Cited by 712Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchCancer Cells and Metastasis

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Adult haematopoietic stem cell niches

Crane, Genevieve M., Jeffery, Elise, Morrison, Sean J.·2017·Nature Reviews Immunology

DOI 10.1038/nri.2017.53

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Abstract

Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of niche factors, genetic tools for functionally identifying niche cells in vivo, and improved imaging techniques. Together, they have shown that HSC niches are perivascular in the bone marrow and spleen. Endothelial cells and mesenchymal stromal cells secrete factors that promote HSC maintenance in these niches, but other cell types also directly or indirectly regulate HSC niches.

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Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168
Self-citation
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531
The bone marrow niche for haematopoietic stem cells
Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451
Self-citation
Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches
Sugiyama, T., Kohara, H., Noda, M., & Nagasawa, T. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.016 · Cited by 2,419
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H., & Kishimoto, T. (1996) · Nature · doi:10.1038/382635a0 · Cited by 2,338
The relationship between the spleen colony-forming cell and the haemopoietic stem cell.
Schofield, R. (1978) · PubMed · Cited by 2,304
Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
Sacchetti, B., Funari, A., Michienzi, S., Di Cesare, S., Piersanti, S., Saggio, I., Tagliafico, E., Ferrari, S., Robey, P. G., Riminucci, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.025 · Cited by 2,226

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Herranz, Ó., Berrocal, P., Sicilia-Navarro, C., Fernández‐Infante, C., Hernández-Cano, L., Porrás, A., & Guerrero, C. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01687-1 · Cited by 4
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Zhang, H., Yeware, A. M., Lee, S., & Zhan, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.753465 · Cited by 4
Megakaryocytes and platelets embrace diversity in face of adversity
Puhm, F., & Boilard, É. (2022) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15761 · Cited by 4
Dynamic crosstalk between hematopoietic stem cells and their niche from emergence to aging
Deng, Z., Ma, L.-Y., Chen, Q., & Liu, Y. (2023) · BioEssays · doi:10.1002/bies.202200121 · Cited by 4
Macrophage depletion overcomes human hematopoietic cell engraftment failure in zebrafish embryo
Omar, R. E., Abdellaoui, N., Coulibaly, T. G. S., Fontenille, L., Lanza, F., Gachet, C., Freund, J., Negroni, M., Kissa, K., & Tavian, M. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06682-x · Cited by 4
Hyperlipidemia-induced hematopoiesis is repressed by MLKL in endothelial cells of the splenic niche
Rasheed, A., Robichaud, S., Dennison, T., Nguyen, M.-A., Geoffrion, M., Reed, J. N., Wyatt, H., Marouf, Y., Baxi, A., Lee, R. G., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00470-8 · Cited by 4
Elevated hematopoietic stem cell frequency in mouse alveolar bone marrow
Niizuma, K., Morikawa, S., Gars, E. J., Xiang, J., Matsubara-Takahashi, T., Saito, R., Takematsu, E., Wang, Y., Xu, H., Wakimoto, A., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.11.004 · Cited by 5
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Tamplin, O. J. (2018) · Cell stem cell · doi:10.1016/j.stem.2017.12.014 · Cited by 4
3D organoid modeling of extramedullary hematopoiesis
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Nestin expression in osteocytes following myeloablation and during bone marrow metastasis
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Huang, D., Yuan, Y., Cao, L., Zhang, D., Jiang, Y., Zhang, Y., Chen, C., Yu, Z., Xie, L., Wei, Y., et al. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00855-0 · Cited by 4
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Ichii, M., & Hosen, N. (2020) · Cancers · doi:10.3390/cancers13010025 · Cited by 4
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Jin, L., Wang, P., & Ni, F. (2021) · Current Stem Cell Reports · doi:10.1007/s40778-020-00183-1 · Cited by 4
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Faisal, M. S., Hassan, M., Kumar, A., Zubair, M. F., Jamal, M., Menghwar, H., Saad, M., & Kloczkowski, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137285 · Cited by 4
Regulation of stem cell dynamics through volume exclusion
García-Tejera, R., Schumacher, L. J., & Grima, R. (2022) · Proceedings of the Royal Society A Mathematical Physical and Engineering Sciences · doi:10.1098/rspa.2022.0376 · Cited by 4
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Stella, G. M., Marchiò, C., Bari, E., Ferrarotti, I., Bertuccio, F. R., Gennaro, A. D., Abbott, D. M., Putignano, P., Campo, I., Torre, M. L., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043496 · Cited by 4
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Pastrana-Otero, I., Majumdar, S., Gilchrist, A. E., Gorman, B. L., Harley, B. A. C., & Kraft, M. L. (2020) · The Analyst · doi:10.1039/d0an01153c · Cited by 4
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Jiang, X.-X., Song, M., Li, Q., Wei, Y., Huang, Y., & Ma, Y. (2024) · BMC Molecular and Cell Biology · doi:10.1186/s12860-024-00503-x · Cited by 3
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Mehatre, S. H., Sanam, S., Agrawal, H., Hejjaji, A. V., Kumar, A. S., Alam, M. T., & Khurana, S. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00477-2 · Cited by 3
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Potchanant, E. A. S., Capitano, M. L., Edwards, D. M., Ramdas, B., Cooper, S. H., Ropa, J. P., Pay, S. L., Sheth, A. S., Snider, P. L., Vernon, H. J., et al. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10945-1 · Cited by 3
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Authors: Crane, G. M., Jeffery, E., & Morrison, S. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Morrison, Sean J.
ORCID: Crane, Genevieve M.
Morrison, Sean J.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2017-06-12
Volume: 17
Issue: 9
Pages: 573-590
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2017.53
OpenAlex: W2624346565
Cited by: 712
References: 185
Citations by year: 2026: 30 · 2025: 41 · 2024: 75 · 2023: 68 · 2022: 79 · 2021: 133 · 2020: 103 · 2019: 78 · 2018: 86 · 2017: 17
FWCI: 12.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: hematopoietic stem cells, stem cell niche, bone marrow, spleen, perivascular niche, niche cells, endothelial cells, mesenchymal stem cells, niche factors, HSC maintenance
MeSH terms: Adult, Bone Marrow, Hematopoiesis, Hematopoietic Stem Cells, Humans, Spleen, Leukopoiesis, Adult Stem Cells, Stem Cell Niche

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