The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
The gut microbiota shapes intestinal immune responses during health and disease
Open accessAbstract
Immunological dysregulation is the cause of many non-infectious human diseases such as autoimmunity, allergy and cancer. The gastrointestinal tract is the primary site of interaction between the host immune system and microorganisms, both symbiotic and pathogenic. In this Review we discuss findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut. We also highlight the molecular pathways that mediate host-symbiont interactions that regulate proper immune function. Finally, we present recent evidence to support that disturbances in the bacterial microbiota result in dysregulation of adaptive immune cells, and this may underlie disorders such as inflammatory bowel disease. This raises the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“which is believed to be caused by complex interactions between gut microbiome (including commensal and pathogenic microbes) (2), intestinal mucosa, and immune components (3).”
From Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip (2016) · cites this paper as [2]
In the citing paper
“Intestinal microbiota may well be an active participant in this scenario through stimulation of the immune system,153 likely in the subgroup of subjects showing increased epithelial permeability which could154 expose the immune system to an abnormal microbial antigenic load.”
From Intestinal microbiota in functional bowel disorders: a Rome foundation report (2013) · cites this paper as [153]
In the citing paper
“A mutualistic relationship between beneficial symbionts and commensals is important for the maintenance of health and wellbeing; alterations in this balance leads to dysbiosis and ultimately clinical disease expression.1”
From Probiotics and the gut microbiota in intestinal health and disease (2010) · cites this paper as [1]
In the citing paper
“Studies suggest that in the gut, greater microbial diversity is associated with protection from inflammation and inflammatory disease[316,317]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [316]
In the citing paper
“In the gut, the GM and its metabolites have been shown to modulate gastrointestinal functions via their effects on intestinal permeability (32–35), mucosal immune function (36–38), intestinal motility and sensitivity (39, 40), and the enteric nervous system (ENS) (21, 24, 25, 41).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [36]
In the citing paper
“Commensal gut microbiota play an important role in regulating metabolic and inflammatory conditions.”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [1]
In the citing paper
“Previous studies have reported a multitude of genetic polymorphisms that either increase or lower the risk of developing IBD,30 while others have demonstrated a considerable role for intestinal microbes in their pathogenesis.1,31,32”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [1]
In the citing paper
“These mice experience immune dysfunction and are more susceptible to infections than mice kept in conventional facilities [13, 15].”
From The Gut Microbiota and Dysbiosis in Autism Spectrum Disorders (2018) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Diversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Evolution of mammals and their gut microbes
Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463
Flagged first, then by citations
Cited by
Sorted by citations
Items 901–1,000 of 1,040
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas
McCurry, M. D., D’Agostino, G. D., Walsh, J. T., Bisanz, J. E., Zalosnik, M. I., Dong, X., Morris, D. J., Korzenik, J. R., Edlow, A. G., Balskus, E. P., et al. (2024) · Cell · doi:10.1016/j.cell.2024.05.005 · Cited by 117
Identification of trypsin-degrading commensals in the large intestine
Li, Y., Watanabe, E., Kawashima, Y., Plichta, D. R., Wang, Z., Ujike, M., Ang, Q. Y., Wu, R., Furuichi, M., Takeshita, K., et al. (2022) · Nature · doi:10.1038/s41586-022-05181-3 · Cited by 106
Prevention of Virus-Induced Type 1 Diabetes with Antibiotic Therapy
Hara, N., Alkanani, A. K., Ir, D., Robertson, C. E., Wagner, B. D., Frank, D. N., & Zipris, D. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201257 · Cited by 107
Alizadeh, A., Akbari, P., Difilippo, E., Schols, H. A., Ulfman, L. H., Schoterman, M. H. C., Garssen, J., Fink‐Gremmels, J., & Braber, S. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515004997 · Cited by 116
Using the gut microbiota as a novel tool for examining colobine primate GI health
Amato, K. R., Metcalf, J. L., Song, S. J., Hale, V. L., Clayton, J. B., Ackermann, G. L., Humphrey, G. C., Niu, K., Cui, D., Zhao, H., et al. (2016) · Global Ecology and Conservation · doi:10.1016/j.gecco.2016.06.004 · Cited by 112
Gut Microbiota: A Contributing Factor to Obesity
Harakeh, S., Khan, I., Kumosani, T. A., Barbour, E. K., Almasaudi, S. B., Bahijri, S., Alfadul, S. M., Ajabnoor, G., & Azhar, E. I. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2016.00095 · Cited by 111
Hypoxia Inducible Factor (HIF) Hydroxylases as Regulators of Intestinal Epithelial Barrier Function
Manresa, M. C., & Taylor, C. T. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.02.004 · Cited by 107
Adaptive immunity in the host–microbiota dialog
Feng, T., & Elson, C. O. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.60 · Cited by 107
Sun, H., Ni, X., Song, X., Wen, B., Zhou, Y., Zou, F., Yang, M., Peng, Z., Zhu, H., Zeng, Y., et al. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7619-0 · Cited by 105
Jalanka, J., Mattila, E. J., Jouhten, H., Hartman, J., de Vos, W. M., Arkkila, P., & Satokari, R. M. (2016) · BMC Medicine · doi:10.1186/s12916-016-0698-z · Cited by 107
Composition and immunological significance of the upper respiratory tract microbiota
Schenck, L. P., Surette, M. G., & Bowdish, D. M. E. (2016) · FEBS Letters · doi:10.1002/1873-3468.12455 · Cited by 108
Kasahara, K., Tanoue, T., Yamashita, T., Yodoi, K., Matsumoto, T., Emoto, T., Mizoguchi, T., Hayashi, T., Kitano, N., Sasaki, N., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m072165 · Cited by 105
Microbiota and Aging. A Review and Commentary
García‐Peña, C., Álvarez‐Cisneros, T., Quiroz‐Baez, R., & Friedland, R. P. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.11.005 · Cited by 109
The Gut Microbiome in Multiple Sclerosis: A Potential Therapeutic Avenue
Kirby, T. O., & Ochoa‐Repáraz, J. (2018) · Medical Sciences · doi:10.3390/medsci6030069 · Cited by 114
Skalski, J. H., Limon, J. J., Sharma, P., Gargus, M. D., Nguyen, C., Tang, J., Coelho, A. L., Hogaboam, C. M., Crother, T. R., & Underhill, D. M. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007260 · Cited by 107
The role of autophagy in maintaining intestinal mucosal barrier
Wu, Y., Tang, L., Wang, B., Sun, Q., Zhao, P., & Li, W. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28722 · Cited by 107
Özkul, C., Yalınay, M., & Karakan, T. (2019) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2019.19185 · Cited by 105
Heravi, F. S., Naseri, K., & Hu, H. (2023) · Nutrients · doi:10.3390/nu15204365 · Cited by 113
Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions
Ashonibare, V. J., Akorede, B. A., Ashonibare, P. J., Akhigbe, T. M., & Akhigbe, R. E. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1346035 · Cited by 107
Zhou, H., Huang, D., Sun, Z., & Chen, X. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127725 · Cited by 105
McCord, A. I., Chapman, C. A., Weny, G., Tumukunde, A., Hyeroba, D., Klotz, K., Koblings, A. S., Mbora, D. N. M., Cregger, M. A., White, B. A., et al. (2013) · American Journal of Primatology · doi:10.1002/ajp.22238 · Cited by 108
Factors Shaping the Human Exposome in the Built Environment: Opportunities for Engineering Control
Dai, D., Prussin, A. J., Marr, L. C., Vikesland, P. J., Edwards, M. A., & Pruden, A. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b01097 · Cited by 105
Liu, Y., Qin, S., Song, Y., Feng, Y., Lv, N., Xue, Y., Liu, F., Wang, S., Zhu, B., Ma, J., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00598 · Cited by 109
Newstead, L. L., Varjonen, K., Nuttall, T. J., & Paterson, G. K. (2020) · Antibiotics · doi:10.3390/antibiotics9020040 · Cited by 106
Johansson, E., Nilsson, A. C., Östman, E. M., & Björck, I. (2013) · Nutrition Journal · doi:10.1186/1475-2891-12-46 · Cited by 105
Role of the microbiome in swine respiratory disease
Niederwerder, M. C. (2017) · Veterinary Microbiology · doi:10.1016/j.vetmic.2017.02.017 · Cited by 108
Ohue‐Kitano, R., Watanabe‐Yasuoka, Y., Goto, T., Kitamura, N., Park, S., Kishino, S., Kimura, I., Kasubuchi, M., Takahashi, H., Li, Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201700273r · Cited by 105
Sethi, V., Vitiello, G. A., Saxena, D. B., Miller, G., & Dudeja, V. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.045 · Cited by 104
The hypothalamus for whole-body physiology: from metabolism to aging
Liu, T., Xu, Y., Yi, C., Tong, Q., & Cai, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00834-x · Cited by 109
A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes
Bousbaine, D., Fisch, L., London, M., Bhagchandani, P., Castro, T. B. R., Mimee, M., Olesen, S. W., Reis, B. S., VanInsberghe, D., Bortolatto, J., et al. (2022) · Science · doi:10.1126/science.abg5645 · Cited by 106
Host-microbe interactions in the gut of Drosophila melanogaster
Kuraishi, T., Hori, A., & Kurata, S. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00375 · Cited by 103
Wessels, J. M., Felker, A. M., Dupont, H. A., & Kaushic, C. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.035147 · Cited by 102
Diet and host–microbial crosstalk in postnatal intestinal immune homeostasis
Jain, N., & Walker, W. A. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.153 · Cited by 108
Current Concepts of the Intestinal Microbiota and the Pathogenesis of Infection
Wardwell-Scott, L., Huttenhower, C., & Garrett, W. S. (2010) · Current Infectious Disease Reports · doi:10.1007/s11908-010-0147-7 · Cited by 104
Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model
Iraporda, C., Romanin, D., Bengoa, A. A., Errea, A. J., Cayet, D., Foligné, B., Sirard, J., Garrote, G. L., Abraham, A. G., & Rumbo, M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00651 · Cited by 106
Wu, Y., Yang, Y., Cao, L., Yin, H., Xu, M., Wang, Z., Liu, Y., Wang, X., & Deng, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-31731-9 · Cited by 103
Whiley, L., Nye, L. C., Grant, I., Andreas, N., Chappell, K. E., Sarafian, M. H., Misra, R., Plumb, R. S., Lewis, M. R., Nicholson, J. K., et al. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.8b05884 · Cited by 103
Environmental filtering increases with elevation for the assembly of gut microbiota in wild pikas
Li, H., Zhou, R., Zhu, J., Huang, X., & Qu, J. (2019) · Microbial Biotechnology · doi:10.1111/1751-7915.13450 · Cited by 102
Changes in intestinal barrier functions and gut microbiota in rats exposed to zearalenone
Zhang, W., Zhang, S., Wang, J., Shan, A., & Li, X. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111072 · Cited by 105
Capsaicin and Gut Microbiota in Health and Disease
Roşca, A. E., Ieșanu, M. I., Zahiu, C. D. M., Voiculescu, S. E., Paslaru, A. C., & Zăgrean, A. (2020) · Molecules · doi:10.3390/molecules25235681 · Cited by 105
Aghamajidi, A., & Vareki, S. M. (2022) · Cancers · doi:10.3390/cancers14153563 · Cited by 105
Intestinal Delivery of Probiotics: Materials, Strategies, and Applications
Li, C., Wang, Z., Xiao, H., & Wu, F. (2024) · Advanced Materials · doi:10.1002/adma.202310174 · Cited by 103
The Metabolic and Ecological Interactions of Oxalate-Degrading Bacteria in the Mammalian Gut
Miller, A., & Dearing, D. (2013) · Pathogens · doi:10.3390/pathogens2040636 · Cited by 101
Eilam, Y., Khattib, H., Pintel, N., & Avni, D. (2023) · Global Challenges · doi:10.1002/gch2.202200177 · Cited by 101
Regulation of intestinal homeostasis by innate and adaptive immunity
Kayama, H., & Takeda, K. (2012) · International Immunology · doi:10.1093/intimm/dxs094 · Cited by 108
He, S., Wang, Q., Li, S., Ran, C., Guo, X., Zhang, Z., & Zhou, Z. (2017) · Science China Life Sciences · doi:10.1007/s11427-016-9072-6 · Cited by 105
Chen, Y., Zhang, H., Liu, R., Mats, L., Zhu, H., Pauls, K. P., Deng, Z., & Tsao, R. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.12.013 · Cited by 106
Genetic Studies of Inflammatory Bowel Disease-Focusing on Asian Patients
Park, S. C., & Jeen, Y. T. (2019) · Cells · doi:10.3390/cells8050404 · Cited by 101
Ahmad, A., Ansari, M. M., Mishra, R. K., Kumar, A., Vyawahare, A., Verma, R. K., Raza, S. S., & Khan, R. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111582 · Cited by 101
The significance of biofilms to human, animal, plant and ecosystem health
Sentenac, H., Loyau, A., Leflaive, J., & Schmeller, D. S. (2021) · Functional Ecology · doi:10.1111/1365-2435.13947 · Cited by 107
Natividad, J. M., Hayes, C. L., Motta, J., Jury, J., Galipeau, H. J., Philip, V., García‐Ródenas, C. L., Kiyama, H., Berčík, P., & Verdu, E. F. (2013) · Applied and Environmental Microbiology · doi:10.1128/aem.02470-13 · Cited by 101
Microbiota abnormalities in inflammatory airway diseases — Potential for therapy
Gollwitzer, E. S., & Marsland, B. J. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.08.002 · Cited by 100
Metabolomics and microbiomes as potential tools to evaluate the effects of the Mediterranean diet
Jin, Q., Black, A., Kales, S. N., Vattem, D., Ruiz-Canela, M., & Sotos-Prieto, M. (2019) · Nutrients · doi:10.3390/nu11010207 · Cited by 100
Minamoto, Y., Dhanani, N. H., Markel, M. E., Steiner, J. M., & Suchodolski, J. S. (2014) · Veterinary Microbiology · doi:10.1016/j.vetmic.2014.10.005 · Cited by 100
Wang, J., & Aksoy, S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116431109 · Cited by 100
Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System
Hudson, L. E., McDermott, C. D., Stewart, T. P., Hudson, W. H., Ríos, D., Fasken, M. B., Corbett, A. H., & Lamb, T. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153351 · Cited by 103
The Kynurenine Pathway As a Novel Link between Allergy and the Gut Microbiome
der Leek, A. V., Yanishevsky, Y., & Kozyrskyj, A. L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01374 · Cited by 103
Therapeutic Potential of Fulvic Acid in Chronic Inflammatory Diseases and Diabetes
Winkler, J., & Ghosh, S. (2018) · Journal of Diabetes Research · doi:10.1155/2018/5391014 · Cited by 100
Pathways linking obesity to neuropsychiatric disorders
Martins, L. B., Monteze, N. M., Calarge, C. A., Ferreira, A. V. M., & Teixeira, A. L. (2019) · Nutrition · doi:10.1016/j.nut.2019.03.017 · Cited by 110
Cai, X., Han, Y., Gu, M., Song, M., Wu, X., Li, Z., Li, F., Goulette, T., & Xiao, H. (2019) · Food & Function · doi:10.1039/c9fo01537j · Cited by 100
Anastomotic leak in colorectal cancer patients: New insights and perspectives
Foppa, C., Ng, S. C., Montorsi, M., & Spinelli, A. (2020) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2020.02.027 · Cited by 101
Changes in the Gut Microbiome and Pathologies in Pregnancy
Gorczyca, K., Obuchowska, A., Kimber-Trojnar, Ż., Wierzchowska-Opoka, M., & Leszczyńska‐Gorzelak, B. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19169961 · Cited by 103
Wang, C., Sun, G., Li, S., Li, X., & Liu, Y. (2017) · Journal of Oceanology and Limnology · doi:10.1007/s00343-017-6203-5 · Cited by 100
Wallace, J. G., Bellissimo, C. J., Yeo, E., Xia, Y. F., Petrik, J., Surette, M. G., Bowdish, D. M. E., & Sloboda, D. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-54098-x · Cited by 102
The Intestinal Barrier Dysfunction as Driving Factor of Inflammaging
Untersmayr, E., Brandt, A., Koidl, L., & Bergheim, I. (2022) · Nutrients · doi:10.3390/nu14050949 · Cited by 104
Advances and future perspectives in epithelial drug delivery
Mohammed, Y., Holmes, A. M., Kwok, P. C. L., Kumeria, T., Namjoshi, S., Imran, M., Matteucci, L., Ali, M., Tai, W., Benson, H. A., et al. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114293 · Cited by 99
Dou, Y., Yu, X., Luo, Y., Chen, B., Ma, D., & Zhu, J. (2022) · Nutrients · doi:10.3390/nu14163298 · Cited by 104
The relationships between the gut microbiota and its metabolites with thyroid diseases
Jiang, W., Lu, G., Gao, D., Lv, Z., & Li, D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.943408 · Cited by 102
Kaci, G., Lakhdari, O., Dore, J. M., Ehrlich, S. D., Renault, P., Blottière, H. M., & Delorme, C. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.03021-10 · Cited by 99
The microbiota–microglia axis in central nervous system disorders
Mossad, O., & Erny, D. (2020) · Brain Pathology · doi:10.1111/bpa.12908 · Cited by 98
Dargenio, V. N., Dargenio, C., Castellaneta, S., De Giacomo, A., Laguardia, M., Schettini, F., Francavilla, R., & Cristofori, F. (2023) · Nutrients · doi:10.3390/nu15071620 · Cited by 98
Phage-Mediated Selection on Microbiota of a Long-Lived Host
Koskella, B. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.038 · Cited by 100
Wong, E. B., Akilimali, N. A., Govender, P., Sullivan, Z. A., Cosgrove, C., Pillay, M., Lewinsohn, D. M., Bishai, W. R., Walker, B. D., Ndung’u, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083474 · Cited by 101
Gut Microbiota and Lifestyle Interventions in NAFLD
Houghton, D., Stewart, C. J., Day, C. P., & Trenell, M. I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040447 · Cited by 99
Risely, A., Waite, D. W., Újvári, B., Hoye, B. J., & Klaassen, M. (2017) · Journal of Animal Ecology · doi:10.1111/1365-2656.12784 · Cited by 98
Knutie, S. A. (2020) · Journal of Applied Ecology · doi:10.1111/1365-2664.13567 · Cited by 98
An Intestine-on-a-Chip Model of Plug-and-Play Modularity to Study Inflammatory Processes
Gijzen, L., Marescotti, D., Raineri, E. J. M., Nicolas, A., Lanz, H. L., Guerrera, D., van Vught, R., Joore, J., Vulto, P., Peitsch, M. C., et al. (2020) · SLAS TECHNOLOGY · doi:10.1177/2472630320924999 · Cited by 98
Dietary and Microbial Determinants in Food Allergy
Victor, E. S., Crestani, E., & Chatila, T. A. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.025 · Cited by 101
Parmar, A., Alakulppi, N. S., Paavola–Sakki, P., Kurppa, K., Halme, L., Färkkilä, M. A., Turunen, U., Lappalainen, M., KONTULA, K. K., Kaukinen, K., et al. (2012) · Tissue Antigens · doi:10.1111/tan.12016 · Cited by 98
Moreno‐Indias, I., Sánchez‐Alcoholado, L., Sanchez-Garrido, M. A., Martín‐Núñez, G. M., Pérez‐Jiménez, F., Tena‐Sempere, M., Tinahones, F. J., & Queipo‐Ortuño, M. I. (2016) · Endocrinology · doi:10.1210/en.2016-1317 · Cited by 100
Impact of Probiotics on Risk Factors for Cardiovascular Diseases. A Review
Ebel, B., Lemetais, G., Beney, L., Cachon, R., Sokol, H., Langella, P., & Gervais, P. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.579361 · Cited by 97
Lakhdari, O., Cultrone, A., Tap, J., Gloux, K., Bernard, F., Ehrlich, S. D., Lefèvre, F., Dore, J. M., & Blottière, H. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013092 · Cited by 107
Pedicord, V. A., Lockhart, A. A. K., Rangan, K. J., Craig, J. W., Loschko, J., Rogoz, A., Hang, H. C., & Mucida, D. (2016) · Science Immunology · doi:10.1126/sciimmunol.aai7732 · Cited by 99
Microbial Colonization From the Fetus to Early Childhood—A Comprehensive Review
Senn, V., Bassler, D., Choudhury, R. A., Scholkmann, F., Righini‐Grunder, F., Vuille-dit-Bille, R. N., & Restin, T. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.573735 · Cited by 103
Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease
Shen, Z., Luo, W., Tan, B., Nie, K., Deng, M., Wu, S., Xiao, M., Wu, X., Meng, X., Tong, T., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104285 · Cited by 100
Caspase-8 in inflammatory diseases: a potential therapeutic target
Zhang, W., Zhu, C., Liao, Y., Zhou, M., Xu, W., & Zou, Z. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00646-x · Cited by 108
Dubey, S. R., Turnbull, C., Pandey, A., Zhao, A., Kurera, M., Al-Zidan, R. N., Shen, C. X., Gautam, M., Mahajan, S., Jadhav, P. S., et al. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01354-y · Cited by 101
Mishiro, T., Kusunoki, R., Otani, A., Ansary, M. M. U., Tongu, M., Harashima, N., Yamada, T., Sato, S., Amano, Y., Itoh, K., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.70 · Cited by 97
Regulatory T Cells in Post-stroke Immune Homeostasis
Liesz, A., & Kleinschnitz, C. (2016) · Translational Stroke Research · doi:10.1007/s12975-016-0465-7 · Cited by 97
Oral microbiome alterations of healthy volunteers with proton pump inhibitor
Mishiro, T., Oka, K., Kuroki, Y., Takahashi, M., Tatsumi, K., Saitoh, T., Tobita, H., Ishimura, N., Sato, S., Ishihara, S., et al. (2018) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.14040 · Cited by 96
Microbiota–immune system interaction: an uneasy alliance
Salzman, N. H. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.09.018 · Cited by 96
Houghton, D., Hardy, T., Stewart, C. J., Errington, L., Day, C. P., Trenell, M. I., & Avery, L. (2018) · Diabetologia · doi:10.1007/s00125-018-4632-0 · Cited by 97
Dong, R., Bai, M., Zhao, J., Wang, D., Ning, X., & Sun, S. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.557368 · Cited by 96
Gut microbiota as a key regulator of intestinal mucosal immunity
Wang, J., He, M., Yang, M., & Ai, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122612 · Cited by 103
Pathophysiology of Food Allergy
Vickery, B. P., Chin, S. J., & Burks, A. W. (2011) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.02.012 · Cited by 96
Bugging allergy; role of pre-, pro- and synbiotics in allergy prevention
West, C. E., Dzidic, M., Prescott, S. L., & Jenmalm, M. C. (2017) · Allergology International · doi:10.1016/j.alit.2017.08.001 · Cited by 97
Patrone, V., Puglisi, E., Cardinali, M., Schnitzler, T. S., Svegliati, S., Festa, A., Gabrielli, A., & Morelli, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-14889-6 · Cited by 95
Sun, Y., Liu, Y., Ai, C., Song, S., & Chen, X. (2019) · Food & Function · doi:10.1039/c9fo00713j · Cited by 97
Role of the microbiome in occurrence, development and treatment of pancreatic cancer
Wang, Y., Yang, G., You, L., Yang, J., Feng, M., Qiu, J., Zhao, F., Liu, Y., Cao, Z., Zheng, L., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1103-2 · Cited by 97
Montoya-Ciriaco, N. M., Gómez-Acata, S., Muñoz-Arenas, L. C., Dendooven, L., Estrada‐Torres, A., de la Vega-Pérez, A. H. D., & Navarro‐Noya, Y. E. (2020) · Microbiome · doi:10.1186/s40168-020-0783-6 · Cited by 97
Metadata
- Authors
- Round, J. L., & Mazmanian, S. K.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Mazmanian, Sarkis K.
- Venue
- Nature Reviews Immunology
- Published
- 2009-05
- Volume
- 9
- Issue
- 5
- Pages
- 313-323
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4095778
- OpenAlex
- W2034082915
- Cited by
- 5,029
- References
- 118
- Citations by year
- 2026: 205 · 2025: 284 · 2024: 333 · 2023: 300 · 2022: 401 · 2021: 423 · 2020: 398 · 2019: 390 · 2018: 395 · 2017: 382 · 2016: 345 · 2015: 262 · 2014: 221 · 2013: 223 · 2012: 177
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Update notices
- erratum (2009-07-17)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK078938)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- gut microbiota, intestinal immune response, host-microbe interactions, bacterial colonization, inflammatory bowel disease, immune dysregulation, autoimmunity, allergy, cancer, symbiotic bacteria, pathogenic bacteria
- MeSH terms
- Animals, Disease, Health, Homeostasis, Humans, Intestines, Inflammatory Bowel Diseases, Immune System Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
