Targeting gut microbiome: a novel and potential therapy for autism

The gut microbiota shapes intestinal immune responses during health and disease

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Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

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Ingestion of <i>Lactobacillus</i> strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

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Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

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Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

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The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems.

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Gut biogeography of the bacterial microbiota

Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535 · see citing works

A microbial symbiosis factor prevents intestinal inflammatory disease

Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340 · see citing works

Oxytocin, vasopressin, and the neurogenetics of sociality

Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works

Interactions between commensal intestinal bacteria and the immune system

Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,607 · see citing works

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota

Round, J. L., Lee, S. M., Li, J., Tran, G., Jabri, B., Chatila, T. A., & Mazmanian, S. K. (2011) · Science · doi:10.1126/science.1206095 · Cited by 1,604 · see citing works

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

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The role of gut microbiota in immune homeostasis and autoimmunity

Wu, H.-J., & Wu, E. (2012) · Gut Microbes · doi:10.4161/gmic.19320 · Cited by 1,426 · see citing works

Microbiota Transfer Therapy Alters Gut Ecosystem and Improves Gastrointestinal and Autism Symptoms: An Open-Label Study

Kang, D.-W., Adams, J. B., Gregory, A. C., Borody, T., Chittick, L., Fasano, A., Khoruts, A., Geis, E., Maldonado, J., McDonough-Means, S., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0225-7 · Cited by 1,391 · see citing works

Microbes in Gastrointestinal Health and Disease

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Assessment of psychotropic-like properties of a probiotic formulation ( <i>Lactobacillus helveticus</i> R0052 and <i>Bifidobacterium longum</i> R0175) in rats and human subjects

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Maternal immune activation: Implications for neuropsychiatric disorders

Estes, M. L., & McAllister, A. K. (2016) · Science · doi:10.1126/science.aag3194 · Cited by 1,206 · see citing works

Consumption of fermented milk product with probiotic modulates brain activity

Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works

Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring

Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163 · see citing works

Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation

Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123 · see citing works

Current Understanding of Dysbiosis in Disease in Human and Animal Models

DeGruttola, A. K., Low, D., Mizoguchi, A., & Mizoguchi, E. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000750 · Cited by 1,122 · see citing works

Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid

Collado, M. C., Rautava, S., Aakko, J., Isolauri, E., & Salminen, S. (2016) · Scientific Reports · doi:10.1038/srep23129 · Cited by 1,098 · see citing works

Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation

Hemarajata, P., & Versalovic, J. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12459294 · Cited by 1,083 · see citing works

Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity

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The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication

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Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression

Desbonnet, L., Garrett, L., Clarke, G., Kiely, B., Cryan, J. F., & Dinan, T. G. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.005 · Cited by 999 · see citing works

Pyrosequencing study of fecal microflora of autistic and control children

Finegold, S. M., Dowd, S. E., Gontcharova, V., Liu, C., Henley, K. E., Wolcott, R. D., Youn, E., Summanen, P. H., Granpeesheh, D., Dixon, D., et al. (2010) · Anaerobe · doi:10.1016/j.anaerobe.2010.06.008 · Cited by 977 · see citing works

Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children

Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works

The role of microbiome in central nervous system disorders

Wang, Y., & Kasper, L. H. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.015 · Cited by 803 · see citing works

Elevated immune response in the brain of autistic patients

Li, X., Chauhan, A., Sheikh, A. M., Patil, S., Chauhan, V., Li, X.-M., Ji, L., Brown, T., & Malik, M. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.12.002 · Cited by 786 · see citing works

Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children

Parracho, H. M., Bingham, M. O., Gibson, G. R., & McCartney, A. L. (2005) · Journal of Medical Microbiology · doi:10.1099/jmm.0.46101-0 · Cited by 784 · see citing works

Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism

Morgan, J. T., Chana, G., Pardo, C. A., Achim, C., Semendeferi, K., Buckwalter, J., Courchesne, E., & Everall, I. P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.024 · Cited by 749 · see citing works

Gastrointestinal Microflora Studies in Late‐Onset Autism

Finegold, S. M., Molitoris, D., Song, Y., Liu, C., Vaisanen, M., Bolte, E., McTeague, M., Sandler, R., Wexler, H., Marlowe, E. M., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/341914 · Cited by 742 · see citing works

Maternal metabolic conditions and risk for autism and other neurodevelopmental disorders

Krakowiak, P., Walker, C. K., Bremer, A. A., Baker, A. S., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2012) · PEDIATRICS · doi:10.1542/peds.2011-2583 · Cited by 675 · see citing works

Chronic Gastrointestinal Inflammation Induces Anxiety-Like Behavior and Alters Central Nervous System Biochemistry in Mice

Bercik, P., Verdu, E. F., Foster, J. A., Macri, J., Potter, M., Huang, X., Malinowski, P., Jackson, W., Blennerhassett, P., Neufeld, K. A., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.06.063 · Cited by 674 · see citing works

A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood

Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · see citing works

Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism

Malkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J., & Patterson, P. H. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.011 · Cited by 662 · see citing works

Creating and Maintaining the Gastrointestinal Ecosystem: What We Know and Need To Know from Gnotobiology

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Microbial genes, brain &amp; behaviour – epigenetic regulation of the gut–brain axis

Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637 · see citing works

The role of immune dysfunction in the pathophysiology of autism

Onore, C., Careaga, M., & Ashwood, P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.08.007 · Cited by 635 · see citing works

Gastrointestinal microbiota in children with autism in Slovakia

Tomova, A., Husarova, V., Lakatosova, S., Bakos, J., Vlkova, B., Babinska, K., & Ostatnikova, D. (2015) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2014.10.033 · Cited by 632 · see citing works

Short-Term Benefit From Oral Vancomycin Treatment of Regressive-Onset Autism

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The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works

Emerging Roles for the Gut Microbiome in Autism Spectrum Disorder

Vuong, H. E., & Hsiao, E. Y. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.024 · Cited by 595 · see citing works

Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology

Dinan, T. G., & Cryan, J. F. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.007 · Cited by 577 · see citing works

The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders

Kohane, I. S., McMurry, A., Weber, G., MacFadden, D., Rappaport, L., Kunkel, L., Bickel, J., Wattanasin, N., Spence, S., Murphy, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033224 · Cited by 562 · see citing works

Real-Time PCR Quantitation of Clostridia in Feces of Autistic Children

Song, Y., Liu, C., & Finegold, S. M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6459-6465.2004 · Cited by 556 · see citing works

Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers

Schmidt, K., Cowen, P. J., Harmer, C. J., Tzortzis, G., Errington, S., & Burnet, P. W. J. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3810-0 · Cited by 522 · see citing works

Maternal infection and immune involvement in autism

Patterson, P. H. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.03.001 · Cited by 520 · see citing works

Recurrent Clostridium difficile Colitis: Case Series Involving 18 Patients Treated with Donor Stool Administered via a Nasogastric Tube

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Mode of delivery affects the bacterial community in the newborn gut

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Histamine Derived from Probiotic Lactobacillus reuteri Suppresses TNF via Modulation of PKA and ERK Signaling

Thomas, C. M., Hong, T., van Pijkeren, J. P., Hemarajata, P., Trinh, D. V., Hu, W., Britton, R. A., Kalkum, M., & Versalovic, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031951 · Cited by 491 · see citing works

Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice

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Diagnosis and Treatment ofClostridium difficilein Adults

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Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders

MacFabe, D. F. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.19260 · Cited by 432 · see citing works

<i> <scp>B</scp> ifidobacteria </i> exert strain‐specific effects on stress‐related behavior and physiology in <scp>BALB</scp> /c mice

Savignac, H. M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2014) · Neurogastroenterology &amp; Motility · doi:10.1111/nmo.12427 · Cited by 418 · see citing works

Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder

Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-42 · Cited by 418 · see citing works

Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder

Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2167-7 · Cited by 412 · see citing works

FAO Technical Meeting on Prebiotics

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Activation of the maternal immune system induces endocrine changes in the placenta via IL-6

Hsiao, E. Y., & Patterson, P. H. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.12.017 · Cited by 402 · see citing works

Compartmentalized and systemic control of tissue immunity by commensals

Belkaid, Y., & Naik, S. (2013) · Nature Immunology · doi:10.1038/ni.2604 · Cited by 382 · see citing works

Microbial biofilms in the human gastrointestinal tract

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Application of Novel PCR-Based Methods for Detection, Quantitation, and Phylogenetic Characterization of <i>Sutterella</i> Species in Intestinal Biopsy Samples from Children with Autism and Gastrointestinal Disturbances

Williams, B. L., Hornig, M., Parekh, T., & Lipkin, W. I. (2012) · mBio · doi:10.1128/mbio.00261-11 · Cited by 378 · see citing works

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine

Savignac, H. M., Corona, G., Mills, H., Chen, L., Spencer, J. P. E., Tzortzis, G., & Burnet, P. W. J. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.10.006 · Cited by 377 · see citing works

The teratology of autism

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Central Nervous System Demyelinating Disease Protection by the Human Commensal <i>Bacteroides fragilis</i> Depends on Polysaccharide A Expression

Ochoa-Repáraz, J., Mielcarz, D. W., Ditrio, L. E., Burroughs, A. R., Begum-Haque, S., Dasgupta, S., Kasper, D. L., & Kasper, L. H. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001443 · Cited by 367 · see citing works

Bifidobacteria modulate cognitive processes in an anxious mouse strain

Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365 · see citing works

Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder

MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365 · see citing works

The association of maternal obesity and diabetes with autism and other developmental disabilities

Li, M., Fallin, M. D., Riley, A., Landa, R., Walker, S. O., Silverstein, M., Caruso, D., Pearson, C., Kiang, S., Dahm, J. L., et al. (2016) · PEDIATRICS · doi:10.1542/peds.2015-2206 · Cited by 338 · see citing works

Maternal hospitalization with infection during pregnancy and risk of autism spectrum disorders

Lee, B. K., Magnusson, C., Gardner, R. M., Blomström, Å., Newschaffer, C. J., Burstyn, I., Karlsson, H., & Dalman, C. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.09.001 · Cited by 337 · see citing works

Alterations in the Vaginal Microbiome by Maternal Stress Are Associated With Metabolic Reprogramming of the Offspring Gut and Brain

Jašarević, E., Howerton, C. L., Howard, C. D., & Bale, T. L. (2015) · Endocrinology · doi:10.1210/en.2015-1177 · Cited by 329 · see citing works

Interactions Between Commensal Bacteria and Gut Sensorimotor Function in Health and Disease

Barbara, G., Stanghellini, V., Brandi, G., Cremon, C., Nardo, G. D., De Giorgio, R., & Corinaldesi, R. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00230.x · Cited by 325 · see citing works

Beneficial effects of Bacteroides fragilis polysaccharides on the immune system

Erin, B. T. (2009) · Frontiers in bioscience · doi:10.2741/3603 · Cited by 322 · see citing works

Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls

Yap, I. K. S., Angley, M. T., Veselkov, K., Holmes, E. C., Lindon, J. C., & Nicholson, J. K. (2010) · Journal of Proteome Research · doi:10.1021/pr901188e · Cited by 316 · see citing works

Maternal obesity and neurodevelopmental and psychiatric disorders in offspring

Edlow, A. G. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4932 · Cited by 310 · see citing works

Altered brain-gut axis in autism: comorbidity or causative mechanisms

Mayer, E. A., Padua, D., & Tillisch, K. (2014) · BioEssays · doi:10.1002/bies.201400075 · Cited by 304 · see citing works

Maternal Infection During Pregnancy and Autism Spectrum Disorders

Zerbo, O., Qian, Y., Yoshida, C., Grether, J. K., Van de Water, J., & Croen, L. A. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-2016-3 · Cited by 298 · see citing works

Differential monocyte responses to TLR ligands in children with autism spectrum disorders

Enstrom, A. M., Onore, C. E., Van de Water, J. A., & Ashwood, P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.08.001 · Cited by 294 · see citing works

Modulatory Effects of Gut Microbiota on the Central Nervous System: How Gut Could Play a Role in Neuropsychiatric Health and Diseases

Yarandi, S., Peterson, D. A., Treisman, G. J., Moran, T. H., & Pasricha, P. J. (2016) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15146 · Cited by 294 · see citing works

Altered colonic function and microbiota profile in a mouse model of chronic depression

Park, A. J., Collins, J., Blennerhassett, P. A., Ghia, J., Verdu, E. F., Berčík, P., & Collins, S. M. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12153 · Cited by 291 · see citing works

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood

Golubeva, A. V., Crampton, S., Desbonnet, L., Edge, D., O'Sullivan, O., Lomasney, K. W., Zhdanov, A. V., Crispie, F., Moloney, R. D., Borre, Y. E., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.06.002 · Cited by 283 · see citing works

Assessing Neurocognition via Gamified Experimental Logic: A Novel Approach to Simultaneous Acquisition of Multiple ERPs

Nair, A. K., Sasidharan, A., John, J. P., Mehrotra, S., & Kutty, B. M. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00001 · Cited by 282 · see citing works

Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders

Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Pessah, I. N., & Van de Water, J. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.10.025 · Cited by 279 · see citing works

Microbiota, Disease, and Back to Health: A Metastable Journey

Blumberg, R. S., & Powrie, F. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004184 · Cited by 279 · see citing works

Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study

Zerbo, O., Iosif, A.-M., Walker, C., Ozonoff, S., Hansen, R. L., & Hertz-Picciotto, I. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1540-x · Cited by 277 · see citing works

Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome

Ohland, C. L., Kish, L., Bell, H., Thiesen, A., Hotte, N., Pankiv, E., & Madsen, K. L. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.008 · Cited by 273 · see citing works

Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders

MacFabe, D. F. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.28177 · Cited by 260 · see citing works

Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism

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Role of Gut Microbiota in Human Health and Diseases

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Influence of the Gut Microbiota, Metabolism and Environment on Neuropsychiatric Disorders

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Microbiota-Gut-Brain Axis

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ESTRATÉGIAS NUTRICIONAIS NO TRANSTORNO DO ESPECTRO AUTISTA

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The Gut-Microbiota-Brain Axis in Autism Spectrum Disorder

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