The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
The origin and specification of cortical interneurons
Abstract
GABA-containing interneurons are crucial to both the development and function of the cerebral cortex. Unlike cortical projection neurons, which have a relatively conserved set of characteristics, interneurons include multiple phenotypes that vary on morphological, physiological and neurochemical axes. This diversity, and the relatively late, context-dependent maturation of defining features, has challenged efforts to uncover the transcriptional control of cortical interneuron development. Here, we discuss recent data that are beginning to illuminate the origins and specification of distinct subgroups of cortical interneurons.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Their 'parvalbumin' fate seems to be established at their origin, as the progenitors leave the cell cycle [127, 128].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [127]
In the citing paper
“In contrast, Martinotti cells and 5-HT3AR-lacking O-LM cells arise from MGE progenitors with specification driven by the homeodomain transcription factor Nkx2.1 (10% of MGE-derived hippocampal interneurons based on assumptions outlined above combined with the fact that O-LMs represent 40% of SST interneurons) (102, 203, 651, 794, 1042, 1134, 1138, 1213).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1213]
In the citing paper
“We also observed that over-expression of Maf at the peak of PV neurogenesis (E14.5) (23) repress PV+ interneuron fates (fig. S24, D and E).”
From Early emergence of cortical interneuron diversity in the mouse embryo (2018) · cites this paper as [23]
Citations
Cites
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Neuregulin 1 and Susceptibility to Schizophrenia
Stefánsson, H., Pétursson, H., Sigurðsson, E., Steinthórsdóttir, V., Bjornsdottir, S., Sigmundsson, T., Ghosh, S., Brynjolfsson, J., Gunnarsdottir, S., Ivarsson, O., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/342734 · Cited by 1,671
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on Dlx Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462
Self-citationGABAergic cell subtypes and their synaptic connections in rat frontal cortex
Kawaguchi, Y. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.6.476 · Cited by 1,416
Cited by
Sorted by citations
Items 101–200 of 979
Tubulin-related cortical dysgeneses: microtubule dysfunction underlying neuronal migration defects
Jaglin, X. H., & Chelly, J. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.10.003 · Cited by 207
“eminences tangentially towards the dorsal telencephalon, to insert into the cortex [ 91 ,92].”
BackgroundGeneration of interneuron diversity in the mouse cerebral cortex
Gelman, D. M., & Marín, O. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07267.x · Cited by 188
“Despite some reservations, today it is largely accepted that distinct types of interneurons exist; they are defined by a constellation of neurochemical, anatomical and electrophysiological characteristics.”
BackgroundDlx5andDlx6Regulate the Development of Parvalbumin-Expressing Cortical Interneurons
Wang, Y., Dye, C. A., Sohal, V. S., Long, J. E., Estrada, R. C., Roztocil, T., Lufkin, T., Deisseroth, K. A., Baraban, S. C., & Rubenstein, J. L. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5963-09.2010 · Cited by 186
Human Models Are Needed for Studying Human Neurodevelopmental Disorders
Zhao, X., & Bhattacharyya, A. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.10.009 · Cited by 192
Genetics and Function of Neocortical GABAergic Interneurons in Neurodevelopmental Disorders
Rossignol, E. (2011) · Neural Plasticity · doi:10.1155/2011/649325 · Cited by 192
“Although this has been debated, it is generally believed that the LGE does not give rise to cortical interneurons, instead generating medium spiny neurons of the striatum, nucleus accumbens, and olfactory tubercules, as well as olfactory bulb and amygdalar interneurons [23, 33, 38, 41, 50, 51].”
BackgroundLate Development of the GABAergic System in the Human Cerebral Cortex and White Matter
Xu, G., Broadbelt, K. G., Haynes, R. L., Folkerth, R. D., Borenstein, N. S., Belliveau, R. A., Trachtenberg, F. L., Volpe, J. J., & Kinney, H. C. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31822f471c · Cited by 188
“Interneurons are mainly GABAergic (7, 10, 11, 14).”
BackgroundImpaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants
Cavallaro, M., Mariani, J., Lancini, C., Latorre, E., Caccia, R., Gullo, F., Valotta, M., Debiasi, S., Spinardi, L., Ronchi, A. E., et al. (2008) · Development · doi:10.1242/dev.010801 · Cited by 193
“5) (Gritti et al., 1996; Gritti et al., 2001), and Ca2+-binding proteins (calretinin and calbindin), which define inhibitory neurons and their different subpopulations (Wonders and Anderson, 2006; Levitt et al., 2004; Makram et al., 2004).”
BackgroundInfluentialLong, J. E., Cobos, I., Potter, G. B., & Rubenstein, J. L. R. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp045 · Cited by 178
“…pallidal cell groups), interneurons that tangentially migrate to the pallium (cortex and hippocampus), striatum (Sussel et al. 1999; Marı´n and Rubenstein 2001; Colombo et al. 2007; Wonders and Anderson 2006; Xu et al. 2008), and oligodendrocytes (Kessaris et al. 2006; Petryniak et al. 2007).”
BackgroundCommon Origins of Hippocampal Ivy and Nitric Oxide Synthase Expressing Neurogliaform Cells
Tricoire, L., Pelkey, K. A., Daw, M. I., Sousa, V. H., Miyoshi, G., Jeffries, B., Cauli, B., Fishell, G., & McBain, C. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-09.2010 · Cited by 171
“Dual origin of nNOS ! interneurons Several recent studies have determined the embryonic sources of various distinct neocortical interneuron populations, yielding considerable insight into the origins of interneuron diversity (Wonders and Anderson, 2006; Batista-Brito and Fishell, 2009).”
BackgroundArid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior
Jung, E., Moffat, J. J., Liu, J., Dravid, S. M., Gurumurthy, C. B., & Kim, W.-Y. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0013-0 · Cited by 181
“Thus, the depletion of interneurons in the cerebral cortex appears to be caused by defective proliferation and maintenance of interneuron progenitors in the MGE, the origin of as much as 60–80% of cortical interneurons 21 .”
Neuronal circuits in barrel cortex for whisker sensory perception
Staiger, J. F., & Petersen, C. C. H. (2021) · Physiological Reviews · doi:10.1152/physrev.00019.2019 · Cited by 165
Favero, M., Sotuyo, N. P., Lopez, E., Kearney, J. A., & Goldberg, E. M. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0193-18.2018 · Cited by 163
“Conditional deletion of Scn1a from Dlx1/2 medial ganglionic eminence (MGE) progenitors, which generate PVINs and SST-INs (Wonders and Anderson, 2006), reproduced the phenotype of the global mutant (Cheah et al., 2012), including temperature-sensitive seizures, epilepsy, and spontaneous death,…”
BackgroundA wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
Gelman, D., Griveau, A., Dehorter, N., Teissier, A., Varela, C., Pla, R., Pierani, A., & Marín, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4068-11.2011 · Cited by 179
“Collectively, the MGE and the CGE are the origin of 90% of the GABAergic interneurons in the cerebral cortex (Wonders and Anderson, 2006; Batista-Brito and Fishell, 2009; Rubin et al., 2010).”
BackgroundInfluentialDanjo, T., Eiraku, M., Muguruma, K., Watanabe, K., Kawada, M., Yanagawa, Y., Rubenstein, J. L. R., & Sasai, Y. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5128-10.2011 · Cited by 185
“Several in vivo studies showed that a majority of MGE-derived cortical interneurons are positive for SOM or PV, whereas the CGE-derived cortical interneurons preferentially express CAR and/or vasointestinal peptide (VIP) (Xu et al., 2004; Butt et al., 2005; Wonders and Anderson, 2006).”
BackgroundWorbe, Y., Gérardin, E., Hartmann, A., Valabrègue, R., Marie Chupin, A., Tremblay, L., Vidailhet, M., Colliot, O., & Lehéricy, S. (2010) · Brain · doi:10.1093/brain/awq293 · Cited by 178
“As cortical and basal ganglia interneurons originate from the same structures during brain development (Wonders and Anderson, 2006), reduced number of inhibitory interneurons may also be present in the cortex, leading to both structural changes and functional abnormalities.”
BackgroundThe Basal Forebrain Cholinergic Projection System in Mice
Záborszky, L., van den Pol, A. N., & Gyengési, E. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-369497-3.10028-7 · Cited by 173
“Cholinergic cells that project to a specific cortical area are dispersed throughout an extensive territory of the basal forebrain, including several cytoarchitectonic areas (Rye et al., 1984; Zaborszky et al., 1986a).”
BackgroundNeurogliaform cells in cortical circuits
Overstreet-Wadiche, L., & McBain, C. J. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3969 · Cited by 152
Inan, M., Welagen, J., & Anderson, S. A. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr148 · Cited by 161
Self-citationWired for behaviors: from development to function of innate limbic system circuitry
Sokolowski, K., & Corbin, J. G. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00055 · Cited by 181
“The embryonic events of neuronal patterning and specification of neurons throughout the entire neuraxis is accomplished via the actions of delineated sets of transcription factors, typically of the homeodomain and bHLH classes (Campbell, 2003; Wonders and Anderson, 2006; Corbin et al., 2008).”
BackgroundDevelopment and specification of GABAergic cortical interneurons
Kelsom, C., & Lu, W. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-19 · Cited by 193
“With regard to interneuron subtype, the MGE gives rise to most of the PV- and SST-expressing interneuron population [80].”
BackgroundInfluentialThe Diverse Genetic Landscape of Neurodevelopmental Disorders
Hu, W. F., Chahrour, M. H., & Walsh, C. A. (2014) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090413-025600 · Cited by 177
“Upon reaching the dorsal cortex, they turn and migrate radially into the cortical plate and integrate with the excitatory projection neurons (138).”
BackgroundRubenstein, J. L. R. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02307.x · Cited by 184
Epilepsy as a Neurodevelopmental Disorder
Bozzi, Y., Casarosa, S., & Caleo, M. (2012) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2012.00019 · Cited by 184
“MIGRATION DEFECTS OF CORTICAL INTERNEURONS Cortical GABAergic interneurons are generated in ganglionic eminences of the basal forebrain, from where they migrate to reach their final location (Wonders and Anderson, 2006).”
BackgroundInfluentialKanatani, S., Yozu, M., Tabata, H., & Nakajima, K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2132-08.2008 · Cited by 163
“In contrast, no signal was observed around the central horizontal levels in the LGE and MGE (Fig.”
BackgroundInfluentialTuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch
Dehorter, N., Ciceri, G., Bartolini, G., Lim, L., del Pino, I., & Marín, O. (2015) · Science · doi:10.1126/science.aab3415 · Cited by 169
Transcranial magnetic stimulation, synaptic plasticity and network oscillations
Huerta, P. T., & Volpe, B. T. (2009) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/1743-0003-6-7 · Cited by 204
Marchis, S. D., Bovetti, S., Carletti, B., Hsieh, Y.-C., Garzotto, D., Peretto, P., Fasolo, A., Puché, A. C., & Rossi, F. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2870-06.2007 · Cited by 167
“Indeed, although different types of neocortical inhibitory interneurons derive from distinct progenitor pools (Wonders and Anderson, 2006), those of the cerebellum originate from multipotent precursors that acquire their mature identities under the influence of local instructive cues (Leto et al.”
BackgroundThe contribution of GABAergic dysfunction to neurodevelopmental disorders
Ramamoorthi, K., & Lin, Y. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.03.003 · Cited by 173
“With a few exceptions in humans and non-human primates [9], GABAergic neurons are derived from the ventral part of the telecephalon (subpallium) [10].”
McGarry, L. M. (2010) · Frontiers in Neural Circuits · doi:10.3389/fncir.2010.00012 · Cited by 166
Dorsal Radial Glia Generate Olfactory Bulb Interneurons in the Postnatal Murine Brain
Ventura, R. E., & Goldman, J. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0399-07.2007 · Cited by 161
“The vast majority, if not all, of the interneurons of the dorsal neocortex derive from precursors that have migrated tangentially from the ventrally situated caudal, medial, and lateral ganglionic eminences (Anderson et al., 1997; Wonders and Anderson, 2006).”
BackgroundColasante, G., Collombat, P., Raimondi, V., Bonanomi, D., Ferrai, C., Maira, M., Yoshikawa, K., Mansouri, A., Valtorta, F., Rubenstein, J. L. R., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1283-08.2008 · Cited by 150
“This observation is consistent with the dynamics of migration of GABAergic cortical interneuron precursors originating from the ventral pallium (Corbin et al., 2001; Marín and Rubenstein, 2001; Métin et al., 2006; Wonders and Anderson, 2006).”
ResultFlandin, P., Zhao, Y., Vogt, D., Jeong, J., Long, J., Potter, G., Westphal, H., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.020 · Cited by 155
“The medial ganglionic eminence (MGE) is a progenitor domain within the embryonic basal ganglia that generates projection neurons, such as those in the globus pallidus (GP) and interneurons of the striatum and pallium (Marı́n and Rubenstein, 2001; Wonders and Anderson, 2006; Batista-Brito and Fishell, 2009).”
Clonal production and organization of inhibitory interneurons in the neocortex
Brown, K. N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Zhang, X.-J., Ding, L., Lopez-Cruz, A., Saur, D., Anderson, S. A., et al. (2011) · Science · doi:10.1126/science.1208884 · Cited by 152
Gradients in the Brain: The Control of the Development of Form and Function in the Cerebral Cortex
Sansom, S. N., & Livesey, F. J. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002519 · Cited by 148
Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor
Manuel, M. N., Mi, D., Mason, J. O., & Price, D. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00070 · Cited by 153
“%) with others coming from the caudal ganglionic eminence (CGE) and areas including the preoptic area (POA; Anderson et al., 2001; Wonders and Anderson, 2006; Fogarty et al., 2007; Gelman et al., 2009; Miyoshi et al., 2010).”
Interneurons in the developing human neocortex
Zečević, N., Hu, F., & Jakovčevski, I. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20812 · Cited by 158
The role of BAF (mSWI/SNF) complexes in mammalian neural development
Son, E., & Crabtree, G. R. (2014) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31416 · Cited by 148
Hevner, R. F. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3180301c06 · Cited by 156
Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala
Hirata, T., Li, P., Lanuza, G. M., Cocas, L. A., Huntsman, M. M., & Corbin, J. G. (2009) · Nature Neuroscience · doi:10.1038/nn.2241 · Cited by 151
“Physiological analysis of Dbx1 -derived medial nuclei cells In addition to expressing unique combinations of immunomarkers, subtypes of telencephalic inhibitory neurons also have distinct electrophysiological signature”
Sun, Y., Paşca, S. P., Portmann, T., Goold, C., Worringer, K. A., Guan, W., Chan, K. C., Gai, H., Vogt, D., Chen, Y.-J. J., et al. (2016) · eLife · doi:10.7554/elife.13073 · Cited by 141
Genes and signaling events that establish regional patterning of the mammalian forebrain
Hoch, R. V., Rubenstein, J. L. R., & Pleasure, S. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.02.005 · Cited by 147
Regulation of neural progenitor cell development in the nervous system
Corbin, J. G., Gaiano, N., Juliano, S. L., Poluch, S., Stancik, E. K., & Haydar, T. F. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05522.x · Cited by 149
Integrative Mechanisms of Oriented Neuronal Migration in the Developing Brain
Evsyukova, I. Y., Plestant, C., & Anton, E. S. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122400 · Cited by 151
“…2009; Faux et al. 2012; Gelman & Marín 2010; Gelman et al. 2009; Ghashghaei et al. 2007; Kriegstein & Noctor 2004; Lavdas et al. 1999; Marín & Rubenstein 2001; Miyoshi et al. 2010; Nery et al. 2002; Tan et al. 1998; Wichterle et al. 1999, 2001; Wonders & Anderson 2006; Yozu et al. 2005) (Figure 1).”
BackgroundAssembloid CRISPR screens reveal impact of disease genes in human neurodevelopment
Meng, X., Yao, D., Imaizumi, K., Chen, X., Kelley, K. W., Reis, N., Thete, M. V., McKinney, A. A., Kulkarni, S., Panagiotakos, G., et al. (2023) · Nature · doi:10.1038/s41586-023-06564-w · Cited by 154
Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position
Vogt, D., Hunt, R. F., Mandal, S., Sandberg, M., Silberberg, S. N., Nagasawa, T., Yang, Z., Baraban, S. C., & Rubenstein, J. L. R. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.030 · Cited by 129
“In rodents, cortical interneurons arise from the subcortical medial and caudal ganglionic eminences (MGE and CGE, respectively) (Anderson et al., 1997; Wonders and Anderson, 2006), and the preoptic area (POA) (Gelman et al.”
Centrosomes, microtubules and neuronal development
Kuijpers, M., & Hoogenraad, C. C. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.05.004 · Cited by 150
“In the mammalian neocortex, studies have demonstrated that many cortical interneurons – originating in the anlagen of the basal telencephalon – migrate tangentially to their final cortical destinations (Vitalis and Rossier, 2011; Wonders and Anderson, 2006) (Fig.”
BackgroundMiyoshi, G., Young, A., Petros, T., Karayannis, T., McKenzie Chang, M., Lavado, A., Iwano, T., Nakajima, M., Taniguchi, H., Huang, Z. J., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1164-15.2015 · Cited by 135
“How then does this diversity develop, and what are the mechanisms by which different subtypes of interneurons become integrated into the cortical network? Work from several research groups has determined the spatiotemporal embryonic origins of GABAergic interneuron diversity (Marín and Rubenstein, 2003; Wonders and An…”
BackgroundOrigin and molecular specification of globus pallidus neurons
Nóbrega-Pereira, S., Gelman, D., Bartolini, G., Pla, R., Pierani, A., & Marín, O. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4023-09.2010 · Cited by 142
“Neuronal diversity in the cerebral cortex also increases with the incorporation of interneurons born at remote locations and that reach the cortex through tangential migration (Corbin et al., 2001; Marín and Rubenstein, 2001; Wonders and Anderson, 2006).”
Inhibitory Interneurons and their Circuit Motifs in the Many Layers of the Barrel Cortex
Feldmeyer, D., Qi, G., Emmenegger, V., & Staiger, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.027 · Cited by 140
3D bioprinting of human neural tissues with functional connectivity
Yan, Y., Li, X., Gao, Y., Mathivanan, S., Kong, L., Tao, Y., Dong, Y. W., Li, X., Bhattacharyya, A., Zhao, X., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2023.12.009 · Cited by 144
Fragkouli, A., van Wijk, N. V., Lopes, R., Kessaris, N., & Pachnis, V. (2009) · Development · doi:10.1242/dev.038083 · Cited by 135
“These immature neurons express early GABAergic interneuron markers (such as Gad67 and Lhx6) but lack molecular markers (such as SST, PV, CR and nNOS) and functional characteristics of mature GABAergic interneurons (Butt et al., 2005; Flames and Marin, 2005; Kawaguchi et al., 1995; Liodis et al., 2007; Tepper and Bolam…”
BackgroundOrigins of Cortical GABAergic Neurons in the Cynomolgus Monkey
Petanjek, Z., Berger, B., & Esclapez, M. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn078 · Cited by 130
“No labeling was observed in the intermediate zone (IZ), SP, CP, and MZ.”
BackgroundDevelopmental Origin of the Neuronal Subtypes That Comprise the Amygdalar Fear Circuit in the Mouse
Waclaw, R. R., Ehrman, L. A., Pierani, A., & Campbell, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5772-09.2010 · Cited by 137
“Within the LA and BLA, we found Dlx5/6-cre fate-mapped cells that coexpressed CB or CR. Cortical interneurons that express CB are known to derive from the MGE, whereas many of the CRexpressing interneurons arise in the CGE (Wonders and Anderson, 2006).”
BackgroundInfluentialDual origins of functionally distinct O-LM interneurons revealed by differential 5-HT3AR expression
Chittajallu, R., Craig, M. T., McFarland, A., Yuan, X., Gerfen, S., Tricoire, L., Erkkila, B., Barron, S. C., Lopez, C. M., Liang, B. J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3538 · Cited by 119
The Parvalbumin/Somatostatin Ratio Is Increased in Pten Mutant Mice and by Human PTEN ASD Alleles
Vogt, D. L., Cho, K. K. A., Lee, A. T., Sohal, V. S., & Rubenstein, J. L. R. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.019 · Cited by 135
“As MGE cells mature, they express specific molecular markers of interneuron subtypes, including somatostatin (SST) and parvalbumin (PV) (Wonders and Anderson, 2006).”
Dlx-Dependent and -Independent Regulation of Olfactory Bulb Interneuron Differentiation
Long, J. E., Garel, S., Álvarez‐Dolado, M., Yoshikawa, K., Osumi, N., Álvarez-Buylla, A., & Rubenstein, J. L. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5265-06.2007 · Cited by 131
“The putative migration into the pallium could include cells that become cortical interneurons and could correspond to the postulated LGE-derived cells (Anderson et al., 2001; Wonders and Anderson, 2006).”
BackgroundThe HTM Spatial Pooler—A Neocortical Algorithm for Online Sparse Distributed Coding
Cui, Y., Ahmad, S., & Hawkins, J. (2017) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2017.00111 · Cited by 142
“Some classes, such as bipolar cells and double bouquet cells exclusively innervate cells within a cortical mini-column (Markram et al., 2004; Wonders and Anderson, 2006).”
BackgroundBuchsbaum, I. Y., & Cappello, S. (2019) · Development · doi:10.1242/dev.163766 · Cited by 132
Gene Expression in Cortical Interneuron Precursors is Prescient of their Mature Function
Batista‐Brito, R., Machold, R. P., Klein, C., & Fishell, G. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm258 · Cited by 133
Genetic programs controlling cortical interneuron fate
Kessaris, N., Magno, L., Rubin, A. N., & Oliveira, M. G. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.12.012 · Cited by 130
Calretinin expression in the mammalian neocortex: a review
Barinka, F., & Druga, R. (2010) · Physiological Research · doi:10.33549/physiolres.931930 · Cited by 128
“While the PV+ and CB+ cells derive predominantly from the medial ganglionic eminence, the CR+ neurons develop in the caudal ganglionic eminence (Xu et al. 2003, Wonders and Anderson 2006).”
BackgroundNeuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits
Tricoire, L., & Vitalis, T. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00082 · Cited by 133
“AEP, entopeduncular region, Amg, amygdala, CGE, caudal ganglionic eminence; Ctx, cortex; Hip, hippocampus; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence; Pir, piriform cortex; POA, preoptic area. have refined these analyses and confirmed that in the cerebral cortex fast spiking PV interneurons (Xu…”
BackgroundInfluentialLineage-specific laminar organization of cortical GABAergic interneurons
Ciceri, G., Dehorter, N., Sols, I., Huang, Z. J., Maravall, M., & Marín, O. (2013) · Nature Neuroscience · doi:10.1038/nn.3485 · Cited by 124
Regulation of neuronal migration, an emerging topic in autism spectrum disorders
Reiner, O., Karzbrun, E., Kshirsagar, A., & Kaibuchi, K. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13403 · Cited by 129
Many specialists for suppressing cortical excitation
Burkhalter, A. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.026.2008 · Cited by 127
“However, gene expression studies and developmental analyses of cell fate specification strongly suggest that cerebral cortex contains multiple distinct classes of interneurons, which are born at specific locations and times and that dysfunction of inhibitory systems are linked to pathologies such as schizophrenia, aut…”
BackgroundPotter, G. B., Petryniak, M. A., Shevchenko, E., McKinsey, G. L., Ekker, M., & Rubenstein, J. L. R. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.10.003 · Cited by 122
GABAergic Interneuron Development and Function Is Modulated by the Tsc1 Gene
Fu, C., Cawthon, B., Clinkscales, W. B., Bruce, A., Winzenburger, P. A., & Ess, K. C. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr300 · Cited by 126
“To test our hypothesis, we generated mice with conditional inactivation of the Tsc1 gene in ventral neural progenitor cells of the medial, lateral, and caudal ganglionic eminences (MGE, LGE, and CGE), which give rise to neocortical and hippocampal GABAergic interneurons (Wonders and Anderson 2006).”
BackgroundMethodHuo, H.-Q., Qu, Z.-Y., Yuan, F., Ma, L., Yao, L., Xu, M., Hu, Y., Ji, J., Bhattacharyya, A., Zhang, S.-C., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.02.001 · Cited by 122
“They may be subdivided into multiple subtypes according to the expression of calbindin (CB), SST, CR, and parvalbumin (PV) (Kawaguchi and Kubota, 1997; Wonders and Anderson, 2006).”
BackgroundAnderson, K. M., Collins, M. A., Chin, R., Ge, T., Rosenberg, M. D., & Holmes, A. J. (2020) · Nature Communications · doi:10.1038/s41467-020-16710-x · Cited by 123
Deriving Excitatory Neurons of the Neocortex from Pluripotent Stem Cells
Hansen, D. V., Rubenstein, J. L. R., & Kriegstein, A. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.006 · Cited by 127
“The inhibitory neurons are not generated locally, but instead originate in the subpallium (ventral telencephalon ) (Wonders and Anderson, 2006).”
Laminar Fate and Phenotype Specification of Cerebellar GABAergic Interneurons
Leto, K., Bartolini, A., Yanagawa, Y., Obata, K., Magrassi, L., Schilling, K., & Rossi, F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0957-09.2009 · Cited by 119
“Furthermore, in different CNS regions, including spinal cord (Lee and Jessell, 1999), cerebral cortex (Wonders and Anderson, 2006; Fogarty et al., 2007), or olfactory system (De Marchis et al., 2007; Lledo et al., 2008), the arrays of local interneurons are generated from separate pools of…”
BackgroundThe organization of the transcriptional network in specific neuronal classes
Winden, K. D., Oldham, M. C., Mirnics, K., Ebert, P. J., Swan, C. H., Levitt, P., Rubenstein, J. L., Horvath, S., & Geschwind, D. H. (2009) · Molecular Systems Biology · doi:10.1038/msb.2009.46 · Cited by 112
“These interneurons are derived from the caudal ganglionic eminence, and they tend to be born later than their counterparts from the medial ganglionic eminence (López-Bendito et al, 2004; Wonders and Anderson, 2006).”
BackgroundInfluentialNeuronal migration disorders: Focus on the cytoskeleton and epilepsy
Stouffer, M. A., Golden, J. A., & Francis, F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.08.003 · Cited by 123
From trans to cis: transcriptional regulatory networks in neocortical development
Shibata, M., Gulden, F. O., & Sestan, N. (2015) · Trends in Genetics · doi:10.1016/j.tig.2014.12.004 · Cited by 109
Nogo-A Expression After Focal Ischemic Stroke in the Adult Rat
Cheatwood, J. L., Emerick, A. J., Schwab, M. E., & Kartje, G. L. (2008) · Stroke · doi:10.1161/strokeaha.107.507426 · Cited by 113
Fuentealba, P., Klausberger, T., Karayannis, T., Suen, W. Y., Huck, J., Tomioka, R., Rockland, K., Capogna, M., Studer, M., Morales, M., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4199-09.2010 · Cited by 113
“The diversity of GABAergic cells is generated at early embryonic stages in the ventral telencephalon (Flames and Marín, 2005; Wonders and Anderson, 2006), and their functional maturation requires cell type-specific transcription factors (Sugiyama et al., 2008).”
BackgroundLodato, S., Tomassy, G. S., De Leonibus, E., Uzcategui, Y. G., Andolfi, G., Armentano, M., Touzot, A., Gaztelu, J. M., Arlotta, P., Menendez de la Prida, L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6580-10.2011 · Cited by 112
“As previously reported, PV and SST interneurons are two MGE early-born subclasses predominantly located in deep layers, whereas VIP cells are primarily CGE late-born interneurons located in superficial layers (Kawaguchi and Kubota, 1997; Butt et al., 2005; Wonders and Anderson, 2006; Miyoshi et al., 2007, 2010).”
BackgroundModulation of apoptosis controls inhibitory interneuron number in the cortex
Denaxa, M., Neves, G., Rabinowitz, A., Kemlo, S., Liodis, P., Burrone, J., & Pachnis, V. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.064 · Cited by 112
“…the subpallium (medial ganglionic eminence-MGE, caudal ganglionic eminence-CGE, preoptic area-POA) and following stereotypic migration routes reach the dorsal telencephalon where they integrate into the local circuits (Bartolini et al., 2013; Marin and Rubenstein, 2001; Wonders and Anderson, 2006).”
BackgroundInfluentialWide dispersion and diversity of clonally related inhibitory interneurons
Harwell, C. C., Fuentealba, L. C., Gonzalez-Cerrillo, A., Parker, P. R. L., Gertz, C. C., Mazzola, E., Garcia, M. T., Alvarez-Buylla, A., Cepko, C. L., & Kriegstein, A. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.030 · Cited by 106
“In contrast, inhibitory interneurons are produced in the embryonic ventral telencephalon and follow a complexmigratory route, including a phase of prolonged tangential migration, in order to populate the cortex and hippocampus, as well as subpallial structures such as the striatum and amygdala (Anderson et al., 2001,…”
Golub, V. M., & Reddy, D. S. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000375 · Cited by 116
Genetic dissection of GABAergic neural circuits in mouse neocortex
Taniguchi, H. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00008 · Cited by 106
“The MGE produces about 50–60% of cortical interneurons in mice, most of which are PV and SOM neurons (Xu et al., 2004; Butt et al., 2005; Wonders and Anderson, 2006; Fogarty et al., 2007; Miyoshi et al., 2007; Figure 2A).”
BackgroundGhanem, N., Yu, M., Long, J. E., Hatch, G., Rubenstein, J. L. R., & Ekker, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4725-06.2007 · Cited by 113
“, 1987; Meinecke and Peters, 1987) (for review, see Markram et al., 2004; Wonders and Anderson, 2006).”
BackgroundThinking out of the dish: what to learn about cortical development using pluripotent stem cells
van den Ameele, J., Tiberi, L., Vanderhaeghen, P., & Espuny-Camacho, I. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.005 · Cited by 110
Evolution of DNA methylation in the human brain
Jeong, H., Mendizabal, I., Berto, S., Chatterjee, P., Layman, T. S., Usui, N., Toriumi, K., Douglas, C., Singh, D., Huh, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21917-7 · Cited by 114
Developmental origin dictates interneuron AMPA and NMDA receptor subunit composition and plasticity
Matta, J. A., Pelkey, K. A., Craig, M. T., Chittajallu, R., Jeffries, B. W., & McBain, C. J. (2013) · Nature Neuroscience · doi:10.1038/nn.3459 · Cited by 108
Transcription factor Sox11 is essential for both embryonic and adult neurogenesis
Wang, Y., Lin, L., Lai, H. C., Parada, L. F., & Lei, L. (2013) · Developmental Dynamics · doi:10.1002/dvdy.23962 · Cited by 110
Kim, T., Yao, R., Monnell, T. E., Cho, J.-H., Vasudevan, A., Koh, A., Peeyush, K. T., Moon, M., Datta, D., Bolshakov, V. Y., et al. (2014) · Stem Cells · doi:10.1002/stem.1704 · Cited by 111
Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons
Denaxa, M., Kalaitzidou, M., Garefalaki, A., Achimastou, A., Lasrado, R., Maes, T., & Pachnis, V. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.003 · Cited by 108
“Among them are the neuropeptides corticotropin releasing hormone (CRH) and NPY and the proteins CR and nNOS (Wonders and Anderson, 2006; Kubota et al., 2011).”
BackgroundHuman fetal brain self-organizes into long-term expanding organoids
Hendriks, D. F. G., Pagliaro, A., Andreatta, F., Ma, Z., van Giessen, J., Massalini, S., López‐Iglesias, C., van Son, G. J. F., DeMartino, J., Damen, M. J. A., et al. (2024) · Cell · doi:10.1016/j.cell.2023.12.012 · Cited by 108
Fertuzinhos, S., Krsnik, Ž., Kawasawa, Y. I., Rašin, M.-R., Kwan, K. Y., Chen, J.-G., Judaš, M., Hayashi, M., & Šestan, N. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp009 · Cited by 106
“1) are restricted to the medial ganglionic eminence (MGE) and give rise to both striatal and cortical NOS1/NPY/SST-positive interneurons (Xu et al. 2004; Wonders and Anderson 2006).”
BackgroundInfluentialDecision making during interneuron migration in the developing cerebral cortex
Guo, J., & Anton, E. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.12.001 · Cited by 104
Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior
Li, S., Pandit, P. K. T., Joshee, S., Kirschstein, T., Subburaju, S., Khalili, J. S., Kloepper, J., Du, C., Elkhal, A., Szabó, G., et al. (2017) · Cell Research · doi:10.1038/cr.2017.135 · Cited by 104
Parvalbumin Deficiency and GABAergic Dysfunction in Mice Lacking PGC-1α
Lucas, E. K., Markwardt, S. J., Gupta, S., Meador‐Woodruff, J. H., Lin, J. D., Overstreet‐Wadiche, L., & Cowell, R. M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0698-10.2010 · Cited by 104
“…as well as those containing somatostatin, in the hippocampus, cortex, and striatum are thought to rise from progenitors in the medial ganglionic eminence during embryonic development and tangentially migrate to these regions (Marin et al., 2000; Danglot et al., 2006; Wonders and Anderson, 2006).”
BackgroundDevelopment and distribution of neuronal cilia in mouse neocortex
Arellano, J. I., Guadiana, S. M., Breunig, J. J., Rakic, P., & Sarkisian, M. R. (2012) · Journal of Comparative Neurology · doi:10.1002/cne.22793 · Cited by 97
“As reported previously (Wong et al., 2000), we observed a very strong signal for glycosylated ACIII between 190 and 200 kDa in olfactory epithelium, which was not observed in cortex (Fig.”
BackgroundPrimate-specific origins and migration of cortical GABAergic neurons
Petanjek, Z. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.026.2009 · Cited by 108
Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy
Jiang, X., Lachance, M., & Rossignol, E. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.04.012 · Cited by 101
“…IH R A uthor M anuscript C IH R A uthor M anuscript neurons to the striatum, amygdala and olfactory bulb, but does not produce cortical INs (Campbell et al., 1995, Batista-Brito et al., 2008, Wichterle et al., 2001, Wonders and Anderson, 2006, Anderson et al., 1997b, Waclaw et al., 2010).”
BackgroundDopamine Systems in the Forebrain
Cave, J. W., & Baker, H. A. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-0322-8_2 · Cited by 102
Sessa, A., Mao, C., Colasante, G., Nini, A., Klein, W. H., & Broccoli, V. (2010) · Genes & Development · doi:10.1101/gad.575410 · Cited by 105
Cell diversity in the human cerebral cortex: from the embryo to brain organoids
Arlotta, P., & Pașca, S. P. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.03.001 · Cited by 99
Diversity and overlap of parvalbumin and somatostatin expressing interneurons in mouse presubiculum
Nassar, M., Simonnet, J., Lofredi, R., Cohen, I., Savary, E., Yanagawa, Y., Miles, R., & Fricker, D. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00020 · Cited by 104
“The Optigrid system permitted the acquisition of structured images Stacks of 50–80 images (zstep, 0.7 μm) were acquired per slice, using an oil immersion objective (20x, NA 0.9).”
MethodInfluential
Metadata
- Authors
- Wonders, C. P., & Anderson, S. A.
- Affiliations
- Cornell University (US)
- Corresponding author
- Anderson, Stewart A.
- ORCID
- Anderson, Stewart A.
- Venue
- Nature Reviews Neuroscience
- Published
- 2006-08-02
- Volume
- 7
- Issue
- 9
- Pages
- 687-696
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2007034511
- Cited by
- 980
- References
- 142
- Citations by year
- 2026: 32 · 2025: 49 · 2024: 39 · 2023: 47 · 2022: 32 · 2021: 42 · 2020: 66 · 2019: 53 · 2018: 43 · 2017: 52 · 2016: 49 · 2015: 49 · 2014: 53 · 2013: 54 · 2012: 50
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cortical interneurons, interneuron specification, GABAergic neurons, cortical development, transcriptional regulation, interneuron subtypes, neuronal maturation
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cerebral Cortex, Humans, Interneurons, Nerve Tissue Proteins, Stem Cells, Telencephalon, Biomarkers, Gene Expression Regulation, Developmental, Cell Lineage
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
