The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
The gut microbiota shapes intestinal immune responses during health and disease
Open accessAbstract
Immunological dysregulation is the cause of many non-infectious human diseases such as autoimmunity, allergy and cancer. The gastrointestinal tract is the primary site of interaction between the host immune system and microorganisms, both symbiotic and pathogenic. In this Review we discuss findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut. We also highlight the molecular pathways that mediate host-symbiont interactions that regulate proper immune function. Finally, we present recent evidence to support that disturbances in the bacterial microbiota result in dysregulation of adaptive immune cells, and this may underlie disorders such as inflammatory bowel disease. This raises the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“which is believed to be caused by complex interactions between gut microbiome (including commensal and pathogenic microbes) (2), intestinal mucosa, and immune components (3).”
From Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip (2016) · cites this paper as [2]
In the citing paper
“Intestinal microbiota may well be an active participant in this scenario through stimulation of the immune system,153 likely in the subgroup of subjects showing increased epithelial permeability which could154 expose the immune system to an abnormal microbial antigenic load.”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [153]
In the citing paper
“A mutualistic relationship between beneficial symbionts and commensals is important for the maintenance of health and wellbeing; alterations in this balance leads to dysbiosis and ultimately clinical disease expression.1”
From Probiotics and the gut microbiota in intestinal health and disease (2010) · cites this paper as [1]
In the citing paper
“Studies suggest that in the gut, greater microbial diversity is associated with protection from inflammation and inflammatory disease[316,317]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [316]
In the citing paper
“In the gut, the GM and its metabolites have been shown to modulate gastrointestinal functions via their effects on intestinal permeability (32–35), mucosal immune function (36–38), intestinal motility and sensitivity (39, 40), and the enteric nervous system (ENS) (21, 24, 25, 41).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [36]
In the citing paper
“Commensal gut microbiota play an important role in regulating metabolic and inflammatory conditions.”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [1]
In the citing paper
“Previous studies have reported a multitude of genetic polymorphisms that either increase or lower the risk of developing IBD,30 while others have demonstrated a considerable role for intestinal microbes in their pathogenesis.1,31,32”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [1]
In the citing paper
“These mice experience immune dysfunction and are more susceptible to infections than mice kept in conventional facilities [13, 15].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Evolution of mammals and their gut microbes
Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 1,040
Armour, C. R., Nayfach, S., Pollard, K. S., & Sharpton, T. J. (2019) · mSystems · doi:10.1128/msystems.00332-18 · Cited by 163
Childhood malnutrition and the intestinal microbiome
Kane, A. V., Dinh, D. M., & Ward, H. (2014) · Pediatric Research · doi:10.1038/pr.2014.179 · Cited by 163
Sordillo, J. E., Zhou, Y., McGeachie, M. J., Ziniti, J. P., Lange, N. E., Laranjo, N., Savage, J. R. K., Carey, V. J., O’Connor, G. T., Sandel, M. T., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.08.045 · Cited by 159
Alteration in the Gut Microbiota Provokes Susceptibility to Tuberculosis
Khan, N., Vidyarthi, A., Nadeem, S., Negi, S., Nair, G. R., & Agrewala, J. N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00529 · Cited by 163
Zhu, Y., Shi, T., Lu, X., Xu, Z., Qu, J., Zhang, Z., Shi, G., Shen, S., Hou, Y., Chen, Y., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020105320 · Cited by 158
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs
Zhao, X., Jiang, L., Fang, X., Guo, Z., Wang, X., Shi, B., & Meng, Q. (2022) · Microbiome · doi:10.1186/s40168-022-01303-1 · Cited by 159
Huang, Y. J., Charlson, E. S., Collman, R. G., Colombini-Hatch, S., Martinez, F. D., & Senior, R. M. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201303-0488ws · Cited by 156
Human Gut-Associated Natural Killer Cells in Health and Disease
Poggi, A. D., Benelli, R., Venè, R., Costa, D., Ferrari, N., Tosetti, F., & Zocchi, M. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00961 · Cited by 161
Gut microbiome and metabolic diseases
Fukuda, S., & Ohno, H. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0399-z · Cited by 156
Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance?
Nettleton, J. E., Reimer, R. A., & Shearer, J. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.029 · Cited by 158
Hydroxycinnamic acids and human health: recent advances
Coman, V., & Vodnar, D. C. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10010 · Cited by 158
Yılmaz, M. T., Taylan, O., Karakaş, C. Y., & Dertli̇, E. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116447 · Cited by 155
Role of NF‐κB in epithelial biology
Pasparakis, M. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01109.x · Cited by 159
Epithelial barrier biology: good fences make good neighbours
Moens, E., & Veldhoen, M. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03506.x · Cited by 169
The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA
Surana, N. K., & Kasper, D. L. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01075.x · Cited by 160
Extensive intra-phylotype diversity in lactobacilli and bifidobacteria from the honeybee gut
Ellegaard, K., Tamarit, D., Javelind, E., Olofsson, T. C., Andersson, S. G. E., & Vásquez, A. (2015) · BMC Genomics · doi:10.1186/s12864-015-1476-6 · Cited by 155
Functional intestinal microbiome, new frontiers in prebiotic design
Candela, M., Maccaferri, S., Turroni, S., Carnevali, P., & Brigidi, P. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.04.017 · Cited by 153
Probiotics function and modulation of the immune system in allergic diseases
Eslami, M., Bahar, A., Keikha, M., Karbalaei, M., Kobyliak, N. M., & Yousefi, B. (2020) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2020.04.005 · Cited by 160
Prebiotics and the Human Gut Microbiota: From Breakdown Mechanisms to the Impact on Metabolic Health
Bedu-Ferrari, C., Biscarrat, P., Langella, P., & Cherbuy, C. (2022) · Nutrients · doi:10.3390/nu14102096 · Cited by 168
Manca, C., Boubertakh, B., Leblanc, N., Deschênes, T., Lacroix, S., Martin, C., Houde, A., Veilleux, A., Flamand, N., Muccioli, G. G., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000424 · Cited by 152
Speciation by Symbiosis: the Microbiome and Behavior
Shropshire, J. D., & Bordenstein, S. R. (2016) · mBio · doi:10.1128/mbio.01785-15 · Cited by 152
Reduced Diversity and Imbalance of Fecal Microbiota in Patients with Ulcerative Colitis
Nemoto, H., Kataoka, K., Ishikawa, H., Ikata, K., Arimochi, H., Iwasaki, T., Ohnishi, Y., Kuwahara, T., & Yasutomo, K. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2236-y · Cited by 152
The Tasmanian devil microbiome—implications for conservation and management
Cheng, Y., Fox, S., Pemberton, D., Hogg, C. J., Papenfuss, A. T., & Belov, K. (2015) · Microbiome · doi:10.1186/s40168-015-0143-0 · Cited by 159
Pathophysiological role of host microbiota in the development of obesity
Kobyliak, N. M., Virchenko, O., & Falalyeyeva, T. M. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0166-9 · Cited by 156
Chen, J., Thomsen, M., & Vitetta, L. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27635 · Cited by 155
Quorum Sensing, Biofilm, and Intestinal Mucosal Barrier: Involvement the Role of Probiotic
Deng, Z., Luo, X., Liu, J., & Wang, H. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.538077 · Cited by 157
Microbes and the mind: emerging hallmarks of the gut microbiota-brain axis
Bauer, K. C., Huus, K. E., & Finlay, B. B. (2016) · Cellular Microbiology · doi:10.1111/cmi.12585 · Cited by 151
Hasegawa, M., Yada, S., Liu, M. Z., Kamada, N., Muñoz-Planillo, R., Do, N., Núñez, G., & Inohara, N. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.010 · Cited by 151
Vidal, A. C., Murphy, S. K., Murtha, A. P., Schildkraut, J. M., Soubry, A., Huang, Z., Neelon, S. E. B., Fuemmeler, B. F., Iversen, E. S., Wang, F., et al. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.47 · Cited by 150
Putignani, L., CHIERICO, F. D., Vernocchi, P., Cicala, M., Cucchiara, S., & Dallapiccola, B. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000602 · Cited by 153
A review of heat stress in chickens. Part I: Insights into physiology and gut health
Brugaletta, G., Teyssier, J.-R., Rochell, S. J., Dridi, S., & Sirri, F. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.934381 · Cited by 150
Chong, E. S. L. (2013) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-013-1499-6 · Cited by 154
Restructuring of the amphibian gut microbiota through metamorphosis
Kohl, K. D., Cary, T. L., Karasov, W. H., & Dearing, M. D. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12092 · Cited by 149
Gheorghe, C. E., Ritz, N. L., Martin, J. A., Wardill, H. R., Cryan, J. F., & Clarke, G. A. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1941711 · Cited by 156
Metabolism of Sialic Acid by Bifidobacterium breve UCC2003
Egan, M., Motherway, M. O., Ventura, M., & van Sinderen, D. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.01114-14 · Cited by 151
Feng, P., Ye, Z., Kakade, A., Virk, A. K., Li, X., & Liu, P. (2018) · Nutrients · doi:10.3390/nu11010022 · Cited by 151
Alpha-Synuclein Pathology and the Role of the Microbiota in Parkinson’s Disease
Fitzgerald, E., Murphy, S. A., & Martinson, H. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00369 · Cited by 151
Noviello, D., Mager, R., Roda, G., Borroni, R. G., Fiorino, G., & Vetrano, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.611256 · Cited by 152
Cellular and molecular basis of thyroid autoimmunity
Bogusławska, J., Godlewska, M., Gajda, E., & Piekiełko-Witkowska, A. (2022) · European Thyroid Journal · doi:10.1530/etj-21-0024 · Cited by 154
Jašarević, E., Rodgers, A. B., & Bale, T. L. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.005 · Cited by 152
Effect of preservation method on spider monkey (Ateles geoffroyi) fecal microbiota over 8 weeks
Hale, V. L., Tan, C. L., Knight, R. D., & Amato, K. R. (2015) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2015.03.021 · Cited by 154
Intestinal microbiota and its relationship with necrotizing enterocolitis
Patel, R. M., & Denning, P. W. (2015) · Pediatric Research · doi:10.1038/pr.2015.97 · Cited by 150
Wei, Y., Yang, J., Wang, J., Yang, Y., Huang, J., Gong, H., Cui, H., & Chen, D. (2016) · Critical Care · doi:10.1186/s13054-016-1491-2 · Cited by 147
Knackstedt, R. W., Knackstedt, T., & Gatherwright, J. R. (2019) · Experimental Dermatology · doi:10.1111/exd.14032 · Cited by 156
Beyaz, S., Chung, C., Mou, H., Bauer-Rowe, K. E., Xifaras, M. E., Ergin, I., Dohnalová, L., Biton, M., Shekhar, K., Eskiocak, O., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.08.007 · Cited by 149
van der Velden, W. J. F. M., Herbers, A. H. E., Netea, M. G., & Blijlevens, N. M. A. (2014) · British Journal of Haematology · doi:10.1111/bjh.13113 · Cited by 146
The microbial ecology of Escherichia coli in the vertebrate gut
Foster-Nyarko, E., & Pallen, M. J. (2022) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuac008 · Cited by 161
Boleij, A., & Tjalsma, H. (2012) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2012.00218.x · Cited by 153
Kellermayer, R., Dowd, S. E., Harris, R. A., Balasa, A., Schaible, T. D., Wolcott, R. D., Tatevian, N., Szigeti, R. G., Li, Z., Versalovic, J. A., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-172205 · Cited by 147
Eeckhaut, V., Wang, J., Parys, A. V., Haesebrouck, F., Joossens, M., Falony, G., Raes, J., Ducatelle, R., & Immerseel, F. V. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01416 · Cited by 148
Human Gut Microbiota: Toward an Ecology of Disease
Selber‐Hnatiw, S., Rukundo, B., Ahmadi, M., Akoubi, H., Al-Bizri, H., Aliu, A. F., Ambeaghen, T. U., Avetisyan, L., Bahar, I., Baird, A., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01265 · Cited by 151
How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans
Cartmell, A., Lowe, E. C., Baslé, A., Firbank, S. J., Ndeh, D. A., Murray, H. D., Terrapon, N., Lombard, V., Henrissat, B., Turnbull, J. E., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704367114 · Cited by 148
Sylvain, F., & Derôme, N. (2017) · Scientific Reports · doi:10.1038/s41598-017-05662-w · Cited by 153
Role of the Human Breast Milk-Associated Microbiota on the Newborns’ Immune System: A Mini Review
Toscano, M., Grandi, R. D., Grossi, E., & Drago, L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02100 · Cited by 145
Trait-based community assembly and succession of the infant gut microbiome
Guittar, J. L., Shade, A. L., & Litchman, E. (2019) · Nature Communications · doi:10.1038/s41467-019-08377-w · Cited by 145
Maseda, D., Candando, K. M., Smith, S. H., Kalampokis, I., Weaver, C. T., Plevy, S. E., Poe, J. C., & Tedder, T. F. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300649 · Cited by 144
“Given that T cells also play critical regulatory roles during IBD development in mice, as well as in humans (1, 3), it is likely that B10 and regulatory Foxp3+ CD4+ T cells share complementary regulatory functions for IBD, as previously shown for experimental autoimmune encephalomyelitis (29).”
BackgroundInfluentialInduction of regulatory T cells: A role for probiotics and prebiotics to suppress autoimmunity
Dwivedi, M., Kumar, P., Laddha, N. C., & Kemp, E. H. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.01.002 · Cited by 145
Dysbiosis signature of mycobiota in colon polyp and colorectal cancer
Gao, R., Kong, C., Li, H., Huang, L., Qu, X., Qin, N., & Qin, H. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3085-6 · Cited by 145
A review of antibiotics, depression, and the gut microbiome
Hao, W., Li, X., Zhang, P.-W., & Chen, J. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.112691 · Cited by 149
Friends or Foes—Microbial Interactions in Nature
Weiland‐Bräuer, N. (2021) · Biology · doi:10.3390/biology10060496 · Cited by 144
Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome
Bennet, S., Öhman, L., & Simrén, M. (2015) · Gut and Liver · doi:10.5009/gnl14344 · Cited by 144
Links between Natural Variation in the Microbiome and Host Fitness in Wild Mammals
Suzuki, T. A. (2017) · Integrative and Comparative Biology · doi:10.1093/icb/icx104 · Cited by 152
Role of the Gut Microbiome in Autism Spectrum Disorders
Pulikkan, J., Mazumder, A., & Grace, T. (2019) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-05542-4_13 · Cited by 142
Yu, Y., Yu, T., Zhao, H., Sun, T., Chen, H., Chen, H., An, H.-F., Weng, Y., Yu, J. Q., Li, M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5166 · Cited by 144
IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria
Flannigan, K. L., Ngo, V. L., Geem, D., Harusato, A., Hirota, S. A., Parkos, C. A., Lukacs, N. W., Nusrat, A., Gaboriau‐Routhiau, V., Cerf–Bensussan, N., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.80 · Cited by 147
Zhai, Q., Cen, S., Li, P., Tian, F., Zhao, J., Zhang, H., & Chen, W. (2018) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.8b00563 · Cited by 146
The microbiome: An emerging key player in aging and longevity
Kim, M., & Benayoun, B. A. (2020) · Translational Medicine of Aging · doi:10.1016/j.tma.2020.07.004 · Cited by 144
Schokker, D., Zhang, J., Vastenhouw, S. A., Heilig, H. G. H. J., Smidt, H., Rebel, J. M. J., & Smits, M. A. (2015) · PLOS ONE · doi:10.1371/journal.pone.0116523 · Cited by 142
Population genetic tools for dissecting innate immunity in humans
Quintana‐Murci, L., & Clark, A. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3421 · Cited by 160
The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation
Canesso, M. C. C., Lemos, L., Neves, T. C., Marim, F. M., Castro, T. B. R., Veloso, É., Queiroz, C. P., Ahn, J., Santiago, H. C., Martins, F. S., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.88 · Cited by 144
Zhou, B., Xia, X., Wang, P., Chen, S., Yu, C., Huang, R., Zhang, R., Wang, Y., Lu, L., Yuan, F., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.06.029 · Cited by 146
Targeting gut microbiome: a novel and potential therapy for autism
Yang, Y., Tian, J., & Yang, B. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.12.027 · Cited by 140
Roto, S. M., Rubinelli, P. M., & Ricke, S. C. (2015) · Frontiers in Veterinary Science · doi:10.3389/fvets.2015.00028 · Cited by 147
Rogler, G., & Rosano, G. M. C. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht271 · Cited by 145
Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon
Kinoshita, M., Kayama, H., Kusu, T., Yamaguchi, T., Kunisawa, J., Kiyono, H., Sakaguchi, S., & Takeda, K. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200420 · Cited by 140
Ravcheev, D. A., Godzik, A., Osterman, A. L., & Rodionov, D. A. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-873 · Cited by 147
Correlation between early-life regulation of the immune system by microbiota and allergy development
Gensollen, T., & Blumberg, R. S. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.02.011 · Cited by 147
Kang, M., & Martín, A. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.04.003 · Cited by 143
Acoustic biosensors for ultrasound imaging of enzyme activity
Lakshmanan, A., Jin, Z., Nety, S. P., Sawyer, D. P., Lee‐Gosselin, A., Malounda, D., Swift, M. B., Maresca, D., & Shapiro, M. G. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0591-0 · Cited by 140
Zhang, J., Xiao, Y., Wang, H., Zhang, H., Chen, W., & Lu, W. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127432 · Cited by 143
Precise modulation and use of reactive oxygen species for immunotherapy
Li, X., Gao, J., Wu, C., Wang, C., Zhang, R., He, J., Xia, Z. J., Joshi, N., Karp, J. M., & Kuai, R. (2024) · Science Advances · doi:10.1126/sciadv.adl0479 · Cited by 140
Integration of ‘omics’ data in aging research: from biomarkers to systems biology
Zierer, J., Menni, C., Kastenmüller, G., & Spector, T. D. (2015) · Aging Cell · doi:10.1111/acel.12386 · Cited by 144
Lopes, H. F., Corrêa‐Giannella, M. L., Consolim‐Colombo, F. M., & Egan, B. M. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0156-2 · Cited by 147
Ponziani, F. R., Zocco, M. A., Cerrito, L., Gasbarrini, A., & Pompili, M. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1481747 · Cited by 139
Microrobots for Targeted Delivery and Therapy in Digestive System
Wang, Y., Shen, J., Handschuh‐Wang, S., Qiu, M., Du, S., & Wang, B. (2022) · ACS Nano · doi:10.1021/acsnano.2c04716 · Cited by 141
The Gut Microbiome and Multiple SclerosisPreprint
Ochoa‐Repáraz, J., Kirby, T. O., & Kasper, L. H. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029017 · Cited by 143
Ueda, Y., Kayama, H., Jeon, S. G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M., & Takeda, K. (2010) · International Immunology · doi:10.1093/intimm/dxq449 · Cited by 144
Myelin as a regulator of development of the microbiota-gut-brain axis
Keogh, C. E., Kim, D. H. J., Pusceddu, M. M., Knotts, T. A., Rabasa, G., Sladek, J. A., Hsieh, M. T., Honeycutt, M., Brust-Mascher, I., Barboza, M., et al. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.11.001 · Cited by 137
The intestinal microbiota and susceptibility to infection in immunocompromised patients
Taur, Y., & Pamer, E. G. (2013) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e3283630dd3 · Cited by 144
Zakharzhevskaya, N. B., Vanyushkina, A., Altukhov, I. A., Shavarda, A. L., Butenko, I., Rakitina, D. V., Nikitina, A. S., Manolov, A. I., Egorova, A. N., Kulikov, E. E., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05264-6 · Cited by 138
Wang, L., Zeng, B., Liu, Z., Liao, Z., Zhong, Q., Gu, L., Wei, H., & Fang, X. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14058 · Cited by 142
Schmidt, E., Mykytczuk, N., & Schulte‐Hostedde, A. I. (2019) · The ISME Journal · doi:10.1038/s41396-019-0345-8 · Cited by 141
Holistic view of intestinal health in poultry
Oviedo-Rondon, E. O. (2019) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2019.01.009 · Cited by 137
Modulation of post-antibiotic bacterial community reassembly and host response by Candida albicans
Erb Downward, J. R., Falkowski, N. R., Mason, K. L., Muraglia, R., & Huffnagle, G. B. (2013) · Scientific Reports · doi:10.1038/srep02191 · Cited by 136
Large-Scale Label-Free Quantitative Proteomics of the Pea aphid-Buchnera Symbiosis
Poliakov, A., Russell, C. W., Ponnala, L., Hoops, H. J., Sun, Q., Douglas, A. E., & van Wijk, K. J. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.007039 · Cited by 136
Metabolism of hydrogen gases and bile acids in the gut microbiome
Hylemon, P. B., Harris, S. C., & Ridlon, J. M. (2018) · FEBS Letters · doi:10.1002/1873-3468.13064 · Cited by 140
Teyssier, A., Lens, L., Matthysen, E., & White, J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01524 · Cited by 136
Zhang, Y., Li, Z., Kholodkevich, S. V., Sharov, A. N., Chen, C., Feng, Y., Ren, N., & Sun, K. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125105 · Cited by 137
Man, A. W. C., Zhou, Y., Xia, N., & Li, H. (2020) · Nutrients · doi:10.3390/nu12103054 · Cited by 138
Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 133
Metadata
- Authors
- Round, J. L., & Mazmanian, S. K.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Mazmanian, Sarkis K.
- Venue
- Nature Reviews Immunology
- Published
- 2009-05
- Volume
- 9
- Issue
- 5
- Pages
- 313-323
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4095778
- OpenAlex
- W2034082915
- Cited by
- 5,029
- References
- 118
- Citations by year
- 2026: 205 · 2025: 284 · 2024: 333 · 2023: 300 · 2022: 401 · 2021: 423 · 2020: 398 · 2019: 390 · 2018: 395 · 2017: 382 · 2016: 345 · 2015: 262 · 2014: 221 · 2013: 223 · 2012: 177
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Update notices
- erratum (2009-07-17)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078938)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- gut microbiota, intestinal immune response, host-microbe interactions, bacterial colonization, inflammatory bowel disease, immune dysregulation, autoimmunity, allergy, cancer, symbiotic bacteria, pathogenic bacteria
- MeSH terms
- Animals, Disease, Health, Homeostasis, Humans, Intestines, Inflammatory Bowel Diseases, Immune System Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
