Adult haematopoietic stem cell niches

Cytokine-mediated regulation of CXCR4 expression in human neutrophils

Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381

SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

Zou, Y.-R., Kottmann, A. H., Kuroda, M., Taniuchi, I., & Littman, D. R. (1998) · Nature · doi:10.1038/31269 · Cited by 2,531

The bone marrow niche for haematopoietic stem cells

Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451

Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches

Sugiyama, T., Kohara, H., Noda, M., & Nagasawa, T. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.016 · Cited by 2,419

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H., & Kishimoto, T. (1996) · Nature · doi:10.1038/382635a0 · Cited by 2,338

The relationship between the spleen colony-forming cell and the haemopoietic stem cell.

Schofield, R. (1978) · PubMed · Cited by 2,304

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

Sacchetti, B., Funari, A., Michienzi, S., Di Cesare, S., Piersanti, S., Saggio, I., Tagliafico, E., Ferrari, S., Robey, P. G., Riminucci, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.025 · Cited by 2,226

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

Kusumbe, A. P., Ramasamy, S. K., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13145 · Cited by 2,155

Endothelial and perivascular cells maintain haematopoietic stem cells

Ding, L., Saunders, T. L., Enikolopov, G., & Morrison, S. J. (2012) · Nature · doi:10.1038/nature10783 · Cited by 2,031

Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

Morrison, S. J., & Spradling, A. C. (2008) · Cell · doi:10.1016/j.cell.2008.01.038 · Cited by 2,026

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908

Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

Medvinsky, A., & Dzierzak, E. A. (1996) · Cell · doi:10.1016/s0092-8674(00)80165-8 · Cited by 1,548

Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006) · Cell · doi:10.1016/j.cell.2005.10.041 · Cited by 1,412

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

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Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

Zhou, B. O., Yue, R., Murphy, M. M., Peyer, J. G., & Morrison, S. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.008 · Cited by 1,381

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

Greenbaum, A. M., Hsu, Y.-M. S., Day, R. B., Schuettpelz, L. G., Christopher, M. J., Borgerding, J. N., Nagasawa, T., & Link, D. C. (2013) · Nature · doi:10.1038/nature11926 · Cited by 1,372

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

Ding, L., & Morrison, S. J. (2013) · Nature · doi:10.1038/nature11885 · Cited by 1,349

G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4

Petit, I., Szyper‐Kravitz, M., Nagler, A., Lahav, M., Peled, A., Habler, L., Ponomaryov, T., Taichman, R. S., Arenzana‐Seisdedos, F., Fujii, N., et al. (2002) · Nature Immunology · doi:10.1038/ni813 · Cited by 1,331

Haematopoietic stem cell release is regulated by circadian oscillations

Méndez‐Ferrer, S., Lucas, D., Battista, M., & Frenette, P. S. (2008) · Nature · doi:10.1038/nature06685 · Cited by 1,310

Arteriolar niches maintain haematopoietic stem cell quiescence

Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J. U., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., et al. (2013) · Nature · doi:10.1038/nature12612 · Cited by 1,290

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

de Sauvage, F. J., Hass, P. E., Spencer, S. D., Malloy, B., Gurney, A. L., Spencer, S. A., Darbonne, W. C., Henzel, W. J., Wong, S. C., Kuang, W.-J., et al. (1994) · Nature · doi:10.1038/369533a0 · Cited by 1,270

Direct measurement of local oxygen concentration in the bone marrow of live animals

Spencer, J. A., Ferraro, F., Roussakis, E., Klein, A., Wu, J., Runnels, J. M., Zaher, W., Mortensen, L. J., Alt, C., Turcotte, R., et al. (2014) · Nature · doi:10.1038/nature13034 · Cited by 1,167

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

Huang, E. J., Nocka, K. H., Beier, D. R., Chu, T.-Y., Buck, J., Lahm, H., Wellner, D., Leder, P., & Besmer, P. (1990) · Cell · doi:10.1016/0092-8674(90)90303-v · Cited by 1,149

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

Raaijmakers, M. H. G. P., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J. A., Ebert, B. L., Al-Shahrour, F., Hasserjian, R. P., Scadden, E. O., et al. (2010) · Nature · doi:10.1038/nature08851 · Cited by 1,115

Granulocyte colony-stimulating factor and its receptor

Demetri, G. D., & Griffin, J. D. (1991) · Blood · doi:10.1182/blood.v78.11.2791.2791 · Cited by 1,066

Haematopoietic stem cells derive directly from aortic endothelium during development

Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y. R., & Traver, D. (2010) · Nature · doi:10.1038/nature08738 · Cited by 1,025

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

Kaushansky, K., Lok, S., Holly, R. D., Broudy, V. C., Lin, N. L., Bailey, M. C., Forstrom, J. W., Buddle, M. M., Oort, P. J., Hagen, F. S., et al. (1994) · Nature · doi:10.1038/369568a0 · Cited by 1,024

Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer

Logan, M., Martin, J. F., Nagy, A., Lobe, C., Olson, E., & Tabin, C. (2002) · Genesis · doi:10.1002/gene.10092 · Cited by 1,022

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

Chen, M. J., Yokomizo, T., Zeigler, B. M., Dzierzak, E. A., & Speck, N. A. (2009) · Nature · doi:10.1038/nature07619 · Cited by 1,016

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

Kissa, K., & Herbomel, P. (2010) · Nature · doi:10.1038/nature08761 · Cited by 961

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

Maes, C., Kobayashi, T., Selig, M. K., Torrekens, S., Roth, S. I., Mackem, S., Carmeliet, G., & Kronenberg, H. M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.010 · Cited by 940

Physiological Migration of Hematopoietic Stem and Progenitor Cells

Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L., & Weissman, I. L. (2001) · Science · doi:10.1126/science.1064081 · Cited by 933

Identification of a ligand for the c-kit proto-oncogene

Williams, D. E., Eisenman, J., Baird, A. M., Rauch, C. T., Ness, K. V., March, C. J., Park, L. S., Martin, U., Mochizukl, D. Y., Boswell, H. S., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90297-r · Cited by 920

Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

Chow, A. T., Lucas, D., Hidalgo, A., Méndez‐Ferrer, S., Hashimoto, D., Scheiermann, C., Battista, M., Leboeuf, M., Prophete, C., van Rooijen, N., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20101688 · Cited by 914

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

Omatsu, Y., Sugiyama, T., Kohara, H., Kondoh, G., Fujii, N., Kohno, K., & Nagasawa, T. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.017 · Cited by 912

In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment

Sipkins, D. A., Wei, X., Wu, J. W., Runnels, J. M., Côté, D. C., Means, T. K., Luster, A. D., Scadden, D. T., & Lin, C. P. (2005) · Nature · doi:10.1038/nature03703 · Cited by 880

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

Baldridge, M. T., King, K. Y., Boles, N. C., Weksberg, D. C., & Goodell, M. A. (2010) · Nature · doi:10.1038/nature09135 · Cited by 877

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

Parmar, K., Mauch, P., Vergilio, J.-A., Sackstein, R., & Down, J. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701152104 · Cited by 867

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

Anderson, D. M., Lyman, S. D., Baird, A. M., Wignall, J. M., Eisenman, J. R., Rauch, C. T., March, C. J., Boswell, H. S., Gimpel, S. D., Cosman, D. J., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90304-w · Cited by 827

Granulocyte colony-stimulating factor and its receptor

Demetri, G. D., & Griffin, J. (1991) · Blood · doi:10.1182/blood.v78.11.2791.bloodjournal78112791 · Cited by 825

Molecular cloning and structure of a pre-B-cell growth-stimulating factor.

Nagasawa, T., Kikutani, H., & Kishimoto, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2305 · Cited by 817

Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche

Yoshihara, H., Arai, F., Hosokawa, K., Hagiwara, T., Takubo, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Matsuoka, S., Miyamoto, K., et al. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.10.020 · Cited by 816

Hematopoiesis is severely altered in mice with an induced osteoblast deficiency

Višnjić, D., Kalajzić, Ž., Rowe, D. W., Katavić, V., Lorenzo, J., & Aguila, H. L. (2004) · Blood · doi:10.1182/blood-2003-11-4011 · Cited by 804

Clonal dynamics of native haematopoiesis

Sun, J., Ramos, A., Chapman, B., Johnnidis, J. B., Le, L., Ho, Y.-J., Klein, A. M., Hofmann, O., & Camargo, F. D. (2014) · Nature · doi:10.1038/nature13824 · Cited by 803

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Winkler, I. G., Sims, N. A., Pettit, A. R., Barbier, V., Nowlan, B., Helwani, F., Poulton, I. J., van Rooijen, N., Alexander, K. A., Raggatt, L. J., et al. (2010) · Blood · doi:10.1182/blood-2009-11-253534 · Cited by 801

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

Yamazaki, S., Ema, H., Karlsson, G., Yamaguchi, T., Miyoshi, H., Shioda, S., Taketo, M. M., Karlsson, S., Iwama, A., & Nakauchi, H. (2011) · Cell · doi:10.1016/j.cell.2011.09.053 · Cited by 797

Cellular Niches Controlling B Lymphocyte Behavior within Bone Marrow during Development

Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B.-I., & Nagasawa, T. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.001 · Cited by 796

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

Zsebo, K. M., Wypych, J., McNiece, I., Lu, H. S., Smith, K. A., Karkare, S. B., Sachdev, R. K., Yuschenkoff, V. N., Birkett, N. C., Williams, L. R., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90300-4 · Cited by 786

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

Casanova-Acebes, M., Pitaval, C., Weiss, L. A., Nombela‐Arrieta, C., Chèvre, R., A-González, N., Kunisaki, Y., Zhang, D., van Rooijen, N., Silberstein, L. E., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.040 · Cited by 785

Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor

Adams, G. B., Chabner, K. T., Alley, I. R., Olson, D. P., Szczepiorkowski, Z. M., Poznansky, M. C., Kos, C. H., Pollak, M. R., Brown, E. M., & Scadden, D. T. (2005) · Nature · doi:10.1038/nature04247 · Cited by 782

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells

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Fundamental properties of unperturbed haematopoiesis from stem cells in vivo

Busch, K., Klapproth, K., Barile, M., Flossdorf, M., Holland-Letz, T., Schlenner, S. M., Reth, M., Höfer, T., & Rodewald, H.-R. (2015) · Nature · doi:10.1038/nature14242 · Cited by 769

Identification and Specification of the Mouse Skeletal Stem Cell

Chan, C. K. F., Seo, E. Y., Chen, J. Y., Lo, D. D., McArdle, A., Sinha, R., Tevlin, R., Seita, J., Vincent-Tompkins, J., Wearda, T. L., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.002 · Cited by 763

Distinct bone marrow blood vessels differentially regulate haematopoiesis

Itkin, T., Gur‐Cohen, S., Spencer, J. A., Schajnovitz, A., Ramasamy, S. K., Kusumbe, A. P., Ledergor, G., Jung, Y., Milo, I., Poulos, M. G., et al. (2016) · Nature · doi:10.1038/nature17624 · Cited by 757

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

Flanagan, J. G., & Leder, P. (1990) · Cell · doi:10.1016/0092-8674(90)90299-t · Cited by 747

Expression and function of c-kit in hemopoietic progenitor cells.

Ogawa, M., Matsuzaki, Y., Nishikawa, S., Hayashi, S., Kunisada, T., Sudo, T., Kina, T., Nakauchi, H., & Nishikawa, S. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.1.63 · Cited by 744

Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size

Stier, S., Ko, Y. D., Forkert, R., Lutz, C., Neuhaus, T., Grünewald, E., Cheng, T., Dombkowski, D., Calvi, L. M., Rittling, S. R., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041992 · Cited by 733

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

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Primary structure and functional expression of rat and human stem cell factor DNAs

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Origin of monocytes and macrophages in a committed progenitor

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SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

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Fate tracing reveals the endothelial origin of hematopoietic stem cells

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Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

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Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

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The Placenta Is a Niche for Hematopoietic Stem Cells

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Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

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Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

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Gremlin 1 Identifies a Skeletal Stem Cell with Bone, Cartilage, and Reticular Stromal Potential

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Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

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Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

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Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

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Bone Marrow Transplantation for Sickle Cell Disease

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Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

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The journey of developing hematopoietic stem cells

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Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche

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The purification and characterization of fetal liver hematopoietic stem cells

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Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

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Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells

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Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function

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