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Telomeres in T and B cells

Hodes, Richard J., Hathcock, Karen S., Weng, Nan-ping·2002·Nature Reviews Immunology

DOI 10.1038/nri890

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 1×
“It was proposed initially that telomerase is expressed in germ-line cells — for which the maintenance of telomeres is crucial to fertility — and in transformed cells that are immortalized or have unlimited growth capacity, but not in normal somatic cell”
Background
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
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The RNA Component of Human Telomerase
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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
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Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
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Essential role of mouse telomerase in highly proliferative organs
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“However, the breeding of successive generations of telomerase-deficient mice results in the progressive shortening of telomeres and, eventually (after ∼5–6 generations), both males and females are sterile, apparently owing to replicative failure and the increased apoptosis of germ-line cell”
Background
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
Hemann, M. T., Strong, M. A., Hao, L.-Y., & Greider, C. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00504-9 · Cited by 1,219

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Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
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The loss of telomerase activity in highly differentiated CD8+CD28−CD27− T cells is associated with decreased Akt (Ser473) phosphorylation
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Telomeres and human aging: facts and fibs
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Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
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Premature ageing of the immune system: the cause of AIDS?
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Will telomere erosion lead to a loss of T-cell memory?
Akbar, A. N., Beverley, P. C. L., & Salmon, M. (2004) · Nature Reviews Immunology · doi:10.1038/nri1440 · Cited by 135
PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation
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Telomere Erosion in Memory T Cells Induced by Telomerase Inhibition at the Site of Antigenic Challenge In Vivo
Reed, J. R., Vukmanovic-Stejic, M., Fletcher, J. M., Soares, M. V. D., Cook, J. E., Orteu, C. H., Jackson, S. E., Birch, K. E., Foster, G. R., Salmon, M., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040178 · Cited by 111
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Telomere length as an indicator of the robustness of B- and T-cell response to influenza in older adults
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Self-citation
Association of immune abnormalities with telomere shortening in autosomal-dominant dyskeratosis congenita
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Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex
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IFN-α Inhibits Telomerase in Human CD8+ T Cells by Both hTERT Downregulation and Induction of p38 MAPK Signaling
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Multifunctional cytomegalovirus (CMV)‐specific CD8+ T cells are not restricted by telomere‐related senescence in young or old adults
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Quiescence and functional reprogramming of Epstein–Barr virus (EBV)-specific CD8+ T cells during persistent infection
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Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice
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Authors: Hodes, R. J., Hathcock, K. S., & Weng, N.-P.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2002-09
Volume: 2
Issue: 9
Pages: 699-706
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri890
OpenAlex: W2093808264
Cited by: 309
References: 26
FWCI: 1.16
Type: journal article
Language: en
Open access: closed

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Telomeres in T and B cells

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