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Protective and pathological roles of mast cells and basophils

Voehringer, David·2013·Nature Reviews Immunology
DOI 10.1038/nri3427
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Abstract

Mast cells and basophils are potent effector cells of the innate immune system, and they have both beneficial and detrimental functions for the host. They are mainly implicated in pro-inflammatory responses to allergens but can also contribute to protection against pathogens. Although both cell types were identified more than 130 years ago by Paul Ehrlich, their in vivo functions remain poorly understood. The precursor cell populations that give rise to mast cells and basophils have recently been characterized and isolated. Furthermore, new genetically modified mouse strains have been developed, which enable more specific targeting of mast cells and basophils. Such advances offer new opportunities to uncover the true in vivo activities of these cells and to revisit their previously proposed effector functions.

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Metadata

Authors
Voehringer, D.
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2013-04-05
Volume
13
Issue
5
Pages
362-375
ISSN
  • 1474-1733
  • 1474-1741
DOI
10.1038/nri3427
Cited by
372
References
4
Language
en
Licence
www.springer.com/tdm (tdm)

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