New approaches to antidepressant drug discovery: beyond monoamines

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Items 101–144 of 144

1. Approaches for discontinuation versus continuation of long-term antidepressant use for depressive and anxiety disorders in adults
   Van Leeuwen, Ellen, van Driel, Mieke L, Horowitz, Mark A, Kendrick, Tony, Donald, Maria, De Sutter, An IM, Robertson, Lindsay, Christiaens, Thierry · 2021 · Cochrane Database of Systematic Reviews
2. Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications
   Highland, Jaclyn N., Zanos, Panos, Riggs, Lace M., Georgiou, Polymnia, Clark, Sarah M., Morris, Patrick J., Moaddel, Ruin, Thomas, Craig J., Zarate, Carlos A., Pereira, Edna F.R. et al. · 2021 · Pharmacological Reviews
3. P2X7 Receptor: A Potential Therapeutic Target for Depression?
   Deussing, Jan M., Arzt, Eduardo · 2018 · Trends in Molecular Medicine
4. Preclinical sex differences in depression and antidepressant response: implications for clinical research
   Kokras, Nikolaos, Dalla, Christina · 2017 · Journal of Neuroscience Research
5. Corticosterone mediates the synaptic and behavioral effects of chronic stress at rat hippocampal temporoammonic synapses
   Kvarta, Mark D., Bradbrook, Keighly E., Dantrassy, Hannah M., Bailey, Aileen M., Thompson, Scott M. · 2015 · Journal of Neurophysiology
6. Antidepressant-like effect of the organoselenium compound ebselen in mice: Evidence for the involvement of the monoaminergic system
   Posser, Thaís, Kaster, Manuella P., Baraúna, Sara Cristiane, Rocha, João B.T., Rodrigues, Ana Lúcia S., Leal, Rodrigo B. · 2009 · European Journal of Pharmacology
7. Effects of acute treadmill running at different intensities on activities of serotonin and corticotropin-releasing factor neurons, and anxiety- and depressive-like behaviors in rats
   Otsuka, Tomomi, Nishii, Ayu, Amemiya, Seiichiro, Kubota, Natsuko, Nishijima, Takeshi, Kita, Ichiro · 2016 · Behavioural Brain Research
8. GSK3β: a master player in depressive disorder pathogenesis and treatment responsiveness
   Duda, Przemysław, Hajka, Daria, Wójcicka, Olga, Rakus, Dariusz, Gizak, Agnieszka · 2020 · Cells
9. Chapter 5 The Endocannabinoid System as A Target for Novel Anxiolytic and Antidepressant Drugs
   Gaetani, Silvana, Dipasquale, Pasqua, Romano, Adele, Righetti, Laura, Cassano, Tommaso, Piomelli, Daniele, Cuomo, Vincenzo · 2009 · International Review of Neurobiology
10. Role of melatonin in mood disorders and the antidepressant effects of agomelatine
    Srinivasan, Venkataramanujam, De Berardis, Domenico, Shillcutt, Samuel D, Brzezinski, Amnon · 2012 · Expert Opinion on Investigational Drugs
11. The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review
    Webb, Lauren M., Phillips, Kathryn E., Ho, Man Choi, Veldic, Marin, Blacker, Caren J. · 2020 · International Journal of Molecular Sciences
12. Lipopolysaccharide-Induced Depressive-Like Behavior is Associated with α1-Adrenoceptor Dependent Downregulation of the Membrane GluR1 Subunit in the Mouse Medial Prefrontal Cortex and Ventral Tegmental Area
    Sekio, Miyu, Seki, Kenjiro · 2015 · International Journal of Neuropsychopharmacology
13. Evaluation of the emotional phenotype and serotonergic neurotransmission of fatty acid amide hydrolase-deficient mice
    Cassano, Tommaso, Gaetani, Silvana, Macheda, Teresa, Laconca, Leonardo, Romano, Adele, Morgese, Maria Grazia, Cimmino, Concetta Stefania, Chiarotti, Flavia, Bambico, Francis R., Gobbi, Gabriella et al. · 2011 · Psychopharmacology
14. Imipramine Induces Brain-Derived Neurotrophic Factor mRNA Expression in Cultured Astrocytes
    Takano, Katsura, Yamasaki, Hiroshi, Kawabe, Kenji, Moriyama, Mitsuaki, Nakamura, Yoichi · 2012 · Journal of Pharmacological Sciences
15. Control of synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications
    Bramham, Clive R. · 2007 · Progress in Brain Research
16. α-Tocopherol administration produces an antidepressant-like effect in predictive animal models of depression
    Lobato, Kelly R., Cardoso, Chandra C., Binfaré, Ricardo W., Budni, Josiane, Wagner, Cristiane L.R., Brocardo, Patrícia S., de Souza, Luiz Felipe, Brocardo, Caroline, Flesch, Samira, Freitas, Andiara E. et al. · 2010 · Behavioural Brain Research
17. Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation
    Etiévant, A., Oosterhof, C., Bétry, C., Abrial, E., Novo-Perez, M., Rovera, R., Scarna, H., Devader, C., Mazella, J., Wegener, G. et al. · 2015 · EBioMedicine
18. Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder
    Croarkin, Paul E., Nakonezny, Paul A., Husain, Mustafa M., Melton, Tabatha, Buyukdura, Jeylan S., Kennard, Betsy D., Emslie, Graham J., Kozel, F. Andrew, Daskalakis, Zafiris J. · 2013 · JAMA Psychiatry
19. Emotional Blunting in Patients With Major Depressive Disorder: A Brief Non-systematic Review of Current Research
    Ma, Hongzhe, Cai, Min, Wang, Huaning · 2021 · Frontiers in Psychiatry
20. Depressive-like behavior induced by tumor necrosis factor-α is abolished by agmatine administration
    Neis, Vivian Binder, Manosso, Luana Meller, Moretti, Morgana, Freitas, Andiara E., Daufenbach, Juliana, Rodrigues, Ana Lúcia S. · 2014 · Behavioural Brain Research
21. Acetylsalicylic acid as an augmentation agent in fluoxetine treatment resistant depressive rats
    Wang, Ying, Yang, Feng, Liu, Yang-Feng, Gao, Fei, Jiang, Wen · 2011 · Neuroscience Letters
22. Ketamine’s rapid antidepressant effects are mediated by Ca2+-permeable AMPA receptors
    Zaytseva, Anastasiya, Bouckova, Evelina, Wiles, McKennon J, Wustrau, Madison H, Schmidt, Isabella G, Mendez-Vazquez, Hadassah, Khatri, Latika, Kim, Seonil · 2023 · eLife
23. The impact of cognitive behavioral therapy on IL-6 levels in unmedicated women experiencing the first episode of depression: a pilot study
    Gazal, Marta, Souza, Luciano D., Fucolo, Briane A., Wiener, Carolina D., Silva, Ricardo A., Pinheiro, Ricardo T., Jansen, Karen, Ghislene, Gabriele, Oses, Jean P., Kaster, Manuella P. · 2013 · Psychiatry Research
24. Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex
    Patton, Michael S, Lodge, Daniel J, Morilak, David A, Girotti, Milena · 2017 · Neuropsychopharmacology
25. Involvement of nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tropisetron and ondansetron in mice forced swimming test and tail suspension test
    Haj-Mirzaian, Arya, Kordjazy, Nastaran, Amiri, Shayan, Haj-Mirzaian, Arvin, Amini-khoei, Hossien, Ostadhadi, Sattar, Dehpour, AhmadReza · 2016 · European Journal of Pharmacology
26. Aligning physiology with psychology: Translational neuroscience in neuropsychiatric drug discovery
    McArthur, Robert A. · 2017 · Neuroscience & Biobehavioral Reviews
27. Erythropoietin modulates neural and cognitive processing of emotional information in biomarker models of antidepressant drug action in depressed patients
    Miskowiak, Kamilla W., Favaron, Elisa, Hafizi, Sepehr, Inkster, Becky, Goodwin, Guy M., Cowen, Philip J., Harmer, Catherine J. · 2010 · Psychopharmacology
28. Oligonucleotides as therapeutic tools for brain disorders: Focus on major depressive disorder and Parkinson’s disease.
    Bortolozzi, Analia, Manashirov, Sharon, Chen, Alon, Artigas, Francesc · 2021 · Pharmacology & Therapeutics
29. Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system
    Barbu, Miruna C., Huider, Floris, Campbell, Archie, Amador, Carmen, Adams, Mark J., Lynall, Mary-Ellen, Howard, David M., Walker, Rosie M., Morris, Stewart W., Van Dongen, Jenny et al. · 2022 · Molecular Psychiatry
30. High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness
    Lewis, Alan S., Picciotto, Marina R. · 2013 · Psychopharmacology
31. Dextromethorphan-Bupropion for the Treatment of Depression: A Systematic Review of Efficacy and Safety in Clinical Trials
    Akbar, Dania, Rhee, Taeho Greg, Ceban, Felicia, Ho, Roger, Teopiz, Kayla M., Cao, Bing, Subramaniapillai, Mehala, Kwan, Angela T. H., Rosenblat, Joshua D., McIntyre, Roger S. · 2023 · CNS Drugs
32. Fluoxetine induces input-specific hippocampal dendritic spine remodeling along the septotemporal axis in adulthood and middle age
    McAvoy, Kathleen, Russo, Craig, Kim, Shannen, Rankin, Genelle, Sahay, Amar · 2015 · Hippocampus
33. Cognitive correlates of hypothalamic–pituitary–adrenal axis in major depression
    Schlosser, Nicole, Wolf, Oliver T, Wingenfeld, Katja · 2011 · Expert Review of Endocrinology & Metabolism
34. Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects
    Kanzari, A, Bourcier-Lucas, C, Freyssin, A, Abrous, D N, Haddjeri, N, Lucas, G · 2018 · Molecular Psychiatry
35. Blockade of the metabotropic glutamate (mGluR2) modulates arousal through vigilance states transitions: Evidence from sleep–wake EEG in rodents
    Ahnaou, A., Ver Donck, L., Drinkenburg, W.H.I.M. · 2014 · Behavioural Brain Research
36. Fluoxetine treatment promotes functional recovery in a rat model of cervical spinal cord injury
    Scali, Manuela, Begenisic, Tatjana, Mainardi, Marco, Milanese, Marco, Bonifacino, Tiziana, Bonanno, Giambattista, Sale, Alessandro, Maffei, Lamberto · 2013 · Scientific Reports
37. Interaction between intensity and duration of acute exercise on neuronal activity associated with depression-related behavior in rats
    Morikawa, Ryoko, Kubota, Natsuko, Amemiya, Seiichiro, Nishijima, Takeshi, Kita, Ichiro · 2021 · The Journal of Physiological Sciences
38. Behavioral and neurochemical characterization of TrkB-dependent mechanisms of agomelatine in glucocorticoid receptor-impaired mice
    Boulle, F., Velthuis, H., Koedam, K., Steinbusch, H.W., van den Hove, D.L.A., Kenis, G., Gabriel, C., Mocaer, E., Franc, B., Rognan, D. et al. · 2016 · European Neuropsychopharmacology
39. Iptakalim alleviates synaptic damages via targeting mitochondrial ATP‐sensitive potassium channel in depression
    Guo, Wei, Tang, Zi‐Yang, Cai, Zhen‐Yu, Zhao, Wen‐E, Yang, Jin, Wang, Xi‐Peng, Ji, Juan, Huang, Xin‐Xin, Sun, Xiu‐Lan · 2021 · The FASEB Journal
40. VEGF regulates antidepressant effects of lamotrigine
    Sun, Rongju, Li, Nanxin, Li, Tanshi · 2012 · European Neuropsychopharmacology
41. Sex‐specific peripheral and central responses to stress‐induced depression and treatment in a mouse model
    Deonaraine, Kristina K., Wang, Qian, Cheng, Haoxiang, Chan, Kenny L., Lin, Hsiao‐Yun, Liu, Kalena, Parise, Lyonna F., Cathomas, Flurin, Leclair, Katherine B., Flanigan, Meghan E. et al. · 2020 · Journal of Neuroscience Research
42. Neuromodulation for treatment resistant depression: State of the art and recommendations for clinical and scientific conduct
    Schlaepfer, Thomas E., Bewernick, Bettina H. · 2014 · Brain Topography
43. Prodepressant- and anxiogenic-like effects of serotonin-selective, but not noradrenaline-selective, antidepressant agents in mice lacking α2-containing GABAA receptors
    Benham, Rebecca S., Hewage, Nishani B., Suckow, Raymond F., Engin, Elif, Rudolph, Uwe · 2017 · Behavioural Brain Research
44. Effects of the KCNQ (Kv7) Channel Opener Ezogabine on Resting-State Functional Connectivity of Striatal Brain Reward Regions, Depression, and Anhedonia in Major Depressive Disorder: Results From a Randomized Controlled Trial
    Chowdhury, Avijit, Boukezzi, Sarah, Costi, Sara, Hameed, Sara, Jacob, Yael, Salas, Ramiro, Iosifescu, Dan V., Han, Ming-Hu, Swann, Alan, Mathew, Sanjay J. et al. · 2025 · Biological Psychiatry