The SYK tyrosine kinase: a crucial player in diverse biological functions

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Davis, R. E., Ngo, V. N., Lenz, G., Tolar, P., Young, R. M., Romesser, P. B., Kohlhammer, H., Lamy, L., Zhao, H., Yang, Y., et al. (2010) · Nature · doi:10.1038/nature08638 · Cited by 1,651

Signalling through C-type lectin receptors: shaping immune responses

Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,449

Antigen receptor tail clue

Reth, M. G. (1989) · Nature · doi:10.1038/338383b0 · Cited by 1,430

F c RECEPTOR BIOLOGY

Daëron, M. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.203 · Cited by 1,227

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

LeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1460 · Cited by 1,191

Dectin-1: a signalling non-TLR pattern-recognition receptor

Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 947

Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

Rogers, N. C., Slack, E. M. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L., Gordon, S., Tybulewicz, V. L. J., Brown, G. D., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.004 · Cited by 897

Impact of lipid rafts on the T -cell-receptor and peptide-major-histocompatibility-complex interactions under different measurement conditions

Li, L., Xu, G., & Song, F. (2017) · Physical review. E · doi:10.1103/physreve.95.012403 · Cited by 14

Identification of pyrazolopyridine derivatives as novel spleen tyrosine kinase inhibitors

Huang, Y., Li, Y., Dong, G., Zhang, W., Liu, N., & Sheng, C. (2018) · Archiv der Pharmazie · doi:10.1002/ardp.201800083 · Cited by 14

Analysis of Syk/PECAM-1 signaling pathway in low shear stress induced atherosclerosis based on ultrasound imaging

Xia, L., Zhang, Q., Sun, Y., Chen, B.-G., & Yu, Z. (2021) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2021.105953 · Cited by 14

Insights on the Functional Role of Beta-Glucans in Fungal Immunity Using Receptor-Deficient Mouse Models

Desamero, M. J. M., Chung, S.-H., & Kakuta, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094778 · Cited by 14

Regulatory interplay between Vav1, Syk and β-catenin occurs in lung cancer cells

Boudria, R., Laurienté, V., Oudar, A., Harouna-Rachidi, S., Dondi, E., Roy, C. L., Gardano, L., Varin‐Blank, N., & Guittat, L. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110079 · Cited by 15

A novel selective spleen tyrosine kinase inhibitor SKI-O-703 (cevidoplenib) ameliorates lupus nephritis and serum-induced arthritis in murine models

Cho, S., Jang, E., Yoon, T., Hwang, H., & Youn, J. (2022) · Clinical & Experimental Immunology · doi:10.1093/cei/uxac096 · Cited by 14

Morus bombycis extract suppresses mast cell activation and IgE-mediated allergic reaction in mice

Kim, J. D., Kim, D. K., Kim, H. S., Kim, A., Kim, B., Her, E., Park, K. H., Kim, H. S., Kim, Y. M., & Choi, W. S. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.12.046 · Cited by 14

Targeting Spleen Tyrosine Kinase (Syk) for Treatment of Human Disease

DiCruz, O. J. (2012) · Journal of Pharmaceutics & Drug Delivery Research · doi:10.4172/2325-9604.1000107 · Cited by 14

Premature Terminal Differentiation Protects from Deregulated Lymphocyte Activation by ITK-Syk

Bach, M. P., Hug, E., Werner, M., Holch, J. W., Sprissler, C., Pechloff, K., Zirlik, K., Zeiser, R., Dierks, C., Ruland, J., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300420 · Cited by 14

Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7

Mohammad, D. K., Nore, B. F., Gustafsson, M. O., Mohamed, A. J., & Smith, C. I. E. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.06.024 · Cited by 14

Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits

Bonasera, S. J., Arikkath, J., Boska, M. D., Chaudoin, T. R., DeKorver, N. W., Goulding, E. H., Hoke, T. A., Mojtahedzedah, V., Reyelts, C. D., Sajja, B. R., et al. (2016) · Aging · doi:10.18632/aging.101040 · Cited by 14

Spleen Tyrosine Kinase Inhibition Ameliorates Tubular Inflammation in IgA Nephropathy

Yiu, W. H., Chan, K. W., Chan, L. Y. Y., Leung, J. C. K., Lai, K. N., & Tang, S. C. W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.650888 · Cited by 14

NF ‐κB activation mediates LPS ‐or zymosan‐induced hypotension and inflammation reversed by BAY 61‐3606, a selective Syk inhibitor, in rat models of septic and non‐septic shock

Fırat, S. Ş., Temiz-Reşitoğlu, M., Güden, D. S., Şenol, Ş. P., Sari, A. N., Cil, M., Unsal, D., Korkmaz, B., Tunçtan, B., Malik, K. U., et al. (2018) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13045 · Cited by 14

Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer

Yu, Y., Rahmanto, Y. S., Shen, Y., Ardighieri, L., Davidson, B., Gaillard, S. L., Ayhan, A., Shi, X., Xuan, J., Wang, T., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.055 · Cited by 15

Immunoregulatory Property of C-Type Lectin-Like Receptors in Fibrosing Interstitial Lung Diseases

Effendi, W. I., Nagano, T., Hasan, H., & Yudhawati, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103665 · Cited by 15

Safety, pharmacokinetics and pharmacodynamics of a topical SYK inhibitor in cutaneous lupus erythematosus: A double‐blind Phase Ib study

Walker, A. L., Erwig, L. P., Foster, K., Nevin, K., Wenzel, J., Worm, M., Williams, N., Ratia, N., Hoang, B. Q., Schneider‐Merck, T., et al. (2020) · Experimental Dermatology · doi:10.1111/exd.14253 · Cited by 14

NLRP3 Inflammasome Contributes to Host Defense Against Talaromyces marneffei Infection

Ma, H., Chan, J. F., Tan, Y. P., Kui, L., Tsang, C., Pei, S. L. C., Lau, Y., Woo, P. C. Y., & Lee, P. P. W. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.760095 · Cited by 14

Platelets are a major player and represent a therapeutic opportunity in systemic lupus erythematosus

Robert, M., & Scherlinger, M. (2023) · Joint Bone Spine · doi:10.1016/j.jbspin.2023.105622 · Cited by 13

Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation

Zhang, P., von Ungern‐Sternberg, S. N. I., Hastenplug, L., Solari, F. A., Sickmann, A., Kuijpers, M. J. E., Heemskerk, J. W. M., Walter, U., & Jurk, K. (2024) · Thrombosis and Haemostasis · doi:10.1055/a-2311-0117 · Cited by 13

Involvement of Siglec-15 in regulating RAP1/RAC signaling in cytoskeletal remodeling in osteoclasts mediated by macrophage colony-stimulating factor

Kobayashi, H., Terkawi, M. A., Ota, M., Hasegawa, T., Yamamoto, T., Shimizu, T., Sato, D., Fujita, R., Murakami, T., Amizuka, N., et al. (2024) · Bone Research · doi:10.1038/s41413-024-00340-w · Cited by 13

SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy

Millan, A. J., Allain, V., Nayak, I., Libang, J. B., Quijada-Madrid, L. M., Arakawa-Hoyt, J. S., Ureno, G., Rothrock, A., Shemesh, A., Aguilar, O. A., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf012 · Cited by 13

Efficacy and Safety of Syk and BTK Inhibitors in Immune Thrombocytopenia: A Comprehensive Review of Emerging Evidence

Heidari, A., Mazid, A. S., Behroozfar, M., Ghotbi, N., Fathabadi, F. F., Eghbali, S., & Heidari, N. (2025) · Mediators of Inflammation · doi:10.1155/mi/5578929 · Cited by 13

Expression analysis of the estrogen receptor target genes in renal cell carcinoma

Liu, Z., Lü, Y., He, Z., Chen, L., & Lu, Y. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2014.2766 · Cited by 13

Novel treatment approaches and future perspectives in follicular lymphoma

Sutamtewagul, G., & Link, B. K. (2019) · Therapeutic Advances in Hematology · doi:10.1177/2040620718820510 · Cited by 13

SYK-3BP2 Pathway Activity in Parenchymal and Myeloid Cells Is a Key Pathogenic Factor in Metabolic Steatohepatitis

Luci, C., Vieira, E., Bourinet, M., Rousseau, D., Bonnafous, S., Patouraux, S., Lefevre, L., Larbret, F., Prod’homme, V., Iannelli, A., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.08.004 · Cited by 14

Signaling through Syk or CARD9 Mediates Species-Specific Anti-CandidaProtection in Bone Marrow Chimeric Mice

Zajta, E., Csonka, K., Tóth, A., Tiszlavicz, L., Németh, T., Orosz, A., Novák, Á., Csikós, M., Vágvölgyi, C., Mócsai, A., et al. (2021) · mBio · doi:10.1128/mbio.01608-21 · Cited by 16

A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

Kim, M., Reinhard, C., & Niehrs, C. (2021) · eLife · doi:10.7554/elife.70885 · Cited by 14

Antithrombotic Effects of Fostamatinib in Combination with Conventional Antiplatelet Drugs

Harbi, M. H., Smith, C. W., Alenazy, F. O., Nicolson, P. L. R., Tiwari, A., Watson, S. P., & Thomas, M. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136982 · Cited by 13

Candidalysin amplifies the immune inflammatory response in Candida albicans keratitis through the TREM-1/DAP12 pathway

Hu, L., Bai, G., Xu, Q., Zhao, G., Jiang, N., Yao, H., Liu, X., & Du, Z. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110195 · Cited by 13

TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities

Su, P., Zhang, J., Wu, J., Chen, H., Luo, W., & Hu, M. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115058 · Cited by 13

A CARD9 Polymorphism Is Associated with Decreased Likelihood of Persistent Conjugated Hyperbilirubinemia in Intestinal Failure

Burghardt, K. M., Avinashi, V., Kosar, C., Xu, W., Wales, P. W., Avitzur, Y., & Muise, A. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085915 · Cited by 13

Myeloperoxidase deficiency enhances zymosan phagocytosis associated with up-regulation of surface expression of CD11b in mouse neutrophils

Fujimoto, K., Motowaki, T., Tamura, N., & Aratani, Y. (2016) · Free Radical Research · doi:10.1080/10715762.2016.1244821 · Cited by 13

SYK kinase mediates brown fat differentiation and activation

Knoll, M., Winther, S., Natarajan, A., Yang, H., Jiang, M., Thiru, P., Shahsafaei, A., Chavarria, T. E., Lamming, D. W., Sun, L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02162-3 · Cited by 14

Spleen tyrosine kinase regulates crosstalk of hypoxia-inducible factor-1α and nuclear factor (erythroid-derived2)-like 2 for B cell survival

Jang, J.-W., Park, S., & Moon, E. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107509 · Cited by 13

Fine-Tuning of Platelet Responses by Serine/Threonine Protein Kinases and Phosphatases—Just the Beginning

Shiravand, Y., Walter, U., & Jurk, K. (2021) · Hämostaseologie · doi:10.1055/a-1476-7873 · Cited by 13

Activation of Innate Immunity in Graft-versus-Host Disease: Implications for Novel Targets?

Zeiser, R. (2015) · Oncology Research and Treatment · doi:10.1159/000381296 · Cited by 13

Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs

Lee, S. J., Choi, J., Han, B., Kim, H. S., Song, H., Lee, J., Nam, S., Goh, S., Kim, J. H., Koh, J. S., et al. (2016) · FEBS Journal · doi:10.1111/febs.13831 · Cited by 13

Integrated transcriptomics and proteomics assay identifies the role of FCGR1A in maintaining sperm fertilization capacity during semen cryopreservation in sheep

Bai, J., Zhou, G., Hao, S., Liu, Y., Guo, Y., Wang, J., Liu, H., Wang, L., Li, J., Liu, A., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1177774 · Cited by 12

N-terminal processing by dipeptidyl peptidase 9: Cut and Go!

Zolg, S., Donzelli, L., & Geiss‐Friedlander, R. (2024) · Biochimie · doi:10.1016/j.biochi.2024.03.002 · Cited by 13

A dual-targeting therapeutic nanobubble for imaging-guided atherosclerosis treatment

Lin, J., Chen, X., Li, Y., Yu, L., Chen, Y., & Zhang, B. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101037 · Cited by 12

Balancing immune response: SHP1 controls neutrophil activation in inflamed lungs

Ghimire, L., & Luo, H. R. (2024) · Journal of Clinical Investigation · doi:10.1172/jci187056 · Cited by 12

Syk mediates airway contractility independent of leukocyte function

Wang, X., Khanna, N., Wu, J. K. Y., Pollitt, K. J. G., Evans, G. J., Chow, C., & Scott, J. A. (2015) · Allergy · doi:10.1111/all.12564 · Cited by 12

SYK is a target of lymphocyte-derived microparticles in the induction of apoptosis of human retinoblastoma cells

Qiu, Q., Yang, C., Xiong, W., Tahiri, H., Payeur, M., Superstein, R., Carret, A., Hamel, P., Ellezam, B., Bussières, M., et al. (2015) · APOPTOSIS · doi:10.1007/s10495-015-1177-2 · Cited by 12

Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression

Wang, Y., Jiang, L., Mo, X., Lan, Y., Yang, X. Y., Liu, X., Zhang, J., Zhu, L., Liu, J., & Wu, X. (2017) · Molecular Pharmacology · doi:10.1124/mol.116.107417 · Cited by 12

Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis

Clarke, A. S., Rousseau, E., Wang, K., Kim, J., Murray, B. P., Bannister, R. M., Matzkies, F., Currie, K., & Paolo, J. A. D. (2018) · Thrombosis Research · doi:10.1016/j.thromres.2018.08.012 · Cited by 12

Spleen Tyrosine Kinase (SYK) in the Progression of Peritoneal Fibrosis Through Activation of the TGF-β1/Smad3 Signaling Pathway

Liu, K., Zhou, N., Zou, Y., Yang, Y., OuYang, S.-X., & Liang, Y. (2019) · Medical Science Monitor · doi:10.12659/msm.917287 · Cited by 12

Different effectiveness of fungal pathogen-associated molecular patterns (PAMPs) in activating rat peritoneal mast cells

Żelechowska, P., Brzezińska‐Błaszczyk, E., Agier, J., & Kozłowska, E. (2022) · Immunology Letters · doi:10.1016/j.imlet.2022.06.002 · Cited by 12

SYK Is Associated With Malignant Phenotype and Immune Checkpoints in Diffuse Glioma

Zhou, Q., Wei, M., Shen, W., Huang, S., Fan, J., & Huang, H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.899883 · Cited by 12

Syk promotes phagocytosis by inducing reactive oxygen species generation and suppressing SOCS1 in macrophage-mediated inflammatory responses

Yi, Y., Kim, H. G., Kim, J. H., Yang, W. S., Kim, E., Park, J. G., Aziz, N., Parameswaran, N., & Cho, J. Y. (2022) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320221133018 · Cited by 13

Comprehensive analysis of LILR family genes expression and tumour‐infiltrating immune cells in early‐stage pancreatic ductal adenocarcinoma

Gao, Q., Mo, S., Han, C., Liao, X., Yang, C., Wang, X., Liang, T., He, Y., Chen, Z., Zhu, G., et al. (2023) · IET Systems Biology · doi:10.1049/syb2.12058 · Cited by 12

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM

Bashore, F. M., Katis, V. L., Du, Y., Sikdar, A., Wang, D., Bradshaw, W. J., Rygiel, K. A., Leisner, T. M., Chalk, R., Mishra, S., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0293548 · Cited by 12

Gene Expression Profile of THP-1 Monocytes Following Knockdown of DAP12, A Causative Gene for Nasu-Hakola Disease

Satoh, J., Shimamura, Y., & Tabunoki, H. (2011) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-011-9769-z · Cited by 12

Role of spleen tyrosine kinase in the pathogenesis of chronic lymphocytic leukemia

Feng, G., & Wang, X. (2014) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2014.891026 · Cited by 12

The arthritis severity locus Cia5a regulates the expression of inflammatory mediators including Syk pathway genes and proteases in pristane-induced arthritis

Brenner, M., & Gulko, P. S. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-710 · Cited by 12

Inhibition of Spleen Tyrosine Kinase Reduces Renal Allograft Injury in a Rat Model of Acute Antibody-Mediated Rejection in Sensitized Recipients

Chandran, S. R., Han, Y., Tesch, G. H., Paolo, J. A. D., Mulley, W. R., Kanellis, J., Ma, F. Y., & Nikolic‐Paterson, D. J. (2017) · Transplantation · doi:10.1097/tp.0000000000001826 · Cited by 12

Davallia mariesiiMoore Improves FcεRI-Mediated Allergic Responses in the Rat Basophilic Leukemia Mast Cell Line RBL-2H3 and Passive Cutaneous Anaphylaxis in Mice

Ju, H., Oh, T. W., Yang, J., Park, K., & Yeul, J. (2017) · Mediators of Inflammation · doi:10.1155/2017/8701650 · Cited by 12

Jacareubin inhibits FcεRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation of mast cells

Castillo-Arellano, J. I., Guzmán‐Gutiérrez, S. L., Ibarra-Sánchez, A., Hernández‐Ortega, S., Nieto‐Camacho, A., Medina‐Campos, O. N., Pedraza‐Chaverrí, J., Reyes‐Chilpa, R., & González‐Espinosa, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.05.002 · Cited by 12

Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expression

Fathi, N. N., Mohammad, D. K., Görgens, A., Andaloussi, S. E., Zain, R., Nore, B. F., & Rjh, S. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.09.019 · Cited by 12

Low intensity pulsed ultrasound (LIPUS) maintains osteogenic potency by the increased expression and stability of Nanog through spleen tyrosine kinase (Syk) activation

Kusuyama, J., Seong, C., Makarewicz, N., Ohnishi, T., Shima, K., Semba, I., Bandow, K., & Matsuguchi, T. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109345 · Cited by 12

miR-25-3p promotes endothelial cell angiogenesis in aging mice via TULA-2/SYK/VEGFR-2 downregulation

Lian, C., Zhao, L., Qiu, J., Wang, Y., Chen, R., Liu, Z., Cui, J., Zhu, X., Wen, X., Wang, S., et al. (2020) · Aging · doi:10.18632/aging.103834 · Cited by 12

A Previously Unknown Unique Challenge for Inhibitors of SYK ATP-Binding Site: Role of SYK as A Cell Cycle Checkpoint Regulator

Uckun, F. M., Ma, H., Özer, Z., Goodman, P. A., Zhang, J., & Qazi, S. (2014) · EBioMedicine · doi:10.1016/j.ebiom.2014.10.019 · Cited by 12

Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling

Argade, A. B., Bhamidipati, S., Li, H., Sylvain, C., Clough, J., Carroll, D., Keim, H., Braselmann, S., Taylor, V., Zhao, H., et al. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.03.072 · Cited by 12

Entropic allostery dominates the phosphorylation‐dependent regulation of Syk tyrosine kinase release from immunoreceptor tyrosine‐based activation motifs

Feng, C., Roy, A., & Post, C. B. (2018) · Protein Science · doi:10.1002/pro.3489 · Cited by 12

New Insights into Platelet Signalling Pathways by Functional and Proteomic Approaches

Jurk, K., & Walter, U. (2018) · Hämostaseologie · doi:10.1055/s-0038-1675356 · Cited by 12

RANKL-independent osteoclastogenesis in the SH3BP2 cherubism mice

Kittaka, M., Yoshimoto, T., Hoffman, H. T., Levitan, M. E., & Ueki, Y. (2020) · Bone Reports · doi:10.1016/j.bonr.2020.100258 · Cited by 12

Cytoplasmic Protein Serine/Threonine Kinases

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_5 · Cited by 11

Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk

Li, W., Li, M., Anthony, S. M., & Yu, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-92910-9 · Cited by 11

Spleen tyrosine kinase: a novel pharmacological target for sepsis-induced cardiac dysfunction and multi-organ failure

Verra, C., Paulmann, M. K., Wegener, J., Marzani, E., Alves, G. F., Collino, M., Coldewey, S. M., & Thiemermann, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1447901 · Cited by 11

CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder

Zhang, W., Han, Y., Huang, H., Su, Y., Ren, H., Qi, C., Li, J., Yang, H., Xu, J., Chang, G., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03305-2 · Cited by 11

Exploring the comorbidity mechanisms between atherosclerosis and hashimoto’s thyroiditis based on microarray and single-cell sequencing analysis

Ma, Y., Wu, S., Lai, J., Wan, Q., Hu, J., Liu, Y., Zhou, Z., & Wu, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-85112-0 · Cited by 11

TAK-242 alleviates neuroinflammation and poststroke cognitive impairment by targeting the TLR4/SYK/NF-κB pathway in a cerebral ischemia/reperfusion rat model

Zhang, H., Yun, Q., Xu, Z., Wang, Y., Zhou, X., Deng, L., & He, B. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178813 · Cited by 11

9q22 Deletion - First Familial Case

Siggberg, L., Peippo, M. M., Sipponen, M., Miikkulainen, T., Shimojima, K. Y., Yamamoto, T., Ignatius, J., & Knuutila, S. (2011) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-6-45 · Cited by 11

Spleen Tyrosine Kinase Induces MUC5AC Expression in Human Airway Epithelial Cell

Na, H. G., Bae, C. H., Choi, Y. S., Song, S., & Kim, Y. (2016) · American Journal of Rhinology and Allergy · doi:10.2500/ajra.2016.30.4276 · Cited by 11

Leukocyte Immunoglobulin-Like Receptors A2 and A6 are Expressed in Avian Macrophages and Modulate Cytokine Production by Activating Multiple Signaling Pathways

Truong, A. D., Rengaraj, D., Hong, Y., Tran, H. T. T., Dang, H. V., Nguyen, V. K., LILLEHOJ, H. S., & Hong, Y. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092710 · Cited by 11

The expression and clinical significance of different forms of LILRA3 in systemic lupus erythematosus

Du, Y., Sun, F., Zhou, M., Wu, X., Sun, W., Jiang, Y., Cheng, Q., Chen, X., Wu, H., & Xue, J. (2019) · Clinical Rheumatology · doi:10.1007/s10067-019-04624-z · Cited by 11

The FcεRI signaling pathway is involved in the pathogenesis of lacrimal gland benign lymphoepithelial lesions as shown by transcriptomic analysis

Li, J., Liu, R., Sun, M., Wang, J., Wang, N., Zhang, X., Ge, X., & Ma, J. (2021) · Scientific Reports · doi:10.1038/s41598-021-01395-z · Cited by 11

Investigational drugs for immune thrombocytopenia

Provan, D., & Newland, A. C. (2022) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2022.2075340 · Cited by 11

FCGR3A Is a Prognostic Biomarker and Correlated with Immune Infiltrates in Lower-Grade Glioma

Sun, K., Fei, X., Xu, M., Xu, R., & Xu, M. (2022) · Journal of Oncology · doi:10.1155/2022/9499317 · Cited by 11

miR ‐128‐3p inhibits high‐glucose‐induced peritoneal mesothelial cells fibrosis via PAK2 / SyK / TGF ‐β1 axis

Zhang, Y., Xiao, W., Huang, Y., Yang, Y., Ouyang, S., Liang, Y., & Liu, K. (2022) · Therapeutic Apheresis and Dialysis · doi:10.1111/1744-9987.13912 · Cited by 11

New small molecules in dermatology: for the autoimmunity, inflammation and beyond

Criado, P. R., Lorenzini, D., Miot, H. A., Filho, R. B., Carneiro, F. R. O., & Ianhez, M. (2023) · Inflammation Research · doi:10.1007/s00011-023-01744-w · Cited by 11

TULA Proteins in Men, Mice, Hens, and Lice: Welcome to the Family

Tsygankov, A. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119126 · Cited by 11

Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase

Hall, J., AULABAUGH, A. E., Rajamohan, F., Liu, S., Kaila, N., Wan, Z., RYAN, M. S., Magyar, R. A., & Qiu, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.311993 · Cited by 11

Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors

Garton, N. S., Barker, M. D., Davis, R. P., Douault, C., Hooper‐Greenhill, E., Jones, E. J., Lewis, H. D., Liddle, J., Lugo, D., McCleary, S., et al. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.08.070 · Cited by 11

Spleen tyrosine kinase mediates the actions of EPO and GM-CSF and coordinates with TGF-β in erythropoiesis

Chang, H., Huang, D.-Y., Wu, M.-S., Chu, C., Tzeng, S., & Lin, W. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.01.014 · Cited by 11

Tyrosine kinase 4 is involved in the reproduction of the platyhelminth parasite Schistosoma japonicum

Ding, H., Liu, F., Zhu, L., Wu, F., Liu, Q., He, S., Shao, W., Du, Y., Ren, C., Shen, J., et al. (2017) · Parasites & Vectors · doi:10.1186/s13071-017-2453-5 · Cited by 11

In silico structural anatomization of spleen tyrosine kinase inhibitors: Pharmacophore modeling, 3D QSAR analysis and molecular docking studies

Ganjoo, A., & Chetti, P. (2019) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2019.04.009 · Cited by 11

Syk inhibitor R406 downregulates inflammation in an in vitro model of Pseudomonas aeruginosa infection

Alhazmi, A., Choi, J., & Ulanova, M. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0307 · Cited by 12

Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk/Ros pathway

Zhu, J., Du, J., Kou, W., Liu, C., Fan, J., Zhu, Z., Deng, L., Guan, L., Wang, Y., & Ai-mei, Y. (2024) · Aging · doi:10.18632/aging.205593 · Cited by 10

Characterization of transcriptional profiles associated with stress-induced neuronal activation in Arc-GFP mice

Butto, T., Chongtham, M. C., Mungikar, K., Hartwich, D., Linke, M., Ruffini, N., Radyushkin, K., Schweiger, S., Winter, J., & Gerber, S. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02555-z · Cited by 12

BLNK negatively regulates innate antifungal immunity through inhibiting c-Cbl-mediated macrophage migration

Yang, Y., Xie, K.-F., Yang, S., Wang, H., Ma, H.-H., Zhou, M., Wang, Z., Gu, Y., & Jia, X. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2400920121 · Cited by 11

The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures

Bradshaw, W. J., Harris, G., Gileadi, O., & Katis, V. L. (2024) · Structure · doi:10.1016/j.str.2024.09.024 · Cited by 10

Platelet spleen tyrosine kinase is a key regulator of anti-PF4 antibody–induced immunothrombosis

Zlamal, J., Ripoll, V. M., Lee, C. S. M., Toma, F., Althaus, K., Rigoni, F., Witzemann, A., Whittaker, S. P., Capraro, D., Uzun, G., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024014167 · Cited by 10

Variability of daily feed intake as an indicator of resilience in Pietrain pigs

Casto‐Rebollo, C., Núñez, P., Gol, S., Reixach, J., & Ibáñez‐Escriche, N. (2024) · animal · doi:10.1016/j.animal.2024.101415 · Cited by 10

TREM2 inhibits LPS-induced pyroptosis and inflammation by promoting mitophagy via SYK in BV2 cells

Jiang, W., Fan, X., Wu, H., Song, J., Yang, C., & Zhao, Z. (2025) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2025.107500 · Cited by 10

METTL3 promotes neutrophil extracellular trap formation via SYK/ERK/MEK signaling during acute lung injury

Luo, S., Zhang, Q., Zhou, W., Zhang, L., Liao, C., Zeng, D., Zhang, L., Xiang, F.-L., Xu, J., & Tang, J. Y. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.01.044 · Cited by 10

Spleen tyrosine kinase contributes to acute renal allograft rejection in the rat

Chandran, S. R., Tesch, G. H., Han, Y., Woodman, N., Mulley, W. R., Kanellis, J., Blease, K., Ma, F. Y., & Nikolic‐Paterson, D. J. (2014) · International Journal of Experimental Pathology · doi:10.1111/iep.12110 · Cited by 10

jSplice: a high-performance method for accurate prediction of alternative splicing events and its application to large-scale renal cancer transcriptome data

Christinat, Y., Pawłowski, R., & Krek, W. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw145 · Cited by 10

Effect ofRhus vernicifluaExtract on IgE-Antigen-Mediated Allergic Reaction in Rat Basophilic Leukemic RBL-2H3 Mast Cells and Passive Cutaneous Anaphylaxis in Mice

Ju, H., Hwang, Y. J., Yang, H. J., & Park, K. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/6497691 · Cited by 10

The Spleen Tyrosine Kinase Inhibitor, Entospletinib (GS-9973) Restores Chemosensitivity in Lung Cancer Cells by Modulating ABCG2-mediated Multidrug Resistance

Narayanan, S., Wu, Z., Wang, J., Ma, H., Acharekar, N., Koya, J., Yoganathan, S., Fang, S., Chen, Z., & Pan, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.61229 · Cited by 10

Differential Regulation of GPVI-Induced Btk and Syk Activation by PKC, PKA and PP2A in Human Platelets

Zhang, P., Solari, F. A., Heemskerk, J. W. M., Kuijpers, M. J. E., Sickmann, A., Walter, U., & Jurk, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097776 · Cited by 10

Spleen Tyrosine Kinase: A Novel Target in Autoimmunity

Stephen, P., & Tam, F. W. K. (2012) · InTech eBooks · doi:10.5772/26526 · Cited by 1

Tyrosine kinase SYK: essential functions for immunoreceptor signalling

Turner, M., Schweighoffer, E., Colucci, F., Santo, J. P. D., & Tybulewicz, V. L. J. (2000) · Immunology Today · doi:10.1016/s0167-5699(99)01574-1 · Cited by 400

Spleen tyrosine kinase: An Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases

Ghosh, D., & Tsokos, G. C. (2009) · Autoimmunity · doi:10.3109/08916930903374717 · Cited by 51

Linking inflammation and cancer: the unexpected SYK world

Fueyo-Margareto, J., Alonso, M. M., Kerrigan, B. C. P., & Gomez‐Manzano, C. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy036 · Cited by 18

Syk kinase as a treatment target for therapy in autoimmune diseases

Kyttaris, V. C., & Tsokos, G. C. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.06.005 · Cited by 42