Cited by 199MicroRNA in disease regulationTreatment of Major DepressionStress Responses and Cortisol

Identification of MicroRNA-124-3p as a Putative Epigenetic Signature of Major Depressive Disorder

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Roy, Bhaskar, Dunbar, Michael, Shelton, Richard C, Dwivedi, Yogesh·2017·Neuropsychopharmacology

Abstract

Major depressive disorder (MDD) is predicted to be the second leading cause of global disease burden by 2030. A large number of MDD patients do not respond to the currently available medication because of its poorly understood etiology. Recently, studies of microRNAs (miRNAs), which act as a molecular switch of gene expression, have shown promise in identifying a molecular network that could provide significant clues to various psychiatric illnesses. Using an in vitro system, a rodent depression model, and a human postmortem brain, we investigated the role of a brain-enriched, neuron-specific miRNA, miR-124-3p, whose expression is highly dysregulated in stressed rodents, and identified a set of target genes involved in stress response and neural plasticity. We also found that miR-124-3p is epigenetically regulated and its interaction with the RNA-induced silencing complex (RISC) is compromised in MDD. Using blood serum, we found similar dysregulation of miR-124-3p in antidepressant-free MDD subjects. Altogether, our study demonstrates potential contribution of miR-124-3p in the pathophysiology of MDD and suggests that this miRNA may serve as a novel target for drug development and a biomarker for MDD pathogenesis.

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Authors
Roy, B., Dunbar, M., Shelton, R. C., & Dwivedi, Y.
Affiliations
University of Alabama at Birmingham (US)
Corresponding author
Dwivedi, Yogesh
Venue
Neuropsychopharmacology
Published
2016-08-31
Volume
42
Issue
4
Pages
864-875
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W2510657589
Cited by
199
References
62
Citations by year
2026: 6 · 2025: 21 · 2024: 18 · 2023: 15 · 2022: 32 · 2021: 32 · 2020: 19 · 2019: 22 · 2018: 19 · 2017: 15
FWCI
7.77
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R21MH081099, R01MH101890, R01MH082802, R01MH100616, R01MH107183)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
major depressive disorder, epigenetic regulation, RNA-induced silencing complex, stress response, neuroplasticity, serum biomarkers, antidepressant resistance, depression pathophysiology, postmortem brain
MeSH terms
Adult, Animals, Major Depressive Disorder, Disease Models, Animal, Humans, Neuronal Plasticity, Stress, Psychological, Prefrontal Cortex, MicroRNAs, Epigenesis, Genetic, Rats

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