Cited by 3,952Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

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Intestinal mucosal barrier function in health and disease

Turner, Jerrold R.·2009·Nature reviews. Immunology

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Abstract

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.

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Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,889
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., & Kaibuchi, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20246 · Cited by 2,009
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982
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Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927
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Fujino, S., Andoh, A., Bamba, S., Ogawa, A., Hata, K., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Gut · doi:10.1136/gut.52.1.65 · Cited by 1,713
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Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684
CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M. L., Ploegh, H. L., Fox, J. G., et al. (2005) · Science · doi:10.1126/science.1102901 · Cited by 1,609
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Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483

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Nighot, M., Rawat, M., Al–Sadi, R., Castillo, E. F., Nighot, P. K., & Ma, T. Y. (2019) · American Journal Of Pathology · doi:10.1016/j.ajpath.2018.12.016 · Cited by 111
SCFAs improve disease resistance via modulate gut microbiota, enhance immune response and increase antioxidative capacity in the host
Li, S., Heng, X., Guo, L., Lessing, D. J., & Chu, W. (2021) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2021.12.035 · Cited by 109
Gastro-Intestinal Vascular Emergencies
Corcos, O., & Nuzzo, A. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.08.006 · Cited by 104
Intestinal alkaline phosphatase targets the gut barrier to prevent aging
Kühn, F., Adiliaghdam, F., Cavallaro, P. M., Hamarneh, S. R., Tsurumi, A., Hoda, R. S., Munoz, A. R., Dhole, Y., Ramirez, J. M., Liu, E., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.134049 · Cited by 107
The effects of Lactobacillus plantarum on small intestinal barrier function and mucosal gene transcription; a randomized double-blind placebo controlled trial
Mujagic, Z., de Vos, P., Boekschoten, M. V., Govers, C., Pieters, H., de Wit, N. J. W., Bron, P. A., Masclee, A., & Troost, F. J. (2017) · Scientific Reports · doi:10.1038/srep40128 · Cited by 108
Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders
Waldman, S. A., & Camilleri, M. (2018) · Gut · doi:10.1136/gutjnl-2018-316029 · Cited by 110
A bridge for short-chain fatty acids to affect inflammatory bowel disease, type 1 diabetes, and non-alcoholic fatty liver disease positively: by changing gut barrier
Liu, W., Luo, X., Tang, J., Mo, Q., Zhong, H., Zhang, H., & Feng, F. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02431-w · Cited by 111
Small intestinal permeability is increased in diarrhoea predominant IBS, while alterations in gastroduodenal permeability in all IBS subtypes are largely attributable to confounders
Mujagić, Z., Ludidi, S., Keszthelyi, D., Hesselink, M., Kruimel, J., Lenaerts, K., Hanssen, N., Conchillo, J., Jonkers, D., & Masclee, A. (2014) · Alimentary Pharmacology and Therapeutics · doi:10.1111/apt.12829 · Cited by 115
A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut
Teng, F., Goc, J., Zhou, L., Chu, C., Shah, M. A., Eberl, G., & Sonnenberg, G. F. (2019) · Science Immunology · doi:10.1126/sciimmunol.aax1215 · Cited by 112
Maresin 1 alleviates dextran sulfate sodium-induced ulcerative colitis by regulating NRF2 and TLR4/NF-kB signaling pathway
Qiu, S., Li, P., Zhao, H., & Li, X. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.106018 · Cited by 110
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene
Wang, Y., Zhao, H., Liu, Y., Li, J., Nie, X., Huang, P., & Xing, M. (2021) · Environmental Pollution · doi:10.1016/j.envpol.2021.116597 · Cited by 108
Staphylococcal trafficking and infection—from ‘nose to gut’ and back
Raineri, E. J. M., Altulea, D., & van Dijl, J. M. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab041 · Cited by 110
The Effect of Bacterial Infections, Probiotics and Zonulin on Intestinal Barrier Integrity
Serek, P., & Oleksy-Wawrzyniak, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111359 · Cited by 120
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Costantini, T. W., Krzyżaniak, M., Cheadle, G. A., Putnam, J. G., Hageny, A., Lopez, N., Eliceiri, B. P., Bansal, V., & Coimbra, R. S. M. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.04.005 · Cited by 112
Alcohol and the Intestine
Patel, S., Behara, R., Swanson, G. B., Forsyth, C. B., Voigt, R. M., & Keshavarzian, A. (2015) · Biomolecules · doi:10.3390/biom5042573 · Cited by 115
Claudin-2-dependent paracellular channels are dynamically gated
Weber, C. R., Liang, G. H., Wang, Y., Das, S., Shen, L., Yu, A. S. L., Nelson, D. J., & Turner, J. R. (2015) · eLife · doi:10.7554/elife.09906 · Cited by 106
Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells
Hoffmann, P., Burmester, M., Langeheine, M., Brehm, R., Empl, M. T., Seeger, B., & Breves, G. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257824 · Cited by 106
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Qiao, Y., Liu, C., Guo, Y., Zhang, W., Guo, W., Кисельов, О. Б., & Wang, Z. (2022) · Poultry Science · doi:10.1016/j.psj.2022.101905 · Cited by 106
The food contaminant deoxynivalenol activates the mitogen activated protein kinases in the intestine: Interest of ex vivo models as an alternative to in vivo experiments
Lucioli, J., Pinton, P., Callu, P., Laffitte, J., Grosjean, F., Kolf‐Clauw, M., Oswald, I. P., & Bracarense, A. P. F. R. L. (2013) · Toxicon · doi:10.1016/j.toxicon.2013.01.024 · Cited by 105
Specific roles of threonine in intestinal mucosal integrity and barrier function
Li, D. (2011) · Frontiers in Bioscience-Elite · doi:10.2741/e322 · Cited by 105
Acute Exposure to Commonly Ingested Emulsifiers Alters Intestinal Mucus Structure and Transport Properties
Lock, J. Y., Carlson, T. L., Wang, C.-M., Chen, A., & Carrier, R. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-27957-2 · Cited by 109
The role of autophagy in maintaining intestinal mucosal barrier
Wu, Y., Tang, L., Wang, B., Sun, Q., Zhao, P., & Li, W. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28722 · Cited by 107
Extracellular vesicles and soluble factors secreted by Escherichia coli Nissle 1917 and ECOR63 protect against enteropathogenic E. coli-induced intestinal epithelial barrier dysfunction
Álvarez-Villagómez, C. S., Gíménez, R., Cañas, M.-A., Vera, R., Díaz‐Garrido, N., Badı́a, J., & Baldomà, L. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1534-3 · Cited by 105
Chk2-dependent HuR phosphorylation regulates occludin mRNA translation and epithelial barrier function
Yu, T., Wang, P., Rao, J. N., Zou, T., Liu, L., Xiao, L., Gorospe, M., & Wang, J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr567 · Cited by 104
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Ruan, D., Wang, W., Lin, C., Fouad, A. M., Chen, W., Xia, W., Wang, S., Luo, X., Zhang, W. H., Yan, S., et al. (2018) · animal · doi:10.1017/s1751731118000678 · Cited by 106
Effects of chronic noise exposure on the microbiome-gut-brain axis in senescence-accelerated prone mice: implications for Alzheimer’s disease
Cui, B., Su, D., Li, W., She, X., Zhang, M., Wang, R., & Zhai, Q. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1223-4 · Cited by 108

Authors: Turner, J. R.
Affiliations: University of Chicago (US)
Corresponding author: Turner, Jerrold R.
ORCID: Turner, Jerrold R.
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-11
Volume: 9
Issue: 11
Pages: 799-809
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2653
OpenAlex: W2145189896
Cited by: 3,952
References: 120
Citations by year: 2026: 404 · 2025: 298 · 2024: 341 · 2023: 313 · 2022: 356 · 2021: 302 · 2020: 303 · 2019: 262 · 2018: 210 · 2017: 212 · 2016: 183 · 2015: 178 · 2014: 161 · 2013: 126 · 2012: 139
FWCI: 15.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL091889, HL091889)
National Cancer Institute (CA 14599, P30CA014599)
National Institute of Diabetes and Digestive and Kidney Diseases (DK068271, DK061931, P01DK067887, DK042086, DK-67887, P30DK042086, R01DK068271, R01DK061931)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: intestinal barrier, intestinal epithelium, mucosal immunity, nutrient absorption, selective permeability, dietary antigens, microbial products, barrier dysfunction, intestinal diseases
MeSH terms: Animals, Cell Membrane Permeability, Cytoskeleton, Epithelial Cells, Homeostasis, Humans, Intestinal Diseases, Intestinal Mucosa, Membrane Proteins, Cytokines, Immunity, Mucosal, Tight Junctions, Gastrointestinal Tract

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