Cited by 115RNA Research and SplicingAmyotrophic Lateral Sclerosis ResearchGenetics and Neurodevelopmental Disorders

RNA-binding proteins in neurodegeneration: Seq and you shall receive

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Nussbacher, Julia K., Batra, Ranjan, Lagier-Tourenne, Clotilde, Yeo, Gene W.·2015·Trends in Neurosciences

Abstract

As critical players in gene regulation, RNA binding proteins (RBPs) are taking center stage in our understanding of cellular function and disease. In our era of bench-top sequencers and unprecedented computational power, biological questions can be addressed in a systematic, genome-wide manner. Development of high-throughput sequencing (Seq) methodologies provides unparalleled potential to discover new mechanisms of disease-associated perturbations of RNA homeostasis. Complementary to candidate single-gene studies, these innovative technologies may elicit the discovery of unexpected mechanisms, and enable us to determine the widespread influence of the multifunctional RBPs on their targets. Given that the disruption of RNA processing is increasingly implicated in neurological diseases, these approaches will continue to provide insights into the roles of RBPs in disease pathogenesis.

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Crossref · 10.1016/j.tins.2015.02.003

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  • Whole genome analyses brought a new appreciation of the pervasiveness and regulatory reach of alternative splicing in metazoan organisms.

    “The advent of whole genome analyses10,12,188,189 brought a new appreciation of its pervasiveness and regulatory reach in metazoan organisms190,191.”

    From The neurogenetics of alternative splicing (2016) · cites this paper as [12]

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Authors
Nussbacher, J. K., Batra, R., Lagier-Tourenne, C., & Yeo, G. W.
Affiliations
  • University of California San Diego (US)
  • National University of Singapore (SG)
Corresponding author
Yeo, Gene W.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2015-04
Volume
38
Issue
4
Pages
226-236
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2170944200
Cited by
115
References
128
Citations by year
2026: 6 · 2025: 4 · 2024: 15 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 16 · 2019: 9 · 2018: 17 · 2017: 14 · 2016: 13 · 2015: 6
FWCI
1.62
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (P50AG005131)
  • National Human Genome Research Institute (HG004659, R01HG004659, U54HG007005)
  • National Institute of Neurological Disorders and Stroke (R01NS075449, R01NS087227, NS075449)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
RNA-binding proteins, neurodegeneration, RNA homeostasis, RNA processing, next-generation sequencing, genome-wide characterization, gene expression regulation, pathogenesis
MeSH terms
Animals, Humans, RNA Processing, Post-Transcriptional, RNA-Binding Proteins, Neurodegenerative Diseases, High-Throughput Nucleotide Sequencing

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