Cited by 3,952Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.

Intestinal mucosal barrier function in health and disease

Turner, Jerrold R.·2009·Nature reviews. Immunology

Open this paper in CoChat — free account

Abstract

Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.

Integrity signals

Registry

Crossref · 10.1038/nri2653

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,889
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., & Kaibuchi, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20246 · Cited by 2,009
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927
Increased expression of interleukin 17 in inflammatory bowel disease
Fujino, S., Andoh, A., Bamba, S., Ogawa, A., Hata, K., Araki, Y., Bamba, T., & Fujiyama, Y. (2003) · Gut · doi:10.1136/gut.52.1.65 · Cited by 1,713
Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection
Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684
CX 3 CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance
Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M. L., Ploegh, H. L., Fox, J. G., et al. (2005) · Science · doi:10.1126/science.1102901 · Cited by 1,609
Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483

Show all 120 references

Sorted by citations

Items 701–800 of 1,009

Regulation of Collective Metastasis by Nanolumenal Signaling
Wrenn, E. D., Yamamoto, A., Moore, B. M., Huang, Y. C., McBirney, M., Thomas, A. J., Greenwood, E., Rabena, Y., Rahbar, H., Partridge, S. C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.045 · Cited by 83
Silicon dioxide nanoparticles induced neurobehavioral impairments by disrupting microbiota–gut–brain axis
Diao, J., Xia, Y., Jiang, X., Qiu, J., Cheng, S., Su, J., Duan, X., Gao, M., Qin, X., Zhang, J., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00916-2 · Cited by 80
Co-Cultures of Lactobacillus acidophilus and Bacillus subtilis Enhance Mucosal Barrier by Modulating Gut Microbiota-Derived Short-Chain Fatty Acids
Xie, Z., Li, M., Qian, M., Yang, Z., & Han, X. (2022) · Nutrients · doi:10.3390/nu14214475 · Cited by 83
L. plantarum, L. salivarius, and L. lactis Attenuate Th2 Responses and Increase Treg Frequencies in Healthy Mice in a Strain Dependent Manner
Smelt, M. J., de Haan, B. J., Bron, P. A., van Swam, I. I., Meijerink, M., Wells, J. M., Faas, M. M., & de Vos, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047244 · Cited by 77
Antibiotic-Driven Dysbiosis Mediates Intraluminal Agglutination and Alternative Segregation of Enterococcus faecium from the Intestinal Epithelium
Hendrickx, A. P. A., Top, J., Bayjanov, J. R., Kemperman, H., Rogers, M. R. C., Paganelli, F. L., Bonten, M. J. M., & Willems, R. J. L. (2015) · mBio · doi:10.1128/mbio.01346-15 · Cited by 78
Serotonin 5-HT7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract
Guseva, D., Holst, K., Kaune, B., Meier, M., Keubler, L. M., Glage, S., Büettner, M., Bleich, A., Pabst, O., Bachmann, O. P., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000150 · Cited by 78
IL-13–induced intestinal secretory epithelial cell antigen passages are required for IgE-mediated food-induced anaphylaxis
Noah, T. K., Knoop, K. A., McDonald, K. G., Gustafsson, J. K., Waggoner, L., Vanoni, S., Batie, M. R., Arora, K., Naren, A. P., Wang, Y., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.04.030 · Cited by 78
Gastroduodenal Mechanisms Underlying Functional Gastric Disorders
Carbone, F., & Tack, J. F. (2014) · Digestive Diseases · doi:10.1159/000357854 · Cited by 79
Temporal and regional intestinal changes in permeability, tight junction, and cytokine gene expression following ovariectomy-induced estrogen deficiency
Collins, F. L., Rios‐Arce, N. D., Atkinson, S., Bierhalter, H., Schoenherr, D. T., Bazil, J. N., McCabe, L. R., & Parameswaran, N. (2017) · Physiological Reports · doi:10.14814/phy2.13263 · Cited by 84
Clinical Practice Guidelines of the Russian Scientific Liver Society, Russian Gastroenterological Association, Russian Association of Endocrinologists, Russian Association of Gerontologists and Geriatricians and National Society for Preventive Cardiology on Diagnosis and Treatment of Non-Alcoholic Liver Disease
Ivashkin, V. T., Maevskaya, M. V., Жаркова, М. С., Kotovskaya, Y. V., Ткачева, О. Н., Troshina, E. A., Shestakova, M. V., Maev, I. V., Breder, V. V., Geyvandova, N. I., et al. (2022) · Russian Journal of Gastroenterology Hepatology Coloproctology · doi:10.22416/1382-4376-2022-32-4-104-140 · Cited by 86
Requirement of Cellular Prion Protein for Intestinal Barrier Function and Mislocalization in Patients With Inflammatory Bowel Disease
Petit, C. S. V., Barreau, F., Besnier, L., Gandille, P., Riveau, B., Château, D., Roy, M., Berrebi, D. D., Svrcek, M., Cardot, P., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.03.029 · Cited by 77
1,25-Dihydroxyvitamin D3 preserves intestinal epithelial barrier function from TNF-α induced injury via suppression of NF-kB p65 mediated MLCK-P-MLC signaling pathway
Chen, S., Zhu, J., Chen, G., Zuo, S., Zhang, J., Chen, Z., Wang, X., Li, J., Liu, Y., & Wang, P. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.03.125 · Cited by 77
The Neuromodulation of the Intestinal Immune System and Its Relevance in Inflammatory Bowel Disease
Giovangiulio, M. D., Verheijden, S., Bosmans, G., Stakenborg, N., Boeckxstaens, G. E., & Matteoli, G. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00590 · Cited by 81
Claudin-1 promotes TNF-α-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells
Bhat, A. A., Ahmad, R., Uppada, S. B., Singh, A. B., & Dhawan, P. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.10.005 · Cited by 77
Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions
Chen, Q., Chen, O., Martins, I. M., Hou, H., Zhao, X., Blumberg, J. B., & Li, B. (2017) · Food & Function · doi:10.1039/c6fo01347c · Cited by 77
Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice
Wen, L., Javed, T. A., Yimlamai, D., Mukherjee, A., Xiao, X., & Husain, S. Z. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.036 · Cited by 77
Oral administration of yeast β-glucan ameliorates inflammation and intestinal barrier in dextran sodium sulfate-induced acute colitis
Han, F., Hanxue, F., Yao, M., Yang, S., & Han, J. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.05.036 · Cited by 76
Increased Small Intestinal Permeability during Severe Acute Exacerbations of COPD
Sprooten, R. T. M., Lenaerts, K., Braeken, D. C. W., Grimbergen, I., Rutten, E. P. A., Wouters, E. F. �., & Rohde, G. G. U. (2018) · Respiration · doi:10.1159/000485935 · Cited by 76
Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis
Vancamelbeke, M., Laeremans, T., Vanhove, W., Arnauts, K., Ramalho, A. S., Farré, R., Cleynen, I., Ferrante, M., & Vermeire, S. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz064 · Cited by 77
Physiological functions of junctional adhesion molecules (JAMs) in tight junctions
Hartmann, C., Schwietzer, Y. A., Otani, T., Furuse, M., & Ebnet, K. (2020) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2020.183299 · Cited by 84
AhR activation defends gut barrier integrity against damage occurring in obesity
Postal, B. G., Ghezzal, S., Aguanno, D., André, S., Garbin, K., Genser, L., Brot‐Laroche, E., Poitou, C., Soula, H. A., Leturque, A., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101007 · Cited by 79
Connection between the Gut Microbiome, Systemic Inflammation, Gut Permeability and FOXP3 Expression in Patients with Primary Sjögren’s Syndrome
Cano-Ortiz, A., Laborda-Illanes, A., Plaza-Andrades, I. J., Membrillo, A., Villarrubia, A., Rodríguez‐Calvo‐de‐Mora, M., Gea, I. L., Sánchez‐Alcoholado, L., & Queipo‐Ortuño, M. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228733 · Cited by 79
Carbonate alkalinity and dietary protein levels affected growth performance, intestinal immune responses and intestinal microflora in Songpu mirror carp (Cyprinus carpio Songpu)
Fan, Z., Wu, D., Zhang, Y., Li, J., Xu, Q., & Wang, L. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737135 · Cited by 75
Bilirubin Nanomedicine Rescues Intestinal Barrier Destruction and Restores Mucosal Immunity in Colitis
Rahman, A. T., Shin, J., Whang, C., Jung, W., Yoo, D., Seo, C., Cho, B., & Jon, S. (2023) · ACS Nano · doi:10.1021/acsnano.3c03252 · Cited by 76
TNFAIP3 Maintains Intestinal Barrier Function and Supports Epithelial Cell Tight Junctions
Kolodziej, L. E., Lodolce, J. P., Chang, J. E., Schneider, J. R., Grimm, W. A., Bartulis, S. J., Zhu, X., Messer, J. S., Murphy, S. F., Reddy, N. R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026352 · Cited by 76
(−)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity
Contreras, T. C., Ricciardi, E., Cremonini, E., & Oteiza, P. I. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.01.024 · Cited by 76
Antigen sampling in the fish intestine
Løkka, G., & Koppang, E. O. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.02.014 · Cited by 80
Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness
Forsyth, C. B., Voigt, R. M., & Keshavarzian, A. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.002 · Cited by 76
Epithelial Cells as a Transmitter of Signals From Commensal Bacteria and Host Immune Cells
Goto, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02057 · Cited by 78
Environmental contaminant BPA causes intestinal damage by disrupting cellular repair and injury homeostasis in vivo and in vitro
Wang, K., Qiu, L., Zhu, J., Sun, Q., Qu, W., Yu, Y., Zhao, Z., Yu, Y., & Shao, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111270 · Cited by 77
Nonalcoholic Fatty Liver Disease (NAFLD) as Model of Gut–Liver Axis Interaction: From Pathophysiology to Potential Target of Treatment for Personalized Therapy
Fianchi, F., Liguori, A., Gasbarrini, A., Grieco, A., & Miele, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126485 · Cited by 77
The Microbiota–Gut–Brain Axis and Epilepsy
Yue, Q., Cai, M., Xiao, B., Zhan, Q., & Zeng, C. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01130-2 · Cited by 80
Hyperthermia induces injury to the intestinal mucosa in the mouse: evidence for an oxidative stress mechanism
Oliver, S. R., Phillips, N. A., Novosad, V. L., Bakos, M. P., Talbert, E. E., & Clanton, T. L. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00595.2011 · Cited by 74
Gut matters: Microbe-host interactions in allergic diseases
Hörmannsperger, G., Clavel, T., & Haller, D. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.993 · Cited by 74
Epithelial RAC1-dependent cytoskeleton dynamics controls cell mechanics, cell shedding and barrier integrity in intestinal inflammation
Martínez-Sánchez, L. D. C., Ngo, P. A., Pradhan, R., Becker, L. S., Boehringer, D., Soteriou, D., Kubánková, M., Schweitzer, C., Koch, T., Thonn, V., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325520 · Cited by 80
Research progress on the relationship between intestinal microecology and intestinal bowel disease
Fu, Q.-H., Song, T., Ma, X., & Cui, J. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12262 · Cited by 76
The Chronic Kidney Disease—Colonic Axis
Pahl, M. V., & Vaziri, N. D. (2015) · Seminars in Dialysis · doi:10.1111/sdi.12381 · Cited by 74
The new link between gut–brain axis and neuropsychiatric disorders
Fetissov, S. O., & Déchelotte, P. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834936e7 · Cited by 78
Statin pleiotropy prevents rho kinase-mediated intestinal epithelial barrier compromise induced byBlastocystiscysteine proteases
Mirza, H., Wu, Z., Teo, J. D. W., & Tan, K. S. W. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01814.x · Cited by 74
Combined effect of diet and cervical microbiome on the risk of cervical intraepithelial neoplasia
Seo, S., Oh, H. Y., Lee, J. K., Kong, J.-S., Lee, D. O., & Kim, M. K. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.03.019 · Cited by 76
Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children
Medeiros, P. H. Q. S., Pinto, D. V., de Almeida, J. Z., Rêgo, J. M. D. C., Rodrigues, F. A. P., Lima, A. Â. M., Bolick, D. T., Guerrant, R. L., & Oriá, R. B. (2018) · Nutrients · doi:10.3390/nu10091128 · Cited by 76
Nutritional Interventions Improved Rumen Functions and Promoted Compensatory Growth of Growth-Retarded Yaks as Revealed by Integrated Transcripts and Microbiome Analyses
Hu, R., Zou, H., Wang, Z., Cao, B., Peng, Q., Jing, X., Wang, Y., Shao, Y., Pei, Z., Zhang, X., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00318 · Cited by 76
Ascorbic acid inhibits cadmium-induced disruption of the blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways
Chen, N., Su, P., Wang, M., & Li, Y.-M. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-2138-4 · Cited by 73
Mechanisms of deoxynivalenol-induced endocytosis and degradation of tight junction proteins in jejunal IPEC-J2 cells involve selective activation of the MAPK pathways
Li, E., Horn, N. L., & Ajuwon, K. M. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03044-w · Cited by 76
Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model
Wan, F., Wang, M., Zhong, R., Liang, C., Han, H. L., Liu, L., Zhao, Y. M., Lv, H., Hou, F., Yi, B., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.798052 · Cited by 73
Partially Acid-Hydrolyzed Porphyran Improved Dextran Sulfate Sodium-Induced Acute Colitis by Modulation of Gut Microbiota and Enhancing the Mucosal Barrier
Yu, B., Wang, M., Teng, B., Veeraperumal, S., Cheung, P. C. K., Zhong, S., & Cheong, K. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c08564 · Cited by 72
Pathogenesis of Human Enterovirulent Bacteria: Lessons from Cultured, Fully Differentiated Human Colon Cancer Cell Lines
Moal, V. L.-L., & Servin, A. L. (2013) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00064-12 · Cited by 88
Emerging integrated nanohybrid drug delivery systems to facilitate the intravenous-to-oral switch in cancer chemotherapy
Luo, C., Sun, J., Du, Y., & He, Z. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.12.030 · Cited by 75
Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis
Dhillon, A. K., Kummen, M., Trøseid, M., Åkra, S., Liaskou, E., Moum, B. A., Vesterhus, M., Karlsen, T. H., Seljeflot, I., & Hov, J. R. (2018) · Liver International · doi:10.1111/liv.13979 · Cited by 73
Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease
Raya Tonetti, F., Eguileor, A., Mrdjen, M., Pathak, V., Travers, J., Nagy, L. E., & Llorente, C. (2024) · Hepatology · doi:10.1097/hep.0000000000000924 · Cited by 78
Molecular and cellular cues governing nanomaterial–mucosae interactions: from nanomedicine to nanotoxicology
das Neves, J., Arzi, R. S., & Sosnik, A. (2020) · Chemical Society Reviews · doi:10.1039/c8cs00948a · Cited by 74
Polysaccharide from the seeds of Plantago asiatica L. alleviates nonylphenol induced intestinal barrier injury by regulating tight junctions in human Caco-2 cell line
Li, F., Du, P., Yang, W., Huang, D., Nie, S., & Xie, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.259 · Cited by 72
Targeting of Mammalian Glycans Enhances Phage Predation in the Gastrointestinal Tract
Green, S. I., Liu, C. G., Yu, X. Q., Gibson, S., Salmen, W., Rajan, A., Carter, H. E., Clark, J. R., Song, X., Ramig, R. F., et al. (2021) · mBio · doi:10.1128/mbio.03474-20 · Cited by 73
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels
Huang, X., Oshima, T., Tomita, T., Fukui, H., & Miwa, H. (2021) · Biology · doi:10.3390/biology10030205 · Cited by 72
Lactobacillus paracasei modulates the gut microbiota and improves inflammation in type 2 diabetic rats
Zeng, Z., Guo, X., Zhang, J., Yuan, Q., & Chen, S. (2021) · Food & Function · doi:10.1039/d1fo00515d · Cited by 72
Foodborne Carbon Dot Exposure Induces Insulin Resistance through Gut Microbiota Dysbiosis and Damaged Intestinal Mucus Layer
Zhang, B., Fan, X., Du, H., Zhao, M., Zhang, Z., Zhu, R., He, B., Zhang, Y., Li, X., Li, J., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c01005 · Cited by 72
Structure-function effects of different pectin chemistries and its impact on the gastrointestinal immune barrier system
Tang, X., & de Vos, P. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2290230 · Cited by 76
Implications of the human microbiome in inflammatory bowel diseases
Bakhtiar, S. M., LeBlanc, J. G., Salvucci, E., Ali, A., Martín, R., Langella, P., Chatel, J., Miyoshi, A., Bermúdez‐Humarán, L. G., & Azevedo, V. (2013) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12111 · Cited by 74
Circadian rhythms, alcohol and gut interactions
Forsyth, C. B., Voigt, R. M., Burgess, H. J., Swanson, G. R., & Keshavarzian, A. (2014) · Alcohol · doi:10.1016/j.alcohol.2014.07.021 · Cited by 73
Epithelial Cell-Intrinsic Notch Signaling Plays an Essential Role in the Maintenance of Gut Immune Homeostasis
Obata, Y., Takahashi, D., Ebisawa, M., Kakiguchi, K., Yonemura, S., Jinnohara, T., Kanaya, T., Fujimura, Y., Ohmae, M., Hase, K., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101128 · Cited by 71
The immunomodulatory effects of adipose‐derived mesenchymal stem cells and mesenchymal stem cells‐conditioned medium in chronic colitis
Heidari, M., Pouya, S., Baghaei, K., Aghdaei, H. A., Namaki, S., Zali, M. R., & Hashemi, S. M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26765 · Cited by 72
Influence of orally fed a select mixture of Bacillus probiotics on intestinal T-cell migration in weaned MUC4 resistant pigs following Escherichia coli challenge
Yang, G., Zhu, Y., Zhang, W., Zhou, D. B., Zhai, C.-C., & Wang, J. (2016) · Veterinary Research · doi:10.1186/s13567-016-0355-8 · Cited by 71
Dietary l -arginine inhibits intestinalClostridium perfringenscolonisation and attenuates intestinal mucosal injury in broiler chickens
Zhang, B., Lv, Z., Li, H., Guo, S., Liu, D., & Guo, Y. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517002094 · Cited by 71
Investigating Gut Permeability in Animal Models of Disease
González-González, M., Díaz-Zepeda, C., Eyzaguirre‐Velásquez, J., González‐Arancibia, C., Bravo, J. A., & Julio‐Pieper, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01962 · Cited by 71
Essential Oils as an Intervention Strategy to Reduce Campylobacter in Poultry Production: A Review
Micciche, A. C., Rothrock, M. J., Yang, Y., & Ricke, S. C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01058 · Cited by 76
Loricrin: Past, Present, and Future
Ishitsuka, Y., & Roop, D. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072271 · Cited by 76
Influence of Glycyrrhiza glabra Extract on Growth, Gene Expression of Gut Integrity, and Campylobacter jejuni Colonization in Broiler Chickens
Ibrahim, D., Sewid, A. H., Arisha, A. H., El‐fattah, A. H. A., Abdelaziz, A. M., Al-Jabr, O. A., & Kishawy, A. T. Y. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.612063 · Cited by 71
Effect of dietary supplementation of Cetobacterium somerae XMX-1 fermentation product on gut and liver health and resistance against bacterial infection of the genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
Zhou, W., Xie, M., Xie, Y., Liang, H., Li, M., Ran, C., & Zhou, Z. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.04.019 · Cited by 71
Lactobacillus rhamnosus CY12 Enhances Intestinal Barrier Function by Regulating Tight Junction Protein Expression, Oxidative Stress, and Inflammation Response in Lipopolysaccharide-Induced Caco-2 Cells
Zheng, J., Ahmad, A. A., Yang, Y., Liang, Z., Shen, W., Feng, M., Shen, J., Lan, X., & Ding, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911162 · Cited by 73
The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
Huo, C., Li, G., Hu, Y., & Sun, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214195 · Cited by 76
Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis
Oami, T., Abtahi, S., Shimazui, T., Chen, C., Sweat, Y. Y., Liang, Z., Burd, E. M., Farris, A. B., Roland, J. T., Tsukita, S., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217877121 · Cited by 74
Roseburia intestinalis ‐derived extracellular vesicles ameliorate colitis by modulating intestinal barrier, microbiome, and inflammatory responses
Han, H. S., Hwang, S., Choi, K. Y., Hitayezu, E., Mabwi, H. A., Enkhbayar, A., Song, D., Kim, M., Park, J. S., Park, Y., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12487 · Cited by 72
The natural compound celastrol inhibits necroptosis and alleviates ulcerative colitis in mice
Jia, Z., Xu, C., Shen, J., Xia, T., Yang, J., & He, Y. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.09.029 · Cited by 71
Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction
Ma, Y., Semba, S., Khan, M. R. I., Bochimoto, H., Watanabe, T., Fujiya, M., Kohgo, Y., Liu, Y., & Taniguchi, T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.006 · Cited by 71
The effects of the microbiota on the host immune system
Karczewski, J., Poniedziałek, B., Adamski, Z., & Rzymski, P. (2014) · Autoimmunity · doi:10.3109/08916934.2014.938322 · Cited by 73
Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells
LaFemina, M. J., Rokkam, D., Chandrasena, A., Pan, J., Bajaj, A., Johnson, M. D., & Frank, J. A. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00233.2010 · Cited by 74
A Novel Approach to Maintain Gut Mucosal Integrity Using an Oral Enzyme Supplement
Hamarneh, S. R., Mohamed, M. M. R., Economopoulos, K. P., Morrison, S. A., Phupitakphol, T., Tantillo, T. J., Gul, S. S., Gharedaghi, M. H., Tao, Q., Kaliannan, K., et al. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000916 · Cited by 71
Effect of barrier microbes on organ-based inflammation
Garn, H., Neves, J. F., Blumberg, R. S., & Renz, H. E. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.04.031 · Cited by 70
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability
Nalle, S. C., Zuo, L., Ong, M. L. D. M., Singh, G., Worthylake, A. M., Choi, W., Manresa, M. C., Southworth, A. P., Edelblum, K. L., Baker, G. J., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci98554 · Cited by 70
Gastrointestinal synthetic epithelial linings
Li, J., Wang, T., Kirtane, A. R., Shi, Y., Jones, A., Moussa, Z., Lopes, A., Collins, J., Tamang, S. M., Hess, K., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abc0441 · Cited by 70
Gut Microbiota‐Bile Acid Crosstalk in Diarrhea‐Irritable Bowel Syndrome
Zhan, K., Zheng, H., Jian-qing, L., Wu, H., Qin, S., Luo, L., & Huang, S. (2020) · BioMed Research International · doi:10.1155/2020/3828249 · Cited by 72
The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life
Kaczmarczyk, M., Löber, U., Adamek, K., Węgrzyn, D., Skonieczna‐Żydecka, K., Malinowski, D., Łoniewski, I., Markó, L., Ulas, T., Forslund, S. K., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02839-w · Cited by 72
Orally‐Delivered, Cytokine‐Engineered Extracellular Vesicles for Targeted Treatment of Inflammatory Bowel Disease
Liu, J., Ren, H., Zhang, C., Li, J., Qiu, Q., Zhang, N., Jiang, N., Lovell, J. F., & Zhang, Y. (2023) · Small · doi:10.1002/smll.202304023 · Cited by 72
Transepithelial antigen delivery in the small intestine
Knoop, K. A., Miller, M. J., & Newberry, R. D. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835cf1cd · Cited by 70
Porcine lactoferrin-derived peptide LFP-20 protects intestinal barrier by maintaining tight junction complex and modulating inflammatory response
Zong, X., Hu, W., Song, D., Li, Z., Du, H., Lu, Z., & Wang, Y. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.01.009 · Cited by 70
Contribution of Zinc and Zinc Transporters in the Pathogenesis of Inflammatory Bowel Diseases
Ohashi, W., & Fukada, T. (2019) · Journal of Immunology Research · doi:10.1155/2019/8396878 · Cited by 74
A Multifunctional Nanotherapy for Targeted Treatment of Colon Cancer by Simultaneously Regulating Tumor Microenvironment
Zhang, Q., Zhang, F., Li, S., Liu, R., Jin, T., Dou, Y., Zhou, Z., & Zhang, J. (2019) · Theranostics · doi:10.7150/thno.34377 · Cited by 70
Dietary Chitooligosaccharide Inclusion as an Alternative to Antibiotics Improves Intestinal Morphology, Barrier Function, Antioxidant Capacity, and Immunity of Broilers at Early Age
Li, J., Cheng, Y., Chen, Y., Qu, H., Zhao, Y., Wen, C., & Zhou, Y. (2019) · Animals · doi:10.3390/ani9080493 · Cited by 70
Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells
Li, W., Gao, M., & Han, T. (2020) · Food & Function · doi:10.1039/d0fo00030b · Cited by 69
Serum zonulin and claudin-5 levels in patients with schizophrenia
Usta, A., Kılıç, F., Demirdaş, A., Işık, Ü., Doğuç, D. K., & Bozkurt, M. (2020) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-020-01152-9 · Cited by 68
Bifidobacterium longum Ameliorates Dextran Sulfate Sodium-Induced Colitis by Producing Conjugated Linoleic Acid, Protecting Intestinal Mechanical Barrier, Restoring Unbalanced Gut Microbiota, and Regulating the Toll-Like Receptor-4/Nuclear Factor-κB Signaling Pathway
Chen, Y., Chen, H., Ding, J., Stanton, C., Ross, R. P., Zhao, J., Zhang, H., Yang, B. K., & Chen, W. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c06176 · Cited by 72
A review of gut failure as a cause and consequence of critical illness
Soranno, D. E., Coopersmith, C. M., Brinkworth, J. F., Factora, F. N., Muntean, J. H., Mythen, M. G., Raphael, J., Shaw, A., Vachharajani, V., & Messer, J. S. (2025) · Critical Care · doi:10.1186/s13054-025-05309-7 · Cited by 77
Clinical Characteristics Associated With Postoperative Intestinal Epithelial Barrier Dysfunction in Children With Congenital Heart Disease*
Typpo, K., Larmonier, C. B., Deschenes, J., Redford, D. T., Kiela, P. R., & Ghishan, F. K. (2014) · Pediatric Critical Care Medicine · doi:10.1097/pcc.0000000000000256 · Cited by 74
A Selected Lactobacillus rhamnosus Strain Promotes EGFR-Independent Akt Activation in an Enterotoxigenic Escherichia coli K88-Infected IPEC-J2 Cell Model
Zhang, W., Zhu, Y., Yang, J.-C., Yang, G., Zhou, D. B., & Wang, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125717 · Cited by 69
Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase
Bhargava, A., Cotton, J. A., Dixon, B. R., Gedamu, L., Yates, R. M., & Buret, A. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136102 · Cited by 69
New therapeutic agents for acromegaly
Melmed, S. K. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.196 · Cited by 69
Protective effect of hydrogen sulfide on TNF-α and IFN-γ-induced injury of intestinal epithelial barrier function in Caco-2 monolayers
Chen, S.-W., Zhu, J., Zuo, S., Zhang, J., Chen, Z., Chen, G., Wang, X., Pan, Y., Liu, Y., & Wang, P. (2015) · Inflammation Research · doi:10.1007/s00011-015-0862-5 · Cited by 69
Chlorogenic acid ameliorates intestinal mitochondrial injury by increasing antioxidant effects and activity of respiratory complexes
Zhou, Y., Zhou, L., Ruan, Z., Mi, S., Jiang, M., Li, X., Wu, X., Deng, Z., & Yin, Y. (2016) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2015.1127130 · Cited by 68
Immunomodulatory potential of dietary soybean-derived isoflavones and saponins in pigs1
Smith, B. N., & Dilger, R. N. (2018) · Journal of Animal Science · doi:10.1093/jas/sky036 · Cited by 69
CCAT1 lncRNA Promotes Inflammatory Bowel Disease Malignancy by Destroying Intestinal Barrier via Downregulating miR-185-3p
Ma, D., Cao, Y., Wang, Z., He, J., Chen, H., Xiong, H., Ren, L., Shen, C., Zhang, X., Yan, T., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy381 · Cited by 69

Authors: Turner, J. R.
Affiliations: University of Chicago (US)
Corresponding author: Turner, Jerrold R.
ORCID: Turner, Jerrold R.
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-11
Volume: 9
Issue: 11
Pages: 799-809
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2653
OpenAlex: W2145189896
Cited by: 3,952
References: 120
Citations by year: 2026: 404 · 2025: 298 · 2024: 341 · 2023: 313 · 2022: 356 · 2021: 302 · 2020: 303 · 2019: 262 · 2018: 210 · 2017: 212 · 2016: 183 · 2015: 178 · 2014: 161 · 2013: 126 · 2012: 139
FWCI: 15.07
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL091889, HL091889)
National Cancer Institute (CA 14599, P30CA014599)
National Institute of Diabetes and Digestive and Kidney Diseases (DK068271, DK061931, P01DK067887, DK042086, DK-67887, P30DK042086, R01DK068271, R01DK061931)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: intestinal barrier, intestinal epithelium, mucosal immunity, nutrient absorption, selective permeability, dietary antigens, microbial products, barrier dysfunction, intestinal diseases
MeSH terms: Animals, Cell Membrane Permeability, Cytoskeleton, Epithelial Cells, Homeostasis, Humans, Intestinal Diseases, Intestinal Mucosa, Membrane Proteins, Cytokines, Immunity, Mucosal, Tight Junctions, Gastrointestinal Tract

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intestinal mucosal barrier function in health and disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks