The many faces of insulin-like peptide signalling in the brain

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Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

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The self-tuning neuron: synaptic scaling of excitatory synapses

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Cell death and control of cell survival in the oligodendrocyte lineage

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Ageing as a Risk Factor for Disease

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Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

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Trends in insulin resistance: insights into mechanisms and therapeutic strategy

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Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

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The Role of Sirtuins in Antioxidant and Redox Signaling

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Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

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The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

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Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

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The neuroprotective actions of oestradiol and oestrogen receptors

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Sirtuins, a promising target in slowing down the ageing process

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Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

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Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis

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Insulin and Insulin Resistance in Alzheimer’s Disease

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The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity

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Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

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Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides

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Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults

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The Link Between Angiogenesis and Endothelial Metabolism

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Traumatic Brain Injury: Oxidative Stress and Neuroprotection

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Repairing mitochondrial dysfunction in disease

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How does brain insulin resistance develop in Alzheimer's disease?

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Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

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Alzheimer's disease as type 3 diabetes: common pathophysiological mechanisms between Alzheimer's disease and type 2 diabetes

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Connecting Mitochondria, Metabolism, and Stem Cell Fate

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Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: Targets for disease modification?

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Aberrant insulin signaling in Alzheimer's disease: current knowledge

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Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline

Spinelli, M., Fusco, S., & Grassi, C. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00788 · Cited by 290

IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain

Nieto‐Estévez, V., Defteralı, Ç., & Vicario‐Abejón, C. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00052 · Cited by 275

Human conditions of insulin-like growth factor-I (IGF-I) deficiency

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Factors that regulate insulin producing cells and their output in Drosophila

Nässel, D. R., Kubrak, O. I., Liu, Y., Luo, J., & Lushchak, O. V. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00252 · Cited by 268

Insulin-Like Growth Factor 1: At the Crossroads of Brain Development and Aging

Wrigley, S., Arafa, D., & Tropea, D. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00014 · Cited by 274

Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential

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PKR: A Kinase to Remember

Gal-Ben-Ari, S., Barrera, I., Ehrlich, M., & Rosenblum, K. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00480 · Cited by 274

The Substrate Specificity of Sirtuins

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Impaired insulin action in the human brain: causes and metabolic consequences

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Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

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Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett syndrome

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The sirtuin family’s role in aging and age-associated pathologies

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Mitochondria in the signaling pathways that control longevity and health span

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Insulin Resistance in Alzheimer's Disease

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Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics

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Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

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SIRT7 antagonizes TGF-β signaling and inhibits breast cancer metastasis

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Insulin-Like Growth Factor-1 and Neuroinflammation

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Protective Functions of Reactive Astrocytes Following Central Nervous System Insult

Linnerbauer, M., & Rothhammer, V. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.573256 · Cited by 235

The human NAD metabolome: Functions, metabolism and compartmentalization

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The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction

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Macrophages redirect phagocytosis by non-professional phagocytes and influence inflammation

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Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions

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Tau deletion promotes brain insulin resistance

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The nucleolus—guardian of cellular homeostasis and genome integrity

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Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses

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Glucose metabolic crosstalk and regulation in brain function and diseases

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Neurotrophic and Neuroregenerative Effects of GH/IGF1

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The Role of Sirtuins in Cellular Homeostasis

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Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

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Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age‐related disorders

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NAD + metabolism: A therapeutic target for age-related metabolic disease

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Sirtuins in metabolism, DNA repair and cancer

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Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications

Hamed, S. A. (2017) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1293521 · Cited by 195

How Does Exercise Reduce the Rate of Age-Associated Cognitive Decline? A Review of Potential Mechanisms

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Placental phenotype and the insulin‐like growth factors: resource allocation to fetal growth

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Conserved insulin signaling in the regulation of oocyte growth, development, and maturation

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Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome

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Recent Advances in Biomarkers for Parkinson’s Disease

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SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer

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Insulin action in the brain: cell types, circuits, and diseases

Chen, W., Cai, W., Hoover, B., & Kahn, C. R. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.03.001 · Cited by 184

A causal role for hyperinsulinemia in obesity

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Systematic review and meta-analysis of the effects of exercise on depression in adolescents

Wang, X., Cai, Z.-D., Jiang, W.-T., Fang, Y.-Y., Sun, W.-X., & Wang, X. (2022) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-022-00453-2 · Cited by 169

Blastocyst metabolism

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Signaling networks determining life span

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Insulin-mediated synaptic plasticity in the CNS: Anatomical, functional and temporal contexts

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Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

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An acute bout of aerobic or strength exercise specifically modifies circulating exerkine levels and neurocognitive functions in elderly individuals with mild cognitive impairment

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Depression as a risk factor for Alzheimer’s disease: Genes, steroids, cytokines and neurogenesis – What do we need to know?

Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150

Diabetes drugs and neurological disorders: new views and therapeutic possibilities

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Adaptive Cellular Stress Pathways as Therapeutic Targets of Dietary Phytochemicals: Focus on the Nervous System

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Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy

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Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice

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The somatotropic axis in human aging: framework for the current state of knowledge and future research

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Nose-to-brain delivery of insulin enhanced by a nanogel carrier

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Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer’s disease: An integrative review

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Novel pathogenic pathways in diabetic neuropathy

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Metabolic Syndrome as a Risk Factor for Alzheimer’s Disease: A Focus on Insulin Resistance

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Emerging Roles for SIRT5 in Metabolism and Cancer

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The Neurovascular Unit Dysfunction in Alzheimer’s Disease

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IGF-1 Receptor Differentially Regulates Spontaneous and Evoked Transmission via Mitochondria at Hippocampal Synapses

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Physical Exercise Enhances Neuroplasticity and Delays Alzheimer’s Disease

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Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus of Mice Exposed to Long-Term High-Fat Diet

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Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease

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Update on Vascular Cognitive Impairment Associated with Subcortical Small-Vessel Disease

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