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Exploring the full spectrum of macrophage activation
Open accessAbstract
Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities - host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.
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“During cancer development, tumor cells and tumor‐associated stromal cells continuously change the composition and organization of ECM through deposition/degradation cycles and extensive crosslinking, shaping it more supportive for tumor growth.[ 33 ]”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [33]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A more recent model also hypothesizes the existence of a macrophage spectrum between M1 and M2, regulated through three major homeostatic processes involving the host defense, wound healing, and immune modulation.[ 40 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [40]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Common examples of cytokines that polarize macrophages are IFN‐γ and LPS, which skew macrophages toward the M1 phenotype, whereas cytokines such as IL‐4 and IL‐13 promote a regenerative M2 phenotype (Figure 2 ).[ 40 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [40]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This M1–M2 transition is critical for the resolution of inflammation and tipping the balance to tissue repair [49].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [49]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Aβ deposition elicits a robust “M1” microglia-mediated inflammatory response contributing to disease pathogenesis (Gordon, 2003; Mosser and Edwards, 2008; Mandrekar-Colucci and Landreth, 2010).”
From Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor-γ-Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease (2012) · cites this paper as Mosser and Edwards, 2008
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“The biochemical composition of the microenvironment is especially important for the determination of macrophage phenotypes.”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [40]
The cited source says what the claim attributes to it.
In the citing paper
“Macrophages/microglia are capable of exhibiting a spectrum of phenotypic activation states which dictate their activities (Gordon, 2003; Mosser and Edwards, 2008; Mandrekar-Colucci and Landreth, 2010).”
From Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor-γ-Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease (2012) · cites this paper as Mosser and Edwards, 2008
In the citing paper
“the heterogeneity of cell morphologies observed (elongated and round cells) reflect the diverse plasticity of macrophage cells that define its myriad of phenotypes [56].”
From Characterization of topographical effects on macrophage behavior in a foreign body response model (2010) · cites this paper as [56]
In the citing paper
“It has been shown that macrophages, as part of their myeloid lineage, do not possess stress fibers,58 which may in large part be due to the fact that their interaction with their surrounding matrix, when not migrating, is not a key part of their innate function.29”
From Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)‐based hydrogels (2012) · cites this paper as [29]
In the citing paper
“A pro-inflammatory macrophage phenotype correlates with elevated expression of Tumor Necrosis Factor α (TNF α), Interleukin 1 (IL1), and Interferon Regulatory Factor 5 (IRF5)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [44]
In the citing paper
“There is a broad spectrum of macrophage activations which can be categorized into three states namely, classical activation (pro-inflammatory, MClassic), alternative activation (pro-healing, MWound), and regulatory activation (MReg)44.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [44]
In the citing paper
“A pro-wound healing phenotype of macrophage correlates with up regulation in expression of Dendritic Cell Immune Receptor (Dcir), Stabilin 1 (Stab1), chemokine (C-C motif) ligand 22 (CCL22), Chitinase-like 3 (YM1), and Arginase 1 (Arg1)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [44]
In the citing paper
“Meanwhile, a regulatory macrophage phenotype has been characterized to correlate with elevated expression of Interleukin 10 (IL10), TNF superfamily member 14 (Light), and Sphingosine Kinase 1 (Sphk1)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [44]
In the citing paper
“Alternatively, the M2c subset is induced by IL-10 and plays a major role in tissue remodeling and suppression of inflammatory immune reactions by secreting transforming growth factor-b (TGF-b) and IL-10 [1,23].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [23]
In the citing paper
“Rather, macrophage phenotype has been described as occurring along a continuum between the M1 and M2 extremes [12].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [12]
In the citing paper
“While the term ‘M2’ encompasses all non-classically activated macrophages, M2 macrophages have been shown to include three well recognized sub-populations (M2a, M2b, and M2c), each with its own distinct inducers, markers, and functions.”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [12]
In the citing paper
“Macrophages, like the monocytes from which they derive, are a heterogeneous cell population each with different markers and functions [1,8–12].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [12]
In the citing paper
“Indeed, macrophages serve three primary functions in the body: host defense, wound healing, and immune regulation.95”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [95]
In the citing paper
“Moreover, individual macrophages hold the potential for a dynamic phenotype switch, which affects the functional properties ofthe macrophage155,156.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [155]
In the citing paper
“However, this nomenclature is now deemed inaccurate as accumulating evidence has revealed a broad diversity of macrophage activation statuses and shown that macrophages show remarkable plasticity to change phenotypes in response to environmental cues25,26.”
From Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight (2018) · cites this paper as [25]
In the citing paper
“Transitioning from a pro-inflammatory macrophage-dominant wound to an anti-inflammatory macrophage-dominant milieu is essential in resolving inflammation and preparing the wound for effective repair [72].”
From Immunology of Wound Healing (2018) · cites this paper as [72]
In the citing paper
“In the late stages of the inflammatory phase of wound healing, macrophages are found to switch from a proinflammatory to an alternatively activated phenotype, which has been assumed to be requisite for the switch from the inflammatory to the proliferative stages in wound healing as discussed below in more detail.46”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [46]
In the citing paper
“Thus, available evidence indicates that M1 and M2a/b/c are not discrete Mp differentiation states but instead represent convenient but limited and arbitrary in vitro-defined reference points on a time-dependent and multidimensional continuum of possible Mp phenotypes and functions [9].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [9]
In the citing paper
“Finally and perhaps most importantly, rodent and human Mp do not exhibit entirely similar responses to in vitro activation [9,34,66,80], and it remains to be determined whether there are also species-dependent differences in Mp function during in vivo tissue repair.”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [9]
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Cites
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Interleukin-12 and the regulation of innate resistance and adaptive immunity
Trinchieri, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1001 · Cited by 4,007
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
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Zhang, M., Wang, X., Wang, Y., Niu, A., Wang, S., Zou, C., & Harris, R. C. (2016) · Kidney International · doi:10.1016/j.kint.2016.08.020 · Cited by 205
Du, L., Lin, L., Li, Q., Liu, K., Huang, Y., Wang, X., Cao, K., Chen, X., Cao, W., Li, F., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.006 · Cited by 203
Macrophage p38α promotes nutritional steatohepatitis through M1 polarization
Zhang, X., Fan, L., Wu, J., Xu, H., Leung, W. Y., Fu, K., Wu, J., Liu, K., Man, K., Yang, X., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.014 · Cited by 205
CAFs Interacting With TAMs in Tumor Microenvironment to Enhance Tumorigenesis and Immune Evasion
Günaydın, G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.668349 · Cited by 211
Chen, Z., Yuen, J., Crawford, R., Chang, J., Wu, C., & Xiao, Y. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.04.044 · Cited by 205
The role of tumor-associated macrophages in breast cancer progression
Obeid, E. I., Nanda, R., Fu, Y., & Olopade, O. I. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1938 · Cited by 210
Sierra‐Filardi, E., Vega, M. A., Sánchez‐Mateos, P., Corbí, A. L., & Puig‐Kröger, A. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.020 · Cited by 209
Macrophage polarization: a key event in the secondary phase of acute spinal cord injury
Kong, X., & Gao, J. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13034 · Cited by 206
Andorko, J. I., & Jewell, C. M. (2017) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10063 · Cited by 209
The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer
Yin, J., Valin, K. L., Dixon, M. L., & Leavenworth, J. W. (2017) · Journal of Immunology Research · doi:10.1155/2017/5150678 · Cited by 220
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Apo, E. G., Mondragón‐Maya, A., Ferrari-Díaz, M., & Silva‐Pereyra, J. (2021) · Journal of Obesity · doi:10.1155/2021/6613385 · Cited by 218
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Al‐Qazazi, R., Lima, P., Prisco, S. Z., Potus, F., Dasgupta, A., Chen, K., Tian, L., Bentley, R. E. T., Mewburn, J., Martin, A. Y., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202110-2274oc · Cited by 214
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Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases
Peng, Y., Zhou, M., Hong, Y., Qu, R., Qiu, Y., Hao, J., Bi, H., & Guo, D. (2023) · Mediators of Inflammation · doi:10.1155/2023/8821610 · Cited by 217
Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis
Ghatak, S., Maytin, E. V., Mack, J. A., Hascall, V., Atanelishvili, I., Moreno‐Rodriguez, R. A., Markwald, R. R., & Misra, S. (2015) · International Journal of Cell Biology · doi:10.1155/2015/834893 · Cited by 208
Iron Is a Sensitive Biomarker for Inflammation in Multiple Sclerosis Lesions
Mehta, V. B., Pei, W., Yang, G., Li, S., Swamy, E., Boster, A. L., Schmalbrock, P., & Pitt, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057573 · Cited by 209
Ma, S., Chen, Y.-J., Zhang, J., Shen, L., Wang, R., Zhou, J.-S., Hu, J., & Lü, H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.11.007 · Cited by 201
An, C., Shi, Y., Li, P., Hu, X., Gan, Y., Stetler, R. A., Leak, R. K., Gao, Y., Sun, B., Zheng, P., et al. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.002 · Cited by 204
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Fleming, B. D., & Mosser, D. M. (2011) · European Journal of Immunology · doi:10.1002/eji.201141717 · Cited by 202
Self-citationMacrophage Plasticity in Skeletal Muscle Repair
Rigamonti, E., Zordan, P., Sciorati, C., Rovere, P. Q., & Brunelli, S. (2014) · BioMed Research International · doi:10.1155/2014/560629 · Cited by 216
Hou, J., Shi, J., Chen, L., Lv, Z., Chen, X., Cao, H., Xiang, Z., & Han, X. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0300-8 · Cited by 204
Analysis of the intricate relationship between chronic inflammation and cancer
Chai, E. Z. P., Siveen, K. S., Shanmugam, M. K., Arfuso, F., & Sethi, G. (2015) · Biochemical Journal · doi:10.1042/bj20141337 · Cited by 202
Xu, Y., Romero, R. J., Miller, D., Kadam, L., Mial, T. N., Plazyo, O., Garcia‐Flores, V., Hassan, S. S., Xu, Z., Tarca, A. L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502055 · Cited by 202
Tomlin, H., & Piccinini, A. M. (2018) · Immunology · doi:10.1111/imm.12972 · Cited by 205
Laoui, D., Overmeire, E. V., BAETSELIER, P. D., Ginderachter, J. A. V., & Raes, G. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00489 · Cited by 207
Altered Macrophage Phenotype Transition Impairs Skeletal Muscle Regeneration
Wang, H., Melton, D. W., Porter, L., Sarwar, Z. U., McManus, L. M., & Shireman, P. K. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.12.020 · Cited by 212
Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis
Samak, M., Fatullayev, J., Sabashnikov, A., Zeriouh, M., Schmack, B., Farag, M. B., Popov, A., Dohmen, P. M., Choi, Y., Wahlers, T., et al. (2016) · Medical science monitor basic research/Medical science monitor. Basic research · doi:10.12659/msmbr.900437 · Cited by 202
Chedly, J., Soares, S., Montembault, A., von Boxberg, Y., Ravaille‐Veron, M., Mouffle, C., Benassy, M., Taxi, J., David, L., & Nothias, F. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.05.024 · Cited by 205
Dendritic cells and macrophages in the kidney: a spectrum of good and evil
Rogers, N. M., Ferenbach, D. A., Isenberg, J. S., Thomson, A. W., & Hughes, J. (2014) · Nature Reviews Nephrology · doi:10.1038/nrneph.2014.170 · Cited by 206
Tim-3: An Activation Marker and Activation Limiter of Innate Immune Cells
Han, G., Chen, G., Shen, B., & Li, Y. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00449 · Cited by 200
Pettersson, M., Kelk, P., Belibasakis, G. N., Bylund, D., Thorén, M. M., & Johansson, A. S. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12364 · Cited by 200
Fenn, A. M., Henry, C. J., Huang, Y., Dugan, A., & Godbout, J. P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.003 · Cited by 198
Secreted protein lipocalin‐2 promotes microglial M1 polarization
Jang, E., Lee, S., Kim, J., Kim, J., Seo, J., Lee, W., Mori, K., Nakao, K., & Suk, K. (2013) · The FASEB Journal · doi:10.1096/fj.12-222257 · Cited by 198
Waterman, R. S., Henkle, S. L., & Betancourt, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045590 · Cited by 205
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Lee, S., Kivimäe, S., Dolor, A., & Szoka, F. C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.018 · Cited by 198
The JAK/STAT3 axis: A comprehensive drug target for solid malignancies
Huynh, J., Etemadi, N., Hollande, F., Ernst, M., & Büchert, M. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.06.001 · Cited by 201
Markus, R. P., Fernandes, P. A. C. M., Kinker, G. S., Cruz‐Machado, S. D. S., & Marçola, M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14083 · Cited by 196
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Liu, J., Chen, B., Bao, J., Zhang, Y., Lei, L., & Yan, F. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1409-4 · Cited by 198
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Montoya, D. J., Cruz, D., Teles, R. M. B., Lee, D. J., Ochoa, M. T., Krutzik, S. R., Chun, R. F., Schenk, M., Zhang, X., Ferguson, B. G., et al. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.09.002 · Cited by 204
Huang, Z., Luo, Q., Guo, Y., Chen, J., Xiong, G., Peng, Y., Ye, J., & Li, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129744 · Cited by 207
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Rostam, H. M., Reynolds, P. M., Alexander, M. R., Gadegaard, N., & Ghaemmaghami, A. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-03780-z · Cited by 196
Guerrero, A. R., Uchida, K., Nakajima, H., Watanabe, S., Nakamura, M., Johnson, W. E., & Baba, H. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-40 · Cited by 201
Kamper, P., Bendix, K., Hamilton-Dutoit, S. J., Honoré, B., Nyengaard, J. R., & d’Amore, F. (2010) · Haematologica · doi:10.3324/haematol.2010.031542 · Cited by 198
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Amanollahi, M., Jameie, M., Heidari, A., & Rezaei, N. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03102-z · Cited by 207
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Kulkarni, A. A., Chandrasekar, V., Natarajan, S. K., Ramesh, A., Pandey, P. R., Nirgud, J., Bhatnagar, H., Ashok, D., Ajay, A. K., & Sengupta, S. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0254-6 · Cited by 193
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Secombes, C. J., & Wang, T. (2012) · Elsevier eBooks · doi:10.1533/9780857095732.1.3 · Cited by 199
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Rogacev, K. S., Ulrich, C., Blömer, L., Hornof, F., Oster, K., Ziegelin, M., Cremers, B., Grenner, Y., Geisel, J., Schlitt, A., et al. (2009) · European Heart Journal · doi:10.1093/eurheartj/ehp308 · Cited by 190
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Marino, S., Cilfone, N. A., Mattila, J. T., Linderman, J. J., Flynn, J. L., & Kirschner, D. E. (2014) · Infection and Immunity · doi:10.1128/iai.02494-14 · Cited by 201
Shiratori, H., Feinweber, C., Luckhardt, S., Linke, B., Resch, E., Geißlinger, G., Weigert, A., & Parnham, M. J. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.05.027 · Cited by 197
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Crowley, S. D. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5258 · Cited by 196
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Middleton, E. A., Weyrich, A. S., & Zimmerman, G. A. (2016) · Physiological Reviews · doi:10.1152/physrev.00038.2015 · Cited by 228
Wang, M., Yu, Y., Dai, K., Ma, Z., Liu, Y., Wang, J., & Liu, C. (2016) · Biomaterials Science · doi:10.1039/c6bm00290k · Cited by 192
Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities
Bai, Q., Xue, M., & Yong, V. W. (2019) · Brain · doi:10.1093/brain/awz393 · Cited by 191
Macrophage and dendritic cell phenotypic diversity in the context of biomaterials
Kou, P. M., & Babensee, J. E. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32971 · Cited by 190
Characterization of polarized THP-1 macrophages and polarizing ability of LPS and food compounds
Chanput, W. P., Mes, J. J., Savelkoul, H. F. J., & Wichers, H. J. (2012) · Food & Function · doi:10.1039/c2fo30156c · Cited by 198
Caillou, B., Talbot, M., Weyemi, U., Pioche‐Durieu, C., Ghuzlan, A. A., Bidart, J. M., Chouaı̈b, S., Schlumberger, M. J., & Dupuy, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022567 · Cited by 190
Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms
Rommy von Bernhardi, M., & Eugenín, J. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4082 · Cited by 193
Detrimental dermal wound healing: What can we learn from the oral mucosa?
Glim, J. E., van Egmond, M., Niessen, F. B., Everts, V. E., & Beelen, R. H. J. (2013) · Wound Repair and Regeneration · doi:10.1111/wrr.12072 · Cited by 199
Li, H., Huang, N. J., Zhu, W., Wu, J., Yang, X., Teng, W., Tian, J., Fang, Z., Luo, Y., Chen, M., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-4299-4 · Cited by 192
Roles of Macrophages in the Development and Treatment of Gut Inflammation
Han, X., Ding, S., Jiang, H., & Liu, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.625423 · Cited by 196
Effector Mechanisms of Rejection
Moreau, A., Varey, E., Anegon, I., & Cuturi, M.-C. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a015461 · Cited by 189
Inflammatory response of macrophages in infection
Zhang, L., & Wang, C.-C. (2014) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(14)60024-2 · Cited by 194
Wang, X., Sun, R., Wei, H., & Tian, Z. (2012) · Hepatology · doi:10.1002/hep.25982 · Cited by 188
Poole, K. M., Nelson, C. E., Joshi, R. V., Martin, J. R., Gupta, M. K., Haws, S. C., Kavanaugh, T. E., Skala, M. C., & Duvall, C. L. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.016 · Cited by 189
Monocytes and Macrophages as Cellular Targets in Liver Fibrosis
Heymann, F., Trautwein, C., & Tacke, F. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809789352230 · Cited by 187
Molecular Determinants in Phagocyte-Bacteria Interactions
Kaufmann, S. H. E., & Dorhoi, A. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.014 · Cited by 196
M2 macrophages in kidney disease: biology, therapies, and perspectives
Chen, T., Cao, Q., Wang, Y., & Harris, D. C. H. (2019) · Kidney International · doi:10.1016/j.kint.2018.10.041 · Cited by 190
Immunomodulatory bioactive glasses for tissue regeneration
Zheng, K., Niu, W., Lei, B., & Boccaccini, A. R. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.08.023 · Cited by 190
Contribution of adipose tissue to development of cancer
Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188
Macrophage polarization in metabolic disorders
Chinetti, G., & Staels, B. (2011) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32834a77b4 · Cited by 193
Glezeva, N., & Baugh, J. A. (2013) · Heart Failure Reviews · doi:10.1007/s10741-013-9405-8 · Cited by 194
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Weavers, H., Evans, I. R., Martin, P. B., & Wood, W. (2016) · Cell · doi:10.1016/j.cell.2016.04.049 · Cited by 190
Role of Krüppel-like factors in leukocyte development, function, and disease
Cao, Z., Sun, X., Icli, B., Wara, A. K., & Feinberg, M. W. (2010) · Blood · doi:10.1182/blood-2010-05-285353 · Cited by 186
The complex immunological and inflammatory network of adipose tissue in obesity
Apostolopoulos, V., de Courten, M., Stojanovska, L., Blatch, G. L., Tangalakis, K., & de Courten, B. V. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500272 · Cited by 193
Mittal, M., Tiruppathì, C., Nepal, S., Zhao, Y., Grzych, D., Soni, D., Prockop, D. J., & Malik, A. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614935113 · Cited by 188
Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration
Nakazawa, K. R., Walter, B. A., Laudier, D. M., Krishnamoorthy, D., Mosley, G. E., Spiller, K. L., & Iatridis, J. C. (2017) · The Spine Journal · doi:10.1016/j.spinee.2017.09.018 · Cited by 187
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Yahaya, M. A. F., Lila, M. A. M., Ismail, S., Zainol, M., & Rahman, N. M. A. N. A. (2019) · Journal of Immunology Research · doi:10.1155/2019/2368249 · Cited by 190
Editorial: Alveolar Macrophages in Lung Inflammation and Resolution
Hu, G., & Christman, J. W. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02275 · Cited by 189
IL-10 regulation of macrophage VEGF production is dependent on macrophage polarisation and hypoxia
Wei-kang, W., Llewellyn, O., Bates, D. O., Nicholson, L. B., & Dick, A. D. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.025 · Cited by 187
Schulz, D., Severin, Y., Zanotelli, V. R., & Bodenmiller, B. (2019) · Scientific Reports · doi:10.1038/s41598-018-38127-9 · Cited by 187
Rapamycin unbalances the polarization of human macrophages to M 1
Mercalli, A., Calavita, I., Dugnani, E., Citro, A., Cantarelli, E., Nano, R., Melzi, R., Maffi, P., Secchi, A., Sordi, V., et al. (2013) · Immunology · doi:10.1111/imm.12126 · Cited by 192
Gono, T., Kaneko, H., Kawaguchi, Y., Hanaoka, M., Kataoka, S., Kuwana, M., Takagi, K., Ichida, H., Katsumata, Y., Ota, Y., et al. (2014) · Lara D. Veeken · doi:10.1093/rheumatology/keu258 · Cited by 185
Wu, L., Zhang, X., Zhang, B., Shi, H., Yuan, X., Sun, Y., Pan, Z., Qian, H., & Xu, W. (2016) · Tumor Biology · doi:10.1007/s13277-016-5071-5 · Cited by 189
Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue
Sinha, M., Sen, C. K., Singh, K., Das, A., Ghatak, S., Rhea, B., Blackstone, B. N., Powell, H. M., Khanna, S., & Roy, S. (2018) · Nature Communications · doi:10.1038/s41467-018-03208-w · Cited by 182
Benner, B. N., Scarberry, L., Suarez‐Kelly, L. P., Duggan, M. C., Campbell, A. R., Smith, E., Lapurga, G., Jiang, K., Butchar, J. P., Tridandapani, S., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0622-0 · Cited by 188
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Yu, M. W., & Quail, D. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.676301 · Cited by 191
IL ‐17: overview and role in oral immunity and microbiome
Abusleme, L., & Moutsopoulos, N. M. (2016) · Oral Diseases · doi:10.1111/odi.12598 · Cited by 189
The roles of CSF s on the functional polarization of tumor‐associated macrophages
Jeannin, P., Paolini, L., Adam, C., & Delneste, Y. (2017) · FEBS Journal · doi:10.1111/febs.14343 · Cited by 192
Metadata
- Authors
- Mosser, D. M., & Edwards, J. P.
- Affiliations
- University of Maryland, College Park (US)
- Corresponding author
- Mosser, David M.
- Venue
- Nature Reviews Immunology
- Published
- 2008-12
- Volume
- 8
- Issue
- 12
- Pages
- 958-969
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC2724991
- OpenAlex
- W2054472394
- Cited by
- 9,144
- References
- 121
- Citations by year
- 2026: 308 · 2025: 470 · 2024: 582 · 2023: 589 · 2022: 661 · 2021: 706 · 2020: 680 · 2019: 592 · 2018: 534 · 2017: 592 · 2016: 549 · 2015: 587 · 2014: 586 · 2013: 534 · 2012: 461
- FWCI
- 17.23
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-06-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R21AI055576, R01AI055576, AI 55576, R01AI049388, AI49388, R01AI049383)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- macrophage activation, macrophage plasticity, homeostasis, host defense, wound healing, immune regulation, macrophage heterogeneity
- MeSH terms
- Animals, Humans, Immunity, Innate, Inflammation, Macrophage Activation, Macrophages, Wound Healing, Cytokines
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