The SYK tyrosine kinase: a crucial player in diverse biological functions

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Davis, R. E., Ngo, V. N., Lenz, G., Tolar, P., Young, R. M., Romesser, P. B., Kohlhammer, H., Lamy, L., Zhao, H., Yang, Y., et al. (2010) · Nature · doi:10.1038/nature08638 · Cited by 1,651

Signalling through C-type lectin receptors: shaping immune responses

Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,449

Antigen receptor tail clue

Reth, M. G. (1989) · Nature · doi:10.1038/338383b0 · Cited by 1,430

F c RECEPTOR BIOLOGY

Daëron, M. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.203 · Cited by 1,227

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

LeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1460 · Cited by 1,191

Dectin-1: a signalling non-TLR pattern-recognition receptor

Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 947

Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

Rogers, N. C., Slack, E. M. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L., Gordon, S., Tybulewicz, V. L. J., Brown, G. D., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.004 · Cited by 897

Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis

Hang, L., Blum, A. M., Kumar, S., Urban, J. F., Mitreva, M., Geary, T. G., Jardim, A., Stevenson, M. M., Lowell, C. A., & Weinstock, J. V. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600063 · Cited by 26

Asymmetric Fluorination Approach to the Scalable Synthesis of a SYK Inhibitor

Curtis, N. R., Davies, S. H., Gray, M. W., Leach, S., McKie, R. A., Vernon, L. E., & Walkington, A. J. (2015) · Organic Process Research & Development · doi:10.1021/acs.oprd.5b00131 · Cited by 26

Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity

Carmi, Y., Prestwood, T. R., Spitzer, M. H., Linde, I. L., Chabon, J. R., Reticker-Flynn, N. E., Bhattacharya, N., Zhang, H., Zhang, X., Basto, P. A., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.89020 · Cited by 27

Differential Requirements for Src-Family Kinases in SYK or ZAP70-Mediated SLP-76 Phosphorylation in Lymphocytes

Fasbender, F., Claus, M., Wingert, S., Sandusky, M., & Watzl, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00789 · Cited by 29

Postactivated B cells in systemic lupus erythematosus: update on translational aspects and therapeutic considerations

Schrezenmeier, E. V., Weißenberg, S. Y., Stefanski, A., Szelinski, F., Wiedemann, A., Lino, A. C., & Dörner, T. (2018) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000576 · Cited by 26

C-type lectin-like receptor 2 (CLEC-2)-dependent DC migration is controlled by tetraspanin CD37

de Winde, C. M., Matthews, A. L., van Deventer, S. J., van der Schaaf, A., Tomlinson, N., Jansen, E., Eble, J. A., Nieswandt, B., McGettrick, H. M., Figdor, C. G., et al. (2018) · Journal of Cell Science · doi:10.1242/jcs.214551 · Cited by 26

FCGR1A Serves as a Novel Biomarker and Correlates With Immune Infiltration in Four Cancer Types

Xu, J.-L., & Guo, Y. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.581615 · Cited by 26

SYK promotes the formation of neutrophil extracellular traps by inducing PKM2 nuclear translocation and promoting STAT3 phosphorylation to exacerbate hepatic ischemia-reperfusion injury and tumor recurrence

Chen, X., Jiang, C., Chen, M., Li, X., Yu, W., Qiu, A., Sun, L., Pu, L., & Shi, Y. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00907-7 · Cited by 25

OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL

Howard, J. C., Florentinus-Mefailoski, A., Bowden, P., Trimble, W. S., Grinstein, S., & Marshall, J. G. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.07.021 · Cited by 25

New Therapeutic Targets in Antineutrophil Cytoplasm Antibody–Associated Vasculitis

Prendecki, M. F., & McAdoo, S. P. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41407 · Cited by 25

Candida Administration Worsens Neutrophil Extracellular Traps in Renal Ischemia Reperfusion Injury Mice: An Impact of Gut Fungi on Acute Kidney Injury

Saithong, S., Saisorn, W., Dang, C. P., Visitchanakun, P., Chiewchengchol, D., & Leelahavanichkul, A. (2022) · Journal of Innate Immunity · doi:10.1159/000521633 · Cited by 25

Genomic patterns of homozygosity and inbreeding depression in Murciano-Granadina goats

Luigi‐Sierra, M. G., Fernández, A., Martínez, A. M., Guan, D., Bermejo, J. V. D., Álvarez, J. F., Landi, V., Such, X., Jordana, J., Saura, M., et al. (2022) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-022-00684-5 · Cited by 25

Targeting lipid–protein interaction to treat Syk-mediated acute myeloid leukemia

Singaram, I., Sharma, A. K., Pant, S., Lihan, M., Park, M.-J., Pergande, M. R., Buwaneka, P., Hu, Y., Mahmud, N., Kim, Y., et al. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01150-z · Cited by 25

Endocytosis triggers V-ATPase-SYK–mediated priming of cGAS activation and innate immune response

Yang, Y.-L., Cao, L.-B., He, W.-R., Zhong, L., Guo, Y., Yang, Q., Shu, H., & Hu, M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2207280119 · Cited by 25

Neuronal C‐Reactive Protein/Fc γ RI Positive Feedback Proinflammatory Signaling Contributes to Nerve Injury Induced Neuropathic Pain

Liu, F., Zhang, L., Su, S., Fang, Y., Yin, X., Cui, H., Sun, J., Xie, Y., & Ma, C. (2023) · Advanced Science · doi:10.1002/advs.202205397 · Cited by 25

Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice

Luu, L. D. W., Pandey, A., Paramsothy, S., Ngo, C., Castaño‐Rodríguez, N., Liu, C., Kamm, M. A., Borody, T. J., Man, S. M., & Kaakoush, N. O. (2024) · Nature Communications · doi:10.1038/s41467-024-46983-5 · Cited by 25

Cross-linking of glycosphingolipids at the plasma membrane: consequences for intracellular signaling and traffic

Klokk, T. I., Kavaliauskiene, S., & Sandvig, K. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2049-1 · Cited by 25

Tetramethylpyrazine attenuates TNF-α-induced iNOS expression in human endothelial cells: Involvement of Syk-mediated activation of PI3K-IKK-IκB signaling pathways

Zheng, Z., Li, Z., Chen, S., Pan, J., & Ma, X. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.05.018 · Cited by 25

Macrophages Contribute to Cellular But Not Humoral Mechanisms of Acute Rejection in Rat Renal Allografts

Ma, F. Y., Woodman, N., Mulley, W. R., Kanellis, J., & Nikolic‐Paterson, D. J. (2013) · Transplantation · doi:10.1097/tp.0b013e3182a4befa · Cited by 25

Syk inhibitors with high potency in presence of blood

Thoma, G., Blanz, J., Bühlmayer, P., Drückes, P., Kittelmann, M., Smith, A. B., van Eis, M. J., Vangrevelinghe, E., Zerwes, H., Che, J., et al. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.03.075 · Cited by 25

Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with Vav

Chen, C., Martin, V. A., Gorenstein, N., Geahlen, R. L., & Post, C. B. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05043-11 · Cited by 25

FcγRIIIa-Syk Co-signal Modulates CD4+ T-cell Response and Up-regulates Toll-like Receptor (TLR) Expression

Chauhan, A., Moore, T. L., Bi, Y., & Chen, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.684795 · Cited by 25

Spleen Tyrosine Kinase Signaling Promotes Myeloid Cell Recruitment and Kidney Damage after Renal Ischemia/Reperfusion Injury

Ryan, J., Kanellis, J., Blease, K., Ma, F. Y., & Nikolic‐Paterson, D. J. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2016.04.007 · Cited by 25

Synergistic Targeting of the Regulatory and Catalytic Subunits of PI3Kδ in Mature B-cell Malignancies

Cooney, J. D., Lin, A., Jiang, D., Wang, L., Suhasini, A. N., Myers, J., Qiu, Z., Wölfler, A., Sill, H., & Aguiar, R. C. T. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-2218 · Cited by 25

Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytes

Guðmundsdóttir, Á. B., Brynjólfsdóttir, Á., Ólafsdóttir, E. S., Harðardóttir, I., & Freysdóttir, J. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.01.044 · Cited by 25

Immobilized collagen prevents shedding and induces sustained GPVI clustering and signaling in platelets

Pallini, C., Pike, J. A., O’Shea, C., Andrews, R. K., Gardiner, E. E., Watson, S. P., & Poulter, N. S. (2021) · Platelets · doi:10.1080/09537104.2020.1849607 · Cited by 25

Development of New Drugs for Autoimmune Hemolytic Anemia

Xiao, Z., & Murakhovskaya, I. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14051035 · Cited by 25

New insights into SYK targeting in solid tumors

Joshi, S. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2024.08.006 · Cited by 25

Activation of the NLRP3 inflammasome by vault nanoparticles expressing a chlamydial epitope

Zhu, Y., Jiang, J., Sadier, N. S., Boxx, G., Champion, C. I., Tetlow, A. L., Kickhoefer, V. A., Rome, L. H., Ojcius, D. M., & Kelly, K. A. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.11.028 · Cited by 24

Perilla Leaf Extract (PLE) Attenuates COPD Airway Inflammation via the TLR4/Syk/PKC/NF-κB Pathway In Vivo and In Vitro

Yuan, J., Li, X., Fang, N., Li, P., Zhang, Z., Lin, M., & Hou, Q. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.763624 · Cited by 24

A novel dual epigenetic approach targeting BET proteins and HDACs in Group 3 (MYC-driven) Medulloblastoma

Kling, M. J., Kesherwani, V., Mishra, N. K., Alexander, G. R., McIntyre, E. M., Ray, S., Challagundla, K. B., Joshi, S. S., Coulter, D. W., & Chaturvedi, N. K. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02530-y · Cited by 25

An Update on the Emerging Role of Wnt/β-catenin, SYK, PI3K/AKT, and GM-CSF Signaling Pathways in Rheumatoid Arthritis

Prajapati, P. S., & Doshi, G. (2023) · Current Drug Targets · doi:10.2174/0113894501276093231206064243 · Cited by 26

Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4+ T cells

Chauhan, A., & Moore, T. L. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04505.x · Cited by 24

Phosphorylation impact on Spleen Tyrosine kinase conformation by Surface Enhanced Raman Spectroscopy

Cottat, M., Yasukuni, R., Homma, Y., Lidgi‐Guigui, N., Varin‐Blank, N., de la Chapelle, M. L., & Roy, C. L. (2017) · Scientific Reports · doi:10.1038/srep39766 · Cited by 24

Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease

Barker, M. D., Liddle, J., Atkinson, F. L., Wilson, D. M., Dickson, M. C., Ramírez-Molina, C., Lewis, H. D., Davis, R. P., Somers, D. O., Neu, M., et al. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.09.022 · Cited by 24

Suppression of Syk activation by resveratrol inhibits MSU crystal-induced inflammation in human monocytes

Chung, Y., Kim, H. Y., Yoon, B. R., Kang, Y. J., & Lee, W. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-018-01736-y · Cited by 24

Second-Generation SYK Inhibitor Entospletinib Ameliorates Fully Established Inflammation and Bone Destruction in the Cherubism Mouse Model

Yoshimoto, T., Hayashi, T., Kondo, T., Kittaka, M., Reichenberger, E., & Ueki, Y. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3449 · Cited by 24

Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement

Gallo, C., Manzo, E., Barra, G., Fioretto, L., Ziaco, M., Nuzzo, G., d’Ippolito, G., Ferrera, F., Contini, P., Castiglia, D., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04297-z · Cited by 23

Identifying biomarkers associated with immunotherapy response in melanoma by multi-omics analysis

He, Y., & Wang, X. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.107591 · Cited by 23

Mechanical control of antigen detection and discrimination by T and B cell receptors

Rogers, J., Bajur, A. T., Salaita, K. S., & Spillane, K. M. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.05.020 · Cited by 23

Tyrosine Phosphorylation on Spleen Tyrosine Kinase (Syk) Is Differentially Regulated in Human and Murine Platelets by Protein Kinase C Isoforms

Buitrago, L., Bhavanasi, D., Dangelmaier, C., Manne, B. K., Badolia, R., Borgognone, A., Tsygankov, A. Y., McKenzie, S. E., & Kunapuli, S. P. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.464107 · Cited by 23

Blind Pose Prediction, Scoring, and Affinity Ranking of the CSAR 2014 Dataset

Martiny, V. Y., Martz, F., Selwa, E., & Iorga, B. I. (2015) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5b00337 · Cited by 23

Kinase inhibitors as potential agents in the treatment of multiple myeloma

Abramson, H. N. (2016) · Oncotarget · doi:10.18632/oncotarget.10745 · Cited by 23

Oxidative stress in sickle cell disease; more than a DAMP squib

van Beers, E. J., & van Wijk, R. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-189010 · Cited by 23

cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets

Makhoul, S., Trabold, K., Gambaryan, S. P., Tenzer, S., Pillitteri, D., Walter, U., & Jurk, K. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0428-1 · Cited by 23

Syk degradation restrains plasma cell formation and promotes zonal transitions in germinal centers

Davidzohn, N., Biram, A., Stoler‐Barak, L., Grenov, A., Dassa, B., & Shulman, Z. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20191043 · Cited by 23

TREM2 bridges microglia and extracellular microenvironment: Mechanistic landscape and therapeutical prospects on Alzheimer’s disease

Zhao, Y., Guo, Q., Tian, J., Liu, W., & Wang, X. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102596 · Cited by 23

A switch in nucleotide affinity governs activation of the Src and Tec family kinases

von Raußendorf, F., de Ruiter, A., & Leonard, T. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17703-5 · Cited by 22

The Genomic Organization of the LILR Region Remained Largely Conserved Throughout Primate Evolution: Implications for Health And Disease

Storm, L., Bruijnesteijn, J., de Groot, N. G., & Bontrop, R. E. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.716289 · Cited by 22

Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma

Liu, Q., Hua, L., Bao, C., Kong, L., Hu, J., Liu, C., Li, Z., Xu, S., & Liu, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.885053 · Cited by 22

JUN Regulation of Injury-Induced Enhancers in Schwann Cells

Ramesh, R., Manurung, Y., Ma, K. H., Blakely, T., Won, S., Moreno-Ramos, O. A., Wyatt, E. J., Awatramani, R. B., & Svaren, J. P. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.2533-21.2022 · Cited by 22

Targeting macrophage Syk enhances responses to immune checkpoint blockade and radiotherapy in high-risk neuroblastoma

Rohila, D., Park, I. H., Pham, T. V., Jones, R. N., Tapia, E., Liu, K. X., Tamayo, P., Yu, A. L.-T., Sharabi, A. B., & Joshi, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148317 · Cited by 22

Current understanding on TREM-2 molecular biology and physiopathological functions

Bharadwaj, S., Groza, Y., Mierzwicka, J. M., & Malý, P. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112042 · Cited by 23

Syk is indispensable for CpG-induced activation and differentiation of human B cells

Kremlitzka, M., Mácsik‐Valent, B., & Erdei, A. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1806-x · Cited by 22

Swiprosin‐1: Its Expression and Diverse Biological Functions

Thylur, R. P., Gowda, R., Mishra, S., & Jun, C. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26199 · Cited by 22

Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats

Guo, H., Sun, L., Ling, S., & Xu, J.-W. (2018) · Mediators of Inflammation · doi:10.1155/2018/7304096 · Cited by 22

Mannan activates tissue native and IgE-sensitized mast cells to proinflammatory response and chemotaxis in TLR4-dependent manner

Żelechowska, P., Brzezińska‐Błaszczyk, E., Różalska, S., Agier, J., & Kozłowska, E. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.4a0720-452r · Cited by 22

The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis

Sheng, M., Sun, R., Fu, J., & Gao, L. (2024) · BMC Cancer · doi:10.1186/s12885-024-12194-w · Cited by 21

Emerging immunotherapies for rheumatoid arthritis

Reynolds, G., Cooles, F. A. H., Isaacs, J. D., & Hilkens, C. M. U. (2014) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.27910 · Cited by 21

Syk facilitates phagosome-lysosome fusion by regulating actin-remodeling in complement-mediated phagocytosis

Tabata, H., Morita, H., Kaji, H., Tohyama, K., & Tohyama, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-79156-7 · Cited by 21

Identification of Disease-Related Genes That Are Common between Alzheimer’s and Cardiovascular Disease Using Blood Genome-Wide Transcriptome Analysis

Lee, T., Lee, H., & Initiative, T. A. D. N. (2021) · Biomedicines · doi:10.3390/biomedicines9111525 · Cited by 21

CalDAG‐GEFI deficiency protects mice from FcγRIIa‐mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes

Amirkhosravi, A., Boulaftali, Y., Robles-Carrillo, L. D., Meyer, T. V., McKenzie, S. E., Francis, J. L., & Bergmeier, W. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12748 · Cited by 22

New biomarkers in T-cell lymphomas

Bisig, B., Gaulard, P., & de Leval, L. (2012) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2012.01.004 · Cited by 21

A FRET-Based Biosensor for Imaging SYK Activities in Living Cells

Xiang, X., Sun, J., Wu, J., He, H., Wang, Y., & Zhu, C. (2011) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-011-0211-x · Cited by 21

Systems Level Dissection of Candida Recognition by Dectins: A Matter of Fungal Morphology and Site of Infection

Rizzetto, L., Weil, T., & Cavalieri, D. (2015) · Pathogens · doi:10.3390/pathogens4030639 · Cited by 21

Upcoming therapeutic targets in cutaneous lupus erythematous

Klaeschen, A. S., & Wenzel, J. (2016) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2016.1145543 · Cited by 21

Selective Binders of the Tandem Src Homology 2 Domains in Syk and Zap70 Protein Kinases by DNA-Programmed Spatial Screening

Marczynke, M., Gröger, K., & Seitz, O. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00382 · Cited by 21

Boosting half-life and effector functions of therapeutic antibodies by Fc-engineering: An interaction-function review

Fonseca, M. H. G., Furtado, G. P., Bezerra, M. R. L., Pontes, L. Q., & Fernandes, C. F. C. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.141 · Cited by 21

Spleen tyrosine kinase SYK (L) interacts with YY 1 and coordinately suppresses SNAI 2 transcription in lung cancer cells

Gao, D., Wang, L., Zhang, H., Yan, X., Yang, J., Zhou, R., Chang, X., Sun, Y., Tian, S., Yao, Z., et al. (2018) · FEBS Journal · doi:10.1111/febs.14665 · Cited by 22

The Syk Kinase Promotes Mammary Epithelial Integrity and Inhibits Breast Cancer Invasion by Stabilizing the E-Cadherin/Catenin Complex

Kassouf, T., Larive, R. M., Morel, A., Urbach, S., Bettache, N., Marcial-Medina, C., Mérezègue, F., Freiss, G., Peter, M., Boissière‐Michot, F., et al. (2019) · Cancers · doi:10.3390/cancers11121974 · Cited by 21

Evolution of Functional Diversity in the Holozoan Tyrosine Kinome

Yeung, W., Kwon, A., Taujale, R., Bunn, C., Venkat, A., & Kannan, N. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab272 · Cited by 21

Protein-PAINT: Superresolution microscopy with signaling proteins

Farrell, M. V., Nunez, A. C., Yang, Z., Pérez-Ferreros, P., Gaus, K., & Goyette, J. (2022) · Science Signaling · doi:10.1126/scisignal.abg9782 · Cited by 21

CD64+ fibroblast-targeted vilanterol and a STING agonist augment CLDN18.2 BiTEs efficacy against pancreatic cancer by reducing desmoplasia and enriching stem-like CD8+ T cells

Zhou, T., Hou, X., Yan, J., Lin, L., Xie, Y., Bai, W., Jiang, W., Zou, Y., Li, X., Liu, Z., et al. (2024) · Gut · doi:10.1136/gutjnl-2024-332371 · Cited by 20

NOVEL AGENTS AND EMERGING STRATEGIES FOR TARGETING THE B-CELL RECEPTOR PATHWAY IN CLL

Efremov, D. G., Wiestner, A. U., & Laurenti, L. (2012) · Mediterranean Journal of Hematology and Infectious Diseases · doi:10.4084/mjhid.2012.067 · Cited by 20

Current and emerging biologic and small molecule therapies for atopic dermatitis

Li, R., Hadi, S. M., & Guttman‐Yassky, E. (2019) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1573422 · Cited by 20

Blockade of Syk modulates neutrophil immune-responses via the mTOR/RUBCNL-dependent autophagy pathway to alleviate intestinal inflammation in ulcerative colitis

Zhu, F., Jing, D., Zhou, H., Hu, Z., Wang, Y., Jin, G., Yang, Y., & Zhou, G. (2023) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbad025 · Cited by 20

Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors

Choi, J., Hwang, H.-J., Kim, S.-W., Lee, B. I., Lee, J., Song, H., Koh, J. S., Kim, J. H., & Lee, P. H. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.09.011 · Cited by 20

Rapid CD4+ T‐cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9

Atif, S. M., Lee, S., Li, L., Uematsu, S., Akira, S., Gorjestani, S., Lin, X., Schweighoffer, E., Tybulewicz, V. L. J., & McSorley, S. J. (2014) · European Journal of Immunology · doi:10.1002/eji.201444744 · Cited by 20

Syk-Induced Phosphatidylinositol-3-Kinase Activation in Epstein–Barr Virus Posttransplant Lymphoproliferative Disorder

Hatton, O. L., Lambert, S. L., Phillips, L., Vaysberg, M., Natkunam, Y., Esquivel, C. O., Krams, S. M., & Martinez, O. M. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12137 · Cited by 20

Highly potent aminopyridines as Syk kinase inhibitors

Castillo, M., Forns, P., Erra, M., Mir, M., López, M., Maldonado, M., Orellana, A., Carreño, C., Ramis, I., Miralpeix, M., et al. (2012) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2012.07.045 · Cited by 20

Spleen Tyrosine Kinase (Syk)-dependent Calcium Signals Mediate Efficient CpG-induced Exocytosis of Tumor Necrosis Factor α (TNFα) in Innate Immune Cells

Rao, S., Liu, X., Freedman, B. D., & Behrens, E. M. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.454405 · Cited by 22

Small-Molecule Inhibitors of Spleen Tyrosine Kinase as Therapeutic Agents for Immune Disorders: Will Promise Meet Expectations?

Lucas, M. C., & Tan, S. (2014) · Future Medicinal Chemistry · doi:10.4155/fmc.14.126 · Cited by 20

CD11b promotes the differentiation of osteoclasts induced by RANKL through the spleen tyrosine kinase signalling pathway

Yang, G., Chen, X., Zhao, Y., Zhu, Q., & Yang, C. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13254 · Cited by 20

Feedback Regulation of Syk by Protein Kinase C in Human Platelets

Makhoul, S., Dorschel, S., Gambaryan, S. P., Walter, U., & Jurk, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010176 · Cited by 20

Class I phosphoinositide 3-kinases control sustained NADPH oxidase activation in adherent neutrophils

Song, Z., Hudik, E., Bars, R. L., Roux, B., Dang, P. M., Benna, J. E., Nüße, O., & Dupré‐Crochet, S. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.114088 · Cited by 20

BAY61‐3606 protects kidney from acute ischemia/reperfusion injury through inhibiting spleen tyrosine kinase and suppressing inflammatory macrophage response

Tan, R., Li, J., Liu, J., Lei, X., Zhong, X., Wang, C., Yan, Y., Ye, L. L., Duan, D. D., Lan, H., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000261rrr · Cited by 20

Histone methyltransferase DOT1L mediates the TGF-β1/Smad3 signaling pathway through epigenetic modification of SYK in myocardial infarction

Li, F., Li, L., Zhang, J., Yang, X., & Liu, Y. (2021) · Human Cell · doi:10.1007/s13577-021-00625-w · Cited by 20

The effect of PU.1 knockdown on gene expression and function of mast cells

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Spleen Tyrosine Kinase Mediates BEAS-2B Cell Migration and Proliferation and Human Rhinovirus-Induced Expression of Vascular Endothelial Growth Factor and Interleukin-8

Wang, X., Mychajlowycz, M., Lau, C., Gutierrez, C., Scott, J. A., & Chow, C. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.186429 · Cited by 21

Syk Activation in Circulating and Tissue Innate Immune Cells in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

Prendecki, M. F., Gulati, K., Pisacano, N., Pinheiro, D., Bhatt, T. R., Mawhin, M., Toulza, F., Masuda, E. S., Cowburn, A. S., Lodge, K. M., et al. (2022) · Arthritis & Rheumatology · doi:10.1002/art.42321 · Cited by 19

A Novel TLR4-SYK Interaction Axis Plays an Essential Role in the Innate Immunity Response in Bovine Mammary Epithelial Cells

Yang, F., Yuan, L., Xiang, M., Jiang, Q., Zhang, M., Chen, F., Tong, J., Huang, J., & Cai, Y. (2022) · Biomedicines · doi:10.3390/biomedicines11010097 · Cited by 19

Recent progress in ITP treatment

Rodeghiero, F. (2023) · International Journal of Hematology · doi:10.1007/s12185-022-03527-1 · Cited by 19

The spatial resolution limit of phagocytosis

Eisentraut, M., Sabri, A., & Kress, H. (2023) · Biophysical Journal · doi:10.1016/j.bpj.2023.01.030 · Cited by 19

Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models

Futosi, K., Németh, T., Horváth, Á. I., Abram, C. L., Tusnády, S., Lowell, C. A., Helyes, Z., & Mócsai, A. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20221010 · Cited by 19

Review and prospects of targeted therapies for Spleen tyrosine kinase (SYK)

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SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells

Henry, C. M., Castellanos, C. A., Buck, M. D., Giampazolias, E., Frederico, B., Cardoso, A., Rogers, N. C., Schulz, O., Lee, S., Canton, J., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113506 · Cited by 19

Receptor Protein-tyrosine Phosphatase α Regulates Focal Adhesion Kinase Phosphorylation and ErbB2 Oncoprotein-mediated Mammary Epithelial Cell Motility

Boivin, B., Chaudhary, F., Dickinson, B. C., Haque, A., Pero, S. C., Chang, C. J., & Tonks, N. K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.527564 · Cited by 19

Systems Biology Approach for New Target and Biomarker Identification

Wang, I., Stone, D. J., Nickle, D. C., Loboda, A. P., Puig, Ó., & Roberts, C. (2012) · Current topics in microbiology and immunology · doi:10.1007/82_2012_252 · Cited by 19

The kinase inhibitors R406 and GS-9973 impair T cell functions and macrophage-mediated anti-tumor activity of rituximab in chronic lymphocytic leukemia patients

Colado, A., Almejún, M. B., Podaza, E., Risnik, D., Stanganelli, C., Elías, E. E., Santos, P. D., Slavutsky, I. R., Grecco, H. F., Cabrejo, M., et al. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1946-y · Cited by 19

A spleen tyrosine kinase inhibitor attenuates the proliferation and migration of vascular smooth muscle cells

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Spleen Tyrosine Kinase: A Novel Target in Autoimmunity

Stephen, P., & Tam, F. W. K. (2012) · InTech eBooks · doi:10.5772/26526 · Cited by 1

Tyrosine kinase SYK: essential functions for immunoreceptor signalling

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Spleen tyrosine kinase: An Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases

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Linking inflammation and cancer: the unexpected SYK world

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Syk kinase as a treatment target for therapy in autoimmune diseases

Kyttaris, V. C., & Tsokos, G. C. (2007) · Clinical Immunology · doi:10.1016/j.clim.2007.06.005 · Cited by 42