Cited by 1,136Gut microbiota and healthImmune Response and InflammationT-cell and B-cell Immunology

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Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Artis, David·2008·Nature reviews. Immunology

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Abstract

Mucosal surfaces such as the intestinal tract are continuously exposed to both potential pathogens and beneficial commensal microorganisms. This creates a requirement for a homeostatic balance between tolerance and immunity that represents a unique regulatory challenge to the mucosal immune system. Recent findings suggest that intestinal epithelial cells, although once considered a simple physical barrier, are a crucial cell lineage for maintaining intestinal immune homeostasis. This Review discusses recent findings that identify a cardinal role for epithelial cells in sampling the intestinal microenvironment, discriminating pathogenic and commensal microorganisms and influencing the function of antigen-presenting cells and lymphocytes.

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Authors: Artis, D.
Affiliations: University of Pennsylvania (US)
Corresponding author: Artis, David
ORCID: Artis, David
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-06
Volume: 8
Issue: 6
Pages: 411-420
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2316
OpenAlex: W2025114863
Cited by: 1,136
References: 167
Citations by year: 2026: 27 · 2025: 33 · 2024: 38 · 2023: 55 · 2022: 61 · 2021: 54 · 2020: 51 · 2019: 52 · 2018: 60 · 2017: 56 · 2016: 58 · 2015: 63 · 2014: 92 · 2013: 85 · 2012: 81
FWCI: 6.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (T32CA009140, T32-CA09140-30)
National Institute of General Medical Sciences (F31-GM82187, F31GM082187)
National Institute of Allergy and Infectious Diseases (AI74878, T32AI007532, R01AI074878, F32-AI72943, F32AI072943, R01AI061570, AI 61570)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: intestinal epithelial cells, commensal bacteria, immune homeostasis, mucosal immunity, host-microbe interactions, epithelial barrier function, antigen presentation, lymphocytes, pathogen discrimination, gut microbiota
MeSH terms: Animals, Bacteria, Gastric Mucosa, Homeostasis, Humans, Intestinal Mucosa

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Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

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