The DOI matches its Crossref record; 187 of the 187 references it cites were found in a registry or an index.
The many faces of insulin-like peptide signalling in the brain
Abstract
Central and peripheral insulin-like peptides (ILPs), which include insulin, insulin-like growth factor 1 (IGF1) and IGF2, exert many effects in the brain. Through their actions on brain growth and differentiation, ILPs contribute to building circuitries that subserve metabolic and behavioural adaptation to internal and external cues of energy availability. In the adult brain each ILP has distinct effects, but together their actions ultimately regulate energy homeostasis - they affect nutrient sensing and regulate neuronal plasticity to modulate adaptive behaviours involved in food seeking, including high-level cognitive operations such as spatial memory. In essence, the multifaceted activity of ILPs in the brain may be viewed as a system organization involved in the control of energy allocation.
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“Igf1 is abundantly expressed by microglia during postnatal development, aging or following brain injuries and plays a vital role in promoting neuronal survival (59,63–66).”
From Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions (2020) · cites this paper as [64]
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Metadata
- Authors
- Fernandez, A. M., & Torres-Alemán, I.
- Affiliations
- Instituto Cajal (ES)
- ORCID
- Fernandez, Ana M.
- Venue
- Nature reviews. Neuroscience
- Published
- 2012-03-20
- Volume
- 13
- Issue
- 4
- Pages
- 225-239
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2067443877
- Cited by
- 872
- References
- 187
- Citations by year
- 2026: 21 · 2025: 43 · 2024: 40 · 2023: 62 · 2022: 67 · 2021: 66 · 2020: 47 · 2019: 52 · 2018: 47 · 2017: 91 · 2016: 99 · 2015: 81 · 2014: 65 · 2013: 67 · 2012: 22
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- insulin-like peptides, insulin, insulin-like growth factor I, insulin-like growth factor II, brain, energy homeostasis, nutrient sensing, neuroplasticity, brain development, food seeking, spatial memory, energy allocation
- MeSH terms
- Animals, Brain, Cognition, Energy Metabolism, Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Neuronal Plasticity, Neurons
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