Cited by 712Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchCancer Cells and Metastasis

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Adult haematopoietic stem cell niches

Crane, Genevieve M., Jeffery, Elise, Morrison, Sean J.·2017·Nature Reviews Immunology

DOI 10.1038/nri.2017.53

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Abstract

Stem cell niches are specialized microenvironments that promote the maintenance of stem cells and regulate their function. Recent advances have improved our understanding of the niches that maintain adult haematopoietic stem cells (HSCs). These advances include new markers for HSCs and niche cells, systematic analyses of the expression patterns of niche factors, genetic tools for functionally identifying niche cells in vivo, and improved imaging techniques. Together, they have shown that HSC niches are perivascular in the bone marrow and spleen. Endothelial cells and mesenchymal stromal cells secrete factors that promote HSC maintenance in these niches, but other cell types also directly or indirectly regulate HSC niches.

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Authors: Crane, G. M., Jeffery, E., & Morrison, S. J.
Affiliations: The University of Texas Southwestern Medical Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Morrison, Sean J.
ORCID: Crane, Genevieve M.
Morrison, Sean J.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2017-06-12
Volume: 17
Issue: 9
Pages: 573-590
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2017.53
OpenAlex: W2624346565
Cited by: 712
References: 185
Citations by year: 2026: 30 · 2025: 41 · 2024: 75 · 2023: 68 · 2022: 79 · 2021: 133 · 2020: 103 · 2019: 78 · 2018: 86 · 2017: 17
FWCI: 12.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: hematopoietic stem cells, stem cell niche, bone marrow, spleen, perivascular niche, niche cells, endothelial cells, mesenchymal stem cells, niche factors, HSC maintenance
MeSH terms: Adult, Bone Marrow, Hematopoiesis, Hematopoietic Stem Cells, Humans, Spleen, Leukopoiesis, Adult Stem Cells, Stem Cell Niche

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Adult haematopoietic stem cell niches

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