Towards a molecular understanding of microRNA-mediated gene silencing

Most mammalian mRNAs are conserved targets of microRNAs

Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462

Regulation of microRNA biogenesis

Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462

Mammalian microRNAs predominantly act to decrease target mRNA levels

Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886

The impact of microRNAs on protein output

Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592

Widespread changes in protein synthesis induced by microRNAs

Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429

The mechanism of eukaryotic translation initiation and principles of its regulation

Jackson, R. J., Hellen, C. U. T., & Pestova, T. V. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2838 · Cited by 2,759

Gene silencing by microRNAs: contributions of translational repression and mRNA decay

Huntzinger, E., & Izaurralde, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2936 · Cited by 2,339

A brain-specific microRNA regulates dendritic spine development

Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786

Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs

Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,647

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

Pillai, R. S., Bhattacharyya, S. N., Artus-Revel, C. G., Zoller, T., Cougot, N., Basyuk, E. I., Bertrand, É., & Filipowicz, W. (2005) · Science · doi:10.1126/science.1115079 · Cited by 1,489

A Proteome-Scale Map of the Human Interactome Network

Rolland, T., Taşan, M., Charloteaux, B., Pevzner, S. J., Zhong, Q., Sahni, N., Yi, S. S., Lemmens, I. H., Fontanillo, C., Mosca, R., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.050 · Cited by 1,381

Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation

Bagga, S., Bracht, J. R., Hunter, S. E., Massirer, K. B., Holtz, J., Eachus, R., & Pasquinelli, A. E. (2005) · Cell · doi:10.1016/j.cell.2005.07.031 · Cited by 1,347

MicroRNAs direct rapid deadenylation of mRNA

Wu, L., Fan, J., & Belasco, J. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510928103 · Cited by 1,182

Diversifying microRNA sequence and function

Ameres, S. L., & Zamore, P. D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3611 · Cited by 1,175

mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexesPreprint

Behm‐Ansmant, I., Rehwinkel, J., Doerks, T., Stark, A., Bork, P., & Izaurralde, E. (2006) · Genes & Development · doi:10.1101/gad.1424106 · Cited by 1,113

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

Fabian, M. R., & Sonenberg, N. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2296 · Cited by 1,066

Short RNAs Repress Translation after Initiation in Mammalian Cells

Petersen, C. P., Bordeleau, M.-È., Pelletier, J., & Sharp, P. A. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.031 · Cited by 824

miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay

Djuranovic, S., Nahvi, A., & Green, R. (2012) · Science · doi:10.1126/science.1215691 · Cited by 811

The Crystal Structure of Human Argonaute2

Schirle, N. T., & MacRae, I. J. (2012) · Science · doi:10.1126/science.1221551 · Cited by 720

A role for the P-body component GW182 in microRNA function

Liu, J., Rivas, F. V., Wohlschlegel, J. A., Yates, J. R., Parker, R., & Hannon, G. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1333 · Cited by 715

P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

Eulalio, A., Behm-Ansmant, I., Schweizer, D., & Izaurralde, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00128-07 · Cited by 710

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

Bazzini, A. A., Lee, M. T., & Giraldez, A. J. (2012) · Science · doi:10.1126/science.1215704 · Cited by 709

MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function

Humphreys, D. T., Westman, B. J., Martin, D. I. K., & Preiß, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506482102 · Cited by 704

Poly(A)-tail profiling reveals an embryonic switch in translational control

Subtelny, A. O., Eichhorn, S. W., Chen, G. R., Sive, H., & Bartel, D. P. (2014) · Nature · doi:10.1038/nature13007 · Cited by 664

The Structure of Human Argonaute-2 in Complex with miR-20a

Elkayam, E., Kuhn, C., Tocilj, A., Haase, A. D., Greene, E. M., Hannon, G. J., & Joshua‐Tor, L. (2012) · Cell · doi:10.1016/j.cell.2012.05.017 · Cited by 640

MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F

Mathonnet, G., Fabian, M. R., Svitkin, Y. V., Parsyan, A. E., Huck, L., Murata, T., Biffo, S., Merrick, W. C., Darżynkiewicz, E., Pillai, R. S., et al. (2007) · Science · doi:10.1126/science.1146067 · Cited by 593

Identification of Novel Argonaute-Associated Proteins

Meister, G., Landthaler, M., Peters, L., Chen, P., Urlaub, H., Lührmann, R., & Tuschl, T. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.048 · Cited by 581

Structural basis for microRNA targeting

Schirle, N. T., Sheu‐Gruttadauria, J., & MacRae, I. J. (2014) · Science · doi:10.1126/science.1258040 · Cited by 575

Translation Repression in Human Cells by MicroRNA-Induced Gene Silencing Requires RCK/p54

Chu, C., & Rana, T. M. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040210 · Cited by 551

Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

Yamashita, A., Chang, T.-C., Yamashita, Y., Zhu, W., Zhong, Z., Chen, C. A., & Shyu, A. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1016 · Cited by 504

mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues

Eichhorn, S. W., Guo, H., McGeary, S. E., Rodriguez-Mias, R. A., Shin, C., Baek, D., Hsu, S.-H., Ghoshal, K., Villén, J., & Bartel, D. P. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.028 · Cited by 503

Disruption of GW bodies impairs mammalian RNA interference

Jakymiw, A., Lian, S., Eystathioy, T., Li, S., Satoh, M., Hamel, J. C., Fritzler, M. J., & Chan, E. K. L. (2005) · Nature Cell Biology · doi:10.1038/ncb1334 · Cited by 496

A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

Rehwinkel, J., Behm‐Ansmant, I., Gatfield, D., & Izaurralde, E. (2005) · RNA · doi:10.1261/rna.2191905 · Cited by 493

TAIL-seq: Genome-wide Determination of Poly(A) Tail Length and 3′ End Modifications

Chang, H., Lim, J., Ha, M., & Kim, V. N. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.02.007 · Cited by 454

Deadenylation is a widespread effect of miRNA regulation

Eulálio, A., Huntzinger, E., Nishihara, T., Rehwinkel, J., Fauser, M., & Izaurralde, E. (2008) · RNA · doi:10.1261/rna.1399509 · Cited by 429

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

Fabian, M. R., Mathonnet, G., Sundermeier, T. R., Mathys, H., Zipprich, J. T., Svitkin, Y. V., Rivas, F. V., Jínek, M., Wohlschlegel, J. A., Doudna, J. A., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.08.004 · Cited by 427

Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA

Hendrickson, D. G., Hogan, D. J., McCullough, H. L., Myers, J. W., Herschlag, D., Ferrell, J. E., & Brown, P. O. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000238 · Cited by 418

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

Eulálio, A., Huntzinger, E., & Izaurralde, E. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1405 · Cited by 414

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

Chekulaeva, M., Mathys, H., Zipprich, J. T., Attig, J., Čolić, M., Parker, R., & Filipowicz, W. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2166 · Cited by 379

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

Braun, J. E., Huntzinger, E., Fauser, M., & Izaurralde, E. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.09.007 · Cited by 371

Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling

Muddashetty, R. S., Nalavadi, V. C., Gross, C., Yao, X., Xing, L., Laur, O., Warren, S. T., & Bassell, G. J. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.006 · Cited by 364

Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free systemPreprint

Wakiyama, M., Takimoto, K., Ohara, O., & Yokoyama, S. (2007) · Genes & Development · doi:10.1101/gad.1566707 · Cited by 343

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Thermann, R., & Hentze, M. W. (2007) · Nature · doi:10.1038/nature05878 · Cited by 334

Co-translational mRNA decay in Saccharomyces cerevisiae

Hu, W., Sweet, T. J., Chamnongpol, S., Baker, K. E., & Coller, J. M. (2009) · Nature · doi:10.1038/nature08265 · Cited by 334

Structural and Biochemical Insights to the Role of the CCR4-NOT Complex and DDX6 ATPase in MicroRNA Repression

Mathys, H., Basquin, J., Ozgur, S., Czarnocki‐Cieciura, M., Bonneau, F., Aartse, A., Dziembowski, A., Nowotny, M., Conti, E., & Filipowicz, W. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.036 · Cited by 331

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

Fabian, M. R., Cieplak, M. K., Frank, F., Morita, M., Green, J., Srikumar, T., Nagar, B., Yamamoto, T., Raught, B., Duchaine, T. F., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2149 · Cited by 329

Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

Meijer, H. A., Kong, Y. W., Lu, W. T., Wilczynska, A., Spriggs, R. V., Robinson, S. W., Godfrey, J. D., Willis, A. E., & Bushell, M. (2013) · Science · doi:10.1126/science.1231197 · Cited by 326

Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related componentsPreprint

El‐Shami, M., Pontier, D., Lahmy, S., Braun, L., Picart, C., Véga, D., Hakimi, M., Jacobsen, S. E., Cooke, R., & Lagrange, T. (2007) · Genes & Development · doi:10.1101/gad.451207 · Cited by 321

Differential Regulation of Germline mRNAs in Soma and Germ Cells by Zebrafish miR-430

Mishima, Y., Giraldez, A. J., Takeda, Y., Fujiwara, T., Sakamoto, H., Schier, A. F., & Inoue, K. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.086 · Cited by 321

A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing

Chen, Y., Boland, A., Kuzuoğlu‐Öztürk, D., Bawankar, P., Loh, B., Chang, C.-T., Weichenrieder, O., & Izaurralde, E. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.034 · Cited by 306

Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencingPreprint

Eulálio, A., Rehwinkel, J., Stricker, M., Huntzinger, E., Yang, S.-F., Doerks, T., Dorner, S., Peer Bork, B., Boutros, M., & Izaurralde, E. (2007) · Genes & Development · doi:10.1101/gad.443107 · Cited by 297

From guide to target: molecular insights into eukaryotic RNA-interference machinery

Ipsaro, J. J., & Joshua-Tor, L. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2931 · Cited by 281

RNA decay machines: Deadenylation by the Ccr4–Not and Pan2–Pan3 complexes

Wahle, E., & Winkler, G. S. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.01.003 · Cited by 267

A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain

Till, S., Lejeune, E., Thermann, R., Bortfeld‐Miller, M., Hothorn, M., Enderle, D., Heinrich, C., Hentze, M. W., & Ladurner, A. G. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1302 · Cited by 262

Crystal structure of the yeast eIF4A-eIF4G complex: An RNA-helicase controlled by protein–protein interactions

Schutz, P., Bumann, M., Oberholzer, A. E., Bieniossek, C., Trachsel, H., Altmann, M., & Baumann, U. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800418105 · Cited by 260

Systematic Identification of C. elegans miRISC Proteins, miRNAs, and mRNA Targets by Their Interactions with GW182 Proteins AIN-1 and AIN-2

Zhang, L., Lei, D., Cheung, T. H., Dong, M., Chen, J., Sewell, A. K., Liu, X., Yates, J. R., & Han, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.014 · Cited by 245

Gene regulation. Structural basis for microRNA targeting.

Schirle, N. T., Sheu‐Gruttadauria, J., & MacRae, I. J. (2014) · Science · doi:10.2210/pdb4w5n/pdb · Cited by 227

Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

Zheng, D., Ezzeddine, N., Chen, C. A., Zhu, W., He, X., & Shyu, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801196 · Cited by 227

Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

Chen, C. A., Zheng, D., Xia, Z., & Shyu, A. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1709 · Cited by 212

Kinetic analysis reveals successive steps leading to miRNA‐mediated silencing in mammalian cells

Béthune, J., Artus-Revel, C. G., & Filipowicz, W. (2012) · EMBO Reports · doi:10.1038/embor.2012.82 · Cited by 212

Drosophila Argonaute1 and Argonaute2 Employ Distinct Mechanisms for Translational Repression

Iwasaki, S., Kawamata, T., & Tomari, Y. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.010 · Cited by 209

The role of disordered protein regions in the assembly of decapping complexes and RNP granulesPreprint

Jonas, S., & Izaurralde, E. (2013) · Genes & Development · doi:10.1101/gad.227843.113 · Cited by 207

The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

Eulálio, A., Tritschler, F., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1703809 · Cited by 207

The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

Zekri, L., Huntzinger, E., Heimstädt, S., & Izaurralde, E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01081-09 · Cited by 186

A direct interaction between DCP1 and XRN1 couples mRNA decapping to 5′ exonucleolytic degradation

Braun, J. E., Truffault, V., Boland, A., Huntzinger, E., Chang, C.-T., Haas, G., Weichenrieder, O., Coles, M. P., & Izaurralde, E. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2413 · Cited by 180

Akt-Mediated Phosphorylation of Argonaute 2 Downregulates Cleavage and Upregulates Translational Repression of MicroRNA Targets

Horman, S. R., Janas, M. M., Litterst, C. M., Wang, B., MacRae, I. J., Sever, M. J., Morrissey, D. V., Graves, P. R., Luo, B., Umesalma, S., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.03.015 · Cited by 164

Structural Basis of Dcp2 Recognition and Activation by Dcp1

She, M., Decker, C. J., Svergun, D. I., Round, A. R., Chen, N., Muhlrad, D., Parker, R., & Song, H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.01.002 · Cited by 163

Architecture of the Nuclease Module of the Yeast Ccr4-Not Complex: the Not1-Caf1-Ccr4 Interaction

Basquin, J., Roudko, V., Rode, M., Minard‐Basquin, C., Séraphin, B., & Conti, E. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.014 · Cited by 162

CCR4-NOT Deadenylates mRNA Associated with RNA-Induced Silencing Complexes in Human Cells

Piao, X., Zhang, X., Wu, L., & Belasco, J. G. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01481-09 · Cited by 158

The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

Lazzaretti, D., Tournier, I., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1606309 · Cited by 153

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

Lian, S. L., Li, S., Abadal, G. X., Pauley, B. A., Fritzler, M. J., & Chan, E. K. L. (2009) · RNA · doi:10.1261/rna.1229409 · Cited by 150

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression

Zipprich, J. T., Bhattacharyya, S., Mathys, H., & Filipowicz, W. (2009) · RNA · doi:10.1261/rna.1448009 · Cited by 149

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4–NOT deadenylase complex

Petit, A., Wohlbold, L., Bawankar, P., Huntzinger, E., Schmidt, S., Izaurralde, E., & Weichenrieder, O. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks883 · Cited by 146

MicroRNAs Trigger Dissociation of eIF4AI and eIF4AII from Target mRNAs in Humans

Fukao, A., Mishima, Y., Takizawa, N., Oka, S., Imataka, H., Pelletier, J., Sonenberg, N., Thoma, C., & Fujiwara, T. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.005 · Cited by 137

The structural basis of Edc3‐ and Scd6‐mediated activation of the Dcp1:Dcp2 mRNA decapping complex

Fromm, S. A., Truffault, V., Kamenz, J. L., Braun, J. E., Hoffmann, N. A., Izaurralde, E., & Sprangers, R. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.408 · Cited by 133

Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1

Rouya, C., Siddiqui, N., Morita, M., Duchaine, T., Fabian, M., & Sonenberg, N. (2014) · RNA: A publication of the RNA Society · doi:10.1261/rna.045302.114 · Cited by 133

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

Ding, X. C., & Großhans, H. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.275 · Cited by 131

Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

Takimoto, K., Wakiyama, M., & Yokoyama, S. (2009) · RNA · doi:10.1261/rna.1363109 · Cited by 130

A C-terminal silencing domain in GW182 is essential for miRNA function

Eulálio, A., Helms, S., Fritzsch, C., Fauser, M., & Izaurralde, E. (2009) · RNA · doi:10.1261/rna.1605509 · Cited by 130

Structural Basis for the Mutually Exclusive Anchoring of P Body Components EDC3 and Tral to the DEAD Box Protein DDX6/Me31B

Tritschler, F., Braun, J. E., Eulálio, A., Truffault, V., Izaurralde, E., & Weichenrieder, O. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.02.014 · Cited by 129

Translational Repression by Deadenylases

Cooke, A. M., Prigge, A. D., & Wickens, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.150763 · Cited by 125

GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation

Zekri, L., Kuzuoğlu‐Öztürk, D., & Izaurralde, E. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.44 · Cited by 125

The Role of GW182 Proteins in miRNA-Mediated Gene Silencing

Braun, J. E., Huntzinger, E., & Izaurralde, E. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5107-5_9 · Cited by 124

MicroRNAs Block Assembly of eIF4F Translation Initiation Complex in Drosophila

Fukaya, T., Iwakawa, H., & Tomari, Y. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.004 · Cited by 120

Regulation of Poly(A)-binding Protein through PABP-interacting ProteinsPreprint

Derry, M. C., Yanagiya, A., Martineau, Y., & Sonenberg, N. (2006) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2006.71.061 · Cited by 120

The interactions of GW182 proteins with PABP and deadenylases are required for both translational repression and degradation of miRNA targets

Huntzinger, E., Kuzuoğlu‐Öztürk, D., Braun, J. E., Eulálio, A., Wohlbold, L., & Izaurralde, E. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1078 · Cited by 119

MicroRNAs Mediate Gene Silencing via Multiple Different Pathways in Drosophila

Fukaya, T., & Tomari, Y. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.024 · Cited by 116

microRNA-Mediated Messenger RNA Deadenylation Contributes to Translational Repression in Mammalian Cells

Beilharz, T. H., Humphreys, D. T., Clancy, J. L., Thermann, R., Martin, D. I. K., Hentze, M. W., & Preiß, T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006783 · Cited by 115

Structural features of Argonaute–GW182 protein interactions

Pfaff, J., Hennig, J., Herzog, F., Aebersold, R. H., Sattler, M., Niessing, D., & Meister, G. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308510110 · Cited by 115

Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway

Miyoshi, K., Okada, T. N., Siomi, H., & Siomi, M. C. (2009) · RNA · doi:10.1261/rna.1541209 · Cited by 115

Two PABPC1‐binding sites in GW182 proteins promote miRNA‐mediated gene silencing

Huntzinger, E., Braun, J. E., Heimstädt, S., Zekri, L., & Izaurralde, E. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.274 · Cited by 112

NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain

Bawankar, P., Loh, B., Wohlbold, L., Schmidt, S., & Izaurralde, E. (2013) · RNA Biology · doi:10.4161/rna.23018 · Cited by 109

PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding

Moretti, F., Kaiser, C., Zdanowicz-Specht, A., & Hentze, M. W. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2309 · Cited by 107

Poly(A) Nuclease Interacts with the C-terminal Domain of Polyadenylate-binding Protein Domain from Poly(A)-binding Protein

Siddiqui, N., Mangus, D. A., Chang, T.-C., Palermino, J.-M., Shyu, A. B., & Gehring, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701256200 · Cited by 107

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

Jínek, M., Fabian, M. R., Coyle, S. M., Sonenberg, N., & Doudna, J. A. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1768 · Cited by 106

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