Axon degeneration mechanisms: commonality amid diversity

Alzheimer's Disease Is a Synaptic Failure

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Axonal transection in the lesions of multiple sclerosis

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Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

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Axonal damage in acute multiple sclerosis lesions

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Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

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Death by design: apoptosis, necrosis and autophagy

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Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

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Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

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Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

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Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress

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Axonopathy Is Associated with Complex Axonal Transport Defects in a Model of Multiple Sclerosis

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Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons

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A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity

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Overexpression of Wlds or Nmnat2 in mauthner cells by single‐cell electroporation delays axon degeneration in live zebrafish

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Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or superoxide-generating herbicides causes axonal degeneration in mouse DRG cultures

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SARM1 signaling mechanisms in the injured nervous system

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Mitochondria as Crucial Players in Demyelinated Axons: Lessons from Neuropathology and Experimental Demyelination

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Exposure to low-dose rotenone precipitates synaptic plasticity alterations in PINK1 heterozygous knockout mice

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Subtype-specific survival and regeneration of retinal ganglion cells in response to injury

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Embryonic Stem Cell–Based Modeling of Tau Pathology in Human Neurons

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Concepts for regulation of axon integrity by enwrapping glia

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Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer’s disease: implications for axoplasmic transport

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Complex geometric models of diffusion and relaxation in healthy and damaged white matter

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Evolutionary divergence of valosin‐containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum‐associated degradation proteins

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Storage Vesicles in Neurons Are Related to Golgi Complex Alterations in Mucopolysaccharidosis IIIB

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Oxidative damage to mitochondria at the nodes of Ranvier precedes axon degeneration in ex vivo transected axons

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Phosphatidylserine save-me signals drive functional recovery of severed axons in Caenorhabditis elegans

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Contrasting Roles for Axonal Degeneration in an Autoimmune versus Viral Model of Multiple Sclerosis

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Role of the Akt/GSK-3β/CRMP-2 pathway in axon degeneration of dopaminergic neurons resulting from MPP+ toxicity

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Is Abnormal Axonal Transport a Cause, a Contributing Factor or a Consequence of the Neuronal Pathology in Alzheimer‘s Disease?

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White matter microstructural changes in pure Alzheimer's disease and subcortical vascular dementia

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Axonal and neuronal degeneration in myelin diseases

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Familial Mutations and Post-translational Modifications of UCH-L1 in Parkinson's Disease and Neurodegenerative Disorders

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Focal Increases of Axoplasmic Ca2+, Aggregation of Sodium–Calcium Exchanger, N-type Ca2+Channel, and Actin Define the Sites of Spheroids in Axons Undergoing Oxidative Stress

Barsukova, A. G., Forte, M. A., & BOURDETTE, D. N. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0408-12.2012 · Cited by 40

Hippocampal Disconnection in Early Alzheimer's Disease: A 7 Tesla MRI Study

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Effects of the coexistence of late-life depression and mild cognitive impairment on white matter microstructure

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A Human‐Based Functional NMJ System for Personalized ALS Modeling and Drug Testing

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Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

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Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma

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Axonal Transport and Mitochondrial Dysfunction in Alzheimer's Disease

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Mild and repetitive very mild axonal stretch injury triggers cystoskeletal mislocalization and growth cone collapse

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Glycosphingolipid synthesis in cerebellar Purkinje neurons: Roles in myelin formation and axonal homeostasis

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Neurotrimin is an estrogen‐regulated determinant of peripheral sympathetic innervation

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Amyloid precursor protein at node of Ranvier modulates nodal formation

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Microtubule Destabilization Paves the Way to Parkinson’s Disease

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Stimulating neuroregeneration as a therapeutic drug approach for traumatic brain injury

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Effect of Lycium barbarum (Wolfberry) on Alleviating Axonal Degeneration after Partial Optic Nerve Transection

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Microstructural integrity of the cingulum is related to verbal memory performance in elderly with cerebral small vessel disease

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Sensory Neurons Derived from Diabetic Rats Have Diminished Internal Ca 2+ Stores Linked to Impaired Re-uptake by the Endoplasmic Reticulum

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Late onset distal axonal swelling in YFP-H transgenic mice

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MRI of optic neuritis in a rat model

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Connexin- and Pannexin-Based Channels in Normal Skeletal Muscles and Their Possible Role in Muscle Atrophy

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A Perspective on Neuronal Cell Death Signaling and Neurodegeneration

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Network neuroscience of apathy in cerebrovascular disease

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NLRP3 inflammasome is involved in nerve recovery after sciatic nerve injury

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From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer’s and Parkinson’s diseases

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Canine Adipose-Derived Mesenchymal Stromal Cells Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury

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Dysregulation of axonal transport and motorneuron diseases

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Astaxanthin ameliorates prenatal LPS-exposed behavioral deficits and oxidative stress in adult offspring

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Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon

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The WldS mutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro‐striatal pathway in vivo

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Sodium and Potassium Currents Influence Wallerian Degeneration of InjuredDrosophilaAxons

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Axon degeneration: Mechanisms and implications of a distinct program from cell death

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Nucleoside reverse transcriptase inhibitors and human immunodeficiency virus proteins cause axonal injury in human dorsal root ganglia cultures

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Reactive oxygen species induce neurite degeneration before induction of cell death

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Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA/2J Mouse Model of Glaucoma

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Maintaining energy homeostasis is an essential component of WldS-mediated axon protection

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Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 as a Neuroprotective Agent: Promotion of the Morphological Development of Midbrain Dopaminergic Neurons

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Diffusion Tensor Imaging Detects Retinal Ganglion Cell Axon Damage in the Mouse Model of Optic Nerve Crush

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Specific saposin C deficiency: CNS impairment and acid -glucosidase effects in the mouse

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Frataxin silencing alters microtubule stability in motor neurons: implications for Friedreich’s ataxia

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Axonal degeneration in the peripheral nervous system: Implications for the pathogenesis of amyotrophic lateral sclerosis

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C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice

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Preserve and protect: maintaining axons within functional circuits

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Network-wide integration of stem cell-derived neurons and mouse cortical neurons using microfabricated co-culture devices

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APP upregulation contributes to retinal ganglion cell degeneration via JNK3

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Current Insights Into the Pathology of Canine Intervertebral Disc Extrusion-Induced Spinal Cord Injury

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The degeneration of dopaminergic synapses in Parkinson's disease: A selective animal model

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Neurotrophic Effect of Adipose Tissue‐Derived Stem Cells on Erectile Function Recovery by Pigment Epithelium‐Derived Factor Secretion in a Rat Model of Cavernous Nerve Injury

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Axon Biology in ALS: Mechanisms of Axon Degeneration and Prospects for Therapy

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High‐resolution diffusion tensor imaging of fixed brain in a mouse model of Pelizaeus–Merzbacher disease: comparison with quantitative measures of white matter pathology

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Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis

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Axonal spheroids in neurodegeneration

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Imaging of rat optic nerve axons in vivo

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The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy

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Reevaluation of Neurodegeneration inlurcherMice: Constitutive Ion Fluxes Cause Cell Death with, Not by, Autophagy

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Differential Regional and Subtype-Specific Vulnerability of Enteric Neurons to Mitochondrial Dysfunction

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Pathological classification of equine recurrent laryngeal neuropathy

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Identification of a critical site in Wlds: Essential for Nmnat enzyme activity and axon-protective function

Jia, H., Yan, T., Feng, Y., Zeng, C., Shi, X., & Zhai, Q. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.11.067 · Cited by 33

Linking Cell Surface Receptors to Microtubules: Tubulin Folding Cofactor D Mediates Dscam Functions during Neuronal Morphogenesis

Okumura, M., Sakuma, C., Miura, M., & Chihara, T. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0973-14.2015 · Cited by 32

Dysfunctional RNA‐binding protein biology and neurodegeneration in experimental autoimmune encephalomyelitis in female mice

Salapa, H. E., Libner, C. D., & Levin, M. C. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24554 · Cited by 33

The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons

Anderson, E. N., Hirpa, D., Zheng, K. H., Banerjee, R., & Gunawardena, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00540 · Cited by 32

Schwann Cells as Orchestrators of Nerve Repair: Implications for Tissue Regeneration and PathologiesPreprint

Stassart, R. M., Gomez-Sanchez, J. A., & Lloyd, A. C. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041363 · Cited by 32

Axonal dysfunction in internal capsule is closely associated with early motor deficits after intracerebral hemorrhage in mice

Hijioka, M., Anan, J., Matsushita, H., Ishibashi, H., Kurauchi, Y., Hisatsune, A., Seki, T., & Katsuki, H. (2015) · Neuroscience Research · doi:10.1016/j.neures.2015.10.006 · Cited by 31

Efficacy of low-level laser therapy in nerve injury repair—a new era in therapeutic agents and regenerative treatments

Muniz, X. C., de Assis, A. C. C., de Oliveira, B. S. A., Ferreira, L. F. R., Bilal, M., Iqbal, H. M. N., & Soriano, R. N. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05478-7 · Cited by 31

Paranode Abnormalities and Oxidative Stress in Optic Nerve Vulnerable to Secondary Degeneration: Modulation by 670 nm Light Treatment

Szymanski, C. R., Chiha, W., Morellini, N. M., Cummins, N., Bartlett, C. A., Doig, R. O., Savigni, D. L., Payne, S. C., Harvey, A. R., Dunlop, S. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066448 · Cited by 31

Chronology of Erectile Function in Patients with Early Functional Erections Following Radical Prostatectomy

Katz, D. J., Bennett, N., Stasi, J. P., Eastham, J. A., Guillonneau, B. D., Scardino, P. T., & Mulhall, J. P. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01516.x · Cited by 31

Secondary neuroprotective effects of hypotensive drugs and potential mechanisms of action

Shih, G. C., & Calkins, D. J. (2012) · Expert Review of Ophthalmology · doi:10.1586/eop.12.13 · Cited by 31

Loss of translation elongation factor (eEF1A2) expression in vivo differentiates between Wallerian degeneration and dying‐back neuronal pathology

Murray, L. M., Thomson, D., Conklin, A., Wishart, T. M., & Gillingwater, T. H. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.01007.x · Cited by 31

The Mechanisms of Regulated Cell Death: Structural and Functional Proteomic Pathways Induced or Inhibited by a Specific Protein—A Narrative Review

Fernández‐Lázaro, D., Sanz, B., & Seco‐Calvo, J. (2024) · Proteomes · doi:10.3390/proteomes12010003 · Cited by 33

Axo‐glial interaction in the injured PNS

Stassart, R. M., & Woodhoo, A. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22771 · Cited by 30

Developmental exposure to non-dioxin-like polychlorinated biphenyls promotes sensory deficits and disrupts dopaminergic and GABAergic signaling in zebrafish

Brun, N. R., Panlilio, J. M., Zhang, K., Zhao, Y., Ivashkin, E. G., Stegeman, J. J., & Goldstone, J. V. (2021) · Communications Biology · doi:10.1038/s42003-021-02626-9 · Cited by 30

Limited restoration of visual function after partial optic nerve injury; a time course study using the calcium channel blocker lomerizine

Selt, M., Bartlett, C. A., Harvey, A. R., Dunlop, S. A., & Fitzgerald, M. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.11.004 · Cited by 30

Antibodies to the RNA-binding protein hnRNP A1 contribute to neurodegeneration in a model of central nervous system autoimmune inflammatory disease

Douglas, J. N., Gardner, L. A., Salapa, H. E., Lalor, S. J., Lee, S., Segal, B. M., Sawchenko, P. E., & Levin, M. C. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0647-y · Cited by 30

Aging Schwann cells in vitro

Funk, D., Fricke, C., & Schlosshauer, B. (2007) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2006.12.006 · Cited by 30

Molecular Signaling

Coleman, M. P. (2011) · Advances in genetics · doi:10.1016/b978-0-12-380860-8.00005-7 · Cited by 31

Sprouting of axonal collaterals after spinal cord injury is prevented by delayed axonal degeneration

Collyer, E., Catenaccio, A., Lemaitre, D., Díaz, P., Valenzuela, V., Bronfman, F. C., & Court, F. A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.07.014 · Cited by 29

Mitochondrial Complex Enzyme Activities and Cytochrome c Expression Changes in Multiple Sclerosis

Iñarrea, P., Alarcia, R., Álava, M. A., Capablo, J. L., Casanova, A., Íñiguez, C., Iturralde, M., Larrodé, P., Martín, J., Mostacero, E., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8481-z · Cited by 29

Axonal and Cell Body Protection By Nicotinamide Adenine Dinucleotide in Tumor Necrosis Factor-Induced Optic Neuropathy

Kitaoka, Y., Hayashi, Y., Kumai, T., Takeda, H., Munemasa, Y., Fujino, H., Kitaoka, Y., Ueno, S., Sadun, A. A., & Lam, T. T. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181afecfa · Cited by 29

Magnetic resonance imaging of the mouse visual pathway for in vivo studies of degeneration and regeneration in the CNS

Haenold, R., Herrmann, K., Schmidt, S., Reichenbach, J. R., Schmidt, K.-F., Löwel, S., Witte, O. W., Weih, F., & Kretz, A. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.069 · Cited by 29

Acquired axonal degeneration and regeneration

Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001601 · Cited by 24

Axon degeneration: Molecular mechanisms of a self-destruction pathway

Wang, J. T., Medress, Z. A., & Barres, B. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201108111 · Cited by 464

Axonal degeneration as a therapeutic target in the CNS

Lingor, P., Koch, J. C., Tönges, L., & Bähr, M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1362-3 · Cited by 119

Wallerian Degeneration in Injury and Diseases: Concepts and Prevention

Mietto, B. S., Rodrigo, M., de Lima, S., Sergio, T., & Martinez, A. M. B. (2011) · InTech eBooks · doi:10.5772/31927 · Cited by 5

Axon degeneration and rescue

Griffin, J. W., Höke, A., & Nguyen, T. T. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545061.020 · Cited by 3