Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder
Open accessAbstract
Major depressive disorder (MDD) is predicted to be the second leading cause of global disease burden by 2030. A large number of MDD patients do not respond to the currently available medication because of its poorly understood etiology. Recently, studies of microRNAs (miRNAs), which act as a molecular switch of gene expression, have shown promise in identifying a molecular network that could provide significant clues to various psychiatric illnesses. Using an in vitro system, a rodent depression model, and a human postmortem brain, we investigated the role of a brain-enriched, neuron-specific miRNA, miR-124-3p, whose expression is highly dysregulated in stressed rodents, and identified a set of target genes involved in stress response and neural plasticity. We also found that miR-124-3p is epigenetically regulated and its interaction with the RNA-induced silencing complex (RISC) is compromised in MDD. Using blood serum, we found similar dysregulation of miR-124-3p in antidepressant-free MDD subjects. Altogether, our study demonstrates potential contribution of miR-124-3p in the pathophysiology of MDD and suggests that this miRNA may serve as a novel target for drug development and a biomarker for MDD pathogenesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Clinical studies have reported altered expression of miR-124 in patients with major depressive disorder.
“Clinical studies have also reported altered expression of miR-124 in patients with MDD.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [151]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works
A new depression scale designed to be sensitive to change
Montgomery, S. A., & Åsberg, M. (1979) · British Journal of Psychiatry · doi:10.1192/bjp.134.4.382 · Cited by 13,962 · see citing works
(1998) · PubMed · Cited by 10,216 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
MethPrimer: designing primers for methylation PCRs
Li, L.-C., & Dahiya, R. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.11.1427 · Cited by 2,741 · see citing works
Cross-national epidemiology of DSM-IV major depressive episode
Bromet, E., Andrade, L. H., Hwang, I., Sampson, N. A., Alonso, J., de Girolamo, G., de Graaf, R., Demyttenaere, K., Hu, C., Iwata, N., et al. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-90 · Cited by 2,221 · see citing works
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works
MicroRNA biogenesis: coordinated cropping and dicing
Kim, V. N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1644 · Cited by 2,019 · see citing works
Control of translation and mRNA degradation by miRNAs and siRNAs: Table 1.
Valencia-Sanchez, M. A., Liu, J., Hannon, G. J., & Parker, R. (2006) · Genes & Development · doi:10.1101/gad.1399806 · Cited by 1,751 · see citing works
Sempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578 · see citing works
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395 · see citing works
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., Spooner, E., Carr, S. A., & Sabatini, D. M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.003 · Cited by 1,236 · see citing works
Regulation of miRNA expression during neural cell specification
Smirnova, L., Gräfe, A., Seiler, A., Schumacher, S., Nitsch, R., & Wulczyn, F. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03978.x · Cited by 707 · see citing works
Keene, J. D., Komisarow, J. M., & Friedersdorf, M. B. (2006) · Nature Protocols · doi:10.1038/nprot.2006.47 · Cited by 612 · see citing works
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
LaPlant, Q., Vialou, V., Covington, H. E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2619 · Cited by 612 · see citing works
Limbic Regulation of Hypothalamo‐Pituitary‐Adrenocortical Function during Acute and Chronic Stress
Jankord, R., & Herman, J. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.012 · Cited by 578 · see citing works
Yuen, E. Y., Wei, J., Liu, W., Zhong, P., Li, X., & Yan, Z. (2012) · Neuron · doi:10.1016/j.neuron.2011.12.033 · Cited by 558 · see citing works
Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.029 · Cited by 406 · see citing works
Harrison, P. J., Heath, P. R., Eastwood, S. L., Burnet, P. W. J., McDonald, B., & Pearson, R. C. A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12102-a · Cited by 342 · see citing works
Smalheiser, N. R., Lugli, G., Rizavi, H. S., Torvik, V. I., Turecki, G., & Dwivedi, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033201 · Cited by 324 · see citing works
Self-citationZhang, H., Yang, L., Zhu, Y., Yao, X., Zhang, S., Dai, B., Zhu, Y., Shen, Y., Shi, G., & Ye, D. (2010) · The Prostate · doi:10.1002/pros.21246 · Cited by 322 · see citing works
Lopez, J. P., Lim, R., Cruceanu, C., Crapper, L., Fasano, C., Labonte, B., Maussion, G., Yang, J. P., Yerko, V., Vigneault, E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3582 · Cited by 308 · see citing works
Duric, V., Banasr, M., Stockmeier, C. A., Simen, A. A., Newton, S. S., Overholser, J. C., Jurjus, G. J., Dieter, L., & Duman, R. S. (2013) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000016 · Cited by 304 · see citing works
miR-1254 and miR-574-5p: Serum-Based microRNA Biomarkers for Early-Stage Non-small Cell Lung Cancer
Foss, K. M., Chao Sima, A., Ugolini, D., Neri, M., Allen, K. E., & Weiss, G. J. (2011) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e318208c785 · Cited by 281 · see citing works
microRNAs miR-124, let-7d and miR-181a regulate Cocaine-induced Plasticity
Chandrasekar, V., & Dreyer, J. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.08.009 · Cited by 280 · see citing works
REDD1 is essential for stress-induced synaptic loss and depressive behavior
Ota, K. T., Liu, R.-J., Voleti, B., Maldonado-Aviles, J. G., Duric, V., Iwata, M., Dutheil, S., Duman, C., Boikess, S., Lewis, D. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3513 · Cited by 267 · see citing works
Vreugdenhil, E., Veríssimo, C. S., Mariman, R., Kamphorst, J. T., Barbosa, J. S., Zweers, T. J., Champagne, D. L., Schouten, T. G., Meijer, O. C., de Kloet, E. R., et al. (2009) · Endocrinology · doi:10.1210/en.2008-1335 · Cited by 260 · see citing works
Beneyto, M., & Meador‐Woodruff, J. H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301604 · Cited by 255 · see citing works
Jovičić, A., Roshan, R., Moisoi, N., Pradervand, S., Moser, R., Pillai, B., & Luthi-Carter, R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0600-12.2013 · Cited by 251 · see citing works
Gascon, E., Lynch, K., Ruan, H., Almeida, S., Verheyden, J. M., Seeley, W. W., Dickson, D. W., Petrucelli, L., Sun, D., Jiao, J., et al. (2014) · Nature Medicine · doi:10.1038/nm.3717 · Cited by 188 · see citing works
Sheinerman, K. S., & Umansky, S. R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00150 · Cited by 171 · see citing works
Jin, X.-F., Wu, N., Wang, L., & Li, J. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9940-9 · Cited by 154 · see citing works
miRNA-132: a dynamic regulator of cognitive capacity
Hansen, K. F., Karelina, K., Sakamoto, K., Wayman, G. A., Impey, S., & Obrietan, K. H. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0431-4 · Cited by 153 · see citing works
Predictors of Attrition During Initial (Citalopram) Treatment for Depression: A STAR*D Report
Warden, D., Trivedi, M. H., Wisniewski, S. R., Davis, L. L., Nierenberg, A. A., Gaynes, B. N., Zisook, S., Hollon, S. D., Balasubramani, G. K., Howland, R. H., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06071225 · Cited by 146 · see citing works
Meador‐Woodruff, J. H., Hogg, A. J., & Smith, R. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00523-8 · Cited by 141 · see citing works
Dwyer, J. M., & Duman, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.11.011 · Cited by 134 · see citing works
Dwivedi, Y., Roy, B., Lugli, G., Rizavi, H. S., Zhang, H., & Smalheiser, N. R. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.175 · Cited by 133 · see citing works
Self-citationMicroRNA‐132 regulates recognition memory and synaptic plasticity in the perirhinal cortex
Scott, H. L., Tamagnini, F., Narduzzo, K. E., Howarth, J. L., Lee, Y., Wong, L., Brown, M. W., Warburton, E. C., Bashir, Z. I., & Uney, J. B. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08220.x · Cited by 128 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., & Pandey, G. N. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001744 · Cited by 123 · see citing works
Self-citationMaffioletti, E., Tardito, D., Gennarelli, M., & Bocchio‐Chiavetto, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00075 · Cited by 121 · see citing works
Medina, A., Seasholtz, A. F., Sharma, V., Burke, S., Bunney, W. E., Myers, R., Schatzberg, A. F., Akil, H., & Watson, S. J. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.11.002 · Cited by 120 · see citing works
DNA Methylation in the Medial Prefrontal Cortex Regulates Alcohol-Induced Behavior and Plasticity
Barbier, E., Tapocik, J. D., Juergens, N., Pitcairn, C., Borich, A., Schank, J. R., Sun, H., Schuebel, K. E., Zhou, Z., Yuan, Q., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4571-14.2015 · Cited by 116 · see citing works
Smalheiser, N. R., Lugli, G., Rizavi, H. S., Zhang, H., Torvik, V. I., Pandey, G. N., Davis, J. M., & Dwivedi, Y. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710001628 · Cited by 115 · see citing works
Self-citationBeneyto, M., & Meador‐Woodruff, J. H. (2006) · Synapse · doi:10.1002/syn.20329 · Cited by 113 · see citing works
Role of AMPA receptors in synaptic plasticity
Sprengel, R. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0275-4 · Cited by 99 · see citing works
Tsujiura, M., Komatsu, S., Ichikawa, D., Shiozaki, A., Konishi, H., Takeshita, H., Moriumura, R., Nagata, H., Kawaguchi, T., Hirajima, S., et al. (2014) · Gastric Cancer · doi:10.1007/s10120-014-0363-1 · Cited by 96 · see citing works
Hall, B. S., Moda, R. N., & Liston, C. M. (2014) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.10.008 · Cited by 90 · see citing works
Bahí, A., Chandrasekar, V., & Dreyer, J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.04.009 · Cited by 89 · see citing works
Lai, C.-Y., Lee, S.-Y., Scarr, E., Yu, Y., Lin, Y.-T., Liu, C.-M., Hwang, T.-J., Hsieh, M. H., Liu, C.-C., Chien, Y.-L., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.213 · Cited by 80 · see citing works
Biomarkers Predicting Antidepressant Treatment Response: How Can We Advance the Field?
Labermaier, C., Masana, M., & Müller, M. B. (2013) · Disease Markers · doi:10.1155/2013/984845 · Cited by 76 · see citing works
CpG Sites Preferentially Methylated by Dnmt3a in Vivo
Oka, M., Rodić, N., Graddy, J., Chang, L., & Terada, N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511100200 · Cited by 62 · see citing works
Malki, K., Pain, O., Tosto, M. G., Rietz, E. D., Carboni, L., & Schalkwyk, L. C. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.15 · Cited by 53 · see citing works
Wei, Q., Fentress, H. M., Hoversten, M. T., Zhang, L., Hebda‐Bauer, E. K., Watson, S. J., Seasholtz, A. F., & Akil, H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.009 · Cited by 50 · see citing works
Walker, R. M., Rybka, J., Anderson, S. M., Torrance, H. S., Boxall, R., Sussmann, J. E., Porteous, D. J., McIntosh, A. M., & Evans, K. L. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.01.006 · Cited by 44 · see citing works
The pro-differentiating role of miR-124: Indicating the road to become a neuron
Maiorano, N. A., & Mallamaci, A. (2010) · RNA Biology · doi:10.4161/rna.7.5.12262 · Cited by 44 · see citing works
Enoxacin Elevates MicroRNA Levels in Rat Frontal Cortex and Prevents Learned Helplessness
Smalheiser, N. R., Zhang, H., & Dwivedi, Y. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00006 · Cited by 43 · see citing works
Self-citationComprehensive behavioural study of GluR4 knockout mice: implication in cognitive function
Sagata, N., Iwaki, A., Aramaki, T., Takao, K., Kura, S., Tsuzuki, T., Kawakami, R., Ito, I., Kitamura, T., Sugiyama, H., et al. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00629.x · Cited by 43 · see citing works
MicroRNAs: new biomarkers and therapeutic targets after cardiac arrest?
Devaux, Y., Stammet, P., Friberg, H., Hassager, C., Kuiper, M. A., Wise, M. P., & Nielsen, N. (2015) · Critical Care · doi:10.1186/s13054-015-0767-2 · Cited by 39 · see citing works
MicroRNAs in Memory Processing
Fischbach, S., & Carew, T. J. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.007 · Cited by 25 · see citing works
Flagged first, then by citations
1 of the 62 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
Remes, O., Mendes, J. F., & Templeton, P. (2021) · Brain Sciences · doi:10.3390/brainsci11121633 · Cited by 482 · see citing works
Stress, epigenetics and depression: A systematic review
Park, C., Rosenblat, J. D., Brietzke, E., Pan, Z., Lee, Y., Cao, B., Zuckerman, H., Kalantarova, A., & McIntyre, R. S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.010 · Cited by 465 · see citing works
Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
van den Berg, M. M. J., Krauskopf, J., Ramaekers, J. G., Kleinjans, J. C. S., Prickaerts, J., & Briedé, J. J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101732 · Cited by 253 · see citing works
Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works
Wei, Z.-X., Xie, G.-J., Mao, X., Zou, X.-P., Liao, Y.-J., Liu, Q.-S., Wang, H., & Cheng, Y. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0622-2 · Cited by 227 · see citing works
The stressed synapse 2.0: pathophysiological mechanisms in stress-related neuropsychiatric disorders
Sanacora, G., Yan, Z., & Popoli, M. (2022) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00540-x · Cited by 197 · see citing works
Epigenetic mechanisms of major depression: Targeting neuronal plasticity
Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works
MicroRNAs and exosomes in depression: Potential diagnostic biomarkers
Tavakolizadeh, J., Roshanaei, K., Salmaninejad, A., Yari, R., Nahand, J. S., Khoshdel‐Sarkarizi, H., Mousavi, S. M., Salarinia, R., Rahmati, M., Mousavi, S. F., et al. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26599 · Cited by 160 · see citing works
MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior
Allen, L., & Dwivedi, Y. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0597-8 · Cited by 148 · see citing works
Self-citationGorinski, N., Bijata, M., Prasad, S., Wirth, A., Galil, D. A., Zeug, A., Базовкина, Д. В., Kondaurova, E. M., Kulikova, E. A., Ilchibaeva, T. V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11876-5 · Cited by 134 · see citing works
Lopez, J. P., Kos, A., & Turecki, G. (2018) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000379 · Cited by 108 · see citing works
Exploiting Circulating MicroRNAs as Biomarkers in Psychiatric Disorders
Roy, B., Yoshino, Y., McKibben, L. A., Prall, K., Schell, G., & Dwivedi, Y. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00464-9 · Cited by 95 · see citing works
Self-citationFang, Y., Qiu, Q., Zhang, S., Sun, L., Li, G., Xiao, S., & Li, X. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.090 · Cited by 90 · see citing works
Circulating microRNAs as biomarkers for depression: Many candidates, few finalists
Yuan, H., Mischoulon, D., Fava, M., & Otto, M. W. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.058 · Cited by 86 · see citing works
Dissecting early life stress-induced adolescent depression through epigenomic approach
Ochi, S., & Dwivedi, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01907-x · Cited by 90 · see citing works
Self-citationAdvance in Stress for Depressive Disorder
Ding, Y., & Dai, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_8 · Cited by 82 · see citing works
Cell-free nucleic acid patterns in disease prediction and monitoring—hype or hope?
Crigna, A. T., Samec, M., Koklesová, L., Líšková, A., Giordano, F. A., Kubatka, P., & Golubnitschaja, O. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00226-x · Cited by 79 · see citing works
MiR-218: a molecular switch and potential biomarker of susceptibility to stress
Torres-Berrío, A., Nouel, D., Cuesta, S., Parise, E. M., Restrepo-Lozano, J. M., Larochelle, P., Nestler, E. J., & Flores, C. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0421-5 · Cited by 79 · see citing works
Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior
Yoshino, Y., & Dwivedi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.543893 · Cited by 82 · see citing works
Self-citationmicroRNA-124 targets glucocorticoid receptor and is involved in depression-like behaviors
Wang, S., Mu, R.-H., Li, C., Dong, S., Geng, D., Liu, Q., & Yi, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.024 · Cited by 80 · see citing works
Non-coding RNAs in depression: Promising diagnostic and therapeutic biomarkers
Shi, Y., Wang, Q., Song, R., Kong, Y., & Zhang, Z. (2021) · eBioMedicine · doi:10.1016/j.ebiom.2021.103569 · Cited by 79 · see citing works
MicroRNAs in depression and suicide: Recent insights and future perspectives
Dwivedi, Y. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.075 · Cited by 77 · see citing works
Self-citationGruzdev, S. K., Yakovlev, A. A., Druzhkova, T. A., Guekht, A. B., & Gulyaeva, N. V. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00684-6 · Cited by 75 · see citing works
Xu, J., Wang, R., Liu, Y., Liu, D., Jiang, H., & Pan, F. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.08.010 · Cited by 75 · see citing works
MicroRNA-dependent control of neuroplasticity in affective disorders
Martins, H. C., & Schratt, G. M. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01379-7 · Cited by 73 · see citing works
The role of microRNAs in glucocorticoid action
Clayton, S. A., Jones, S. W., Kurowska‐Stolarska, M., & Clark, A. R. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.000366 · Cited by 73 · see citing works
Yoshino, Y., Roy, B., & Dwivedi, Y. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00861-y · Cited by 68 · see citing works
Self-citationBahí, A. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.03.010 · Cited by 70 · see citing works
Periyasamy, P., Thangaraj, A., Guo, M., Hu, G., Callen, S. E., & Buch, S. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3474-17.2018 · Cited by 65 · see citing works
Role of non-coding RNA in the pathogenesis of depression
Liu, N., Wang, Z., Zhao, M., Zhang, Y., & Chen, N. (2019) · Gene · doi:10.1016/j.gene.2019.144276 · Cited by 61 · see citing works
Mauer, J., Xavier, G., Ota, V., Chehimi, S. N., Mafra, F., Cuóco, C., Ito, L. T., Ormond, R., Asprino, P. F., Oliveira, A., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02326-4 · Cited by 61 · see citing works
Xu, J., Wang, R., Liu, Y., Wang, W., Liu, D., Jiang, H., & Pan, F. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.11.008 · Cited by 59 · see citing works
miR-124 ameliorates depressive-like behavior by targeting STAT3 to regulate microglial activation
Lou, D., Wang, J., & Wang, X. (2019) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2019.101470 · Cited by 58 · see citing works
MicroRNAs as critical biomarkers of major depressive disorder: a comprehensive perspective
Ortega, M. A., Alvarez-Mon, M. A., García-Montero, C., Fraile-Martinez, O., Lahera, G., Monserrat, J., Muñoz-Merida, L., Mora, F., Rodríguez-Jiménez, R., Fernandez-Rojo, S., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9111659 · Cited by 57 · see citing works
The role of microRNAs in depression
Ding, R., Su, D., Zhao, Q., Wang, Y., Wang, J., Lv, S., & Ji, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1129186 · Cited by 57 · see citing works
Żurawek, D., & Turecki, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111312 · Cited by 60 · see citing works
MiR-221 is involved in depression by regulating Wnt2/CREB/BDNF axis in hippocampal neurons
Lian, N., Niu, Q., Lei, Y., Li, X., Li, Y., & Song, X. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1556060 · Cited by 54 · see citing works
Roy, B., Dunbar, M., Agrawal, J., Allen, L., & Dwivedi, Y. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz071 · Cited by 53 · see citing works
Self-citationEpigenetic mechanisms impacted by chronic stress across the rodent lifespan
Dion, A., Muñoz, P., & Franklin, T. B. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100434 · Cited by 54 · see citing works
Zhou, L., Zhu, Y., Chen, W., & Tang, Y. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.063 · Cited by 49 · see citing works
Integrated MicroRNA and mRNA Profiling in Zika Virus-Infected Neurons
Azouz, F., Arora, K., Krause, K. K., Nerurkar, V. R., & Kumar, M. (2019) · Viruses · doi:10.3390/v11020162 · Cited by 50 · see citing works
Huang, Y.-L., Zeng, N.-X., Chen, J., Niu, J., Luo, W.-L., Liu, P., Yan, C., & Wu, L.-L. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.270414 · Cited by 48 · see citing works
Fan, D., Cao, M.-Q., Liu, Q., Sun, N.-N., & Wu, Z. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.232478 · Cited by 47 · see citing works
Ferrúa, C. P., Giorgi, R., Camerini, L., do Amaral, C. C., Ghisleni, G., Pinheiro, R. T., & Nedel, F. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.101650 · Cited by 44 · see citing works
microRNA-124: a putative therapeutic target and biomarker for major depression
Dwivedi, Y. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1328501 · Cited by 44 · see citing works
Self-citationAltered expression of long noncoding RNAs in patients with major depressive disorder
Seki, T., Yamagata, H., Uchida, S., Chen, C., Kobayashi, A., Kobayashi, M., Harada, K., Matsuo, K., Watanabe, Y., & Nakagawa, S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.07.004 · Cited by 42 · see citing works
A new perspective on depression and neuroinflammation: Non-coding RNA
Zhou, S., Chen, R., She, Y., Liu, X., Zhao, H., Li, C., & Jia, Y. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.007 · Cited by 42 · see citing works
Mitochondria: A Connecting Link in the Major Depressive Disorder Jigsaw
Sharma, S., & Akundi, R. S. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180302120322 · Cited by 42 · see citing works
Yoshino, Y., Roy, B., Kumar, N., Mukhtar, M. S., & Dwivedi, Y. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01159-9 · Cited by 43 · see citing works
Self-citationBortolozzi, A., Manashirov, S., Chen, A., & Artigas, F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107873 · Cited by 37 · see citing works
MicroRNAs, Multiple Sclerosis, and Depression
Wang, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157802 · Cited by 45 · see citing works
Rasheed, M., Asghar, R., Firdoos, S., Ahmad, N., Nazir, A., Ullah, K. M., Li, N., Zhuang, F., Chen, Z., & Deng, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031294 · Cited by 41 · see citing works
Roy, B., Wang, Q., & Dwivedi, Y. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy010 · Cited by 38 · see citing works
Self-citationMiR-124 suppression in the prefrontal cortex reduces depression-like behavior in mice
Gu, Z., Pan, J., & Chen, L. (2019) · Bioscience Reports · doi:10.1042/bsr20190186 · Cited by 39 · see citing works
Yoshino, Y., & Dwivedi, Y. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.001 · Cited by 38 · see citing works
Self-citationXu, Y., Xia, Q., Xia, Q., Zhang, X., & Liang, J. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s237116 · Cited by 40 · see citing works
miRNAs in depression vulnerability and resilience: novel targets for preventive strategies
Lopizzo, N., Zonca, V., Cattane, N., Pariante, C. M., & Cattaneo, A. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02048-2 · Cited by 37 · see citing works
Dash, S., Balasubramaniam, M., Martínez-Rivera, F. J., Godino, A., Peck, E. G., Patnaik, S., Suar, M., Calipari, E. S., Nestler, E. J., Villalta, F., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-68144-6 · Cited by 36 · see citing works
The Role of MicroRNA and Microbiota in Depression and Anxiety
Rosa, J. M., Formolo, D. A., Yu, J., Lee, T. H.-Y., & Yau, S. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.828258 · Cited by 37 · see citing works
Synaptic plasticity and depression: the role of miRNAs dysregulation
Rahmani, S., Kadkhoda, S., & Ghafouri‐Fard, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07461-7 · Cited by 36 · see citing works
Potential Use of MicroRNA for Monitoring Therapeutic Response to Antidepressants
Belzeaux-R, R., Lin, R., & Turecki, G. (2017) · CNS Drugs · doi:10.1007/s40263-017-0418-z · Cited by 36 · see citing works
Gender Differences in Cortisol and Cortisol Receptors in Depression: A Narrative Review
Teo, C. H., Wong, A. C. H., Sivakumaran, R. N., Parhar, I. S., & Soga, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087129 · Cited by 35 · see citing works
Suster, I., & Feng, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136765 · Cited by 37 · see citing works
Li, X., Zhao, J., Li, Z., Zhang, L., & Huo, Z. (2020) · Neural Plasticity · doi:10.1155/2020/8850653 · Cited by 35 · see citing works
Stress, microRNAs, and stress-related psychiatric disorders: an overview
Musazzi, L., Mingardi, J., Ieraci, A., Barbon, A., & Popoli, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02139-3 · Cited by 33 · see citing works
Ma, K., Zhang, H., Wei, G., Dong, Z., Zhao, H., Han, X., Song, X., Zhang, H., Zong, X., Baloch, Z., et al. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s200264 · Cited by 32 · see citing works
MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence
Morgunova, A., & Flores, C. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.04.011 · Cited by 33 · see citing works
Roy, B., Ochi, S., & Dwivedi, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054664 · Cited by 33 · see citing works
Self-citationA review of pre-clinical models for Gulf War Illness
Ribeiro, A. C. R., & Deshpande, L. S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107936 · Cited by 32 · see citing works
MicroRNAs in Major Depressive Disorder
Fries, G. R., Zhang, W., Benevenuto, D., & Quevedo, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-05542-4_9 · Cited by 31 · see citing works
Inkster, B., Simmons, A., Cole, J. H., Schoof, E. M., Linding, R., Nichols, T., Muglia, P., Holsboer, F., Sämann, P. G., McGuffin, P., et al. (2018) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000203 · Cited by 29 · see citing works
McKibben, L. A., & Dwivedi, Y. (2021) · Epigenomics · doi:10.2217/epi-2021-0037 · Cited by 29 · see citing works
Self-citationMcKibben, L. A., & Dwivedi, Y. (2021) · BMC Genomics · doi:10.1186/s12864-021-08003-4 · Cited by 27 · see citing works
Self-citationYoshino, Y., Roy, B., & Dwivedi, Y. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.06.004 · Cited by 27 · see citing works
Self-citationMolecular Mechanisms Involved in the Regulation of Neurodevelopment by miR-124
Gu, X., Xu, X., Jia, C., Wang, J., Zhang, J., Gao, Q., & Chen, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03271-5 · Cited by 27 · see citing works
Roy, B., Ochi, S., & Dwivedi, Y. (2022) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyac068 · Cited by 25 · see citing works
Self-citationHeterogeneity in major depressive disorder: The need for biomarker-based personalized treatments
Suseelan, S., & Pinna, G. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.09.001 · Cited by 26 · see citing works
Wang, Q., Zhao, G., Yang, Z., Liu, X., & Xie, P. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3235 · Cited by 26 · see citing works
Nguyen, H. D., & Kim, M. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.108 · Cited by 25 · see citing works
Roy, B., & Dwivedi, Y. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105040 · Cited by 27 · see citing works
Self-citationWang, X., Sundquist, K., Palmér, K., Hedelius, A., Memon, A. A., & Sundquist, J. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy001 · Cited by 25 · see citing works
Chen, Y., & Wang, H. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200425214906 · Cited by 25 · see citing works
Chen, H., Chung, Y.-C. E., Chen, H., Liu, Y.-W., Chen, I., Lu, M., Hsiao, F. S., Chen, C.-H., Huang, M., Shih, W., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-24773-7 · Cited by 24 · see citing works
Liu, X., Dong, L., Jiang, Z., Song, M., & Yan, P. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1390366 · Cited by 24 · see citing works
The molecular basis of depression: implications of sex-related differences in epigenetic regulation
Kawatake-Kuno, A., Murai, T., & Uchida, S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.708004 · Cited by 23 · see citing works
miR-124 antagonizes the antidepressant-like effects of standardized gypenosides in mice
Yi, L., Mu, R.-H., Dong, S., Wang, S., Li, C., Geng, D., & Liu, Q. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118758304 · Cited by 23 · see citing works
Inkster, B., Zai, G. C., Lewis, G., & Miskowiak, K. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0270-z · Cited by 23 · see citing works
Duarte-Silva, E. P., Oriá, A. C., Mendonça, I. P., de Melo, M. G., de Paiva, I. H. R., Maes, M. H. J., Joca, S. R. L., & Peixoto, C. A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104582 · Cited by 21 · see citing works
Corticosterone-mediated regulation and functions of miR-218-5p in rat brain
Yoshino, Y., Roy, B., & Dwivedi, Y. (2022) · Scientific Reports · doi:10.1038/s41598-021-03863-y · Cited by 21 · see citing works
Self-citationmiRNAs as potential diagnostic biomarkers and pharmacogenomic indicators in psychiatric disorders
Tsermpini, E. E., Kalogirou, C., Kyriakopoulos, G. C., Patrinos, G. P., & Stathopoulos, C. (2022) · The Pharmacogenomics Journal · doi:10.1038/s41397-022-00283-7 · Cited by 22 · see citing works
Liu, Z., Yang, J., Fang, Q., Shao, H., Yang, D., Sun, J., & Gao, L. (2021) · Brain and Behavior · doi:10.1002/brb3.2107 · Cited by 22 · see citing works
Song, W., Shen, Y., Zhang, Y., Peng, S., Zhang, R., Ning, A., Li, H., Li, X., Lin, G. N., & Yu, S. (2019) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-019-0964-z · Cited by 21 · see citing works
Distribution of microRNAs associated with major depressive disorder among blood compartments
Homorogan, C., ENĂTESCU, V. R., Nițușcă, D., Marcu, A., Șeclăman, E. P., & Marian, C. (2021) · Journal of International Medical Research · doi:10.1177/03000605211006633 · Cited by 21 · see citing works
McKibben, L. A., & Dwivedi, Y. (2021) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.05.009 · Cited by 21 · see citing works
Self-citationZhang, Y., Pang, Y., Feng, W., Jin, Y., Chen, S., Ding, S., Wang, Z., Zou, Y., Li, Y., Wang, T., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04533-6 · Cited by 21 · see citing works
Abd‐Elmawla, M. A., Essam, R. M., Ahmed, K. A., & Abdelmonem, M. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00013 · Cited by 21 · see citing works
Epigenetic mechanisms linking early-life adversities and mental health
Cánepa, E. T., & Berardino, B. G. (2024) · Biochemical Journal · doi:10.1042/bcj20230306 · Cited by 21 · see citing works
Llorens, F., Thüne, K., Andrés‐Benito, P., Tahir, W., Ansoleaga, B., Hernández‐Ortega, K., Martı́, E., Zerr, I., & Ferrer, I. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0971-4 · Cited by 21 · see citing works
Periodontal Pathogens and Neuropsychiatric Health
Wadhawan, A., Reynolds, M. A., Makkar, H., Scott, A. J., Potocki, E., Hoisington, A. J., Brenner, L. A., Dagdag, A., Lowry, C. A., Dwivedi, Y., et al. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200110161105 · Cited by 22 · see citing works
Self-citationHomorogan, C., Nițușcă, D., Șeclăman, E. P., ENĂTESCU, V. R., & Marian, C. (2021) · Life · doi:10.3390/life11101073 · Cited by 20 · see citing works
- Authors
- Roy, B., Dunbar, M., Shelton, R. C., & Dwivedi, Y.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Dwivedi, Yogesh
- Venue
- Neuropsychopharmacology
- Published
- 2016-08-31
- Volume
- 42
- Issue
- 4
- Pages
- 864-875
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5312059
- OpenAlex
- W2510657589
- Cited by
- 199
- References
- 62
- Citations by year
- 2026: 6 · 2025: 21 · 2024: 18 · 2023: 15 · 2022: 32 · 2021: 32 · 2020: 19 · 2019: 22 · 2018: 19 · 2017: 15
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R21MH081099, R01MH101890, R01MH082802, R01MH100616, R01MH107183)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, epigenetic regulation, RNA-induced silencing complex, stress response, neuroplasticity, serum biomarkers, antidepressant resistance, depression pathophysiology, postmortem brain
- MeSH terms
- Adult, Animals, Major Depressive Disorder, Disease Models, Animal, Humans, Neuronal Plasticity, Stress, Psychological, Prefrontal Cortex, MicroRNAs, Epigenesis, Genetic, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review