The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
TREMs in the immune system and beyond
Abstract
Triggering receptors expressed by myeloid cells (TREMs) belong to a rapidly expanding family of receptors that include activating and inhibitory isoforms encoded by a gene cluster linked to the MHC. TREM1 and TREM2 activate myeloid cells by signalling through the adaptor protein DAP12. TREM1 triggers phagocyte secretion of pro-inflammatory chemokines and cytokines, amplifying the inflammation that is induced by bacteria and fungi. TREM2 activates monocyte-derived dendritic cells and regulates osteoclast development. Remarkably, TREM2 deficiency leads to a severe disease that is characterized by bone cysts and demyelination of the central nervous system, which results in dementia, implying that the function of TREM2 extends beyond the immune system.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“loss of function mutations in TREM2 (triggering receptor expressed on myeloid cells 2), which affect microglia phagocytosis and inflammation, are risk factors for ALS [425–427]”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [426]
In the citing paper
“confirming the pivotal role played by microglia in ALS pathogenesis.”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [426]
In the citing paper
“An important aspect of our BAC transgene design is the deletion of essential exons in three other TREM-like genes on the BAC, which are known to have important innate immunity function (Colonna, 2003; Ford and McVicar, 2009), and may play distinct roles in AD (Carrasquillo et al., 2017).”
From Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models (2018) · cites this paper as Colonna, 2003
Citations
Cites
Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,496
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
The Acute Respiratory Distress Syndrome
Matthay, M. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605303342209 · Cited by 4,924
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
The Acute Respiratory Distress Syndrome
Ware, L. B., & Matthay, M. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421806 · Cited by 4,666
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Bone Resorption by Osteoclasts
Teitelbaum, S. L. (2000) · Science · doi:10.1126/science.289.5484.1504 · Cited by 3,962
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386
Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.
Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J., Lanier, L., & Spies, T. (1999) · Science · doi:10.1126/science.285.5428.727 · Cited by 3,272
Research works printed but not linked: 6
- Colonna, M. & Facchetti, F. TREM-1: a new player in acute inflammatory responses. J. Infect. Dis. (in the press).
- Oldenborg, P. A. et al. Role of CD47 as a marker of self on red blood cells. Science 288, 2051–2054 (2000). · DOI
- Dietrich, J., Cella, M., Seiffert, M., Buhring, H. J. & Colonna, M. Cutting edge: signal-regulatory protein β1 is a DAP12-associated activating receptor expressed in myeloid cells. J. Immunol. 164, 9–12 (2000). · DOI
- Wright, G. J. et al. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13, 233–242 (2000). · DOI
- Hoek, R. M. et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290, 1768–1771 (2000). · DOI · Paper page
- Barclay, A. N., Wright, G. J., Brooke, G. & Brown, M. H. CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol. 23, 285–290 (2002). · DOI
Cited by
Sorted by citations
Items 501–600 of 700
Role of TREM2 in neuroinflammation
Abdulkhaliq, A. A., Alasiri, G. A., Almoghrabi, Y. M., Kim, B., Khan, J., Ajoolabady, A., Ren, J. T., Tuomilehto, J. O., Borai, A., & Praticò, D. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115547 · Cited by 10
Katsumoto, A., Kokiko‐Cochran, O. N., Bemiller, S. M., Xu, G., Ransohoff, R. M., & Lamb, B. T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.978423 · Cited by 11
Evidence for reduced anti-inflammatory microglial phagocytic response in late-life major depression
Plaska, C. R., Heslegrave, A., Bruno, D., Ramos‐Cejudo, J., Lee, S., Osorio, R. S., Imbimbo, B. P., Zetterberg, H., Blennow, K., & Pomara, N. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.05.030 · Cited by 11
Novel insights into the role of TREM2 in cerebrovascular diseases
Awuah, W. A., Ben-Jaafar, A., Kong, J. S. H., Sanker, V., Shah, M. H., Poornaselvan, J., Frimpong, M., Imran, S., Alocious, T., Abdul-Rahman, T., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149245 · Cited by 10
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau
Iyer, A. K., Vermunt, L., Mirfakhar, F. S., Minaya, M., Acquarone, M., Koppisetti, R. K., Renganathan, A., You, S., Danhash, E., Schache, K. J., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03073-2 · Cited by 14
Leng, F., Initiative, O. B. O. A. D. N., Zhan, Z., Sun, Y., Liu, F., Edison, P., Sun, Y., & Wang, Z. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220102 · Cited by 11
Frontotemporal dementia presentation in patients with heterozygous p.H157Y variant of TREM2
Ogonowski, N. S., Santamaría‐García, H. A., Báez, S., López, A., Laserna, A., Garcia-Cifuentes, E. R., Ayala‐Ramírez, P., Zarante, I., Suárez‐Obando, F., Reyes, P. A., et al. (2023) · Journal of Medical Genetics · doi:10.1136/jmg-2022-108627 · Cited by 11
Han, X., Han, J., Wang, N., Ji, G., Guo, R., Li, J., Wu, H., Ma, S., Fang, P., & Song, X. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.891670 · Cited by 10
Mechanistic Role of Jak3 in Obesity-Associated Cognitive Impairments
Kumar, P., Mishra, J., & Kumar, N. (2022) · Nutrients · doi:10.3390/nu14183715 · Cited by 10
How, C., Hou, S., Shih, H., Yen, D. H.-T., Huang, C., Lee, C.-H., & Tang, G. (2010) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2010.01.010 · Cited by 10
Ubagai, T., Tansho, S., Ieki, R., & Ono, Y. (2012) · Japanese Journal of Infectious Diseases · doi:10.7883/yoken.65.376 · Cited by 9
Wang, Z.-T., Fu, Y., Chen, S., Huang, Y., Ma, Y., Wang, Y., Tan, L., & Yu, J. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14129 · Cited by 8
Kogut, M. H., Genovese, K. J., Nerren, J. R., & He, H. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.06.015 · Cited by 9
TREM2 promotes natural killer cell development in CD3−CD122+NK1.1+ pNK cells
Lee, H.-Y., Lee, E., Yi, J., Ji, K.-Y., Kim, S., Choi, H.-R., Yee, S., Kang, H., & Kim, E. (2021) · BMC Immunology · doi:10.1186/s12865-021-00420-0 · Cited by 10
Xie, Z., Li, X., He, Y., Wu, S., Wang, S., Sun, J., He, Y., Lun, Y., Xin, S., & Zhang, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.646793 · Cited by 9
PET Imaging of Neuroinflammation
Chaney, A. M., Deal, E. M., Jackson, I. M., & James, M. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816386-3.00047-8 · Cited by 9
Schwarz, H., Bässler, S., Balta, D., Socher, E., Zunke, F., & Arnold, P. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.113977 · Cited by 8
The Genetic Basis of Alzheimer's Disease
Hooli, B. V., & Tanzi, R. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800105-9.00034-2 · Cited by 9
Ji, Z., Zhang, R., Yang, M., Zuo, W., Yao, Y., Qu, Y., Su, Y., Liu, Z., Gu, Z., & Ma, G. (2021) · PeerJ · doi:10.7717/peerj.11655 · Cited by 7
Commentary: Regulated equilibrium between opposite signals: a general paradigm for T cell function?
Moretta, A., & Bottino, C. (2004) · European Journal of Immunology · doi:10.1002/eji.200425388 · Cited by 9
Amukti, D. P., Wazni, A. R., Irham, L. M., Sulistyani, N., Ma’ruf, M. F., Adikusuma, W., Sarasmita, M. A., Khairi, S., Purwanto, B. D., Suyatmi, S., et al. (2024) · E3S Web of Conferences · doi:10.1051/e3sconf/202450101021 · Cited by 8
The role of TREM‐1 in septic myocardial pyroptosis and septic cardiomyopathy in vitro and in vivo
Chen, Y., Mao, L., Liu, S., Huang, S., Lin, Q., Zeng, M., Huang, H., Sun, X., Chen, H., Huang, J., et al. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31445 · Cited by 8
Que, X., Zhang, T., Liu, X. Y., Yin, Y., Xia, X., Gong, P., Song, W., Qin, Q., Xu, Q., & Tang, Y. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102732 · Cited by 8
Amyloids and brain cancer: molecular linkages and crossovers
Singh, S., Joshi, V., & Upadhyay, A. (2023) · Bioscience Reports · doi:10.1042/bsr20230489 · Cited by 8
He, S., Yu, Y., Chen, P.-Q., Sun, H., Gao, X., Sun, H., & Ge, J. (2024) · Journal of Diabetes Research · doi:10.1155/2024/5661751 · Cited by 8
Unveiling the impact of TREM-2+ Macrophages in metabolic disorders
Contreras, M., Matos, A. D. O., Dantas, P. H. D. S., Neto, J. R. D. C., Silva‐Sales, M., & Sales‐Campos, H. (2024) · Cellular Immunology · doi:10.1016/j.cellimm.2024.104882 · Cited by 10
Insight into the WNT system and its drug related response
Tamanini, S., Idolazzi, L., Gatti, D., Viapiana, O., Fassio, A., & Rossini, M. (2013) · Reumatismo · doi:10.4081/reumatismo.2013.219 · Cited by 8
Bai, Y. Z., Ma, L., Deng, D., Tian, D., Liu, W., & Diao, Z. (2023) · Biochemical Genetics · doi:10.1007/s10528-023-10336-6 · Cited by 8
Radhakrishnan, S., Cabrera, R., Bruns, K. M., Keulen, V. P. V., Hansen, M. J., Felts, S. J., & Pease, L. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005373 · Cited by 8
RetractedKaitani, A., Izawa, K., Maehara, A., Isobe, M., Takamori, A., Matsukawa, T., Takahashi, M., Yamanishi, Y., Oki, T., Yamada, H., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25646-8 · Cited by 8
Carpenter, K. J., Buckland, K. F., Xing, Z., & Hogaboam, C. M. (2005) · Infection and Immunity · doi:10.1128/iai.73.12.8402-8406.2005 · Cited by 8
Fan, Y., Xu, Y., Huo, Z., Zhang, H., Peng, L., Jiang, X., Thomson, A. W., & Dai, H. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003197 · Cited by 7
Zhang, Y., Guo, X., Zhao, J., Gao, X., Zhang, L., Huang, T., Wang, Y., Niu, Q. L., & Zhang, Q. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117107 · Cited by 8
Phospholipase C-γ as a Potential Therapeutic Target for Graves’ Orbitopathy
Roh, T. H., Chae, M. K., Ko, J., Kikkawa, D. O., Jang, S. Y., & Yoon, J. S. (2023) · Endocrinology and Metabolism · doi:10.3803/enm.2023.1780 · Cited by 8
Sperling, B., Viertlboeck, B. C., & Göbel, T. (2015) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.02.004 · Cited by 7
Tian, M.-L., Ni, X.-N., Li, J., Tan, C., Cao, X., Tan, L., & Initiative, A. D. N. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00742 · Cited by 6
Veloz, M. F. V., Martín‐Román, C., Valdivieso, M. P. R., White, T. J. H., Kushner, S. A., & Zeeuw, C. I. D. (2020) · Genes Brain & Behavior · doi:10.1111/gbb.12656 · Cited by 8
Li, J., Yang, S. L., Liu, S., Chen, Y., Liu, H., Su, Y., Liu, R., Cui, Y., Song, Y., Teng, Y., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.749618 · Cited by 7
The potential of targeting TREM-1 in IBD
Vinolo, E., Maillefer, M., Jolly, L., Colné, N., Meiffren, G., Carrasco, K., & Derive, M. (2024) · Advances in pharmacology · doi:10.1016/bs.apha.2024.10.010 · Cited by 6
An, Y., Zhai, T., Wang, F., Zhang, K., Feng, M., Song, D., Li, Z., & Guo, F. (2025) · The FASEB Journal · doi:10.1096/fj.202501909r · Cited by 6
Experimental procedures for flow cytometry of wild-type mouse brain: a systematic review
Sharp, R. C., Guenther, D. T., & Farrer, M. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1281705 · Cited by 7
Zhang, L., Peng, C., Chu, Y.-Q., Zhou, Z.-M., Hua, R., & Zhang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1412699 · Cited by 8
Xue, J.-Y., Chen, M., Jian, Y.-H., Liang, L., Yang, X., Sun, S.-H., Liu, P., Liu, Q., Jiang, Y., & Liu, M. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123555 · Cited by 6
Huang, H., Yang, Y., Song, T., Yang, Y., Zhu, Y., Liu, Z., Li, L., & Wang, X. (2022) · International Journal of Medical Sciences · doi:10.7150/ijms.67806 · Cited by 6
Wang, F., Wang, Y., Wang, R., Qiu, H., & Chen, L. (2016) · American Journal of Reproductive Immunology · doi:10.1111/aji.12543 · Cited by 6
The Genetic Basis of Alzheimer’s Disease
Hooli, B. V., & Tanzi, R. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802173-6.00002-2 · Cited by 6
Pertussis toxin targets the innate immunity through DAP12, FcRγ, and MyD88 adaptor proteins
Phongsisay, V., Iizasa, E., Hara, H., & Yoshida, H. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.12.004 · Cited by 6
Plasticity of the immunoglobulin domain in the evolution of immunity
Cannon, J. P. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp018 · Cited by 6
Galimberti, D., Fenoglio, C., Ghezzi, L., Serpente, M., Arcaro, M., D’Anca, M., Riz, M. A. D., Arighi, A., Fumagalli, G., Pietroboni, A. M., et al. (2019) · Cytokine · doi:10.1016/j.cyto.2018.12.024 · Cited by 6
Singh, O. P., Syn, G., Nylén, S., Engwerda, C. R., Sacks, D. L., Wilson, M. E., Kumar, R., Chakravarty, J., Sundar, S., Blackwell, J. M., et al. (2020) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaa381 · Cited by 6
Nouveaux acteurs de l’immunité innée : les récepteurs TREM
Gibot, S. (2004) · médecine/sciences · doi:10.1051/medsci/2004205503 · Cited by 6
The properties of TREM1 and its emerging role in pain-related diseases
Fan, Z., Wang, L., Sun, S., & Ge, Z. (2025) · Molecular Brain · doi:10.1186/s13041-025-01187-w · Cited by 7
Li, H., Jing, F., Xu, W., Peng, Y., Yan, P.-J., Xu, Y., Qin, G., & Teng, F. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114509 · Cited by 8
Wu, W., Chen, W., Wan, S., Luo, X., Yang, D., Wang, C., Zhu, H., Yu, H., Li, N., & Hua, J. (2025) · Research in Veterinary Science · doi:10.1016/j.rvsc.2025.105750 · Cited by 5
Liu, W., Liu, Y., Guo, X., Cao, C., Weng, S., & Peng, D. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116167 · Cited by 5
Substrate Selection Criteria in Regulated Intramembrane Proteolysis
Moser, C., Guschtschin-Schmidt, N., Silber, M., Flum, J., & Muhle‐Goll, C. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.4c00068 · Cited by 5
TREM2 as a Therapeutic Target in Atherosclerosis
Xu, S., Yang, B., Yu, W., Gao, Y., Cai, H., & Wang, Z. (2025) · Cell Biology International · doi:10.1002/cbin.12279 · Cited by 7
Chen, N., Jin, J., Qiao, B., Gao, Z., Tian, Y., & Ping, J. (2025) · Virus Research · doi:10.1016/j.virusres.2025.199577 · Cited by 5
Bakry, S. A. E., Bassyouni, I. H., El-Shazly, R., & Abou-Elalla, A. A. (2013) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2012.11.004 · Cited by 5
Niu, W., Ma, L., Tao, T., Tian, F., He, T., Qiao, M., He, H., Liu, X., & Zhao, X. (2020) · Acta Histochemica · doi:10.1016/j.acthis.2020.151553 · Cited by 5
Sek, A. C., Percopo, C. M., Boddapati, A. K., Ma, M., Geslewitz, W. E., Krumholz, J. O., Lack, J., & Rosenberg, H. F. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a0920-620r · Cited by 5
TREM2 coding variants in Slovak Alzheimer's disease patients
Ďurmanová, V., Javor, J., Párnická, Z., Minárik, G., Ocenasova, A., Vašečková, B., Kiralyova, I., Šutovský, S., Petrovič, R., & Shawkatová, I. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2104105 · Cited by 5
Keeping the liver fit with TREM2 during hepatic carcinogenesis
Cubero, F. J. (2020) · Gut · doi:10.1136/gutjnl-2020-322638 · Cited by 5
Turhan, U., & Ertaş, S. (2020) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2020.1846706 · Cited by 5
Shiber, S., Kliminski, V., Orvin, K., Sagy, I., Vaturi, M., Kornowski, R., Drescher, M. J., & Molad, Y. (2021) · Mediators of Inflammation · doi:10.1155/2021/8872686 · Cited by 5
General Principles of Tumor Immunotherapy
Kaufman, H. L., & Wolchok, J. D. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6087-8 · Cited by 15
Pashaei, S., Shabani, S., Mohammadi, S., Morozova‐Roche, L. A., Salari, N., Rahimi, Z., & Khodarahmi, R. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04253-2 · Cited by 4
Hou, K., An, Z., Xu, Y., Wang, J., Zhou, M., Liu, Y., Zhu, X., & Wei, J. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-025-01247-x · Cited by 5
Li, S., Tang, S., Wang, Y., Li, S., Jia, Y., & Chen, S. (2024) · Quantitative Biology · doi:10.1002/qub2.33 · Cited by 4
Nguyen, N. M., & Conrady, C. D. (2024) · Microorganisms · doi:10.3390/microorganisms12122513 · Cited by 5
Bibliometric Analysis of TREM2 (2001-2022): Trends, Hotspots and Prospects in Human Disease
Qian, M., Zhong, J., Lu, Z., Zhang, W., Weng, M., Zhang, K., & Jin, Y. (2024) · International Journal of Medical Sciences · doi:10.7150/ijms.96851 · Cited by 4
Possible role of microgliopathy in the pathogenesis of Nasu–Hakola disease
Satoh, J. (2013) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12046 · Cited by 4
Steinhoff, M., Griffiths, C. E. M., Church, M. K., & Luger, T. A. (2004) · Wiley eBooks · doi:10.1002/9780470750520.ch9 · Cited by 4
Kaneko, T., Esmail, S., Voss, C., Martin, C. M., Slessarev, M., Hovey, O. F. J., Liu, X., Ye, M., Kim, S. H., Fraser, D. D., et al. (2021) · medRxiv · doi:10.1101/2021.03.19.21253675 · Cited by 4
Tejchman, A., Strzelec, M., Kot, M., Chlebanowska, P., Badyra, B., Sobocińska, M. K., Zecca, L., & Majka, M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.28.538536 · Cited by 4
Decoding the Epigenetic Landscape: Insights into 5mC and 5hmC Patterns in Mouse Cortical Cell TypesPreprint
Wei, X., Li, J., Cheng, Z., Wei, S., Yu, G., & Olsen, M. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.06.602342 · Cited by 4
Zhang, P., Li, Y., Xu, P., Zou, P., Sheng, S., Xiao, R., Xu, P., Chen, Y., Du, Y., Ma, L., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094036 · Cited by 3
TREM1 as a novel prognostic biomarker and tumor immune microenvironment evaluator in glioma
Lu, Q., Xie, Y., Qi, X., & Yang, S. (2023) · Medicine · doi:10.1097/md.0000000000036410 · Cited by 3
Yi, F., Wu, H., & Zhao, H. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v13.i9.100312 · Cited by 3
Genome‐wide association study of novel feedlot profitability‐related traits in Nelore cattle
Pereira, L. S., Baldi, F. S., Rosa, G. J. M., Stafuzza, N. B., Albertini, T. Z., Carvalho, M. E., Lôbo, R. B., Peripolli, E., Eifert, E. D. C., & Magnabosco, C. D. U. (2025) · Animal Genetics · doi:10.1111/age.70018 · Cited by 3
Zhou, X., Bi, J., Chen, H., Wang, Y., Li, Y., Huang, D., Ma, X., Cai, W., Jiang, D., & Guan, T. (2025) · The FASEB Journal · doi:10.1096/fj.202501934rr · Cited by 3
Puglisi, C. H., Ander, B. P., Peterson, C., Keiter, J. A., Hull, H., Hawk, C. W., Kalistratova, V. S., Izadi, A., Gurkoff, G. G., Sharp, F. R., et al. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01061-0 · Cited by 3
Endosomal Toll-Like Receptors as Therapeutic Targets for Autoimmune Diseases
Miyake, K., Shibata, T., Fukui, R., Murakami, Y., Sato, R., & Hiranuma, R. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-9781-7_7 · Cited by 3
Sawy, E. R. A., Saber, M. M., Nassar, N. N., & Sayed, N. S. E. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-01738-6 · Cited by 3
Neuroprotection Versus Neurotoxicity
Biber, K. P. H., & Block, M. L. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1429-6_6 · Cited by 3
Průcha, M., Zazula, R., Müller, M., Hyánek, T., Dostál, M., & Sedláčková, L. (2011) · PubMed · Cited by 3
Keratinocytes and Activation of TREM-1 Pathway in Cutaneous Leishmaniasis Lesions
Nunes, S., Ampuero, M. R., Bonyek-Silva, Í., Lima, R., Lima, F. R., Arruda, S. M., Khouri, R., Oliveira, P. R. S., Barral, A. M. P., Boaventura, V. S., et al. (2021) · Microbiology Research · doi:10.3390/microbiolres12040056 · Cited by 3
La génétique de la maladie d’Alzheimer
Halla, S. B., Moutawakil, B. E., Kadmiri, N. E., & Nadifi, S. (2019) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2018.11.006 · Cited by 4
Cell autonomous microglia defects in a stem cell model of frontotemporal dementiaPreprint
Iyer, A. K., Vermunt, L., Mirfakhar, F. S., Minaya, M., Acquarone, M., Koppisetti, R. K., Renganathan, A., You, S., Danhash, E., Verbeck, A. C., et al. (2024) · medRxiv · doi:10.1101/2024.05.15.24307444 · Cited by 3
Plaza‐Florido, A., Perlsteyn, M., Haddad, F., Cooper, D. M., Bar‐Yoseph, R., Lucía, A., & Radom‐Aizik, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1625437 · Cited by 2
Dai, Y., Feng, Y., Wang, C., Zhang, H., & Shang, P. (2026) · Cancers · doi:10.3390/cancers18030359 · Cited by 2
Li, P., Wang, R., Dong, W., Wang, G., Zhang, A., Chen, H., & Tan, C. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106535 · Cited by 2
Ziegenfuss, J. S. (2012) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/7wx4-q868 · Cited by 2
Tency, I., Verstraelen, H., Saerens, B., Verhasselt, B., Vaneechoutte, M., Degomme, O., Verhelst, R., & Temmerman, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056050 · Cited by 2
Adams, S., Bhardwaj, N., & O’Neill, D. W. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6087-8_11 · Cited by 2
Preliminary Study of the Relationship between Osteopontin and Relapsed Hodgkin’s Lymphoma
Re, V. D., Lopci, E., Brisotto, G., Elia, C., Mussolin, L., Mascarin, M., & dʼAmore, E. S. G. (2023) · Biomedicines · doi:10.3390/biomedicines12010031 · Cited by 3
TRAPC : A novel Triggering Receptor expressed on Antigen Presenting Cells
van der Holst, R. (2007) · Figshare · Cited by 2
Cell-Cell Signalling Properties of Chaperonins
Coates, A. R. M., & Tormay, P. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546310.007 · Cited by 2
Inflammation, Immunology and Allergy
Steinhoff, M. S. (2016) · Wiley eBooks · doi:10.1002/9781118441213.rtd0008 · Cited by 2
Ralapanawa, U., & Sivakanesan, R. (2021) · Health Sciences · doi:10.15342/hs.3.595 · Cited by 1
Metadata
- Authors
- Colonna, M.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Colonna, Marco
- ORCID
- Colonna, Marco
- Venue
- Nature Reviews Immunology
- Published
- 2003-06-01
- Volume
- 3
- Issue
- 6
- Pages
- 445-453
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1986899130
- Cited by
- 701
- References
- 84
- Citations by year
- 2026: 20 · 2025: 36 · 2024: 39 · 2023: 39 · 2022: 35 · 2021: 42 · 2020: 31 · 2019: 34 · 2018: 30 · 2017: 43 · 2016: 43 · 2015: 34 · 2014: 33 · 2013: 36 · 2012: 19
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Academy of Sciences of Ukraine
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- TREM-1, TREM2, DAP12, myeloid cell activation, innate immunity, inflammation, dendritic cells, osteoclast development, TREM2 deficiency, bone cysts, demyelination, dementia
- MeSH terms
- Triggering Receptor Expressed on Myeloid Cells-1, Animals, Bone Cysts, Cell Differentiation, Dendritic Cells, Humans, Inflammation, Membrane Glycoproteins, Membrane Proteins, Phagocytes, Receptors, Immunologic, Signal Transduction, Cytokines, Chemokines, Hereditary Central Nervous System Demyelinating Diseases, Myeloid Cells, Adaptor Proteins, Signal Transducing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
