Cited by 819Nerve injury and regenerationHereditary Neurological DisordersAutophagy in Disease and Therapy

The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.

Axon degeneration mechanisms: commonality amid diversity

Coleman, Michael·2005·Nature reviews. Neuroscience

Open this paper in CoChat — free account

Abstract

A wide range of insults can trigger axon degeneration, and axons respond with diverse morphology, topology and speed. However, recent genetic, immunochemical, morphological and pharmacological investigations point to convergent degeneration mechanisms. The principal convergence points - poor axonal transport, mitochondrial dysfunction and an increase in intra-axonal calcium - have been identified by rescuing axons with the slow Wallerian degeneration gene (Wld(S)) and studies with blockers of sodium or calcium influx. By understanding how the pathways fit together, we can combine our knowledge of mechanisms, and potentially also treatment strategies, from different axonal disorders.

Integrity signals

Registry

Crossref · 10.1038/nrn1788

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029
Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP
Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042
Axonal damage in acute multiple sclerosis lesions
Ferguson, B. (1997) · Brain · doi:10.1093/brain/120.3.393 · Cited by 1,532
Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
Fischer, L. R., Culver, D. G., Tennant, P., Davis, A. A., Wang, M.-S., Castellano-Sanchez, A. A., Khan, J., Polak, M. A., & Glass, J. D. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2003.10.004 · Cited by 1,383
Death by design: apoptosis, necrosis and autophagy
Edinger, A. L., & Thompson, C. B. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.09.011 · Cited by 1,362
Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease
Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., et al. (2005) · Science · doi:10.1126/science.1105681 · Cited by 1,214
Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Sirén, A., Fratelli, M., Brines, M. L., Goemans, C. G., Casagrande, S., Lewczuk, P., Keenan, S., Gleiter, C. H., Pasquali, C., Capobianco, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051606598 · Cited by 1,019

Flagged first, then by citations

Show all 122 references

Research works printed but not linked: 1

Wishart, T. M. et al. Transcriptional regulation of pituitary tumour transforming gene-1 by the neuroprotective WldS gene in mouse cerebellar granule cells and HEK293 cell lines. J. Physiol. 565P, C74 (2004).

Sorted by citations

Items 101–200 of 811

ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
Wakatsuki, S., Saitoh, F., & Araki, T. (2011) · Nature Cell Biology · doi:10.1038/ncb2373 · Cited by 145
Rich club analysis in the Alzheimer's disease connectome reveals a relatively undisturbed structural core network
Daianu, M., Jahanshad, N., Nir, T. M., Jack, C. R., Weiner, M. W., Bernstein, M. A., Thompson, P. M., & Initiative, T. A. D. N. (2015) · Human Brain Mapping · doi:10.1002/hbm.22830 · Cited by 147
Pathophysiology of neuropathic lysosomal storage disorders
Bellettato, C. M., & Scarpa, M. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-010-9075-9 · Cited by 141
Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms
Crish, S. D., & Calkins, D. J. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.12.036 · Cited by 144
WldS requires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration
Avery, M. A., Sheehan, A. E., Kerr, K. S., Wang, J., & Freeman, M. R. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200808042 · Cited by 143
Post-mortem assessment in vascular dementia: advances and aspirations
McAleese, K. E., Alafuzoff, I. I., Charidimou, A., Reuck, J. D., Grinberg, L. T., Hainsworth, A. H., Hortobágyi, T., Ince, P. G., Jellinger, K. A., Gao, J., et al. (2016) · BMC Medicine · doi:10.1186/s12916-016-0676-5 · Cited by 144
A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity
Fang, Y., Soares, L., Teng, X., Geary, M., & Bonini, N. M. (2012) · Current Biology · doi:10.1016/j.cub.2012.01.065 · Cited by 139
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress
Press, C., & Milbrandt, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0525-08.2008 · Cited by 137
“These changes are followed by calpain activation and eventual axonal protein degradation (Coleman, 2005).”
Background
Akt Suppresses Retrograde Degeneration of Dopaminergic Axons by Inhibition of Macroautophagy
Cheng, H.-C., Kim, S. R., Oo, T. F., Kareva, T., Yarygina, O., Rzhetskaya, M., Wang, C., During, M. J., Tallóczy, Z., Tanaka, K., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5519-10.2011 · Cited by 138
Direct evidence for axonal transport defects in a novel mouse model of mutant spastin‐induced hereditary spastic paraplegia (HSP) and human HSP patients
Kasher, P. R., Vos, K. J. D., Wharton, S. B., Manser, C., Bennett, E., Bingley, M., Wood, J., Milner, R. D. B., McDermott, C. J., Miller, C. C. J., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06104.x · Cited by 137
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model
Beirowski, B., Babetto, E., Coleman, M. P., & Martin, K. R. G. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06426.x · Cited by 135
Self-citation
Review: Neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy
Murray, L. M., Talbot, K., & Gillingwater, T. H. (2010) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2009.01061.x · Cited by 140
Differential aging of cerebral white matter in middle-aged and older adults: A seven-year follow-up
Bender, A. R., Voelkle, M. C., & Raz, N. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.030 · Cited by 143
1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C
Morfini, G. A., Pigino, G. F., Opalach, K., Serulle, Y., Moreira, J. E., Sugimori, M., Llinás, R. R., & Brady, S. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611231104 · Cited by 132
JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death
Fernandes, K. A., Harder, J. M., Fornarola, L. B., Freeman, R. S., Clark, A. F., Pang, I., John, S. W. M., & Libby, R. T. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.02.003 · Cited by 132
Guidance Molecules in Axon Pruning and Cell DeathPreprint
Vanderhaeghen, P., & Cheng, H.-J. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001859 · Cited by 132
Age-dependent axonal degeneration in an Alzheimer mouse model
Wirths, O., Weis, J., Kayed, R., Saido, T. C., & Bayer, T. A. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.07.021 · Cited by 127
Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon
Ma, M. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.08.010 · Cited by 125
Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy
Bowerman, M., Murray, L. M., Boyer, J. G., Anderson, C. L., & Kothary, R. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-24 · Cited by 125
A recoverable state of axon injury persists for hours after spinal cord contusion in vivo
Williams, P. R., Marincu, B.-N., Sorbara, C. D., Mahler, C. F., Schumacher, A.-M., Griesbeck, O., Kerschensteiner, M., & Misgeld, T. (2014) · Nature Communications · doi:10.1038/ncomms6683 · Cited by 124
Role of Inflammation and Cytokines in Peripheral Nerve Regeneration
Dubový, P., Jančálek, R., & Kubek, T. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-410499-0.00007-1 · Cited by 123
NAD+ and NADH in brain functions, brain diseases and brain aging
Ying, W. (2006) · Frontiers in bioscience · doi:10.2741/2194 · Cited by 124
New Aspects of the Pathogenesis of Canine Distemper Leukoencephalitis
Lempp, C., Spitzbarth, I., Puff, C., Cana, A., Kegler, K., Techangamsuwan, S., Baumgärtner, W., & Seehusen, F. (2014) · Viruses · doi:10.3390/v6072571 · Cited by 124
Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective PotencyIn Vivo
Babetto, E., Beirowski, B., Janečková, L., Brown, R., Gilley, J., Thomson, D., Ribchester, R. R., & Coleman, M. P. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1189-10.2010 · Cited by 124
Self-citation
Morphological evidence for a transport of ribosomes from Schwann cells to regenerating axons
Court, F. A., Midha, R., Cisterna, B. A., Grochmal, J. K., Shakhbazau, A., Hendriks, W. T. J., & van Minnen, J. (2011) · Glia · doi:10.1002/glia.21196 · Cited by 121
Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration
Ma, M., Ferguson, T. A., Schoch, K. M., Li, J., Qian, Y., Shofer, F. S., Saatman, K. E., & Neumar, R. W. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.03.009 · Cited by 120
Genetic Modulation of BDNF Signaling Affects the Outcome of Axonal Competition In Vivo
Cao, L., Albers, A. D., Mukai, J., Blazeski, R., Lodovichi, C., Mason, C. A., & Gogos, J. A. (2007) · Current Biology · doi:10.1016/j.cub.2007.04.040 · Cited by 120
MicroRNAs Modulate Schwann Cell Response to Nerve Injury by Reinforcing Transcriptional Silencing of Dedifferentiation-Related Genes
Viader, A., Chang, L., Fahrner, T. J., Nagarajan, R., & Milbrandt, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3931-11.2011 · Cited by 123
Mammalian Sir2-related protein (SIRT) 2–mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: A crucial role of tubulin deacetylation
Suzuki, K., & Koike, T. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.059 · Cited by 122
Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis
Singh, S., Dallenga, T., Winkler, A., Roemer, S., Maruschak, B., Siebert, H., Brück, W., & Stadelmann, C. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0831-8 · Cited by 118
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice
Ghazi-Noori, S., Froud, K. E., Mizielinska, S., Powell, C., Smidak, M., Fernandez de Marco, M., O’Malley, C., Farmer, M., Parkinson, N., Fisher, E. M. C., et al. (2012) · Brain · doi:10.1093/brain/aws006 · Cited by 115
Sciatic nerve injury: A simple and subtle model for investigating many aspects of nervous system damage and recovery
Savastano, L. E., Laurito, S. R., Fitt, M. R., Rasmussen, J., Polo, V. G., & Patterson, S. I. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.01.020 · Cited by 115
Long-Term In Vivo Imaging and Measurement of Dendritic Shrinkage of Retinal Ganglion Cells
Leung, C. K.-S., Weinreb, R. N., Li, Z., Liu, S., Lindsey, J. D., Choi, N., Liu, L., Cheung, C. Y.-L., Ye, C., Qiu, K., et al. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6012 · Cited by 115
Unique Function of Kinesin Kif5A in Localization of Mitochondria in Axons
Campbell, P. D., Shen, K., Sapio, M. R., Glenn, T. D., Talbot, W. S., & Marlow, F. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2770-14.2014 · Cited by 121
The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease
Jung, Y., & Damoiseaux, J. S. (2023) · Brain · doi:10.1093/brain/awad267 · Cited by 123
WldS protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice
Conforti, L., Wilbrey, A. L., Morreale, G., Janečková, L., Beirowski, B., Adalbert, R., Mazzola, F., Stefano, M. D., Hartley, R., Babetto, E., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200807175 · Cited by 116
Self-citation
SIRT1 and neuronal diseases
Tang, B. L., & Chua, C. E. L. (2007) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2007.02.001 · Cited by 114
Impaired dopaminergic neuron development and locomotor function in zebrafish with loss ofpink1function
Xi, Y., Ryan, J., Noble, S., Yu, M., Yilbas, A. E., & Ekker, M. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07091.x · Cited by 118
Mechanical membrane injury induces axonal beading through localized activation of calpain
Kilinc, D., Gallo, G., & Barbee, K. A. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.014 · Cited by 110
Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons
Yang, Y., Fukui, K., Koike, T., & Zheng, X. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05914.x · Cited by 109
Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration
Pease-Raissi, S. E., Pazyra‐Murphy, M. F., Li, Y., Wachter, F., Fukuda, Y., Fenstermacher, S. J., Barclay, L. A., Bird, G. H., Walensky, L. D., & Segal, R. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.034 · Cited by 109
Sirtuins in Neuroendocrine Regulation and Neurological Diseases
Fujita, Y., & Yamashita, T. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00778 · Cited by 110
The role of SIRT1 in ocular aging
Mimura, T., Kaji, Y., Noma, H., Funatsu, H., & Okamoto, S. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.07.017 · Cited by 114
Diffusion MRI and the detection of alterations following traumatic brain injury
Hutchinson, E. B., Schwerin, S. C., Avram, A., Juliano, S. L., & Pierpaoli, C. M. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24065 · Cited by 113
Hereditary diffuse leukoencephalopathy with spheroids: clinical, pathologic and genetic studies of a new kindred
Baba, Y., Ghetti, B., Baker, M. C., Uitti, R. J., Hutton, M. L., Yamaguchi, K., Bird, T., Lin, W., DeLucia, M. W., Dickson, D. W., et al. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0046-z · Cited by 106
Regulation of Poly(ADP-ribose) Polymerase-1-dependent Gene Expression through Promoter-directed Recruitment of a Nuclear NAD+ Synthase
Zhang, T., Berrocal, J. G., Yao, J., DuMond, M. E., Krishnakumar, R., Ruhl, D. D., Ryu, K. W., Gamble, M. J., & Kraus, W. L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.304469 · Cited by 111
Mechanisms of Axonal Spheroid Formation in Central Nervous System Wallerian Degeneration
Beirowski, B., Nógrádi, A., Babetto, E., Garcia-Alias, G., & Coleman, M. P. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181da84db · Cited by 104
Self-citation
Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons
Ohno, N., Chiang, H., Mahad, D., Kidd, G. J., Liu, L., Ransohoff, R. M., Sheng, Z., Komuro, H., & Trapp, B. D. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1401155111 · Cited by 109
Diffusion-MRI in neurodegenerative disorders
Goveas, J., O’Dwyer, L., Mascalchi, M., Cosottini, M., Diciotti, S., De Santis, S., Passamonti, L., Tessa, C., Toschi, N., & Giannelli, M. (2015) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2015.04.006 · Cited by 104
CD8 + T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability
Melzer, N., Meuth, S. G., & Wiendl, H. (2009) · The FASEB Journal · doi:10.1096/fj.09-136200 · Cited by 105
Amyloid Precursor Protein Cleavage-Dependent and -Independent Axonal Degeneration Programs Share a Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway
Vohra, B. P. S., Sasaki, Y., Miller, B. R., Chang, J., DiAntonio, A., & Milbrandt, J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2939-10.2010 · Cited by 103
Axonopathy is a compounding factor in the pathogenesis of Krabbe disease
Cantuti‐Castelvetri, L., Givogri, M. I., Zhu, H., Smith, B. R., Lopez‐Rosas, A., Qiu, X., van Breemen, R. B., & Bongarzone, E. R. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0814-2 · Cited by 103
Transfer of Vesicles From Schwann Cells to Axons: a Novel Mechanism of Communication in the Peripheral Nervous System
Lopez‐Verrilli, M. A., & Court, F. A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00205 · Cited by 100
WldS and PGC-1α Regulate Mitochondrial Transport and Oxidation State after Axonal Injury
O’Donnell, K. C., Vargas, M. E., & Sagasti, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1331-13.2013 · Cited by 105
Mechanisms of amyloid plaque pathogenesis
Fiala, J. C. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0284-8 · Cited by 99
Non-Nuclear Wld S Determines Its Neuroprotective Efficacy for Axons and Synapses In Vivo
Beirowski, B., Babetto, E., Gilley, J., Mazzola, F., Conforti, L., Janečková, L., Magni, G., Ribchester, R. R., & Coleman, M. P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3814-08.2009 · Cited by 101
Self-citation
Axonal Degeneration in AD: The Contribution of Aβ and Tau
Salvadores, N., Gerónimo‐Olvera, C., & Court, F. A. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.581767 · Cited by 101
Addressing neurodegeneration in glaucoma: Mechanisms, challenges, and treatments
Ghanem, G. O. B., Wareham, L. K., & Calkins, D. J. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101261 · Cited by 103
Valve-based microfluidic compression platform: single axon injury and regrowth
Hosmane, S., Fournier, A. J., Wright, R. M., Rajbhandari, L., Siddique, R., Yang, I. H., Ramesh, K. T., Venkatesan, A., & Thakor, N. V. (2011) · Lab on a Chip · doi:10.1039/c1lc20549h · Cited by 97
Computational Modeling of Axonal Microtubule Bundles under Tension
Peter, S. J., & Mofrad, M. R. K. (2012) · Biophysical Journal · doi:10.1016/j.bpj.2011.11.4024 · Cited by 96
A Conditioning Lesion Protects Axons from Degeneration via the Wallenda/DLK MAP Kinase Signaling Cascade
Xiong, X., & Collins, C. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3586-11.2012 · Cited by 96
NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo
Stefano, M. D., Loreto, A., Orsomando, G., Mori, V., Zamporlini, F., Hulse, R. P., Webster, J., Donaldson, L. F., Gering, M., Raffaelli, N., et al. (2017) · Current Biology · doi:10.1016/j.cub.2017.01.070 · Cited by 95
Self-citation
Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology
McAleese, K. E., Miah, M., Graham, S., Hadfield, G. M., Walker, L., Johnson, M. A., Colloby, S. J., Thomas, A. J., DeCarli, C. S., Koss, D. J., et al. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02376-2 · Cited by 95
Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: Identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration
Barrette, B., Calvo, E. L., Vallières, N., & Lacroix, S. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.07.249 · Cited by 96
Biophysical Challenges to Axonal Transport: Motor-Cargo Deficiencies and Neurodegeneration
Encalada, S. E., & Goldstein, L. S. B. (2014) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-051013-022746 · Cited by 95
Toll/Interleukin-1 Receptor Domain-Containing Adapter Inducing Interferon-β Mediates Microglial Phagocytosis of Degenerating Axons
Hosmane, S., Tegenge, M. A., Rajbhandari, L., Uapinyoying, P., Kumar, N. G., Thakor, N. V., & Venkatesan, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0203-12.2012 · Cited by 93
Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity
Yan, T., Feng, Y., Zheng, J., Ge, X., Zhang, Y., Wu, D., Zhao, J., & Zhai, Q. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2009.09.007 · Cited by 92
Application of fibrin-based hydrogels for nerve protection and regeneration after spinal cord injury
Yu, Z., Li, H., Xia, P., Kong, W., Chang, Y., Fu, C., Wang, K., Yang, X., & Qi, Z. (2020) · Journal of Biological Engineering · doi:10.1186/s13036-020-00244-3 · Cited by 92
Protective effects of progesterone administration on axonal pathology in mice with experimental autoimmune encephalomyelitis
Garay, L. I., Deniselle, M. C. G., Meyer, M., Costa, J. J. L., Lima, A. E., Roig, P., & DeNicola, A. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.057 · Cited by 92
Mutant HSPB8 causes motor neuron-specific neurite degeneration
Irobi, J., Almeida-Souza, L., Asselbergh, B., Winter, V. D., Goethals, S., Dierick, I., Krishnan, J., Timmermans, J., Robberecht, W., Jonghe, P. D., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq234 · Cited by 92
Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation
Vogelaar, C. F., Mandal, S., Lerch, S., Birkner, K., Birkenstock, J., Bühler, U., Schnatz, A., Raine, C. S., Bittner, S., Vogt, J., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao2304 · Cited by 93
Axon injury signaling and compartmentalized injury response in glaucoma
Syc‐Mazurek, S. B., & Libby, R. T. (2019) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2019.07.002 · Cited by 92
Pathophysiology of neurodegenerative diseases: An interplay among axonal transport failure, oxidative stress, and inflammation?
Tesco, G., & Lomoio, S. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101628 · Cited by 102
Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson’s disease
Phan, J.-A., Stokholm, K., Zarȩba-Pasławska, J., Jakobsen, S., Vang, K., GJEDDE, A. H., Landau, A. M., & Romero‐Ramos, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-06724-9 · Cited by 91
KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome
Lyons, D. A., Naylor, S. G., Mercurio, S., Dominguez, C. X., & Talbot, W. S. (2008) · Development · doi:10.1242/dev.012377 · Cited by 90
Loss of MEC-17 Leads to Microtubule Instability and Axonal Degeneration
Neumann, B., & Hilliard, M. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.004 · Cited by 90
Primary Traumatic Axonopathy in Mice Subjected to Impact Acceleration: A Reappraisal of Pathology and Mechanisms with High-Resolution Anatomical Methods
Ziogas, N. K., & Koliatsos, V. E. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2343-17.2018 · Cited by 89
Cryo-Immunogold Electron Microscopy for Prions: Toward Identification of a Conversion Site
Godsave, S. F., Wille, H., Kujala, P., Latawiec, D., DeArmond, S. J., Serban, A. V., Prusiner, S. B., & Peters, P. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4474-08.2008 · Cited by 91
Extrinsic cellular and molecular mediators of peripheral axonal regeneration
Bosse, F. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1389-5 · Cited by 88
Prospective longitudinal MRI study of brain volumes and diffusion changes during the first year after moderate to severe traumatic brain injury
Brezova, V., Moen, K. G., Skandsen, T., Vik, A., Brewer, J. B., Salvesen, Ø. O., & Haberg, A. K. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.03.012 · Cited by 88
Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice
Mollá, B., Muñoz-Lasso, D. C., Riveiro, F., Bolinches-Amorós, A., Pallardó, F. V., Fernandez-Vilata, A., de la Iglesia-Vayá, M., Palau, F., & González‐Cabo, P. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00264 · Cited by 87
Engulfment of Axon Debris by Microglia Requires p38 MAPK Activity
Tanaka, T., Ueno, M., & Yamashita, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005603 · Cited by 86
RNA Trafficking in Axons
Sotelo-Silveira, J. R., Calliari, A. J., Kun, A., KOENIG, E. C., & Sotelo, J. R. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00405.x · Cited by 85
Curcumin protects axons from degeneration in the setting of local neuroinflammation
Tegenge, M. A., Rajbhandari, L., Shrestha, S., Mithal, A., Hosmane, S., & Venkatesan, A. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2013.12.016 · Cited by 85
Differential Proteomics Analysis of Synaptic Proteins Identifies Potential Cellular Targets and Protein Mediators of Synaptic Neuroprotection Conferred by the Slow Wallerian Degeneration (Wld) Gene
Wishart, T. M., Paterson, J. M., Short, D. M., Meredith, S., Robertson, K. A., Sutherland, C. D., Cousin, M. A., Dutia, M. B., & Gillingwater, T. H. (2007) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m600457-mcp200 · Cited by 86
DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury
Fernandes, K. A., Harder, J. M., John, S. W. M., Shrager, P. G., & Libby, R. T. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.015 · Cited by 84
Neurofilament changes in serum and cerebrospinal fluid after acute ischemic stroke
Pujol-Calderón, F., Portelius, E., Zetterberg, H., Blennow, K., Rosengren, L., & Höglund, K. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.12.042 · Cited by 84
Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review
Carrera‐Juliá, S., Moreno, M. L., Barrios, C., Ortí, J. E. D. L. R., & Drehmer, E. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00063 · Cited by 87
Neuronal protein trafficking associated with Alzheimer disease
Tang, B. L. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.1.7254 · Cited by 85
Circular compartmentalized microfluidic platform: Study of axon–glia interactions
Hosmane, S., Yang, I. H., Ruffin, A., Thakor, N. V., & Venkatesan, A. (2010) · Lab on a Chip · doi:10.1039/b918640a · Cited by 83
The Roles of Microtubules and Membrane Tension in Axonal Beading, Retraction, and Atrophy
Datar, A., Ameeramja, J., Bhat, A., Srivastava, R., Mishra, A. K., Bernal, R., Prost, J., Callan-Jones, A., & Pullarkat, P. A. (2019) · Biophysical Journal · doi:10.1016/j.bpj.2019.07.046 · Cited by 82
Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma
Crish, S. D., Smith, M. A., Inman, D. M., Wilson, G. N., Young, J. W., & Crish, S. D. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00290 · Cited by 82
Wallerian-Like Degeneration of Central Neurons After Synchronized and Geometrically Registered Mass Axotomy in a Three-Compartmental Microfluidic Chip
Kilinc, D., Peyrin, J., Soubeyre, V., Magnifico, S., Saïas, L., Viovy, J., & Brugg, B. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9152-8 · Cited by 88
The intricate relationship between microtubules and their associated motor proteins during axon growth and maintenance
Prokop, A. (2013) · Neural Development · doi:10.1186/1749-8104-8-17 · Cited by 84
Autophagy in axonal degeneration in glaucomatous optic neuropathy
Munemasa, Y., & Kitaoka, Y. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.03.002 · Cited by 82
JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration
Ries, V., Silva, R. M., Oo, T. F., Cheng, H., Rzhetskaya, M., Kholodilov, N. G., Flavell, R. A., Kuan, C.-Y., RAKIC, P. T., & Burke, R. E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05713.x · Cited by 81
In vivo evaluation of demyelination and remyelination in a nerve crush injury model
Bélanger, E., Henry, F. P., Vallée, R., Randolph, M. A., Kochevar, I. E., Winograd, J. M., Lin, C. P., & Côté, D. C. (2011) · Biomedical Optics Express · doi:10.1364/boe.2.002698 · Cited by 81
Roles of NAD / NADH and NADP+ / NADPH in Cell Death
Xia, W., Wang, Z., Wang, Q., Han, J., Zhao, C., Hong, Y., Zeng, L., Tang, L., & Ying, W. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787185832 · Cited by 82
Microstructural alteration of the anterior cingulum is associated with apathy in Alzheimer disease
Kim, J. W., Lee, D. Y., Choo, I. H., Seo, E. H., Kim, S. G., Park, S. Y., & Woo, J. I. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e31820dcc73 · Cited by 79
Secondary Retinal Ganglion Cell Death and the Neuroprotective Effects of the Calcium Channel Blocker Lomerizine
Fitzgerald, M., Payne, S. C., Bartlett, C. A., Evill, L., Harvey, A. R., & Dunlop, S. A. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3717 · Cited by 80

Authors: Coleman, M.
Affiliations: Babraham Institute (GB)
Corresponding author: Coleman, Michael
ORCID: Coleman, Michael
Venue: Nature reviews. Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-10-14
Volume: 6
Issue: 11
Pages: 889-898
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1788
OpenAlex: W2042991032
Cited by: 819
References: 122
Citations by year: 2026: 15 · 2025: 30 · 2024: 13 · 2023: 22 · 2022: 18 · 2021: 35 · 2020: 40 · 2019: 32 · 2018: 40 · 2017: 48 · 2016: 43 · 2015: 51 · 2014: 47 · 2013: 58 · 2012: 53
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: axonal degeneration, Wallerian degeneration, axonal transport, mitochondrial dysfunction, intracellular calcium, sodium influx, calcium influx
MeSH terms: Animals, Axons, Axonal Transport, Central Nervous System, Humans, Nerve Tissue Proteins, Wallerian Degeneration

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Axon degeneration mechanisms: commonality amid diversity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks