Cited by 980Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

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The origin and specification of cortical interneurons

Wonders, Carl P., Anderson, Stewart A.·2006·Nature Reviews Neuroscience

DOI 10.1038/nrn1954

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Abstract

GABA-containing interneurons are crucial to both the development and function of the cerebral cortex. Unlike cortical projection neurons, which have a relatively conserved set of characteristics, interneurons include multiple phenotypes that vary on morphological, physiological and neurochemical axes. This diversity, and the relatively late, context-dependent maturation of defining features, has challenged efforts to uncover the transcriptional control of cortical interneuron development. Here, we discuss recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons.

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“Specifically, PV + and CB + cells predominantly originate from the medial ganglionic eminence, while CR + neurons primarily come from the caudal ganglionic eminence (Wonders and Anderson, 2006).”
Background
Interneuron migration impairment and brain region-specific DNA damage response following irradiation during early neurogenesis in mice
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“It has been established in mouse that the same progenitor domains within the ventral telencephalon give rise to both cortical inhibitory interneurons and oligodendrocytes (Rowitch & Kriegstein, 2010; Wonders & Anderson, 2006).”
Background
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“(LIM homeobox 6-positive); CGE located in caudoventral GE is marked by COUP-TFII (COUP transcription factor 2, also known as NR2F2 [nuclear receptor subfamily 2, group F, member 2]) expression (20-24).”
Background
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“The most common genetic markers for cortical INs include parvalbumin (PV), somatostatin (SST), and vasoactive intestinal peptide (VIP) (Rudy et al. 2011; Taniguchi et al. 2011; Wonders and Anderson 2006; Xu et al. 2010).”
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Background
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Authors: Wonders, C. P., & Anderson, S. A.
Affiliations: Cornell University (US)
Corresponding author: Anderson, Stewart A.
ORCID: Anderson, Stewart A.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2006-08-02
Volume: 7
Issue: 9
Pages: 687-696
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1954
OpenAlex: W2007034511
Cited by: 980
References: 142
Citations by year: 2026: 32 · 2025: 49 · 2024: 39 · 2023: 47 · 2022: 32 · 2021: 42 · 2020: 66 · 2019: 53 · 2018: 43 · 2017: 52 · 2016: 49 · 2015: 49 · 2014: 53 · 2013: 54 · 2012: 50
FWCI: 3.02
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health
National Institute of Neurological Disorders and Stroke
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: cortical interneurons, interneuron specification, GABAergic neurons, cortical development, transcriptional regulation, interneuron subtypes, neuronal maturation
MeSH terms: Animals, Cell Differentiation, Cell Movement, Cerebral Cortex, Humans, Interneurons, Nerve Tissue Proteins, Stem Cells, Telencephalon, Biomarkers, Gene Expression Regulation, Developmental, Cell Lineage

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The origin and specification of cortical interneurons

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