Cited by 1,368Immune Response and InflammationNF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

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The SYK tyrosine kinase: a crucial player in diverse biological functions

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Mócsai, Attila, Ruland, Jürgen, Tybulewicz, Victor L. J.·2010·Nature Reviews Immunology

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Abstract

Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.

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Authors: Mócsai, A., Ruland, J., & Tybulewicz, V. L. J.
Affiliations: Semmelweis University (HU)
TUM Klinikum (DE)
National Institute for Medical Research (GB)
Corresponding author: Mócsai, Attila
ORCID: Mócsai, Attila
Ruland, Jürgen
Tybulewicz, Victor L. J.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2010-05-14
Volume: 10
Issue: 6
Pages: 387-402
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2765
PMC: PMC4782221
OpenAlex: W2017341404
Cited by: 1,368
References: 194
Citations by year: 2026: 71 · 2025: 94 · 2024: 107 · 2023: 111 · 2022: 99 · 2021: 100 · 2020: 78 · 2019: 76 · 2018: 75 · 2017: 87 · 2016: 78 · 2015: 70 · 2014: 87 · 2013: 78 · 2012: 84
FWCI: 6.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Site cant be reached (submittedVersion)
Funders: Wellcome Trust (087782)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords: Syk, innate immune recognition, C-type lectin, integrins, NLRP3 inflammasome, osteoclast maturation, bone metabolism, platelet activation, vascular development, cell adhesion, autoimmune disease, B-cell lymphoma, therapeutic target, Drosophila melanogaster
MeSH terms: Syk Kinase, Animals, Cell Adhesion, Humans, Protein-Tyrosine Kinases, Receptors, Immunologic, Signal Transduction, Cell Lineage, Intracellular Signaling Peptides and Proteins

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The SYK tyrosine kinase: a crucial player in diverse biological functions

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