RNA targets of wild-type and mutant FET family proteins

The Human Genome Browser at UCSC

Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400 · see citing works

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

Sonenberg, N., & Hinnebusch, A. G. (2009) · Cell · doi:10.1016/j.cell.2009.01.042 · Cited by 3,304 · see citing works

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

Hafner, M., Landthaler, M., Burger, L., Khorshid, M., Hausser, J., Berninger, P., Rothballer, A., Ascano, M., Jungkamp, A.-C., Munschauer, M., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.009 · Cited by 2,873 · see citing works

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

Vance, C. A., Rogelj, B., Hortobágyi, T., Vos, K. J. D., Nishimura, A. L., Sreedharan, J., Hu, X., Smith, B. N., Ruddy, D., Wright, P. D., et al. (2009) · Science · doi:10.1126/science.1165942 · Cited by 2,531 · see citing works

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

Kwiatkowski, T. J., Bosco, D. A., LeClerc, A. L., Tamrazian, E., Vanderburg, C. R., Russ, C., Davis, A., Gilchrist, J. M., Kasarskis, E. J., Munsat, T. L., et al. (2009) · Science · doi:10.1126/science.1166066 · Cited by 2,526 · see citing works

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

Wu, C., Orozco, C., Boyer, J., Leglise, M., Goodale, J., Batalov, S., Hodge, C. L., Haase, J., Janes, J. O., Huss, J. W., et al. (2009) · Genome biology · doi:10.1186/gb-2009-10-11-r130 · Cited by 1,374 · see citing works

RNA regulons: coordination of post-transcriptional events

Keene, J. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2111 · Cited by 1,321 · see citing works

RNA and Disease

Cooper, T. A., Wan, L., & Dreyfuss, G. (2009) · Cell · doi:10.1016/j.cell.2009.02.011 · Cited by 1,160 · see citing works

mRNA localization: Gene expression in the spatial dimension

Martin, K. C., & Ephrussi, A. (2009) · Cell · doi:10.1016/j.cell.2009.01.044 · Cited by 1,048 · see citing works

Pre-mRNA Processing Reaches Back toTranscription and Ahead to Translation

Moore, M. J., & Proudfoot, N. J. (2009) · Cell · doi:10.1016/j.cell.2009.02.001 · Cited by 835 · see citing works

RNA processing and its regulation: global insights into biological networks

Licatalosi, D. D., & Darnell, R. B. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2673 · Cited by 760 · see citing works

A quantitative analysis of CLIP methods for identifying binding sites of RNA-binding proteins

Kishore, S., Jaśkiewicz, Ł., Burger, L., Hausser, J., Khorshid, M., & Zavolan, M. (2011) · Nature Methods · doi:10.1038/nmeth.1608 · Cited by 463 · see citing works

The TET Family of Proteins: Functions and Roles in Disease

Tan, A. Y., & Manley, J. L. (2009) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjp025 · Cited by 271 · see citing works

Identification of an RNA Binding Specificity for the Potential Splicing Factor TLS

Lerga, A., Hallier, M., Delva, L., Orvain, C., Gallais, I., Marie, J., & Moreau-Gachelin, F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008304200 · Cited by 189 · see citing works

Pathology of protein synthesis and degradation systems in ALS

Okamoto, K., Fujita, Y., & Mizuno, Y. (2010) · Neuropathology · doi:10.1111/j.1440-1789.2009.01088.x · Cited by 10 · see citing works

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

Patel, A., Lee, H. O., Jawerth, L. M., Maharana, S., Jahnel, M., Hein, M. Y., Stoynov, S., Mahamid, J., Saha, S., Franzmann, T. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.047 · Cited by 2,927 · see citing works

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

Ling, S.-C., Polymenidou, M., & Cleveland, D. W. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.033 · Cited by 1,811 · see citing works

A compendium of RNA-binding motifs for decoding gene regulation

Ray, D., Kazan, H., Cook, K. B., Weirauch, M. T., Najafabadi, H. S., Li, X., Gueroussov, S., Albu, M., Zheng, H., Yang, A., et al. (2013) · Nature · doi:10.1038/nature12311 · Cited by 1,480 · see citing works

Alternative polyadenylation of mRNA precursors

Tian, B., & Manley, J. L. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.116 · Cited by 1,179 · see citing works

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Maharana, S., Wang, J., Papadopoulos, D. K., Richter, D., Pozniakovsky, A., Poser, I., Bickle, M., Rizk, S., Guillén‐Boixet, J., Franzmann, T. M., et al. (2018) · Science · doi:10.1126/science.aar7366 · Cited by 1,111 · see citing works

RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation

Guillén‐Boixet, J., Kopach, A., Holehouse, A. S., Wittmann, S., Jahnel, M., Schlüßler, R., Kim, K., Trussina, I. R. E. A., Wang, J., Matějů, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.049 · Cited by 869 · see citing works

Cell-free Formation of RNA Granules: Bound RNAs Identify Features and Components of Cellular Assemblies

Han, T. W., Kato, M., Xie, S., Wu, L. C., Mirzaei, H., Pei, J., Chen, M., Xie, Y., Allen, J. D., Xiao, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.016 · Cited by 758 · see citing works

Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

Lagier‐Tourenne, C., Polymenidou, M., Hutt, K. R., Vu, A. Q., Baughn, M. W., Huelga, S. C., Clutario, K. M., Ling, S., Liang, T. Y., Mazur, C., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3230 · Cited by 730 · see citing works

Defining the RGG/RG Motif

Thandapani, P., O’Connor, T. R., Bailey, T. L., & Richard, S. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.021 · Cited by 690 · see citing works

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

King, O. D., Gitler, A. D., & Shorter, J. (2012) · Brain Research · doi:10.1016/j.brainres.2012.01.016 · Cited by 637 · see citing works

Protein aggregation in amyotrophic lateral sclerosis

Blokhuis, A. M., Groen, E. J. N., Koppers, M., van den Berg, L. H., & Pasterkamp, R. J. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1125-6 · Cited by 573 · see citing works

Advances in understanding the molecular basis of frontotemporal dementia

Rademakers, R., Neumann, M., & Mackenzie, I. R. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.117 · Cited by 414 · see citing works

RGG/RG Motif Regions in RNA Binding and Phase Separation

Chong, P. A., Vernon, R. M., & Forman-Kay, J. D. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.06.014 · Cited by 408 · see citing works

Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges

Lovci, M. T., Ghanem, D., Marr, H., Arnold, J., Gee, S., Parra, M., Liang, T. Y., Stark, T. J., Gehman, L. T., Hoon, S., et al. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2699 · Cited by 385 · see citing works

Physiological functions and pathobiology of TDP ‐43 and FUS / TLS proteins

Ratti, A., & Buratti, E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13625 · Cited by 384 · see citing works

HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients

Guo, W., Naujock, M., Fumagalli, L., Vandoorne, T., Baatsen, P., Boon, R., Ordovás, L., Patel, A., Welters, M., Vanwelden, T., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00911-y · Cited by 373 · see citing works

RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation

Bechara, E., Sebestyén, E., Bernardis, I., Eyras, E., & Valcárcel, J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.11.010 · Cited by 374 · see citing works

ALS Genetics: Gains, Losses, and Implications for Future Therapies

Kim, G., Gautier, O., Tassoni-Tsuchida, E., Ma, X. R., & Gitler, A. D. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.022 · Cited by 370 · see citing works

The role of FUS gene variants in neurodegenerative diseases

Deng, H., Gao, K., & Jankovic, J. J. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.78 · Cited by 357 · see citing works

Global analysis of yeast mRNPs

Mitchell, S. F., Jain, S., She, M., & Parker, R. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2468 · Cited by 341 · see citing works

Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization

West, J. A., Mito, M., Kurosaka, S., Takumi, T., Tanegashima, C., Chujo, T., Yanaka, K., Kingston, R. E., Hirose, T., Bond, C. S., et al. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201601071 · Cited by 331 · see citing works

RNA stores tau reversibly in complex coacervates

Zhang, X., Lin, Y., Eschmann, N. A., Zhou, H., Rauch, J. N., Hernández, I., Guzman, E., Kosik, K. S., & Han, S. (2017) · PLoS Biology · doi:10.1371/journal.pbio.2002183 · Cited by 308 · see citing works

RNA Seeds Higher-Order Assembly of FUS Protein

Schwartz, J. C., Wang, X., Podell, E. R., & Cech, T. R. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.11.017 · Cited by 313 · see citing works

GraphProt: modeling binding preferences of RNA-binding proteins

Maticzka, D., Lange, S., Costa, F., & Backofen, R. (2014) · Genome Biology · doi:10.1186/gb-2014-15-1-r17 · Cited by 283 · see citing works

TDP-43 and FUS RNA-binding Proteins Bind Distinct Sets of Cytoplasmic Messenger RNAs and Differently Regulate Their Post-transcriptional Fate in Motoneuron-like Cells

Colombrita, C., Onesto, E., Megiorni, F., Pizzuti, A., Baralle, F. E., Buratti, E., Silani, V., & Ratti, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333450 · Cited by 291 · see citing works

Widespread binding of FUS along nascent RNA regulates alternative splicing in the brain

Rogelj, B., Easton, L. E., Bogu, G. K., Stanton, L. W., Rot, G., Curk, T., Zupan, B., Sugimoto, Y., Modic, M., Haberman, N., et al. (2012) · Scientific Reports · doi:10.1038/srep00603 · Cited by 278 · see citing works

Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)

Bentmann, E., Neumann, M., Tahirović, S., Rodde, R., Dormann, D., & Haass, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.328757 · Cited by 277 · see citing works

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.

Qiu, H.-Y., Lee, S., Shang, Y., Wang, W.-Y., Au, K., Kamiya, S., Barmada, S. J., Finkbeiner, S., Lui, H., Carlton, C. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72723 · Cited by 73 · see citing works

Disruption of RNA Metabolism in Neurological Diseases and Emerging Therapeutic Interventions

Nussbacher, J. K., Tabet, R., Yeo, G. W.-M., & Lagier‐Tourenne, C. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.014 · Cited by 264 · see citing works

The long non-coding RNA nuclear-enriched abundant transcript 1_2 induces paraspeckle formation in the motor neuron during the early phase of amyotrophic lateral sclerosis

Nishimoto, Y., Nakagawa, S., Hirose, T., Okano, H. J., Takao, M., Shibata, S., Suyama, S., Kuwako, K.-I., Imai, T., Murayama, S., et al. (2013) · Molecular Brain · doi:10.1186/1756-6606-6-31 · Cited by 272 · see citing works

The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

Mastrocola, A. S., Kim, S. H., Trinh, A. T., Rodenkirch, L. A., & Tibbetts, R. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497974 · Cited by 262 · see citing works

Prediction of RNA-protein sequence and structure binding preferences using deep convolutional and recurrent neural networks

Pan, X., Rijnbeek, P. R., Yan, J., & Shen, H. (2018) · BMC Genomics · doi:10.1186/s12864-018-4889-1 · Cited by 252 · see citing works

A deep learning framework for modeling structural features of RNA-binding protein targets

Zhang, S., Zhou, J., Hu, H., Gong, H., Chen, L., Cheng, C., & Zeng, J. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1025 · Cited by 246 · see citing works

Different Material States of Pub1 Condensates Define Distinct Modes of Stress Adaptation and Recovery

Kroschwald, S., Munder, M. C., Maharana, S., Franzmann, T. M., Richter, D., Ruer, M., Hyman, A. A., & Alberti, S. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.041 · Cited by 244 · see citing works

FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2Preprint

Schwartz, J. C., Ebmeier, C. C., Podell, E. R., Heimiller, J., Taatjes, D. J., & Cech, T. R. (2012) · Genes & Development · doi:10.1101/gad.204602.112 · Cited by 240 · see citing works

FUS stimulates microRNA biogenesis by facilitating co‐transcriptional Drosha recruitment

Morlando, M., Modigliani, S. D., Torrelli, G., Rosa, A., Carlo, V. D., Caffarelli, E., & Bozzoni, I. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.319 · Cited by 229 · see citing works

Intrinsically disordered RGG/RG domains mediate degenerate specificity in RNA binding

Akdogan‐Ozdilek, B., Thompson, V. F., Ahmed, N. S., White, C. I., Batey, R., & Schwartz, J. C. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx460 · Cited by 232 · see citing works

Biochemical Properties and Biological Functions of FET Proteins

Schwartz, J. C., Cech, T. R., & Parker, R. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034325 · Cited by 230 · see citing works

ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP

Sun, S., Ling, S., Qiu, J., de Albuquerque, C. P., Zhou, Y., Tokunaga, S., Li, H., Qiu, H., Bui, A., Yeo, G. W.-M., et al. (2015) · Nature Communications · doi:10.1038/ncomms7171 · Cited by 229 · see citing works

RNA-binding proteins in neurodegeneration: mechanisms in aggregatePreprint

Conlon, E. G., & Manley, J. L. (2017) · Genes & Development · doi:10.1101/gad.304055.117 · Cited by 221 · see citing works

Genetic mutations in RNA-binding proteins and their roles in ALS

Kapeli, K., Martinez, F. J., & Yeo, G. W.-M. (2017) · Human Genetics · doi:10.1007/s00439-017-1830-7 · Cited by 221 · see citing works

Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions

Ishigaki, S., Masuda, A., Fujioka, Y., Iguchi, Y., Katsuno, M., Shibata, A., Urano, F., Sobue, G., & Ohno, K. (2012) · Scientific Reports · doi:10.1038/srep00529 · Cited by 219 · see citing works

Identification of RNA–protein interaction networks using PAR‐CLIP

Ascano, M., Hafner, M., Čekan, P., Gerstberger, S. C., & Tuschl, T. (2011) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1103 · Cited by 218 · see citing works

Paraspeckle formation during the biogenesis of long non-coding RNAs

Naganuma, T., & Hirose, T. (2013) · RNA Biology · doi:10.4161/rna.23547 · Cited by 218 · see citing works

The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity

Loughlin, F. E., Lukavsky, P. J., Kazeeva, T., Reber, S., Hock, E., Colombo, M., von Schroetter, C., Pauli, P., Cléry, A., Mühlemann, O., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.11.012 · Cited by 214 · see citing works

ALS-Associated FUS Mutations Result in Compromised FUS Alternative Splicing and Autoregulation

Zhou, Y., Liu, S., Liu, G., Öztürk, A., & Hicks, G. G. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003895 · Cited by 210 · see citing works

RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations

Daigle, J. G., Lanson, N. A., Smith, R. B., Casci, I., Maltare, A., Monaghan, J., Nichols, C. D., Kryndushkin, D. S., Shewmaker, F. P., & Pandey, U. B. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds526 · Cited by 206 · see citing works

RNA Dysregulation in Amyotrophic Lateral Sclerosis

Butti, Z., & Patten, S. A. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00712 · Cited by 195 · see citing works

PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage

Rulten, S. L., Rotheray, A., Green, R. L., Grundy, G. J., Moore, D. A. Q., Gómez-Herreros, F., Hafezparast, M., & Caldecott, K. W. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt835 · Cited by 190 · see citing works

Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty

Badowski, C., He, B., & Garmire, L. X. (2022) · npj Precision Oncology · doi:10.1038/s41698-022-00283-7 · Cited by 189 · see citing works

Predicting RNA–protein binding sites and motifs through combining local and global deep convolutional neural networks

Pan, X., & Shen, H. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty364 · Cited by 179 · see citing works

FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress

Sama, R. R. K., Ward, C. L., Kaushansky, L. J., Lemay, N., Ishigaki, S., Urano, F., & Bosco, D. A. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24395 · Cited by 178 · see citing works

CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17

Han, K., Wang, F., Cao, C., Ling, H., Chen, J.-W., Chen, R.-X., Feng, Z.-H., Luo, J., Jin, X.-H., Duan, J., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01184-8 · Cited by 175 · see citing works

Misregulated RNA processing in amyotrophic lateral sclerosis

Polymenidou, M., Lagier-Tourenne, C., Hutt, K. R., Bennett, C. F., Cleveland, D. W., & Yeo, G. W. (2012) · Brain Research · doi:10.1016/j.brainres.2012.02.059 · Cited by 169 · see citing works

TDP ‐43 and FUS en route from the nucleus to the cytoplasm

Ederle, H., & Dormann, D. (2017) · FEBS Letters · doi:10.1002/1873-3468.12646 · Cited by 169 · see citing works

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses

Kapeli, K., Pratt, G. A., Vu, A. Q., Hutt, K. R., Martinez, F. J., Sundararaman, B., Batra, R., Freese, P., Lambert, N. J., Huelga, S. C., et al. (2016) · Nature Communications · doi:10.1038/ncomms12143 · Cited by 169 · see citing works

Disrupted neuronal trafficking in amyotrophic lateral sclerosis

Burk, K., & Pasterkamp, R. J. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-01964-7 · Cited by 162 · see citing works

Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics

Baron, D. M., Kaushansky, L. J., Ward, C. L., Sama, R. R. K., Chian, R.-J., Boggio, K. J., Quaresma, A. J. C., Nickerson, J. A., & Bosco, D. A. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-30 · Cited by 154 · see citing works

Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis

Shang, Y., & Huang, E. J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.036 · Cited by 154 · see citing works

Activity-dependent FUS dysregulation disrupts synaptic homeostasis

Sephton, C. F., Tang, A. A., Kulkarni, A., West, J. D., Brooks, M., Stubblefield, J. J., Liu, Y., Zhang, M. Q., Green, C. B., Huber, K. M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406162111 · Cited by 145 · see citing works

Comparative interactomics analysis of different ALS-associated proteins identifies converging molecular pathways

Blokhuis, A. M., Koppers, M., Groen, E. J. N., van den Heuvel, D. M. A., Modigliani, S. D., Anink, J. J., Fumoto, K., van Diggelen, F., Snelting, A., Sodaar, P., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1575-8 · Cited by 139 · see citing works

Resources for the Comprehensive Discovery of Functional RNA Elements

Sundararaman, B., Zhan, L., Blue, S. M., Stanton, R., Elkins, K., Olson, S., Wei, X., Nostrand, E. L. V., Pratt, G. A., Huelga, S. C., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.02.012 · Cited by 138 · see citing works

Fused in sarcoma (FUS): An oncogene goes awry in neurodegeneration

Dormann, D., & Haass, C. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.03.006 · Cited by 134 · see citing works

Emerging connections between RNA and autophagy

Frankel, L. B., Lubas, M., & Lund, A. H. (2016) · Autophagy · doi:10.1080/15548627.2016.1222992 · Cited by 134 · see citing works

Nucleic acid-binding specificity of human FUS protein

Wang, X., Schwartz, J. C., & Cech, T. R. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv679 · Cited by 130 · see citing works

RNA-Binding Proteins in Amyotrophic Lateral Sclerosis.

Zhao, M., Kim, J. R., van Bruggen, R., & Park, J. (2018) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2018.0243 · Cited by 131 · see citing works

Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads

Murthy, A. C., Tang, W. S., Jovic, N., Janke, A. M., Seo, D. H., Perdikari, T. M., Mittal, J., & Fawzi, N. L. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00677-4 · Cited by 129 · see citing works

Functions of FUS/TLS From DNA Repair to Stress Response: Implications for ALS

Sama, R. R. K., Ward, C. L., & Bosco, D. A. (2014) · ASN NEURO · doi:10.1177/1759091414544472 · Cited by 128 · see citing works

Position-specific binding of FUS to nascent RNA regulates mRNA lengthPreprint

Masuda, A., Takeda, J., Okuno, T., Okamoto, T., Ohkawara, B., Ito, M., Ishigaki, S., Sobue, G., & Ohno, K. (2015) · Genes & Development · doi:10.1101/gad.255737.114 · Cited by 128 · see citing works

NY‐ESO‐1 is a ubiquitous immunotherapeutic target antigen for patients with myxoid/round cell liposarcoma

Pollack, S. M., Jungbluth, A. A., Hoch, B. L., Farrar, E. A., Bleakley, M., Schneider, D. J., Loggers, E. T., Rodler, E. T., Eary, J. F., Conrad, E. U., et al. (2012) · Cancer · doi:10.1002/cncr.27446 · Cited by 126 · see citing works

Genome sequence–independent identification of RNA editing sites

Zhang, Q., & Xiao, X. G. (2015) · Nature Methods · doi:10.1038/nmeth.3314 · Cited by 126 · see citing works

Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia

Benussi, A., Padovani, A., & Borroni, B. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00171 · Cited by 122 · see citing works

Orthogonal matrix factorization enables integrative analysis of multiple RNA binding proteins

Stražar, M., Žitnik, M., Zupan, B., Ule, J., & Curk, T. (2016) · Bioinformatics · doi:10.1093/bioinformatics/btw003 · Cited by 119 · see citing works

Minor intron splicing is regulated by FUS and affected by ALS‐associated FUS mutants

Reber, S., Stettler, J., Filosa, G., Colombo, M., Jutzi, D., Lenzken, S. C., Schweingruber, C., Bruggmann, R., Bachi, A., Barabino, S. M. L., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593791 · Cited by 120 · see citing works

Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging

Wei, Y.-N., Hu, H.-Y., Xie, G.-C., Fu, N., Ning, Z.-B., Zeng, R., & Khaitovich, P. (2015) · Genome Biology · doi:10.1186/s13059-015-0608-2 · Cited by 117 · see citing works

RNA-binding proteins in neurodegeneration: Seq and you shall receive

Nussbacher, J. K., Batra, R., Lagier-Tourenne, C., & Yeo, G. W. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.02.003 · Cited by 115 · see citing works

Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2

Zhang, S., Huang, W., Ren, L., Ju, X., Gong, M., Rao, J. Y., Sun, L., Li, P., Ding, Q., Wang, J., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00581-y · Cited by 115 · see citing works

Structure–function studies of STAR family Quaking proteins bound to their in vivo RNA target sitesPreprint

Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T., & Patel, D. J. (2013) · Genes & Development · doi:10.1101/gad.216531.113 · Cited by 110 · see citing works

FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination

Yasuda, K., Soper, S. F. C., Jackrel, M. E., Shorter, J., & Mili, S. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201608022 · Cited by 110 · see citing works

FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved introns

Nakaya, T., Alexiou, P., Maragkakis, M., Chang, A., & Mourelatos, Z. (2013) · RNA · doi:10.1261/rna.037804.112 · Cited by 110 · see citing works

DeepCLIP: predicting the effect of mutations on protein–RNA binding with deep learning

Grønning, A. G. B., Doktor, T. K., Larsen, S. J., Petersen, U. S. S., Holm, L. L., Bruun, G. H., Hansen, M. B., Hartung, A.-M., Baumbach, J., & Andresen, B. S. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa530 · Cited by 108 · see citing works

Role of FET proteins in neurodegenerative disorders

Svetoni, F., Frisone, P., & Paronetto, M. P. (2016) · RNA Biology · doi:10.1080/15476286.2016.1211225 · Cited by 107 · see citing works

Axonal transport defects are a common phenotype in Drosophila models of ALS

Baldwin, K. R., Godena, V. K., Hewitt, V. L., & Whitworth, A. J. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw105 · Cited by 105 · see citing works

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

Halliday, G. M., Bigio, E. H., Cairns, N. J., Neumann, M., Mackenzie, I. R., & Mann, D. M. A. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1030-4 · Cited by 98 · see citing works

Genome-wide identification of miRNA targets by PAR-CLIP

Hafner, M., Lianoglou, S., Tuschl, T., & Betel, D. (2012) · Methods · doi:10.1016/j.ymeth.2012.08.006 · Cited by 102 · see citing works

MechRNA: prediction of lncRNA mechanisms from RNA–RNA and RNA–protein interactions

Gawronski, A., Uhl, M., Zhang, Y., Lin, Y., Niknafs, Y. S., Ramnarine, V. R., Malik, R., Feng, F. Y.-C., Chinnaiyan, A. M., Collins, C. C., et al. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty208 · Cited by 99 · see citing works

Dysregulation of RNA-Binding Proteins in Amyotrophic Lateral Sclerosis

Xue, Y. C., Ng, C. S., Xiang, P., Liu, H., Zhang, K., Mohamud, Y., & Luo, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00078 · Cited by 95 · see citing works

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

Sephton, C. F., & Yu, G. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1943-x · Cited by 91 · see citing works

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

Orozco, D., Tahirović, S., Rentzsch, K., Schwenk, B. M., Haass, C., & Edbauer, D. (2012) · EMBO Reports · doi:10.1038/embor.2012.90 · Cited by 93 · see citing works

Activity of sunitinib in extraskeletal myxoid chondrosarcoma

Stacchiotti, S., Pantaleo, M. A., Astolfi, A., Dagrada, G. P., Negri, T., Tos, A. P. D., Indio, V., Morosi, C., Gronchi, A., Colombo, C., et al. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2014.03.013 · Cited by 92 · see citing works

RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration

Ito, D., Hatano, M., & Suzuki, N. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5436 · Cited by 92 · see citing works

FUS Regulates Activity of MicroRNA-Mediated Gene Silencing

Zhang, T., Wu, Y., Mullane, P., Ji, Y. J., Liu, H., He, L., Arora, A., Hwang, H., Alessi, A. F., Niaki, A. G., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.02.001 · Cited by 92 · see citing works

PIPE-CLIP: a comprehensive online tool for CLIP-seq data analysis

Chen, B., Yun, J., Kim, M. S., Mendell, J. T., & Xie, Y. (2014) · Genome biology · doi:10.1186/gb-2014-15-1-r18 · Cited by 85 · see citing works

Amyotrophic Lateral Sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity

Nakaya, T., & Maragkakis, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-33964-0 · Cited by 88 · see citing works

RNase-mediated protein footprint sequencing reveals protein-binding sites throughout the human transcriptome

Silverman, I. M., Li, F., Alexander, A. V., Goff, L. A., Trapnell, C., Rinn, J. L., & Gregory, B. D. (2014) · Genome biology · doi:10.1186/gb-2014-15-1-r3 · Cited by 87 · see citing works

U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish

Yu, Y., Chi, B., Xia, W., Gangopadhyay, J. P., Yamazaki, T., Winkelbauer-Hurt, M. E., Yin, S., Eliasse, Y., Adams, E., Shaw, C. E., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv157 · Cited by 84 · see citing works

RNA Binding Proteins in the miRNA Pathway

Connerty, P., Ahadi, A., & Hutvágner, G. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms17010031 · Cited by 83 · see citing works

ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAsPreprint

Tsai, Y.-L., Coady, T. H., Lü, L., Zheng, D., Alland, I., Tian, B., Shneider, N. A., & Manley, J. L. (2020) · Genes & Development · doi:10.1101/gad.335836.119 · Cited by 83 · see citing works

CapR: revealing structural specificities of RNA-binding protein target recognition using CLIP-seq data

Fukunaga, T., Ozaki, H., Terai, G., Asai, K., Iwasaki, W., & Kiryu, H. (2014) · Genome biology · doi:10.1186/gb-2014-15-1-r16 · Cited by 81 · see citing works

Design and bioinformatics analysis of genome-wide CLIP experiments

Wang, T., Xiao, G., Chu, Y., Zhang, M. Q., Corey, D. R., & Xie, Y. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv439 · Cited by 75 · see citing works

Functional characterization of the FET family of RNA-binding proteins

Baethge, K. (2014) · doi:10.18452/16996

FET proteins in frontotemporal dementia and amyotrophic lateral sclerosis

Mackenzie, I. R., & Neumann, M. (2011) · Brain Research · doi:10.1016/j.brainres.2011.12.010 · Cited by 91 · see citing works

Biochemical Properties and Biological Functions of FET Proteins

Schwartz, J. C., Cech, T. R., & Parker, R. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034325 · Cited by 230 · see citing works

FUS and TAF15 safeguard the critical functions of the ribonucleoprotein network formed by EWSR1 and newly synthesized RNAPreprint

Rajan, S. S., Khan, I., Jones, T., Brownmiller, T., Ebegboni, V. J., Lim, L., Tran, A. D., Kruhlak, M. J., & Caplen, N. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.24.713985

RNA metabolism in neurological disease

Gao, F., & Taylor, J. P. (2014) · Brain Research · doi:10.1016/j.brainres.2014.09.011 · Cited by 7 · see citing works