146b-5p targets IFI35 to inhibit inflammatory response and apoptosis via JAK1/STAT1 signalling in lipopolysaccharide-induced glomerular cells
Zhang, L., Jiang, S.-Z., Guo, X. N., Xiao, B., Li, Q., Chen, J., Huang, J.-R., & Rao, H. (2021) · Autoimmunity · doi:10.1080/08916934.2020.1864730 · Cited by 18
ADAR1- and ADAR2-mediated regulation of maturation and targeting of miR-376b to modulate GABA neurotransmitter catabolism
Widmark, A., Sagredo, E. A., Karlström, V., Behm, M., Biryukova, I., Friedländer, M. R., Daniel, C., & Öhman, M. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101682 · Cited by 18
RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration
Castelli, L. M., Benson, B. C., Huang, W.-P., Lin, Y.-H., & Hautbergue, G. M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.886563 · Cited by 18
miR‑146a‑5p negatively regulates the IL‑1β‑stimulated inflammatory response via downregulation of the IRAK1/TRAF6 signaling pathway in human intestinal epithelial cells
Li, Y., Tan, S., Shen, Y., & Guo, L. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11552 · Cited by 20
Cellular nanomechanics derived from pattern-dependent focal adhesion and cytoskeleton to balance gene transfection of malignant osteosarcoma
Wang, Y.-T., Wang, N., Yang, Y., Chen, Y., & Zhang, Z. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01713-1 · Cited by 20
Hydrogen sulfide and epigenetics: Novel insights into the cardiovascular effects of this gasotransmitter
Spezzini, J., Piragine, E., Bianca, R. D. D. V., Bucci, M., Martelli, A., & Calderone, V. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16083 · Cited by 19
Decapping factor Dcp2 controls mRNA abundance and translation to adjust metabolism and filamentation to nutrient availability
Vijjamarri, A. K., Niu, X. M., Vandermeulen, M. D., Onu, C., Zhang, F., Qiu, H., Gupta, N., Gaikwad, S., Greenberg, M. L., Cullen, P. J., et al. (2023) · eLife · doi:10.7554/elife.85545 · Cited by 18
miRNAs in the Box: Potential Diagnostic Role for Extracellular Vesicle-Packaged miRNA-27a and miRNA-128 in Breast Cancer
Giordano, C., Accattatis, F. M., Gelsomino, L., Console, P. D., Győrffy, B., Giuliano, M., Veneziani, B. M., Arpino, G., Angelis, C. D., Placido, P. D., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115695 · Cited by 18
Types of RNA therapeutics
Goleij, P., Babamohamadi, M., Rezaee, A., Sanaye, P. M., Tabari, M. A. K., Sadreddini, S., Arefnezhad, R., & Motedayyen, H. (2024) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2023.12.022 · Cited by 20
The microRNA Let-7 and its exosomal form: Epigenetic regulators of gynecological cancers
Wang, F., Zhou, C., Zhu, Y., & Keshavarzi, M. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09884-3 · Cited by 21
Identification of suitable reference genes for miRNA expression normalization in gastric cancer
Anauate, A. C., Leal, M. F., Wisnieski, F., Santos, L. C., Gigek, C. O., Chen, E., Geraldis, J. C., Calcagno, D. Q., de Assumpção, P. P., Demachki, S., et al. (2017) · Gene · doi:10.1016/j.gene.2017.04.016 · Cited by 17
Role of MicroRNAs in Zygotic Genome Activation: Modulation of mRNA During Embryogenesis
Rosa, A., & Brivanlou, A. H. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6988-3_3 · Cited by 20
Aberrantly expressed messenger RNAs and long noncoding RNAs in degenerative nucleus pulposus cells co-cultured with adipose-derived mesenchymal stem cells
Han, Z., Wang, J., Gao, L., Wang, Q., & Wu, J. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1677-x · Cited by 18
Effect of miR-301a/PTEN pathway on the proliferation and apoptosis of cervical cancer
Peng, L., Shi, W., Feng, H., Wei, C., & Yin, Q. (2019) · Innate Immunity · doi:10.1177/1753425919840702 · Cited by 18
Extensive profiling in Arabidopsis reveals abundant polysome-associated 24-nt small RNAs including AGO5-dependent pseudogene-derived siRNAs
Marchais, A., Chevalier, C., & Voinnet, O. (2019) · RNA · doi:10.1261/rna.069294.118 · Cited by 19
Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells
Tong, R., Zhang, J., Wang, C., Li, Q., Wang, L., & Ju, M. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01772-6 · Cited by 18
hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide
Kania, E. E., Carvajal‐Moreno, J., Hernandez, V. A., English, A., Papa, J. L., Shkolnikov, N., Özer, H. G., Yilmaz, A. S., Yalowich, J. C., & Elton, T. S. (2019) · Molecular Pharmacology · doi:10.1124/mol.119.118315 · Cited by 19
miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury
Jansing, J. C., Fiedler, J., Pich, A., Viereck, J., Thum, T., Mühlfeld, C., & Brandenberger, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030822 · Cited by 18
Pdc2/Pat1 increases the range of decay factors and RNA bound by the Lsm1–7 complex
Lobel, J. H., & Gross, J. D. (2020) · RNA · doi:10.1261/rna.075812.120 · Cited by 18
SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors
Xue, Y., Zhu, X., Meehan, B., Venneti, S., Martínez, D., Morin, G., Maïga, R. I., Chen, H., Papadakis, A. I., Johnson, R. M., et al. (2020) · The Journal of Pathology · doi:10.1002/path.5493 · Cited by 18
MicroRNA-6071 Suppresses Glioblastoma Progression Through the Inhibition of PI3K/AKT/mTOR Pathway by Binding to ULBP2
Zhou, Y., An, H., & Wu, G. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s265791 · Cited by 18
CircTP53 promotes colorectal cancer by acting as a miR-876-3p sponge to increase cyclin-dependent kinase-like 3 expression
Yan, S., Wei, H., Li, Q., Si, M., Feng, W., & Chen, Z. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109845 · Cited by 18
Circular RNA hsa_circ_0033144 (CircBCL11B) regulates oral squamous cell carcinoma progression via the miR-579/LASP1 axis
Zeng, W., Guo, M., Lin, Y., & Zhang, D. (2021) · Bioengineered · doi:10.1080/21655979.2021.1953214 · Cited by 18
RNF219 interacts with CCR4–NOT in regulating stem cell differentiation
Du, H., Chen, C., Wang, Y., Yang, Y., Che, Z., Liu, X., Meng, S., Guo, C., Xu, M., Fang, H., et al. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa061 · Cited by 17
Regulation of mRNA stability by RBPs and noncoding RNAs contributing to the pathogenicity of Th17 cells
Zhang, Y., Wei, Z., Dong, H. F., Zhou, J., Yuan, J., Ni, B., Wu, Y., Han, C., & Tian, Y. (2020) · RNA Biology · doi:10.1080/15476286.2020.1862567 · Cited by 17
MicroRNA-directed pathway discovery elucidates an miR-221/222–mediated regulatory circuit in class switch recombination
Wigton, E. J., Mikami, Y., McMonigle, R. J., Castellanos, C. A., Wade-Vallance, A. K., Zhou, S. K., Kageyama, R., Litterman, A. J., Roy, S., Kitamura, D., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201422 · Cited by 14
Post-transcriptional control of haemostatic genes: mechanisms and emerging therapeutic concepts in thrombo-inflammatory disorders
Danckwardt, S., Trégouët, D., & Castoldi, E. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad046 · Cited by 17
MicroRNAs as the pivotal regulators of cisplatin resistance in osteosarcoma
Moghbeli, M. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154743 · Cited by 17
Advances in understanding effects of miRNAs on apoptosis, autophagy, and pyroptosis in knee osteoarthritis
An, F., Sun, B. S., Liu, Y., Wang, C., Wang, J., Wang, J., Liu, Y., & Yan, C. (2023) · Molecular Genetics and Genomics · doi:10.1007/s00438-023-02077-3 · Cited by 19
Cellular and Exosomal MicroRNAs: Emerging Clinical Relevance as Targets for Breast Cancer Diagnosis and Prognosis
Zablon, F. M., Desai, P., Dellinger, K., & Aravamudhan, S. (2024) · Advanced Biology · doi:10.1002/adbi.202300532 · Cited by 17
Clinical Insights into MicroRNAs in Depression: Bridging Molecular Discoveries and Therapeutic Potential
Kaurani, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052866 · Cited by 20
Circulatory miRNAs in essential hypertension
Kostiniuk, D., Marttila, S., & Raitoharju, E. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.119069 · Cited by 17
Lanthanide-doped nanoprobes for microRNA detection
Liu, Y., Huang, Y., Luo, Y., Luo, Y., Jiang, L., Gallego‐Ortega, D., Cheng, Y. Y., Gale, P. A., & Bao, G. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216644 · Cited by 17
Coordinated Regulation of Cap-Dependent Translation and MicroRNA Function by Convergent Signaling Pathways
Olejniczak, S. H., Rocca, G. L., Radler, M. R., Egan, S. M., Xiang, Q., Garippa, R. J., & Thompson, C. B. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.01011-15 · Cited by 17
CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors
Ahmed, K., Kren, B. T., Abedin, M. J., Vogel, R. I., Shaughnessy, D. P., Nacusi, L. P., Korman, V. L., Li, Y., Dehm, S. M., Zimmerman, C. L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11442 · Cited by 17
Toward a Comprehensive View of MicroRNA Biology
Xiao, Y., & MacRae, I. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.001 · Cited by 17
MicroRNA-106b-5p participates in lead (Pb2+)-induced cell viability inhibition by targeting XIAP in HT-22 and PC12 cells
Xue, C., Kang, B., Su, P., Wang, D., Zhao, F., Zhang, J., Wang, X., Lang, H., & Cao, Z. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104876 · Cited by 17

Authors: Jonas, S., & Izaurralde, E.
Affiliations: Max Planck Institute for Developmental Biology (DE)
Corresponding author: Izaurralde, Elisa
ORCID: Jonas, Stefanie
Izaurralde, Elisa
Venue: Nature Reviews Genetics
Publisher: Springer Science and Business Media LLC
Published: 2015-06-16
Volume: 16
Issue: 7
Pages: 421-433
ISSN: 1471-0056 (ISSN-L)
1471-0064
DOI: 10.1038/nrg3965
OpenAlex: W1744683414
Cited by: 1,872
References: 116
Citations by year: 2026: 91 · 2025: 132 · 2024: 142 · 2023: 191 · 2022: 193 · 2021: 216 · 2020: 192 · 2019: 165 · 2018: 217 · 2017: 198 · 2016: 113 · 2015: 20
FWCI: 17.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Gottfried Wilhelm Leibniz Universität Hannover
Max-Planck-Gesellschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: microRNA, gene silencing, post-transcriptional regulation, miRNA-induced silencing complex, Argonaute proteins, mRNA degradation, protein synthesis inhibition, deadenylation, decapping, miRNA target recognition, small RNA
MeSH terms: Animals, Humans, Protein Biosynthesis, Gene Silencing, RNA Stability, MicroRNAs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Towards a molecular understanding of microRNA-mediated gene silencing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks