The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
The SYK tyrosine kinase: a crucial player in diverse biological functions
Open accessAbstract
Spleen tyrosine kinase (SYK) is known to have a crucial role in adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions, including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates new targets, including the CARD9-BCL-10-MALT1 pathway and the NLRP3 inflammasome. Studies using Drosophila melanogaster suggest that there is an evolutionarily ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of the diverse functions of SYK and how this is being translated for therapeutic purposes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“SYK is perhaps best known for the critical role that it plays in mounting protective antifungal immune responses downstream of C-type lectin (CLEC) receptors expressed on innate immune cells (Lionakis et al., 2017; Mocsai et al., 2010).”
From SYK coordinates neuroprotective microglial responses in neurodegenerative disease (2022) · cites this paper as Mocsai et al., 2010
In the citing paper
“However, recent studies indicate that it is also involved in innate immunity and non-immune functions.”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [96]
In the citing paper
“Upon ITAM phosphorylation, the SYK tyrosine kinase is recruited to the receptor and its activation leads to downstream phosphorylation events including activation of SHP-1 and RAC (11, 12)”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [11]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
Davis, R. E., Ngo, V. N., Lenz, G., Tolar, P., Young, R. M., Romesser, P. B., Kohlhammer, H., Lamy, L., Zhao, H., Yang, Y., et al. (2010) · Nature · doi:10.1038/nature08638 · Cited by 1,651
Signalling through C-type lectin receptors: shaping immune responses
Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,449
Reth, M. G. (1989) · Nature · doi:10.1038/338383b0 · Cited by 1,430
Daëron, M. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.203 · Cited by 1,227
LeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1460 · Cited by 1,191
Self-citationDectin-1: a signalling non-TLR pattern-recognition receptor
Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 947
Self-citationRogers, N. C., Slack, E. M. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L., Gordon, S., Tybulewicz, V. L. J., Brown, G. D., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.004 · Cited by 897
Self-citation
Cited by
Sorted by citations
Items 1,001–1,003 of 1,003
Sahillioglu, A. C., & Schumacher, T. N. (2021) · Human Gene Therapy · doi:10.1089/hum.2021.148 · Cited by 3
Wang, W.-H., Krisenko, M. O., Higgins, R. L., Morman, R. E., & Geahlen, R. L. (2019) · ImmunoHorizons · doi:10.4049/immunohorizons.1800084 · Cited by 3
AXL-mediate GEF-H1 phosphorylation was involved in microglia synapse phagocytosis in 5xFAD mice
Chen, G., Zhang, J., Dong, A., Xiao, L., Huang, P., Huang, T., Ye, Q., & Huang, E. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115327 · Cited by 1
Metadata
- Authors
- Mócsai, A., Ruland, J., & Tybulewicz, V. L. J.
- Affiliations
- Semmelweis University (HU)
- TUM Klinikum (DE)
- National Institute for Medical Research (GB)
- Corresponding author
- Mócsai, Attila
- Venue
- Nature Reviews Immunology
- Published
- 2010-05-14
- Volume
- 10
- Issue
- 6
- Pages
- 387-402
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4782221
- OpenAlex
- W2017341404
- Cited by
- 1,368
- References
- 194
- Citations by year
- 2026: 71 · 2025: 94 · 2024: 107 · 2023: 111 · 2022: 99 · 2021: 100 · 2020: 78 · 2019: 76 · 2018: 75 · 2017: 87 · 2016: 78 · 2015: 70 · 2014: 87 · 2013: 78 · 2012: 84
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Site cant be reached (submittedVersion)
- Funders
- Wellcome Trust (087782)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Keywords
- Syk, innate immune recognition, C-type lectin, integrins, NLRP3 inflammasome, osteoclast maturation, bone metabolism, platelet activation, vascular development, cell adhesion, autoimmune disease, B-cell lymphoma, therapeutic target, Drosophila melanogaster
- MeSH terms
- Syk Kinase, Animals, Cell Adhesion, Humans, Protein-Tyrosine Kinases, Receptors, Immunologic, Signal Transduction, Cell Lineage, Intracellular Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
