Cited by 3,952Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

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Intestinal mucosal barrier function in health and disease

Turner, Jerrold R.·2009·Nature reviews. Immunology

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Abstract

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.

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Authors: Turner, J. R.
Affiliations: University of Chicago (US)
Corresponding author: Turner, Jerrold R.
ORCID: Turner, Jerrold R.
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-11
Volume: 9
Issue: 11
Pages: 799-809
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2653
OpenAlex: W2145189896
Cited by: 3,952
References: 120
Citations by year: 2026: 404 · 2025: 298 · 2024: 341 · 2023: 313 · 2022: 356 · 2021: 302 · 2020: 303 · 2019: 262 · 2018: 210 · 2017: 212 · 2016: 183 · 2015: 178 · 2014: 161 · 2013: 126 · 2012: 139
FWCI: 15.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL091889, HL091889)
National Cancer Institute (CA 14599, P30CA014599)
National Institute of Diabetes and Digestive and Kidney Diseases (DK068271, DK061931, P01DK067887, DK042086, DK-67887, P30DK042086, R01DK068271, R01DK061931)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: intestinal barrier, intestinal epithelium, mucosal immunity, nutrient absorption, selective permeability, dietary antigens, microbial products, barrier dysfunction, intestinal diseases
MeSH terms: Animals, Cell Membrane Permeability, Cytoskeleton, Epithelial Cells, Homeostasis, Humans, Intestinal Diseases, Intestinal Mucosa, Membrane Proteins, Cytokines, Immunity, Mucosal, Tight Junctions, Gastrointestinal Tract

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