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Exploring the full spectrum of macrophage activation
Open accessAbstract
Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities - host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.
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“During cancer development, tumor cells and tumor‐associated stromal cells continuously change the composition and organization of ECM through deposition/degradation cycles and extensive crosslinking, shaping it more supportive for tumor growth.[ 33 ]”
From 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor‐on‐a‐Chip (2023) · cites this paper as [33]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A more recent model also hypothesizes the existence of a macrophage spectrum between M1 and M2, regulated through three major homeostatic processes involving the host defense, wound healing, and immune modulation.[ 40 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [40]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Common examples of cytokines that polarize macrophages are IFN‐γ and LPS, which skew macrophages toward the M1 phenotype, whereas cytokines such as IL‐4 and IL‐13 promote a regenerative M2 phenotype (Figure 2 ).[ 40 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [40]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This M1–M2 transition is critical for the resolution of inflammation and tipping the balance to tissue repair [49].”
From Transition from inflammation to proliferation: a critical step during wound healing (2016) · cites this paper as [49]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Aβ deposition elicits a robust “M1” microglia-mediated inflammatory response contributing to disease pathogenesis (Gordon, 2003; Mosser and Edwards, 2008; Mandrekar-Colucci and Landreth, 2010).”
From Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor-γ-Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease (2012) · cites this paper as Mosser and Edwards, 2008
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“The biochemical composition of the microenvironment is especially important for the determination of macrophage phenotypes.”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [40]
The cited source says what the claim attributes to it.
In the citing paper
“Macrophages/microglia are capable of exhibiting a spectrum of phenotypic activation states which dictate their activities (Gordon, 2003; Mosser and Edwards, 2008; Mandrekar-Colucci and Landreth, 2010).”
From Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor-γ-Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease (2012) · cites this paper as Mosser and Edwards, 2008
In the citing paper
“the heterogeneity of cell morphologies observed (elongated and round cells) reflect the diverse plasticity of macrophage cells that define its myriad of phenotypes [56].”
From Characterization of topographical effects on macrophage behavior in a foreign body response model (2010) · cites this paper as [56]
In the citing paper
“It has been shown that macrophages, as part of their myeloid lineage, do not possess stress fibers,58 which may in large part be due to the fact that their interaction with their surrounding matrix, when not migrating, is not a key part of their innate function.29”
From Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1–5, 2012: The effects of substrate stiffness on the in vitro activation of macrophages and in vivo host response to poly(ethylene glycol)‐based hydrogels (2012) · cites this paper as [29]
In the citing paper
“A pro-inflammatory macrophage phenotype correlates with elevated expression of Tumor Necrosis Factor α (TNF α), Interleukin 1 (IL1), and Interferon Regulatory Factor 5 (IRF5)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [44]
In the citing paper
“There is a broad spectrum of macrophage activations which can be categorized into three states namely, classical activation (pro-inflammatory, MClassic), alternative activation (pro-healing, MWound), and regulatory activation (MReg)44.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [44]
In the citing paper
“A pro-wound healing phenotype of macrophage correlates with up regulation in expression of Dendritic Cell Immune Receptor (Dcir), Stabilin 1 (Stab1), chemokine (C-C motif) ligand 22 (CCL22), Chitinase-like 3 (YM1), and Arginase 1 (Arg1)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [44]
In the citing paper
“Meanwhile, a regulatory macrophage phenotype has been characterized to correlate with elevated expression of Interleukin 10 (IL10), TNF superfamily member 14 (Light), and Sphingosine Kinase 1 (Sphk1)44, 45, 46.”
From Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates (2015) · cites this paper as [44]
In the citing paper
“Alternatively, the M2c subset is induced by IL-10 and plays a major role in tissue remodeling and suppression of inflammatory immune reactions by secreting transforming growth factor-b (TGF-b) and IL-10 [1,23].”
From Biomaterial based modulation of macrophage polarization: a review and suggested design principles (2015) · cites this paper as [23]
In the citing paper
“Rather, macrophage phenotype has been described as occurring along a continuum between the M1 and M2 extremes [12].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [12]
In the citing paper
“While the term ‘M2’ encompasses all non-classically activated macrophages, M2 macrophages have been shown to include three well recognized sub-populations (M2a, M2b, and M2c), each with its own distinct inducers, markers, and functions.”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [12]
In the citing paper
“Macrophages, like the monocytes from which they derive, are a heterogeneous cell population each with different markers and functions [1,8–12].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [12]
In the citing paper
“Indeed, macrophages serve three primary functions in the body: host defense, wound healing, and immune regulation.95”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [95]
In the citing paper
“Moreover, individual macrophages hold the potential for a dynamic phenotype switch, which affects the functional properties ofthe macrophage155,156.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [155]
In the citing paper
“However, this nomenclature is now deemed inaccurate as accumulating evidence has revealed a broad diversity of macrophage activation statuses and shown that macrophages show remarkable plasticity to change phenotypes in response to environmental cues25,26.”
From Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight (2018) · cites this paper as [25]
In the citing paper
“Transitioning from a pro-inflammatory macrophage-dominant wound to an anti-inflammatory macrophage-dominant milieu is essential in resolving inflammation and preparing the wound for effective repair [72].”
From Immunology of Wound Healing (2018) · cites this paper as [72]
In the citing paper
“In the late stages of the inflammatory phase of wound healing, macrophages are found to switch from a proinflammatory to an alternatively activated phenotype, which has been assumed to be requisite for the switch from the inflammatory to the proliferative stages in wound healing as discussed below in more detail.46”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [46]
In the citing paper
“Thus, available evidence indicates that M1 and M2a/b/c are not discrete Mp differentiation states but instead represent convenient but limited and arbitrary in vitro-defined reference points on a time-dependent and multidimensional continuum of possible Mp phenotypes and functions [9].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [9]
In the citing paper
“Finally and perhaps most importantly, rodent and human Mp do not exhibit entirely similar responses to in vitro activation [9,34,66,80], and it remains to be determined whether there are also species-dependent differences in Mp function during in vivo tissue repair.”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [9]
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Citations
Cites
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
NITRIC OXIDE AND MACROPHAGE FUNCTION
MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Interleukin-12 and the regulation of innate resistance and adaptive immunity
Trinchieri, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1001 · Cited by 4,007
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
Macrophage activation and polarization
Martinez, F. O. (2008) · Frontiers in Bioscience · doi:10.2741/2692 · Cited by 3,160
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529
Martínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,399
Interleukin-17 Family Members and Inflammation
Kolls, J. K., & Lindén, A. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.018 · Cited by 2,371
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Bastard, J., Maachi, M., Lagathu, C., Kim, M. J., Caron, M., Vidal, H., Capeau, J., & Fève, B. (2006) · PubMed · Cited by 2,090
Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Auffray, C., Fogg, D., Garfa, M., Elain, G., Join-Lambert, O., Kayal, S., Sarnacki, S., Cumano, A., Lauvau, G., & Geissmann, F. (2007) · Science · doi:10.1126/science.1142883 · Cited by 1,973
Stein, M., Keshav, S., Harris, N., & Gordon, S. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.1.287 · Cited by 1,960
The many faces of macrophage activation
Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902
Self-citationAcosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857
How dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643
Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,582
Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061775 · Cited by 1,554
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response
Sunderkötter, C., Nikolic, T., Dillon, M. J., van Rooijen, N., Stehling, M., Drevets, D. A., & Leenen, P. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4410 · Cited by 1,124
INFLAMMATION AND ATHEROSCLEROSIS
Hansson, G. K., Robertson, A.-K. L., & Söderberg‐Nauclér, C. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.1.110304.100100 · Cited by 1,082
Identification and characterization of a novel monocyte subpopulation in human peripheral blood
Passlick, B., Flieger, D., & Ziegler‐Heitbrock, H. W. L. (1989) · Blood · doi:10.1182/blood.v74.7.2527.2527 · Cited by 1,079
Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer
Lin, E. Y., Li, J.-F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesik, D. A., Qian, H., Xue, X.-N., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1278 · Cited by 1,074
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064
Jovanović, D., Battista, J. A. D., Martel‐Pelletier, J., Jolicoeur, F. C., He, Y., Zhang, M., Mineau, F., & Pelletier, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.7.3513 · Cited by 1,062
Denning, T. L., Wang, Y., Patel, S. R., Williams, I. R., & Pulendran, B. (2007) · Nature Immunology · doi:10.1038/ni1511 · Cited by 995
Jovanović, D., Battista, J. A. D., Pelletier, J., Jolicoeur, F. C., He, Y., Zhang, M., Mineau, F., & Martel‐Pelletier, J. (1998) · PubMed · Cited by 973
Stout, R. D., Jiang, C., Matta, B., Tietzel, I., Watkins, S. K., & Suttles, J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.342 · Cited by 968
Differentiation of Phagocytic Monocytes into Lymph Node Dendritic Cells In Vivo
Randolph, G. J., Inaba, K., Robbiani, D. F., Steinman, R. M., & Müller, W. A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80149-1 · Cited by 897
Chen, C.-J., Kono, H., Golenbock, D., Reed, G., Akira, S., & Rock, K. L. (2007) · Nature Medicine · doi:10.1038/nm1603 · Cited by 876
Biochemical and functional characterization of three activated macrophage populations
Edwards, J. P., Zhang, X., Frauwirth, K. A., & Mosser, D. M. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0406249 · Cited by 863
Self-citationCytokine Signaling Modules in Inflammatory Responses
O’Shea, J. J., & Murray, P. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.03.002 · Cited by 833
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
de Visser, K. E., Korets, L. V., & Coussens, L. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.014 · Cited by 818
Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice
Liu, C. H., Chang, S.-H., Narko, K., Trifan, O. C., Wu, M.-T., Smith, E., Haudenschild, C. C., Lane, T. F., & Hla, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010787200 · Cited by 802
Acidic Mammalian Chitinase in Asthmatic Th2 Inflammation and IL-13 Pathway Activation
Zhu, Z., Zheng, T., Homer, R., Kim, Y., Chen, N. Y., Cohn, L. E., Hamid, Q. A., & Elias, J. A. (2004) · Science · doi:10.1126/science.1095336 · Cited by 798
“Re-educating” tumor-associated macrophages by targeting NF-κB
Hagemann, T., Lawrence, T., McNeish, I., Charles, K. A., Kulbe, H., Thompson, R. G., Robinson, S. C., & Balkwill, F. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080108 · Cited by 792
The phagocytes: neutrophils and monocytes
Dale, D. C., Boxer, L. A., & Liles, W. C. (2008) · Blood · doi:10.1182/blood-2007-12-077917 · Cited by 769
Chitin induces accumulation in tissue of innate immune cells associated with allergy
Reese, T. A., Liang, H.-E., Tager, A. M., Luster, A. D., van Rooijen, N., Voehringer, D., & Locksley, R. M. (2007) · Nature · doi:10.1038/nature05746 · Cited by 756
Hesse, M., Modolell, M., Flamme, A. C. L., Schito, M. L., Fuentes, J. M., Cheever, A. W., Pearce, E. J., & Wynn, T. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6533 · Cited by 723
Biswas, S. K. (2005) · Blood · doi:10.1182/blood-2005-01-0428 · Cited by 691
Goerdt, S., & Orfanos, C. E. (1999) · Immunity · doi:10.1016/s1074-7613(00)80014-x · Cited by 678
The macrophage: Past, present and future
Gordon, S. (2007) · European Journal of Immunology · doi:10.1002/eji.200737638 · Cited by 640
Macrophage activation by endogenous danger signals
Zhang, X., & Mosser, D. (2007) · The Journal of Pathology · doi:10.1002/path.2284 · Cited by 629
Self-citationGlucocorticoids and the Th1/Th2 Balance
Elenkov, I. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.010 · Cited by 618
Anti-inflammatory actions of PPAR ligands: new insights on cellular and molecular mechanisms
Straus, D. S., & Glass, C. K. (2007) · Trends in Immunology · doi:10.1016/j.it.2007.09.003 · Cited by 563
Anthony, R. M., Urban, J. F., Alem, F., Hamed, H. A., Rozo, C. T., Boucher, J.-L., Van Rooijen, N., & Gause, W. C. (2006) · Nature Medicine · doi:10.1038/nm1451 · Cited by 522
Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity
Heilbronn, L. K., & Campbell, L. V. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208784246153 · Cited by 496
Inborn errors of IL-12/23- and IFN-γ-mediated immunity: molecular, cellular, and clinical features
Filipe‐Santos, O., Bustamante, J. C., Chapgier, A. L. A., Vogt, G., de Beaucoudrey, L., Feinberg, J. M., Jouanguy, E., Boisson‐Dupuis, S., Fieschi, C., Pïcard, C., et al. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.07.010 · Cited by 475
Immunopathology of schistosomiasis
Wilson, M. S., Mentink‐Kane, M. M., Pesce, J. T., Ramalingam, T. R., Thompson, R. W., & Wynn, T. A. (2006) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100014 · Cited by 474
T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis
Harris, J., Haro, S. A. D., Master, S. S., Keane, J., Roberts, E. A., Delgado, M. A., & Deretic, V. P. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.022 · Cited by 471
Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer
Lin, E. Y., & Pollard, J. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0912 · Cited by 463
Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages
Raes, G., BAETSELIER, P. D., Noël, W., Beschin, A., Brombacher, F., & Gh., G. H. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.597 · Cited by 443
Macrophages define the invasive microenvironment in breast cancer
Pollard, J. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107762 · Cited by 414
FRANCHIMONT, D. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1321.009 · Cited by 408
A potential role of macrophage activation in the treatment of cancer
Klimp, A. H., de Vries, E. G. E., Scherphof, G. L., & Daemen, T. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00203-7 · Cited by 368
Strassmann, G., Patil-koota, V., Finkelman, F. D., Fong, M., & Kambayashi, T. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.6.2365 · Cited by 364
Alternatively activated macrophages in helminth infections
Kreider, T., Anthony, R. M., Urban, J. F., & Gause, W. C. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.07.002 · Cited by 362
Immune-mediated dormancy: an equilibrium with cancer
Teng, M. W. L., Swann, J. B., Koebel, C. M., Schreiber, R. D., & Smyth, M. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1107774 · Cited by 360
Monocyte subpopulations and their differentiation patterns during infection
Strauss‐Ayali, D., Conrad, S. M., & Mosser, D. M. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307191 · Cited by 359
Self-citationγδ T cells: an important source of IL-17
Roark, C. L., Simonian, P. L., Fontenot, A. P., Born, W. K., & O’Brien, R. L. (2008) · Current Opinion in Immunology · doi:10.1016/j.coi.2008.03.006 · Cited by 325
Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
Swann, J. B., Vesely, M. D., Silva, A., Sharkey, J., Akira, S., Schreiber, R. D., & Smyth, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708594105 · Cited by 320
Zeyda, M., & Stulnig, T. M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.07.003 · Cited by 316
Macrophages and their products in rheumatoid arthritis
Szekanecz, Z., & Koch, A. E. (2007) · Current Opinion in Rheumatology · doi:10.1097/bor.0b013e32805e87ae · Cited by 309
Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes
Liu, Y., Cousin, J. M., Hughes, J., Van Damme, J., Seckl, J. R., Haslett, C., Dransfield, I., Savill, J., & Rossi, A. G. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3639 · Cited by 299
Kropf, P., Fuentes, J. M., Fähnrich, E., Arpa, L., Herath, S., Weber, V., Soler, G., Celada, A., Modolell, M., & Müller, I. (2005) · The FASEB Journal · doi:10.1096/fj.04-3416fje · Cited by 295
Munitz, A., Brandt, E. B., Mingler, M. K., Finkelman, F. D., & Rothenberg, M. E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802465105 · Cited by 275
Loke, P., Gallagher, I., Nair, M. G., Zang, X., Brombacher, F., Mohrs, M., Allison, J. P., & Allen, J. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3926 · Cited by 274
Müller, U., Stenzel, W., Köhler, G., Werner, C., Polte, T., Hansen, G., Schütze, N., Straubinger, R. K., Blessing, M., McKenzie, A. N. J., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5367 · Cited by 272
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Gerber, J. S., & Mosser, D. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6861 · Cited by 263
Self-citationKuang, D., Wu, Y., Chen, N., Chéng, J., Zhuang, S., & Zheng, L. (2007) · Blood · doi:10.1182/blood-2007-01-068031 · Cited by 262
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Miles, S. A., Conrad, S. M., Alves, R. G., Jerônimo, S. M. B., & Mosser, D. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041470 · Cited by 262
Self-citationKodelja, V., Müller, C., Politz, O., Hakij, N., Orfanos, C. E., & Goerdt, S. (1998) · PubMed · Cited by 249
Pai, R. K., Convery, M., Hamilton, T. A., Boom, W. H., & Harding, C. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.175 · Cited by 246
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Erwig, L.-P., & Henson, P. M. (2007) · The American Journal of Pathology · doi:10.2353/ajpath.2007.070135 · Cited by 242
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Haskó, G., Pacher, P., Deitch, E. A., & Vizi, E. S. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.003 · Cited by 232
Kodelja, V., Müller, C., Politz, O., Hakij, N., Orfanos, C. E., & Goerdt, S. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.3.1411 · Cited by 223
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Fusetti, F., von Moeller, H., Houston, D. R., Rozeboom, H. J., Dijkstra, B. W., Boot, R. G., Aerts, J. M. F. G., & van Aalten, D. M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201636200 · Cited by 220
Kzhyshkowska, J., Mamidi, S., Gratchev, A., Kremmer, E., Schmuttermaier, C., Krusell, L., Haus, G., Utikal, J., Schledzewski, K., Scholtze, J., et al. (2006) · Blood · doi:10.1182/blood-2005-07-2843 · Cited by 216
Lucas, M., Zhang, X., Prasanna, V., & Mosser, D. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.469 · Cited by 197
Self-citationDelgado, M., Muñoz‐Elías, E. J., Gomariz, R. P., & Ganea, D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1707 · Cited by 197
Zhao, A., Urban, J. F., Anthony, R. M., Sun, R., Stiltz, J. A., van Rooijen, N., Wynn, T. A., Gause, W. C., & Shea‐Donohue, T. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.077 · Cited by 180
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Weigert, A., Tzieply, N., von Knethen, A., Johann, A. M., Schmidt, H., Geißlinger, G., & Brüne, B. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-12-1096 · Cited by 171
Sironi, M., Martínez, F. O., D’Ambrosio, D., Gattorno, M., Polentarutti, N., Locati, M., Gregorio, A., Iellem, A., Cassatella, M. A., Damme, J. V., et al. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005586 · Cited by 167
Nandan, D., & Reiner, N. E. (1995) · Infection and Immunity · doi:10.1128/iai.63.11.4495-4500.1995 · Cited by 165
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Raes, G., Noël, W., Beschin, A., Brys, L., BAETSELIER, P. D., & Hassanzadeh, G. G. (2002) · Journal of Immunology Research · doi:10.1080/1044667031000137629 · Cited by 147
Shirey, K. A., Cole, L. E., Keegan, A. D., & Vogel, S. N. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.4159 · Cited by 144
Benoit, M. E., Barbarat, B., Bernard, A., Olive, D., & Mège, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200738067 · Cited by 123
Sirois, J., Ménard, G., Moses, A. S., & Bissonnette, É. Y. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.2964 · Cited by 116
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Törőcsik, D., Bárdos, H., Nagy, L., & Ádány, R. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5242-9 · Cited by 115
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Ando, M., Tu, W., Nishijima, K.-I., & Iijima, S. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.111 · Cited by 110
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Knowles, H. J., & Harris, A. L. (2001) · Breast Cancer Research · doi:10.1186/bcr314 · Cited by 109
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Wynes, M. W., & Riches, D. W. H. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3550 · Cited by 105
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BAETSELIER, P. D., Namangala, B., Noël, W., Brys, L., Pays, É., & Beschin, A. (2001) · International Journal for Parasitology · doi:10.1016/s0020-7519(01)00170-9 · Cited by 103
Mahalingam, S., & Lidbury, B. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202415999 · Cited by 100
IL-4 production by human polymorphonuclear neutrophils
Brandt, E. B., Woerly, G., Younes‐Chennoufi, A. B., Loiseau, S., & Capron, M. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.125 · Cited by 98
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Huang, H., Park, P., McMullen, M. R., & Nagy, L. E. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05284.x · Cited by 96
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Raes, G., Beschin, A., Ghassabeh, G. H., & BAETSELIER, P. D. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.05.007 · Cited by 95
Romieu, R., Solis, M., Nardin, A., Goubau, D., Baron‐Bodo, V., Lin, R., Massie, B., Salcedo, M., & Hiscott, J. B. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1279 · Cited by 91
IL‐4 induces expression of TARC/CCL17 via two STAT6 binding sites
Wirnsberger, G., Hebenstreit, D., Posselt, G., Horejs‐Hoeck, J., & Duschl, A. (2006) · European Journal of Immunology · doi:10.1002/eji.200635972 · Cited by 89
Martín‐Fuentes, P., Civeira, F., Recalde, D., García-Otín, A. L., Jarauta, E., Marzo, I., & Cenarro, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3242 · Cited by 78
Haskó, G., Szabó, C., Németh, Z. H., & Deitch, E. A. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00459-3 · Cited by 77
Mammalian chitinase-like proteins
Bleau, G., Massicotte, F., Merlen, Y., & Boisvert, C. (1999) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8757-1_15 · Cited by 75
Atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus
Haque, S., Mirjafari, H., & Bruce, I. N. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328304b65f · Cited by 72
Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus
KIM, C. S., Wilcox‐Adelman, S. A., Sano, Y., Tang, W., Collier, R. J., & Park, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800105105 · Cited by 67
Nathan, C. (2008) · Nature Immunology · doi:10.1038/ni0708-695 · Cited by 64
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Rückerl, D., Heßmann, M., Yoshimoto, T., Ehlers, S., & Hölscher, C. (2006) · Immunobiology · doi:10.1016/j.imbio.2006.05.008 · Cited by 62
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Agrawal, A., & Pulendran, B. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4251-4 · Cited by 60
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Mackaness, G. B. (1977) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-8855-9_5 · Cited by 42
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Lam, C. W., Perretti, M., & Getting, S. J. (2005) · Peptides · doi:10.1016/j.peptides.2005.01.031 · Cited by 41
Fernández, A. Z. (2008) · PPAR Research · doi:10.1155/2008/285842 · Cited by 30
Cordeiro‐da‐Silva, A., Tavares, J., Araújo, N., Cerqueira, F., Tomás, A. M., Lin, P. K. T., & Ouaissi, A. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.02.009 · Cited by 26
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Metadata
- Authors
- Mosser, D. M., & Edwards, J. P.
- Affiliations
- University of Maryland, College Park (US)
- Corresponding author
- Mosser, David M.
- Venue
- Nature Reviews Immunology
- Published
- 2008-12
- Volume
- 8
- Issue
- 12
- Pages
- 958-969
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC2724991
- OpenAlex
- W2054472394
- Cited by
- 9,144
- References
- 121
- Citations by year
- 2026: 308 · 2025: 470 · 2024: 582 · 2023: 589 · 2022: 661 · 2021: 706 · 2020: 680 · 2019: 592 · 2018: 534 · 2017: 592 · 2016: 549 · 2015: 587 · 2014: 586 · 2013: 534 · 2012: 461
- FWCI
- 17.23
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-06-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R21AI055576, R01AI055576, AI 55576, R01AI049388, AI49388, R01AI049383)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- macrophage activation, macrophage plasticity, homeostasis, host defense, wound healing, immune regulation, macrophage heterogeneity
- MeSH terms
- Animals, Humans, Immunity, Innate, Inflammation, Macrophage Activation, Macrophages, Wound Healing, Cytokines
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