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Adult haematopoietic stem cell niches
Abstract
Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of niche factors, genetic tools for functionally identifying niche cells in vivo, and improved imaging techniques. Together, they have shown that HSC niches are perivascular in the bone marrow and spleen. Endothelial cells and mesenchymal stromal cells secrete factors that promote HSC maintenance in these niches, but other cell types also directly or indirectly regulate HSC niches.
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“Surface tethering can also be achieved with nanotechnologies, such as nano-imprint lithography, electron-beam, and electrospinning, can fabricate substrates with nanopillars, nanopits, or nanochannels, mimicking the basement membrane for 3D organoid culture90.”
From Organoids (2022) · cites this paper as [90]
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Metadata
- Authors
- Crane, G. M., Jeffery, E., & Morrison, S. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Morrison, Sean J.
- Venue
- Nature Reviews Immunology
- Published
- 2017-06-12
- Volume
- 17
- Issue
- 9
- Pages
- 573-590
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2624346565
- Cited by
- 712
- References
- 185
- Citations by year
- 2026: 30 · 2025: 41 · 2024: 75 · 2023: 68 · 2022: 79 · 2021: 133 · 2020: 103 · 2019: 78 · 2018: 86 · 2017: 17
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- hematopoietic stem cells, stem cell niche, bone marrow, spleen, perivascular niche, niche cells, endothelial cells, mesenchymal stem cells, niche factors, HSC maintenance
- MeSH terms
- Adult, Bone Marrow, Hematopoiesis, Hematopoietic Stem Cells, Humans, Spleen, Leukopoiesis, Adult Stem Cells, Stem Cell Niche
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