Cited by 819Nerve injury and regenerationHereditary Neurological DisordersAutophagy in Disease and Therapy

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Axon degeneration mechanisms: commonality amid diversity

Coleman, Michael·2005·Nature reviews. Neuroscience

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Abstract

A wide range of insults can trigger axon degeneration, and axons respond with diverse morphology, topology and speed. However, recent genetic, immunochemical, morphological and pharmacological investigations point to convergent degeneration mechanisms. The principal convergence points - poor axonal transport, mitochondrial dysfunction and an increase in intra-axonal calcium - have been identified by rescuing axons with the slow Wallerian degeneration gene (Wld(S)) and studies with blockers of sodium or calcium influx. By understanding how the pathways fit together, we can combine our knowledge of mechanisms, and potentially also treatment strategies, from different axonal disorders.

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Wishart, T. M. et al. Transcriptional regulation of pituitary tumour transforming gene-1 by the neuroprotective WldS gene in mouse cerebellar granule cells and HEK293 cell lines. J. Physiol. 565P, C74 (2004).

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Authors: Coleman, M.
Affiliations: Babraham Institute (GB)
Corresponding author: Coleman, Michael
ORCID: Coleman, Michael
Venue: Nature reviews. Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-10-14
Volume: 6
Issue: 11
Pages: 889-898
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1788
OpenAlex: W2042991032
Cited by: 819
References: 122
Citations by year: 2026: 15 · 2025: 30 · 2024: 13 · 2023: 22 · 2022: 18 · 2021: 35 · 2020: 40 · 2019: 32 · 2018: 40 · 2017: 48 · 2016: 43 · 2015: 51 · 2014: 47 · 2013: 58 · 2012: 53
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: axonal degeneration, Wallerian degeneration, axonal transport, mitochondrial dysfunction, intracellular calcium, sodium influx, calcium influx
MeSH terms: Animals, Axons, Axonal Transport, Central Nervous System, Humans, Nerve Tissue Proteins, Wallerian Degeneration

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