A new synaptic player leading to autism risk: Met receptor tyrosine kinase
Open accessAbstract
The validity for assigning disorder risk to an autism spectrum disorder (ASD) candidate gene comes from convergent genetic, clinical, and developmental neurobiology data. Here, we review these lines of evidence from multiple human genetic studies, and non-human primate and mouse experiments that support the conclusion that the MET receptor tyrosine kinase (RTK) functions to influence synapse development in circuits relevant to certain core behavioral domains of ASD. There is association of both common functional alleles and rare copy number variants that impact levels of MET expression in the human cortex. The timing of Met expression is linked to axon terminal outgrowth and synaptogenesis in the developing rodent and primate forebrain, and both in vitro and in vivo studies implicate this RTK in dendritic branching, spine maturation, and excitatory connectivity in the neocortex. This impact can occur in a cell-nonautonomous fashion, emphasizing the unique role that Met plays in specific circuits relevant to ASD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MET tyrosine kinase, implicated in ASD, responds to hepatic growth factor by freeing β-catenin from surface cadherins.
“On one hand, MET tyrosine kinase, which has been implicated in ASD (Judson et al., 2011), responds to hepatic growth factor by liberating β-catenin from binding to surface cadherins (e.g., CDH8).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Judson et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
Stanietsky, N., Simic, H., Arapovic, J., Toporik, A., Levy, O., Novik, A., Levine, Z., Beiman, M., Dassa, L., Achdout, H., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903474106 · Cited by 3,524 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Functional impact of global rare copy number variation in autism spectrum disorders
Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., et al. (2010) · Nature · doi:10.1038/nature09146 · Cited by 2,013 · cited 1× · see citing works
“First, two studies report rare copy number variants that interrupt the MET gene preferentially in ASD but not in control populations (Marshall et al. 2008; Pinto et al. 2010).”
BackgroundStructural Variation of Chromosomes in Autism Spectrum Disorder
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · see citing works
Just, M. A. (2004) · Brain · doi:10.1093/brain/awh199 · Cited by 1,589 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · cited 2× · see citing works
“Changes of this magnitude, while seemingly modest, have been shown to translate into a linear enhancement of Ca++ influx, which on a per spine basis would increase excitatory synaptic transmission (Matsuzaki et al. 2001), consistent with our recent electrophysiological data (see below).”
ResultAutism spectrum disorders: developmental disconnection syndromes
Geschwind, D. H., & Levitt, P. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.009 · Cited by 1,411 · see citing works
Self-citationINFANTILE AUTISM: A GENETIC STUDY OF 21 TWIN PAIRS
Folstein, S., & Rutter, M. (1977) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1977.tb00443.x · Cited by 1,361 · see citing works
MET signalling: principles and functions in development, organ regeneration and cancer
Trusolino, L., Bertotti, A., & Comoglio, P. M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3012 · Cited by 1,244 · see citing works
Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., & Minshew, N. J. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl006 · Cited by 1,081 · see citing works
Abnormal dendritic spines in fragile X knockout mice: Maturation and pruning deficits
Comery, T. A., Harris, J. B., Willems, P. J., Oostra, B. A., Irwin, S. A., Weiler, I. J., & Greenough, W. T. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.10.5401 · Cited by 1,046 · see citing works
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
Tabuchi, K., Blundell, J., Etherton, M. R., Hammer, R. E., Liu, X., Powell, C. M., & Südhof, T. C. (2007) · Science · doi:10.1126/science.1146221 · Cited by 997 · see citing works
Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., Zonca, P. D., Giordano, S., Graziani, A., Panayotou, G., & Comoglio, P. M. (1994) · Cell · doi:10.1016/0092-8674(94)90318-2 · Cited by 994 · see citing works
Molecular cloning of a new transforming gene from a chemically transformed human cell line
Cooper, C. S., Park, M., Blair, D. G., Tainsky, M. A., Huebner, K., Croce, C. M., & Woude, G. F. V. (1984) · Nature · doi:10.1038/311029a0 · Cited by 991 · see citing works
Pten Regulates Neuronal Arborization and Social Interaction in Mice
Kwon, C.-H., Luikart, B. W., Powell, C. M., Zhou, J., Matheny, S. A., Zhang, W., Li, Y., Baker, S. J., & Parada, L. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.03.023 · Cited by 970 · see citing works
Courchesne, E., & Pierce, K. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.03.001 · Cited by 968 · see citing works
Buie, T., Campbell, D. B., Fuchs, G. J., Furuta, G. T., Levy, J., VandeWater, J., Whitaker, A. H., Atkins, D., Bauman, M. L., Beaudet, A. L., et al. (2010) · Pediatrics · doi:10.1542/peds.2009-1878c · Cited by 872 · see citing works
Self-citationMinicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846 · see citing works
Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene
Alarcón, M., Abrahams, B. S., Stone, J. L., Duvall, J. A., Perederiy, J. V., Bomar, J. M., Sebat, J., Wigler, M., Martin, C. L., Ledbetter, D. H., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.005 · Cited by 818 · see citing works
Neuroligins Determine Synapse Maturation and Function
Varoqueaux, F., Aramuni, G., Rawson, R. L., Mohrmann, R., Missler, M., Gottmann, K., Zhang, W., Südhof, T. C., & Brose, N. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.003 · Cited by 818 · see citing works
A Twin Study of Autism in Denmark, Finland, Iceland, Norway and Sweden
Steffenburg, S., Gillberg, C., Hellgren, L., Andersson, L., Gillberg, I. C., Jakobsson, G., & Bohman, M. (1989) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1989.tb00254.x · Cited by 780 · see citing works
Butler, M. G., Dasouki, M. J., Zhou, X.-P., Talebizadeh, Z., Brown, M., Takahashi, T. N., Miles, J. H., Wang, C. H., Stratton, R., Pilarski, R., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2004.024646 · Cited by 778 · see citing works
Laumonnier, F., Bonnet-Brilhault, F., Gomot, M., Blanc, R., David, A., Moizard, M.-P., Raynaud, M., Ronce, N., Lemonnier, E., Calvas, P., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/382137 · Cited by 768 · see citing works
Tsao, D. Y., & Livingstone, M. S. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094238 · Cited by 652 · see citing works
Bourgeron, T. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.06.003 · Cited by 637 · cited 2× · see citing works
“It therefore should not come as a surprise that many of the most compelling candidate genes for rare/syndromic and idiopathic forms of ASD are involved in aspects of brain wiring and synaptic function (Bourgeron 2009).”
BackgroundJohnson, M. B., Kawasawa, Y. I., Mason, C. E., Krsnik, Ž., Coppola, G., Bogdanović, D., Geschwind, D. H., Mane, S. M., State, M. W., & Šestan, N. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.027 · Cited by 603 · see citing works
Diffusion tensor imaging of the corpus callosum in Autism
Alexander, A. L., Lee, J. E., Lazar, M., Boudos, R., DuBray, M. B., Oakes, T. R., Miller, J. N., Lu, J. K., Jeong, E., McMahon, W. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.08.032 · Cited by 593 · see citing works
Neuropsychologic functioning in autism: Profile of a complex information processing disorder.
MINSHEW, N. J., GOLDSTEIN, G., & SIEGEL, D. J. (1997) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617797003032 · Cited by 572 · see citing works
Abnormal Development of Dendritic Spines in<i>FMR1</i>Knock-Out Mice
Nimchinsky, E. A., Oberlander, A. M., & Svoboda, K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05139.2001 · Cited by 560 · see citing works
Bakkaloglu, B., O'Roak, B. J., Louvi, A., Gupta, A. R., Abelson, J. F., Morgan, T. M., Chawarska, K., Klin, A., Ercan-Sencicek, A. G., Stillman, A. A., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.017 · Cited by 537 · see citing works
The origin and evolution of synapses
Ryan, T. J., & Grant, S. G. N. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2717 · Cited by 527 · see citing works
Geschwind, D. H. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.053107.121225 · Cited by 512 · see citing works
Genetic Heterogeneity Between the Three Components of the Autism Spectrum: A Twin Study
RONALD, A., HAPPÉ, F., BOLTON, P., BUTCHER, L. M., PRICE, T. S., WHEELWRIGHT, S., BARON-COHEN, S., & PLOMIN, R. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000215325.13058.9d · Cited by 508 · see citing works
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
Tavazoie, S. F., Alvarez, V. A., Ridenour, D. A., Kwiatkowski, D. J., & Sabatini, B. L. (2005) · Nature Neuroscience · doi:10.1038/nn1566 · Cited by 497 · see citing works
Behavioral phenotyping strategies for mutant mice
Crawley, J. N. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.001 · Cited by 439 · see citing works
Decreased interhemispheric functional connectivity in autism
Anderson, J. S., Druzgal, T. J., Froehlich, A., DuBray, M. B., Lange, N., Alexander, A. L., Abildskov, T., Nielsen, J. A., Cariello, A. N., Cooperrider, J. R., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq190 · Cited by 438 · see citing works
Koshino, H., Kana, R. K., Keller, T. A., Cherkassky, V. L., Minshew, N. J., & Just, M. A. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm054 · Cited by 436 · see citing works
Dindot, S. V., Antalffy, B. A., Bhattacharjee, M. B., & Beaudet, A. L. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm288 · Cited by 418 · see citing works
Patches with Links: A Unified System for Processing Faces in the Macaque Temporal Lobe
Moeller, S., Freiwald, W. A., & Tsao, D. Y. (2008) · Science · doi:10.1126/science.1157436 · Cited by 402 · see citing works
A genetic variant that disrupts <i>MET</i> transcription is associated with autism
Campbell, D. B., Sutcliffe, J. S., Ebert, P. J., Militerni, R., Bravaccio, C., Trillo, S., Elia, M., Schneider, C., Melmed, R., Sacco, R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605296103 · Cited by 401 · see citing works
Self-citationEbens, A. J., Brose, K., Leonardo, E. D., Hanson, M. G., Bladt, F., Birchmeier, C., Barres, B. A., & Tessier‐Lavigne, M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80247-0 · Cited by 400 · see citing works
The molecular and cellular biology of enhanced cognition
Lee, Y.-S., & Silva, A. J. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2572 · Cited by 361 · see citing works
Hung, A. Y., Futai, K., Sala, C., Valtschanoff, J. G., Ryu, J., Woodworth, M. A., Kidd, F. L., Sung, C. C., Miyakawa, T., Bear, M. F., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3032-07.2008 · Cited by 350 · see citing works
Neural Representations of Faces and Body Parts in Macaque and Human Cortex: A Comparative fMRI Study
Pinsk, M. A., Arcaro, M. J., Weiner, K. S., Kalkus, J. F., Inati, S., Gross, C. G., & Kästner, S. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91198.2008 · Cited by 333 · see citing works
Levitt, P. R., Eagleson, K. L., & Powell, E. M. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.008 · Cited by 331 · see citing works
Self-citationUbe3a is required for experience-dependent maturation of the neocortex
Yashiro, K., Riday, T. T., Condon, K. H., Roberts, A. C., Bernardo, D. R., Prakash, R., Weinberg, R. J., Ehlers, M. D., & Philpot, B. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2327 · Cited by 328 · see citing works
Powell, E. M., Mars, W. M., & Levitt, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00264-1 · Cited by 321 · see citing works
Self-citationKana, R. K., Keller, T. A., Cherkassky, V. L., Minshew, N. J., & Just, M. A. (2009) · Social Neuroscience · doi:10.1080/17470910802198510 · Cited by 319 · see citing works
Batshaw, M. L. (2007) · Cited by 304 · see citing works
Incidence of Gastrointestinal Symptoms in Children With Autism: A Population-Based Study
Ibrahim, S. H., Voigt, R. G., Katusic, S. K., Weaver, A. L., & Barbaresi, W. J. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2933 · Cited by 298 · see citing works
Characterization of the Shank Family of Synaptic Proteins
Lim, S., Naisbitt, S., Yoon, J., Hwang, J.-I., Suh, P.-G., Sheng, M., & Kim, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29510 · Cited by 295 · see citing works
Diffusion Tensor Imaging of Frontal Lobe in Autism Spectrum Disorder
Sundaram, S. K., Kumar, A., Makki, M., Behen, M. E., Chugani, H. T., & Chugani, D. C. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn031 · Cited by 292 · see citing works
Representations of faces and body parts in macaque temporal cortex: A functional MRI study
Pinsk, M. A., DeSimone, K., Moore, T., Gross, C. G., & Kästner, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502605102 · Cited by 278 · see citing works
Irwin, S. A., Idupulapati, M., Gilbert, M. E., Harris, J. B., Chakravarti, A. B., Rogers, E. J., Crisostomo, R. A., Larsen, B. P., Mehta, A., Alcantara, C. J., et al. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10500 · Cited by 270 · see citing works
Scott-Van Zeeland, A. A., Abrahams, B. S., Alvarez-Retuerto, A. I., Sonnenblick, L. I., Rudie, J. D., Ghahremani, D., Mumford, J. A., Poldrack, R. A., Dapretto, M., Geschwind, D. H., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001344 · Cited by 252 · see citing works
Levitt, P., & Campbell, D. B. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37934 · Cited by 234 · see citing works
Self-citationPhenotypic and Genetic Overlap Between Autistic Traits at the Extremes of the General Population
Ronald, A., Happe, F. G. E., Price, T. S., Baron‐Cohen, S., & Plomin, R. J. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000230165.54117.41 · Cited by 232 · see citing works
Galvez, R., & Greenough, W. T. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30709 · Cited by 231 · see citing works
Shukla, D. K., Keehn, B., & Müller, R. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02342.x · Cited by 230 · see citing works
Three hypotheses for developmental defects that may underlie some forms of autism spectrum disorder
Rubenstein, J. L. (2010) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328336eb13 · Cited by 230 · see citing works
Fukuda, T., Itoh, M., Ichikawa, T., Washiyama, K., & Goto, Y.-I. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.6.537 · Cited by 221 · see citing works
Synaptogenesis, heterochrony and epigenesis in the mammalian neocortex
Bourgeois, J. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb18340.x · Cited by 216 · see citing works
Sahyoun, C. P., Belliveau, J. W., Soulières, I., Schwartz, S., & Mody, M. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.08.013 · Cited by 210 · see citing works
Fusiform function in children with an Autism Spectrum Disorder is a matter of ‘who’
Pierce, K., & Redcay, E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.013 · Cited by 196 · see citing works
Disruption of cerebral cortex MET signaling in autism spectrum disorder
Campbell, D. B., D'Oronzio, R., Garbett, K., Ebert, P. J., Mirnics, K., Levitt, P., & Persico, A. M. (2007) · Annals of Neurology · doi:10.1002/ana.21180 · Cited by 193 · see citing works
Self-citationGibson, J. R., Huber, K., & Südhof, T. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2457-09.2009 · Cited by 181 · see citing works
Genetic advances in autism: heterogeneity and convergence on shared pathways
Bill, B. R., & Geschwind, D. H. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.04.004 · Cited by 164 · see citing works
Thomas, C., Humphreys, K., Jung, K., Minshew, N. J., & Behrmann, M. (2010) · Cortex · doi:10.1016/j.cortex.2010.07.006 · Cited by 161 · see citing works
Campbell, D. B., Li, C., Sutcliffe, J. S., Persico, A. M., & Levitt, P. (2008) · Autism Research · doi:10.1002/aur.27 · Cited by 154 · see citing works
Self-citationGenomic imprinting of experience-dependent cortical plasticity by the ubiquitin ligase gene Ube3a
Sato, M., & Stryker, M. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001281107 · Cited by 151 · see citing works
Campbell, D. B., Buie, T. M., Winter, H., Bauman, M., Sutcliffe, J. S., Perrin, J. M., & Levitt, P. (2009) · Pediatrics · doi:10.1542/peds.2008-0819 · Cited by 145 · see citing works
Self-citationMicrostructural abnormalities of short-distance white matter tracts in autism spectrum disorder
Shukla, D. K., Keehn, B., Smylie, D. M., & Müller, R.-A. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.02.022 · Cited by 144 · see citing works
Jentarra, G. M., Olfers, S., Rice, S. G., Srivastava, N., Homanics, G. E., Blue, M. E., Naidu, S., & Narayanan, V. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-19 · Cited by 111 · see citing works
Qiu, S., Anderson, C. T., Levitt, P., & Shepherd, G. M. G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6569-10.2011 · Cited by 106 · see citing works
Self-citationTahara, Y., Ido, A., Yamamoto, S., Miyata, Y., Uto, H., Hori, T., Hayashi, K., & Tsubouchi, H. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.054106 · Cited by 102 · see citing works
HGF regulates the development of cortical pyramidal dendrites
Gutiérrez, H., Dolcet, X., Tolcos, M., & Davies, A. (2004) · Development · doi:10.1242/dev.01209 · Cited by 91 · see citing works
MET and autism susceptibility: family and case-control studies
Sousa, I., Clark, T., Toma, C., Kobayashi, K., Choma, M., Holt, R., Sykes, N. H., Lamb, J., Bailey, A., Battaglia, A., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.215 · Cited by 90 · see citing works
Kishi, N., & Macklis, J. D. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.12.007 · Cited by 90 · see citing works
Casanova, M. F., El-Baz, A. S., Vanbogaert, E., Narahari, P., & Switala, A. E. (2009) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00319.x · Cited by 87 · see citing works
Lim, C. S., & Walikonis, R. S. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.013 · Cited by 80 · see citing works
Judson, M. C., Bergman, M. Y., Campbell, D. B., Eagleson, K. L., & Levitt, P. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21969 · Cited by 80 · see citing works
Self-citationA pharmacogenetic study of escitalopram in autism spectrum disorders
Owley, T. B., Brune, C. W., Salt, J., Walton, L., Guter, S. J., Ayuyao, N., Gibbons, R. D., LEVENTHAL, B. L., & Cook, E. H. (2009) · Autism Research · doi:10.1002/aur.109 · Cited by 73 · see citing works
Hepatocyte growth factor as an enhancer of nmda currents and synaptic plasticity in the hippocampus
Akimoto, M., Baba, A., Ikeda-Matsuo, Y., Yamada, M. K., Itamura, R., Nishiyama, N., Ikegaya, Y., & Matsuki, N. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.031 · Cited by 71 · see citing works
Jackson, P. B., Boccuto, L., Skinner, C., Collins, J. S., Neri, G., Gurrieri, F., & Schwartz, C. E. (2009) · Autism Research · doi:10.1002/aur.87 · Cited by 65 · cited 1× · see citing works
“…studies, using nonoverlapping family and case–control cohorts, have demonstrated the association of three allelic variants of the gene encoding the MET receptor tyrosine kinase (MET) with ASD (Campbell et al. 2008; Campbell et al. 2006; Sousa et al. 2009; Jackson et al. 2009; Thanseem et al. 2010).”
BackgroundDisc1 regulates granule cell migration in the developing hippocampus
Meyer, K. D., & Morris, J. A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp266 · Cited by 59 · see citing works
Tyndall, S. J., & Walikonis, R. S. (2006) · Cell Cycle · doi:10.4161/cc.5.14.2918 · Cited by 58 · see citing works
David, M. D., Yeramian, A., Duñach, M., Llovera, M., Cantı́, C., de Herreros, A. G., Comella, J. X., & Herreros, J. (2008) · Journal of Cell Science · doi:10.1242/jcs.029660 · Cited by 55 · see citing works
Judson, M. C., Eagleson, K. L., Wang, L., & Levitt, P. R. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22467 · Cited by 55 · see citing works
Self-citationThe autism risk genes MET and PLAUR differentially impact cortical development
Eagleson, K. L., Campbell, D. B., Thompson, B. L., Bergman, M. Y., & Levitt, P. R. (2010) · Autism Research · doi:10.1002/aur.172 · Cited by 52 · see citing works
Self-citationImplications of multilocus inheritance for gene-disease association studies
Risch, N. (2001) · Theoretical Population Biology · doi:10.1006/tpbi.2001.1538 · Cited by 52 · see citing works
Further evidence for the role of MET in autism susceptibility
Thanseem, I., Nakamura, K., Miyachi, T., Toyota, T., Yamada, S., Tsujii, M., Tsuchiya, K. J., Anitha, A., Iwayama, Y., Yamada, K., et al. (2010) · Neuroscience Research · doi:10.1016/j.neures.2010.06.014 · Cited by 51 · see citing works
Otal, R., Mart�nez, A., & Soriano, E. (2005) · Cell and Tissue Research · doi:10.1007/s00441-004-1020-5 · Cited by 50 · see citing works
Matsubara, Y., Ichinose, M., Yahagi, N., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9808 · Cited by 49 · see citing works
Powell, E. M., Mühlfriedel, S., Bolz, J., & Levitt, P. R. (2003) · Developmental Neuroscience · doi:10.1159/000072268 · Cited by 48 · see citing works
Self-citationCampbell, D. B., Warren, D. E., Sutcliffe, J. S., Lee, E. B., & Levitt, P. R. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30998 · Cited by 48 · see citing works
Self-citationKermorgant, S., Walker, F., Hormi, K., et al. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70046-5 · Cited by 46 · see citing works
Stefan, M., Koch, A., Mancini, A., Mohr, A., Weidner, K. M., Niemann, H., & Tamura, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009333200 · Cited by 44 · see citing works
Expression of hepatocyte growth factor and c-met in ulcerative colitis
Kitamura, S., Kondo, S., Shinomura, Y., et al. (2000) · Inflammation Research · doi:10.1007/pl00000212 · Cited by 38 · see citing works
Tyndall, S. J., Patel, S. J., & Walikonis, R. S. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21390 · Cited by 35 · see citing works
Judson, M. C., Amaral, D., & Levitt, P. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq223 · Cited by 31 · see citing works
Self-citationTyndall, S. J., & Walikonis, R. S. (2007) · Synapse · doi:10.1002/syn.20362 · Cited by 29 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Corticostriatal connectivity and its role in disease
Shepherd, G. M. G. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3469 · Cited by 824 · see citing works
The conundrums of understanding genetic risks for autism spectrum disorders
State, M. W., & Levitt, P. (2011) · Nature Neuroscience · doi:10.1038/nn.2924 · Cited by 306 · see citing works
Self-citationUnifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops
Mullins, C., Fishell, G., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.017 · Cited by 167 · see citing works
Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics · doi:10.1093/eep/dvv012 · Cited by 167 · see citing works
Autism-Associated Promoter Variant in MET Impacts Functional and Structural Brain Networks
Rudie, J. D., Hernandez, L. M., Brown, J. A., Beck-Pancer, D., Colich, N. L., Gorrindo, P., Thompson, P. M., Geschwind, D. H., Bookheimer, S. Y., Levitt, P., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.010 · Cited by 142 · see citing works
Self-citationStamou, M., Streifel, K. M., Goines, P. E., & Lein, P. J. (2013) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2012.12.001 · Cited by 128 · see citing works
MET Receptor Tyrosine Kinase as an Autism Genetic Risk Factor
Peng, Y., Huentelman, M., Smith, C., & Qiu, S. (2013) · International Review of Neurobiology · doi:10.1016/b978-0-12-418700-9.00005-8 · Cited by 49 · see citing works
Hedrick, A., Lee, Y., Wallace, G. L., Greenstein, D., Clasen, L., Giedd, J. N., & Raznahan, A. (2012) · Autism Research · doi:10.1002/aur.1256 · Cited by 35 · see citing works
Eagleson, K. L., Milner, T. A., Xie, Z., & Levitt, P. (2013) · Journal of Comparative Neurology · doi:10.1002/cne.23343 · Cited by 32 · see citing works
Self-citation
- Authors
- Judson, M. C., Eagleson, K. L., & Levitt, P.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of Southern California (US)
- Corresponding author
- Levitt, Pat
- Venue
- Journal of Neurodevelopmental Disorders
- Published
- 2011-04-21
- Volume
- 3
- Issue
- 3
- Pages
- 282-292
- ISSN
- 1866-1947 (ISSN-L)
- 1866-1955
- PMC
- PMC3261279
- OpenAlex
- W2004738185
- Cited by
- 43
- References
- 102
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 8
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neurodevelopmental Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- MET receptor tyrosine kinase, autism spectrum disorder, synaptic development, synaptogenesis, copy number variation, neocortex, dendritic branching, dendritic spine maturation, candidate genes, non-cell-autonomous signaling, nonhuman primate model, mouse model
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
