The SYK tyrosine kinase: a crucial player in diverse biological functions

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332

The Inflammasomes: Guardians of the Body

Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

Davis, R. E., Ngo, V. N., Lenz, G., Tolar, P., Young, R. M., Romesser, P. B., Kohlhammer, H., Lamy, L., Zhao, H., Yang, Y., et al. (2010) · Nature · doi:10.1038/nature08638 · Cited by 1,651

Signalling through C-type lectin receptors: shaping immune responses

Geijtenbeek, T. B. H., & Gringhuis, S. I. (2009) · Nature reviews. Immunology · doi:10.1038/nri2569 · Cited by 1,449

Antigen receptor tail clue

Reth, M. G. (1989) · Nature · doi:10.1038/338383b0 · Cited by 1,430

F c RECEPTOR BIOLOGY

Daëron, M. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.203 · Cited by 1,227

Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17

LeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1460 · Cited by 1,191

Dectin-1: a signalling non-TLR pattern-recognition receptor

Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Groß, O., Poeck, H., Bscheider, M., Dostert, C., Hannesschläger, N., Endres, S., Hartmann, G., Tardivel, A., Schweighoffer, E., Tybulewicz, V. L. J., et al. (2009) · Nature · doi:10.1038/nature07965 · Cited by 947

Syk-Dependent Cytokine Induction by Dectin-1 Reveals a Novel Pattern Recognition Pathway for C Type Lectins

Rogers, N. C., Slack, E. M. C., Edwards, A. D., Nolte, M. A., Schulz, O., Schweighoffer, E., Williams, D. L., Gordon, S., Tybulewicz, V. L. J., Brown, G. D., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.03.004 · Cited by 897

Progress in the development of kinase inhibitors for treating asthma and COPD

McClean, N., Hasday, J. D., & Shapiro, P. (2023) · Advances in pharmacology · doi:10.1016/bs.apha.2023.04.004 · Cited by 10

Discovery of 3-(1H-benzo[d]imidazole-2-yl)-1H-pyrazol-4 -amine derivatives as novel and potent syk inhibitors for the treatment of hematological malignancies

Cui, B., Wang, Y., Zhao, Z., Lü, F., Jiao, Y., Li, H., Feng, J., Tang, W., Lu, T., & Chen, Y. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115597 · Cited by 10

Identification of molecular signatures in acute myocardial infarction based on integrative analysis of proteomics and transcriptomics

Wu, J., Yan, J., Hua, Z., Jia, J., Zhou, Z., Zhang, J., Li, J., & Zhang, J. (2023) · Genomics · doi:10.1016/j.ygeno.2023.110701 · Cited by 10

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

Geyer, C. E., Chen, H., Bye, A. P., Manz, X. D., Guerra, D., Caniels, T. G., Bijl, T. P. L., Griffith, G. R., Hoepel, W., de Taeye, S. W., et al. (2023) · Life Science Alliance · doi:10.26508/lsa.202302106 · Cited by 10

Exploring molecular interactions of potential inhibitors against the spleen tyrosine kinase implicated in autoimmune disorders via virtual screening and molecular dynamics simulations

Samanta, S., Sk, M. F., Koirala, S., & Kar, P. (2023) · SAR and QSAR in environmental research · doi:10.1080/1062936x.2023.2266364 · Cited by 10

Exploring chemical space, scaffold diversity, and activity landscape of spleen tyrosine kinase active inhibitors

Danishuddin, M., Malik, M. Z., Kashif, M., Haque, S., & Kim, J. J. (2024) · SAR and QSAR in environmental research · doi:10.1080/1062936x.2024.2345618 · Cited by 10

Spleen tyrosine kinase (SYK) inhibitor PRT062607 protects against ovariectomy-induced bone loss and breast cancer-induced bone destruction

., G. X., Liu, W., Lian, Z., Xie, D., Yuan, G., Ye, J., Lin, Z., Wang, W., Zeng, J., Shen, H., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114579 · Cited by 10

Characterization of the disposition of fostamatinib in Japanese subjects including pharmacokinetic assessment in dry blood spots: results from two phase I clinical studies

Martin, P. D., Cheung, S. Y. A., Yen, M., Han, D., & Gillen, M. S. (2015) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-015-1961-5 · Cited by 10

The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2

Moon, K., Zhang, X., Zhou, Q., & Geahlen, R. (2011) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamcr.2011.10.001 · Cited by 10

Bruton's tyrosine kinase inhibitors

Ysebaert, L., & Michallet, A. (2014) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000114 · Cited by 10

Profile of Differential Promoter Activity by Nucleotide Substitution at GWAS Signals For Multiple Sclerosis

Ryu, J., Woo, J., Shin, J., Ryoo, H., Kim, Y., & Lee, C. (2014) · Medicine · doi:10.1097/md.0000000000000281 · Cited by 10

Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events

Shim, J., Kennedy, R. H., Weatherly, L. M., Hutchinson, L. M., Pelletier, J. H., Hashmi, H. N., Blais, K., Velez, A., & Gosse, J. A. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3300 · Cited by 10

Role of Malt1 protease activity in pathogenesis of inflammatory disorders mediated by FcγR signaling

Nakamura, Y., Yokoyama, K., Igaki, K., & Tsuchimori, N. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.01.028 · Cited by 10

Spleen tyrosine kinase-dependent Nrf2 activation regulates oxidative stress-induced cell death in WiL2-NS human B lymphoblasts

Park, S., Jang, J., & Moon, E. (2018) · Free Radical Research · doi:10.1080/10715762.2018.1505044 · Cited by 10

Immune Complex Vaccination

Wen, Y., & Shi, Y. (2019) · Current topics in microbiology and immunology · doi:10.1007/82_2019_153 · Cited by 10

Ets-2 deletion in myeloid cells attenuates IL-1α-mediated inflammatory disease caused by a Ptpn6 point mutation

Tartey, S., Gurung, P., Karki, R., Burton, A. R., Hertzog, P. J., & Kanneganti, T. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0398-7 · Cited by 10

The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets

Makhoul, S., Kumm, E. J., Zhang, P., Walter, U., & Jurk, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238939 · Cited by 10

Signaling Lipids

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_2 · Cited by 9

Transcript profiles of microglia/macrophage cells at the borders of chronic active and subpial gray matter lesions in multiple sclerosis

Chomyk, A., Kucinski, R., Kim, J., Christie, E., Cyncynatus, K., Gossman, Z., Chen, Z., Richardson, B., Cameron, M., Turner, T., et al. (2024) · Annals of Neurology · doi:10.1002/ana.26877 · Cited by 9

Targeting B Cells and Plasma Cells in Glomerular Disease

Ahmad, S. B., & Jefferson, J. A. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000772 · Cited by 10

3‐aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors

Shen, J., Li, X., Zhang, Z., Luo, J., Long, H., Tu, Z., Zhou, X., Ding, K., & Lu, X. (2016) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12798 · Cited by 9

SYK Targeting Represents a Potential Therapeutic Option for Relapsed Resistant Pediatric ETV6-RUNX1 B-Acute Lymphoblastic Leukemia Patients

Serafin, V., Porcù, E., Cortese, G., Mariotto, E., Veltri, G., Bresolin, S., Basso, G., & Accordi, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246175 · Cited by 9

Strand Displacement in Coiled‐Coil Structures: Controlled Induction and Reversal of Proximity

Gröger, K., Gavins, G. C., & Seitz, O. (2017) · Angewandte Chemie · doi:10.1002/ange.201705339 · Cited by 9

Integrated identification of key immune related genes and patterns of immune infiltration in calcified aortic valvular disease: A network based meta-analysis

Wu, L., Xiao, F., Sun, J.-Y., Li, F., Chen, Y.-J., Chen, J., Zhang, J., Qian, L., & Wang, R. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.971808 · Cited by 9

Activating FcγR function depends on endosomal-signaling platforms

Benadda, S., Nugue, M., Koumantou, D., Bens, M., Luca, M. D., Pellé, O., Monteiro, R. C., Evnouchidou, I., & Saveanu, L. (2023) · iScience · doi:10.1016/j.isci.2023.107055 · Cited by 9

PHGDH/SYK: a hub integrating anti-fungal immunity and serine metabolism

Chen, A., Zhang, X., Hu, D., Sun, X., Gu, Y., Zhou, Y., Su, C., Liu, S., Zhang, C., Wu, Q., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01374-7 · Cited by 9

Expression of the TEL-Syk Fusion Protein in Hematopoietic Stem Cells Leads to Rapidly Fatal Myelofibrosis in Mice

Graham, M., Abram, C. L., Hu, Y., & Lowell, C. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077542 · Cited by 9

Protein-Protein Interaction Analysis Highlights Additional Loci of Interest for Multiple Sclerosis

Ragnedda, G., Disanto, G., Giovannoni, G., Ebers, G. C., Sotgiu, S., & Ramagopalan, S. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046730 · Cited by 9

Spleen Tyrosine Kinase Modulates Fibrous Airway Obliteration and Associated Lymphoid Neogenesis After Transplantation

Matsuda, Y., Wang, X., Oishi, H., Guan, Z., Saito, M., Liu, M., Keshavjee, S. H., & Chow, C. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13442 · Cited by 9

Schistosoma antigens as activators of inflammasome pathway: from an unexpected stimulus to an intriguing role

Sanches, R. C. O., Souza, C. D. L. R., & Oliveira, S. C. (2020) · Microbes and Infection · doi:10.1016/j.micinf.2020.08.001 · Cited by 9

Characterizing the structure–activity relationships of natural products, tanshinones, reveals their mode of action in inhibiting spleen tyrosine kinase

Tung, M., Tsai, K., Fung, K.-M., Don, M., & Tseng, T. (2021) · RSC Advances · doi:10.1039/d0ra08769f · Cited by 9

Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition

Abecunas, C., Whitehead, C. E., Ziemke, E. K., Baumann, D. G., Frankowski-McGregor, C. L., Sebolt, J. S., & Fallahi‐Sichani, M. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-0883 · Cited by 9

ABATACEPT FOR RHEUMATOID ARTHRITIS: A NOVEL FORMULATION, NEW MECHANISMS, NEW POSSIBILITIES

Nasonov, E. L. (2015) · Rheumatology Science and Practice · doi:10.14412/1995-4484-2015-522-541 · Cited by 9

T cell receptor-associated protein tyrosine kinases: The dynamics of tolerance regulation by phosphorylation and its role in systemic lupus erythematosus

Barrera‐Vargas, A., Gómez‐Martín, D., & Alcocer-Varela, J. C. (2014) · Human Immunology · doi:10.1016/j.humimm.2014.08.207 · Cited by 9

Molecular cloning, expression pattern, and molecular evolution of the spleen tyrosine kinase in lamprey, Lampetra japonica

Liu, C., Su, P., Li, R., Zhang, Q., Zhu, T., Liu, X., & Li, Q. (2015) · Development Genes and Evolution · doi:10.1007/s00427-015-0492-5 · Cited by 9

Orally bioavailable Syk inhibitors with activity in a rat PK/PD model

Thoma, G., Veenstra, S. J., Strang, R. S., Blanz, J., Vangrevelinghe, E., Berghausen, J., Lee, C. C., & Zerwes, H. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.08.037 · Cited by 9

Suppression of Spleen Tyrosine Kinase (Syk) by Histone Deacetylation Promotes, Whereas BAY61‐3606, a Synthetic Syk Inhibitor Abrogates Colonocyte Apoptosis by ERK Activation

Dasgupta, N., Thakur, B. K., Ta, A., Dutta, P., & Das, S. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25625 · Cited by 9

Novel therapeutic targets in Waldenstrom macroglobulinemia

Paulus, A., Ailawadhi, S., & Chanan-Khan, A. A. (2016) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2016.08.020 · Cited by 9

Non-receptor Tyrosine Kinases Role and Significance in Hematological Malignancies

Azevedo, A. P., Silva, S., & Rueff, J. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.84873 · Cited by 9

Tyrosine phosphorylation modulates cell surface expression of chloride cotransporters NKCC2 and KCC3

Loureiro, C. A., Barros, P., Matos, P., & Jordan, P. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.05.022 · Cited by 9

Inhibition of spleen tyrosine kinase decreases donor specific antibody levels in a rat model of sensitization

Tempest-Roe, S., Prendecki, M. F., McAdoo, S. P., Clarke, C., Tanna, A., Turner‐Stokes, T., Masuda, E. S., Willicombe, M. K., Cook, H. T., Roufosse, C. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-06413-2 · Cited by 9

Integrated Single-Cell (Phospho-)Protein and RNA Detection Uncovers Phenotypic Characteristics and Active Signal Transduction of Human Antibody-Secreting Cells

van Buijtenen, E., Janssen, W., Vink, P. M., Habraken, M., Wingens, L., van Elsas, A., Huck, W. T. S., van Buggenum, J. A. G. L., & van Eenennaam, H. (2023) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2023.100492 · Cited by 10

Central role of PI 3K– SYK interaction in fibrinogen‐induced lamellipodia and filopodia formation in platelets

Singh, R. (2016) · FEBS Open Bio · doi:10.1002/2211-5463.12149 · Cited by 9

The Expression and Clinical Significance of Spleen Tyrosine Kinase in Patients with Coronary Heart Disease

Liang, K., Ma, N., Luo, S., Niu, W., Wang, Y., & Bu, P. (2019) · Medical Science Monitor · doi:10.12659/msm.913543 · Cited by 9

Spleen tyrosine kinase aggravates intestinal inflammation through regulating inflammatory responses of macrophage in ulcerative colitis

Chen, L., Zhu, F., Gao, X., Yang, Y., Jin, G., Zhou, Y., Dong, G., & Zhou, G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114122 · Cited by 8

Neuronal guidance signaling in neurodegenerative diseases: Key regulators that function at neuron-glia and neuroimmune interfaces

Yuasa‐Kawada, J., Kinoshita-Kawada, M., Hiramoto, M., Yamagishi, S., Mishima, T., Yasunaga, S., Tsuboi, Y., Hattori, N., & Wu, J. Y. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01330 · Cited by 10

SARS-CoV-2 Immune Complex–Mediated Neutrophil Activation

Allen, K. C., Warner, S., Teague, H., Ramos-Benítez, M. J., Miao, R., Tian, X., Reger, R. N., Burbelo, P. D., Pang, C. W. (., Kanthi, Y. M., et al. (2025) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofaf199 · Cited by 8

The multifunctional regulatory post-proline protease dipeptidyl peptidase 9 and its inhibitors: new opportunities for therapeutics

Nguyen, J. M. H., Zolg, S., Geiss‐Friedlander, R., & Gorrell, M. D. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05719-4 · Cited by 8

Cytoplasmic Protein Tyrosine Kinases

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_4 · Cited by 8

Micromolar concentrations of citalopram or escitalopram inhibit glycoprotein VI-mediated and integrin αIIbβ3-mediated signaling in human platelets

Tseng, Y., Braun, A., Chang, J. P., Chiang, M.-L., Tseng, C., & Chen, W. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.12.016 · Cited by 8

Comparison of SYK Signaling Networks Reveals the Potential Molecular Determinants of Its Tumor-Promoting and Suppressing Functions

Buffard, M., Naldi, A., Freiss, G., Deckert, M., Radulescu, O., Coopman, P. J., & Larive, R. M. (2021) · Biomolecules · doi:10.3390/biom11020308 · Cited by 8

A Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Susceptibility Genes for Juvenile Idiopathic Arthritis in Asia and Europe

Xu, J., Ma, J., Zeng, Y., Si, H., Wu, Y., Zhang, S., & Shen, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.941398 · Cited by 8

Neutrophil-Specific Syk Expression Is Crucial for Skin Disease in Experimental Epidermolysis Bullosa Acquisita

Németh, T., Balogh, L., Káposztás, E., Szilveszter, K. P., & Mócsai, A. (2023) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.12.016 · Cited by 8

Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation

Guillet, E., Brun, É., Férard, C., Hardonnière, K., Nabhan, M., Legrand, F., Pallardy, M. J., & Biola‐Vidamment, A. (2023) · Particle and Fibre Toxicology · doi:10.1186/s12989-023-00527-9 · Cited by 8

Germline immunomodulatory expression quantitative trait loci (ieQTLs) associated with immune-related toxicity from checkpoint inhibition

Ferguson, R., Chat, V., Morales, L. J., Simpson, D., Monson, K. R., Cohen, E., Zusin, S., Madonna, G., Capone, M., Simeone, E., et al. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.05.011 · Cited by 8

GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling promotes atherosclerosis

Tsukui, D., Kimura, Y., & Kono, H. (2023) · iScience · doi:10.1016/j.isci.2023.107293 · Cited by 8

Millingtonia hortensis L.f. ethanol extract exerts in vivo and in vitro anti-inflammatory activities through inhibition of Syk kinase in NF-κB pathway

Liu, Y., Kim, J. H., Lim, H. K., Huang, L., Choi, W., Kopalli, S. R., Lee, S., Lee, B.-H., Lee, J. H., Ju, Y., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118386 · Cited by 8

Circulatory age-associated B cells: Their distinct transcriptomic characteristics and clinical significance in drug-naïve patients with rheumatoid arthritis

Kim, J. G., Kim, M., Hong, B., Choe, Y., Kim, J., Lee, N., You, S., Lee, S.-I., & Kim, W. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110425 · Cited by 8

Centrosomal targeting of Syk kinase is controlled by its catalytic activity and depends on microtubules and the dynein motor

Fargier, G., Favard, C., Parmeggiani, A., Sahuquet, A., Mérezègue, F., Morel, A., Denis, M., Molinari, N., Mangeat, P. H., Coopman, P. J., et al. (2012) · The FASEB Journal · doi:10.1096/fj.11-202465 · Cited by 8

Mechanisms determining a differential threshold for sensing Src family kinase activity by B and T cell antigen receptors

Borna, Š., Fabišik, M., Ilievová, K., Dvoracek, T., & Brdička, T. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013552 · Cited by 8

Engineered IgG1-Fc Molecules Define Valency Control of Cell Surface Fcγ Receptor Inhibition and Activation in Endosomes

Bailey, E. M., Choudhury, A., Vuppula, H., Ortiz, D. F., Schaeck, J. J., Manning, A. M., Bosques, C. J., & Hoppe, A. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.617767 · Cited by 8

Pathological predictive factors for late recurrence of hepatocellular carcinoma in chronic liver disease

Nahm, J. H., Lee, H. S., Kim, H., Yim, S. Y., Shin, J., Yoo, J. E., Ahn, S. H., Choi, J. S., Lee, J., & Park, Y. N. (2021) · Liver International · doi:10.1111/liv.14835 · Cited by 8

De novo identification of maximally deregulated subnetworks based on multi-omics data with DeRegNet

Winkler, S., Winkler, I., Figaschewski, M., Tiede, T., Nordheim, A., & Kohlbacher, O. (2022) · BMC Bioinformatics · doi:10.1186/s12859-022-04670-6 · Cited by 8

Co-localization of Fibronectin Receptors LILRB4/gp49B and Integrin on Dendritic Cell Surface

Takahashi, N., Itoi, S., Su, M., Endo, S., & Takai, T. (2022) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2022.j014 · Cited by 8

Targeting the splicing isoforms of spleen tyrosine kinase affects the viability of colorectal cancer cells

Denis, V., Cassagnard, N., Rio, M. D., Cornillot, E., Bec, N., Larroque, C., Jeanson, L., Jarlier, M., Combès, E., Robert, B., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274390 · Cited by 8

Syk protein tyrosine kinase involves PECAM-1 signaling through tandem immunotyrosine inhibitory motifs in human THP-1 macrophages

Wang, J., Wu, Y., Hu, H., Wang, W., Lü, Y., Mao, H.-M., Liu, X., Liu, Z., & Chen, B.-G. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.09.009 · Cited by 8

Spleen tyrosine kinase suppresses osteoblastic differentiation through MAPK and PKCα

Yoshida, K., Higuchi, C., Nakura, A., & Yoshikawa, H. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.07.023 · Cited by 8

Transition Pattern and Mechanism of B-lymphocyte Precursors in Regenerated Mouse Bone Marrow after Subtotal Body Irradiation

Han, D., Zhang, M., Ma, J., Hong, J., Chen, C., Zhang, B., Huang, L., Lv, W., Yin, L., Zhang, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046560 · Cited by 8

1-(2,3-Dibenzimidazol-2-ylpropyl)-2-methoxybenzene Is a Syk Inhibitor with Anti-Inflammatory Properties

Kim, E., Son, Y., Yang, Y., Shen, T., Kim, I., Aravinthan, A., Kim, J., & Cho, J. Y. (2016) · Molecules · doi:10.3390/molecules21040508 · Cited by 8

Screening of potential gene markers for predicting carotid atheroma plaque formation using bioinformatics approaches

Wang, G., Kuai, D., Yang, Y., Yang, G., Wei, Z., & Zhao, W. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6273 · Cited by 8

Updates of cancer hallmarks in patients with inborn errors of immunity

Wang, Y., & Abolhassani, H. (2022) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000863 · Cited by 8

An inhibitor of spleen tyrosine kinase suppresses experimental crescentic glomerulonephritis

Han, Y., Ma, F. Y., Paolo, J. A. D., & Nikolic‐Paterson, D. J. (2018) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738418783404 · Cited by 8

SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells In Vitro

Tümmler, C., Dumitriu, G., Wickström, M., Coopman, P. J., Valkov, A. Y., Kogner, P., Johnsen, J. I., Moens, U. L., & Sveinbjørnsson, B. (2019) · Cancers · doi:10.3390/cancers11020202 · Cited by 8

2-Aminopyrimidine

Lu, X. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18611-0.00012-7 · Cited by 7

The spleen tyrosine kinase inhibitor entospletinib resolves inflammation to promote repair following acute kidney injury

Elias, E. E., Lau, A. N., Belay, S. G., Derakhshani, A., Andonegui, G., Jenne, C. N., Dufour, A., Bracey, N. A., Chun, J., & Muruve, D. A. (2025) · JCI Insight · doi:10.1172/jci.insight.189601 · Cited by 7

Guanosine Triphosphatases and Their Regulators

Thiriet, M. (2012) · Biomathematical and biomechanical modeling of the circulatory and ventilatory systems · doi:10.1007/978-1-4614-4370-4_9 · Cited by 7

The role of Syk phosphorylation in Fc receptor mediated mIgM+ B lymphocyte phagocytosis in flounder (Paralichthys olivaceus)

Hao, Y., Tang, X., Xing, J., Sheng, X., Chi, H., & Zhan, W. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.09.054 · Cited by 7

Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B–deficient mice

Mazharian, A., Maître, B., Bornert, A., Hennequin, D., Lourenco‐Rodrigues, M., Geer, M. J., Smith, C. W., Heising, S., Walter, M., Montel, F., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022008873 · Cited by 7

Signaling network analysis reveals fostamatinib as a potential drug to control platelet hyperactivation during SARS-CoV-2 infection

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Role of non-receptor tyrosine kinases in epilepsy: significance and potential as therapeutic targets

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Animal models of studying the pathogenesis of multi-organ tissue damage in lupus

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Syk inhibitors reduce tau protein phosphorylation and oligomerization

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Single cell spatial profiling of FFPE splenic tissue from a humanized mouse model of HIV infection

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Gpr109A in TAMs promoted hepatocellular carcinoma via increasing PKA/PPARγ/MerTK/IL-10/TGFβ induced M2c polarization

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Targeting the Dectin-1 Receptor in Neuroinflammation: Therapeutic Implications for Neuropsychiatric Disorders

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A SYK/SHC1 pathway regulates the amount of CFTR in the plasma membrane

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Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors

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Mice with Established Diabetes Show Increased Susceptibility to Renal Ischemia/Reperfusion Injury

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Evaluation of the Synergistic Potential of Simultaneous Pan- or Isoform-Specific BET and SYK Inhibition in B-Cell Lymphoma: An In Vitro Approach

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Src- and Abl-family kinases activate spleen tyrosine kinase to maximize phagocytosis and Leishmania infection

Ullah, I., Barrie, U., Kernen, R. M., Mamula, E. T., Khuong, F. T. H., Booshehri, L. M., Rhodes, E. L., Bradford, J. M., Datta, A., & Wetzel, D. M. (2023) · Journal of Cell Science · doi:10.1242/jcs.260809 · Cited by 7

Expanding Our Knowledge of Molecular Pathogenesis in Histiocytoses

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Controling the cytoskeleton during CEACAM3-mediated phagocytosis

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An Acquired Defect Associated with Abnormal Signaling of the Platelet Collagen Receptor Glycoprotein VI

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A Novel Imidazo[1,5-b]isoquinolinone Derivative, U63A05, Inhibits Syk Activation in Mast Cells to Suppress IgE-Mediated Anaphylaxis in Mice

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Targeting Spleen Tyrosine Kinase-Bruton’s Tyrosine Kinase Axis for Immunologically Mediated Glomerulonephritis

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Systems‐level analysis of clinically different phenotypes of juvenile nasopharyngeal angiofibromas

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Syk Inhibition Induces Platelet Dependent Peri-islet Hemorrhage in the Rat Pancreas

Long, A. J., Sampson, E. R., McCarthy, R. W., Harris, C. M., Barnard, M. R., Shi, D., Conlon, D., Caldwell, R. G., Honor, D. J., Wishart, N., et al. (2016) · Toxicologic Pathology · doi:10.1177/0192623316654015 · Cited by 7

Pathogen-Sensing by Mincle: Function and Molecular Aspects

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Spleen Tyrosine Kinase Inhibition Modulates p53 Activity

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Tyrosine kinase inhibitors for the treatment of rheumatoid arthritis: phase I to Ⅱ clinical trials

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Spleen Tyrosine Kinase: A Novel Target in Autoimmunity

Stephen, P., & Tam, F. W. K. (2012) · InTech eBooks · doi:10.5772/26526 · Cited by 1

Tyrosine kinase SYK: essential functions for immunoreceptor signalling

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Spleen tyrosine kinase: An Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases

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Linking inflammation and cancer: the unexpected SYK world

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Syk kinase as a treatment target for therapy in autoimmune diseases

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