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The GGA proteins: adaptors on the move

Bonifacino, Juan S.·2004·Nature Reviews Molecular Cell Biology
DOI 10.1038/nrm1279
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Abstract

The GGA proteins are a family of ubiquitously expressed, Arf-dependent clathrin adaptors that mediate the sorting of mannose-6-phosphate receptors between the trans-Golgi network and endosomes. Recent studies have elucidated the biochemical and structural bases for the interaction of the GGA proteins with many binding partners, and have shed light on the molecular and cellular mechanisms by which the GGA proteins participate in protein sorting.

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  • GGA proteins are adaptor proteins that, in addition to binding to cargo proteins, also interact with the small GTPase ARF, clathrin, and additional proteins involved in vesicle assembly and targeting.

    “In addition, GGA proteins are adaptor proteins that, in addition to binding to cargo proteins, also interact with the small GTPase ARF, clathrin, and additional proteins involved in vesicle assembly and targeting (Bonifacino, 2004).”

    From GGA1 Is Expressed in the Human Brain and Affects the Generation of Amyloid β-Peptide (2006) · cites this paper as Bonifacino, 2004

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Metadata

Authors
Bonifacino, J. S.
Venue
Nature Reviews Molecular Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2004-01
Volume
5
Issue
1
Pages
23-32
ISSN
  • 1471-0072
  • 1471-0080
DOI
10.1038/nrm1279
Cited by
329
References
4
Language
en
Licence
www.springer.com/tdm (tdm)

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