The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Intestinal mucosal barrier function in health and disease
Abstract
Mucosal surfaces are lined by epithelial cells. These cells establish a barrier between sometimes hostile external environments and the internal milieu. However, mucosae are also responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products. Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli. Here I discuss these discoveries along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.
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“It was reported that solutes and water cross TJs through 2 distinct pathways based on their size and charge selectivity: the pore pathway48, 49, 50 and the leak pathway.48,51”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [49]
Citations
Cites
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Yeung, C.-Y., Chiang Chiau, J.-S., Chan, W.-T., Jiang, C.-B., Cheng, M.-L., Liu, H.-L., & Lee, H.-C. (2013) · Gastroenterology Research and Practice · doi:10.1155/2013/973209 · Cited by 49
Gut permeability, obesity, and metabolic disorders: who is the chicken and who is the egg
Fasano, A. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.148338 · Cited by 45
Between Dysbiosis, Maternal Immune Activation and Autism: Is There a Common Pathway?
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Jin, S., Wetzel, D., & Schirmer, M. (2022) · Current Opinion in Microbiology · doi:10.1016/j.mib.2022.102147 · Cited by 39
Di Caro, V., Alcamo, A. M., Cummings, J. L., Clark, R. S. B., Novak, E. A., Mollen, K. P., Morowitz, M. J., & Aneja, R. K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224838 · Cited by 32
Building gut from scratch — progress and update of intestinal tissue engineering
Tullie, L., Jones, B. C., De Coppi, P., & Li, V. S. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00586-x · Cited by 27
Drobny, A., Ngo, P. A., Neurath, M. F., Zunke, F., & López-Posadas, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.655123 · Cited by 24
Dumitru, C. N., Dumitru, A. O., Goroftei, L., Niculet, E., Ignat, M. D., Baroiu, L., Nechita, A., & Balan, G. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18060651 · Cited by 4
Li, X., Wang, G., Zhang, M., Zhai, Q., Cui, S., Zhao, L., Song, X., Xia, Y., Xiong, Z., & Ai, L. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108354 · Cited by 1
Metadata
- Authors
- Turner, J. R.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Turner, Jerrold R.
- ORCID
- Turner, Jerrold R.
- Venue
- Nature reviews. Immunology
- Published
- 2009-11
- Volume
- 9
- Issue
- 11
- Pages
- 799-809
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2145189896
- Cited by
- 3,952
- References
- 120
- Citations by year
- 2026: 404 · 2025: 298 · 2024: 341 · 2023: 313 · 2022: 356 · 2021: 302 · 2020: 303 · 2019: 262 · 2018: 210 · 2017: 212 · 2016: 183 · 2015: 178 · 2014: 161 · 2013: 126 · 2012: 139
- FWCI
- 15.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL091889, HL091889)
- National Cancer Institute (CA 14599, P30CA014599)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK068271, DK061931, P01DK067887, DK042086, DK-67887, P30DK042086, R01DK068271, R01DK061931)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- intestinal barrier, intestinal epithelium, mucosal immunity, nutrient absorption, selective permeability, dietary antigens, microbial products, barrier dysfunction, intestinal diseases
- MeSH terms
- Animals, Cell Membrane Permeability, Cytoskeleton, Epithelial Cells, Homeostasis, Humans, Intestinal Diseases, Intestinal Mucosa, Membrane Proteins, Cytokines, Immunity, Mucosal, Tight Junctions, Gastrointestinal Tract
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