Cited by 701Inflammation biomarkers and pathwaysImmune Response and InflammationNeuroinflammation and Neurodegeneration Mechanisms

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TREMs in the immune system and beyond

Colonna, Marco·2003·Nature Reviews Immunology

DOI 10.1038/nri1106

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Abstract

Triggering receptors expressed by myeloid cells (TREMs) belong to a rapidly expanding family of receptors that include activating and inhibitory isoforms encoded by a gene cluster linked to the MHC. TREM1 and TREM2 activate myeloid cells by signalling through the adaptor protein DAP12. TREM1 triggers phagocyte secretion of pro-inflammatory chemokines and cytokines, amplifying the inflammation that is induced by bacteria and fungi. TREM2 activates monocyte-derived dendritic cells and regulates osteoclast development. Remarkably, TREM2 deficiency leads to a severe disease that is characterized by bone cysts and demyelination of the central nervous system, which results in dementia, implying that the function of TREM2 extends beyond the immune system.

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Background
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Authors: Colonna, M.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Colonna, Marco
ORCID: Colonna, Marco
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2003-06-01
Volume: 3
Issue: 6
Pages: 445-453
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1106
OpenAlex: W1986899130
Cited by: 701
References: 84
Citations by year: 2026: 20 · 2025: 36 · 2024: 39 · 2023: 39 · 2022: 35 · 2021: 42 · 2020: 31 · 2019: 34 · 2018: 30 · 2017: 43 · 2016: 43 · 2015: 34 · 2014: 33 · 2013: 36 · 2012: 19
FWCI: 2.12
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Academy of Sciences of Ukraine
Topics: Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: TREM-1, TREM2, DAP12, myeloid cell activation, innate immunity, inflammation, dendritic cells, osteoclast development, TREM2 deficiency, bone cysts, demyelination, dementia
MeSH terms: Triggering Receptor Expressed on Myeloid Cells-1, Animals, Bone Cysts, Cell Differentiation, Dendritic Cells, Humans, Inflammation, Membrane Glycoproteins, Membrane Proteins, Phagocytes, Receptors, Immunologic, Signal Transduction, Cytokines, Chemokines, Hereditary Central Nervous System Demyelinating Diseases, Myeloid Cells, Adaptor Proteins, Signal Transducing

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