The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks
Open accessAbstract
Although both homologous recombination (HR) and nonhomologous end joining can repair DNA double-strand breaks (DSBs), the mechanisms by which one of these pathways is chosen over the other remain unclear. Here we show that transcriptionally active chromatin is preferentially repaired by HR. Using chromatin immunoprecipitation-sequencing (ChIP-seq) to analyze repair of multiple DSBs induced throughout the human genome, we identify an HR-prone subset of DSBs that recruit the HR protein RAD51, undergo resection and rely on RAD51 for efficient repair. These DSBs are located in actively transcribed genes and are targeted to HR repair via the transcription elongation-associated mark trimethylated histone H3 K36. Concordantly, depletion of SETD2, the main H3 K36 trimethyltransferase, severely impedes HR at such DSBs. Our study thereby demonstrates a primary role in DSB repair of the chromatin context in which a break occurs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“consistent with a role for (epi)genomic context in modulating DSB repair efficiency (44–47).”
From Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability (2016) · cites this paper as [44]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mapping and analysis of chromatin state dynamics in nine human cell types
Ernst, J., Kheradpour, P., Mikkelsen, T. S., Shoresh, N., Ward, L. D., Epstein, C. B., Zhang, X., Wang, L., Issner, R., Coyne, M., et al. (2011) · Nature · doi:10.1038/nature09906 · Cited by 2,898
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671
An auxin-based degron system for the rapid depletion of proteins in nonplant cells
Nishimura, K., Fukagawa, T., Takisawa, H., Kakimoto, T., & Kanemaki, M. (2009) · Nature Methods · doi:10.1038/nmeth.1401 · Cited by 1,663
A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
The ENCODE Project Consortium (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001046 · Cited by 1,517
Human CtIP promotes DNA end resection
Sartori, A. A., Lukas, C., Coates, J., Mistrik, M., Fu, S., Bartek, J., Baer, R., Lukas, J., & Jackson, S. P. (2007) · Nature · doi:10.1038/nature06337 · Cited by 1,362
Self-citationBotuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 1,011
Bouwman, P., Aly, A., Escandell, J. M., Pieterse, M., Bartkova, J., van der Gulden, H., Hiddingh, S., Thanasoula, M., Kulkarni, A., Yang, Q., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1831 · Cited by 1,001
Escribano‐Diaz, C., Orthwein, A., Fradet‐Turcotte, A., Xing, M., Young, J. T. F., Tkáč, J., Cook, M. A., Rosebrock, A. P., Munro, M., Canny, M. D., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.001 · Cited by 903
ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
Shanbhag, N. M., Rafalska-Metcalf, I. U., Balane-Bolivar, C., Janicki, S. M., & Greenberg, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.04.038 · Cited by 737
Chapman, J. R., Barral, P., Vannier, J., Borel, V., Steger, M., Tomás‐Loba, A., Sartori, A. A., Adams, I. R., Batista, F. D., & Boulton, S. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.002 · Cited by 663
Cited by
Sorted by citations
DNA double-strand break repair-pathway choice in somatic mammalian cells
Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,542
Ribosome biogenesis in cancer: new players and therapeutic avenues
Pelletier, J., Thomas, G., & Volarević, S. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.104 · Cited by 837
R Loops: From Physiological to Pathological Roles
García‐Muse, T., & Aguilera, A. (2019) · Cell · doi:10.1016/j.cell.2019.08.055 · Cited by 707
Clear cell renal cell carcinoma ontogeny and mechanisms of lethality
Jonasch, E. W., Walker, C. L., & Rathmell, W. K. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00359-2 · Cited by 667
Regulation of Single-Strand Annealing and its Role in Genome Maintenance
Bhargava, R., Onyango, D. O., & Stark, J. M. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.06.007 · Cited by 512
Pfister, S. X., Ahrabi, S., Zalmas, L., Sarkar, S., Aymard, F., Bachrati, C. Z., Helleday, T., Legube, G., Thangue, N. B. L., Porter, A. C. G., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.026 · Cited by 496
Self-citationNuclear ARP2/3 drives DNA break clustering for homology-directed repair
Schrank, B. R., Aparicio, T., Li, Y., Chang, W., Chait, B. T., Gundersen, G. G., Gottesman, M. E., & Gautier, J. (2018) · Nature · doi:10.1038/s41586-018-0237-5 · Cited by 400
Loop extrusion as a mechanism for formation of DNA damage repair foci
Arnould, C., Rocher, V., Finoux, A.-L., Clouaire, T., Li, K., Zhou, F., Caron, P., Mangeot, P. E., Ricci, E. P., Mourad, R., et al. (2021) · Nature · doi:10.1038/s41586-021-03193-z · Cited by 341
Self-citationSenataxin resolves RNA:DNA hybrids forming at DNA double-strand breaks to prevent translocations
Cohen, S., Puget, N., Lin, Y., Clouaire, T., Aguirrebengoa, M., Rocher, V., Pasero, P., Canitrot, Y., & Legube, G. (2018) · Nature Communications · doi:10.1038/s41467-018-02894-w · Cited by 338
Self-citationDNA damage foci: Meaning and significance
Rothkamm, K., Barnard, S. G. R., Moquet, J., Ellender, M., Rana, Z., & Burdak‐Rothkamm, S. (2015) · Environmental and Molecular Mutagenesis · doi:10.1002/em.21944 · Cited by 345
Chromatin and nucleosome dynamics in DNA damage and repairPreprint
Hauer, M., & Gasser, S. M. (2017) · Genes & Development · doi:10.1101/gad.307702.117 · Cited by 320
Yasuhara, T., Kato, R., Hagiwara, Y., Shiotani, B., Yamauchi, M., Nakada, S., Shibata, A., & Miyagawa, K. (2018) · Cell · doi:10.1016/j.cell.2018.08.056 · Cited by 317
Coevolution between transposable elements and recombination
Kent, T. V., Uzunović, J., & Wright, S. I. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0458 · Cited by 312
How cells ensure correct repair of DNA double-strand breaks
Her, J., & Bunting, S. F. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000371 · Cited by 326
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation
Pfister, S. X., Markkanen, E., Jiang, Y., Sarkar, S., Woodcock, M., Orlando, G., Mavrommati, I., Pai, C., Zalmas, L., Drobnitzky, N., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.09.015 · Cited by 323
Clouaire, T., Rocher, V., Lashgari, A., Arnould, C., Aguirrebengoa, M., Biernacka, A., Skrzypczak, M., Aymard, F., Fongang, B., Dojer, N., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.020 · Cited by 314
Self-citationMarked for death: Targeting epigenetic changes in cancer
Pfister, S. X., & Ashworth, A. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.256 · Cited by 288
Dual Chromatin and Cytoskeletal Remodeling by SETD2
Park, I. Y., Powell, R. T., Tripathi, D. N., Dere, R., Ho, T. H., Blasius, T. L., Chiang, Y.-C., Davis, I. J., Fahey, C. C., Hacker, K. E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.005 · Cited by 285
Aymard, F., Aguirrebengoa, M., Guillou, E., Javierre, B. M., Bugler, B., Arnould, C., Rocher, V., Iacovoni, J. S., Biernacka, A., Skrzypczak, M., et al. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3387 · Cited by 263
Self-citationJacquet, K., Fradet‐Turcotte, A., Avvakumov, N., Lambert, J., Lopez‐Roques, C., PANDITA, R. K., Paquet, É. R., Herst, P. M., Gingras, A., Pandita, T. K., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.031 · Cited by 280
Self-citationTsouroula, K., Furst, A., Rogier, M., Heyer, V., Maglott, A., Ferrand, A., Reina‐San‐Martin, B., & Soutoglou, E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.002 · Cited by 268
Histone methylation and the DNA damage response
Gong, F., & Miller, K. M. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.09.003 · Cited by 265
Self-citationvan Sluis, M., & McStay, B. (2015) · Genes & Development · doi:10.1101/gad.260703.115 · Cited by 254
Gong, F., Chiu, L.-Y., Cox, B., Aymard, F., Clouaire, T., Leung, J. W., Cammarata, M., Perez, M., Agarwal, P., Brodbelt, J. S., et al. (2015) · Genes & Development · doi:10.1101/gad.252189.114 · Cited by 247
Self-citationALTernative Telomere Maintenance and Cancer
Dilley, R. L., & Greenberg, R. A. (2015) · Trends in cancer · doi:10.1016/j.trecan.2015.07.007 · Cited by 251
Transcription-mediated replication hindrance: a major driver of genome instabilityPreprint
Gómez‐González, B., & Aguilera, A. (2019) · Genes & Development · doi:10.1101/gad.324517.119 · Cited by 235
Jasin, M., & Haber, J. E. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.001 · Cited by 229
A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance
Khurana, S., Kruhlak, M. J., Kim, J., Tran, A. D., Liu, J., Nyswaner, K., Shi, L., Jailwala, P., Sung, M.-H., Hakim, O., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.024 · Cited by 220
DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
Collins, P. L., Purman, C. E., Porter, S. I., Nganga, V. K., Saini, A., Hayer, K. E., Gurewitz, G. L., Sleckman, B. P., Bednarski, J. J., Bassing, C. H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16926-x · Cited by 231
Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair
Lu, W.-T., Hawley, B. R., Skalka, G., Baldock, R. A., Smith, E. M., Bader, A. S., Malewicz, M., Watts, F. Z., Wilczynska, A., & Bushell, M. (2018) · Nature Communications · doi:10.1038/s41467-018-02893-x · Cited by 229
Nuclear position dictates DNA repair pathway choice
Lemaître, C., Grabarz, A., Tsouroula, K., Andronov, L., Furst, A., Pankotai, T., Heyer, V., Rogier, M., Attwood, K. M., Kessler, P., et al. (2014) · Genes & Development · doi:10.1101/gad.248369.114 · Cited by 209
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex
Saredi, G., Huang, H., Hammond, C. M., Alabert, C., Bekker‐Jensen, S., Forné, I., Reverón-Gómez, N., Foster, B. M., Mlejnkova, L. J., Bartke, T., et al. (2016) · Nature · doi:10.1038/nature18312 · Cited by 212
Iliakis, G. E., Murmann-Konda, T., & Soni, A. (2015) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2015.07.001 · Cited by 199
Lee, J. S., Kallehauge, T. B., Pedersen, L. E., & Kildegaard, H. F. (2015) · Scientific Reports · doi:10.1038/srep08572 · Cited by 203
Powers, N. R., Parvanov, E. D., Baker, C. L., Walker, M., Petkov, P. M., & Paigen, K. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006146 · Cited by 203
Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance
Schep, R., Brinkman, E. K., Leemans, C., Vergara, X., van der Weide, R. H., Morris, B., van Schaik, T., Manzo, S. G., Peric‐Hupkes, D., van den Berg, J., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.032 · Cited by 200
The nucleosome remodeling and deacetylase complex in development and disease
Basta, J., & Rauchman, M. (2015) · Translational Research · doi:10.1016/j.trsl.2014.05.003 · Cited by 191
DNA repair mechanisms and their clinical impact in glioblastoma
Erasimus, H., Gobin, M., Niclou, S. P., & Dyck, E. V. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.05.005 · Cited by 203
Histone demethylase KDM5A regulates the ZMYND8–NuRD chromatin remodeler to promote DNA repair
Gong, F., Clouaire, T., Aguirrebengoa, M., Legube, G., & Miller, K. M. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201611135 · Cited by 192
Self-citationm5C modification of mRNA serves a DNA damage code to promote homologous recombination
Chen, H., Yang, H., Zhu, X., Yadav, T., Ouyang, J., Truesdell, S. S., Tan, J. J., Wang, Y., Duan, M.-H., Wei, L., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16722-7 · Cited by 189
Kanu, N., Gronroos, E. C., Martinez, P., Burrell, R. A., Goh, X. Y., Bártková, J., Maya‐Mendoza, A., Mistrík, M., Rowan, A., Patel, H., et al. (2015) · Oncogene · doi:10.1038/onc.2015.24 · Cited by 189
Chromatin compartmentalization regulates the response to DNA damage
Arnould, C., Rocher, V., Saur, F., Bader, A. S., Muzzopappa, F., Collins, S., Lesage, E., Bozec, B. L., Puget, N., Clouaire, T., et al. (2023) · Nature · doi:10.1038/s41586-023-06635-y · Cited by 187
Self-citationTeng, Y., Yadav, T., Duan, M.-H., Tan, J. J., Xiang, Y., Gao, B., Xu, J., Liang, Z., Liu, Y., Nakajima, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06586-3 · Cited by 184
Regulation of repair pathway choice at two-ended DNA double-strand breaks
Shibata, A. (2017) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2017.07.011 · Cited by 190
Checkpoint Responses to DNA Double-Strand Breaks
Waterman, D. P., Haber, J. E., & Smolka, M. B. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011520-104722 · Cited by 184
RNA transcripts stimulate homologous recombination by forming DR-loops
Ouyang, J., Yadav, T., Zhang, J., Yang, H., Rheinbay, E., Guo, H., Haber, D. A., Lan, L., & Zou, L. (2021) · Nature · doi:10.1038/s41586-021-03538-8 · Cited by 166
Yang, H., Wang, Y., Xiang, Y., Yadav, T., Ouyang, J., Phoon, L. Y., Zhu, X., Shi, Y., Zou, L., & Lan, L. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2116251119 · Cited by 166
A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice
Pai, C., Deegan, R. S., Subramanian, L., Gal, C., Sarkar, S., Blaikley, E., Walker, C. A., Hulme, L., Bernhard, E. J., Codlin, S., et al. (2014) · Nature Communications · doi:10.1038/ncomms5091 · Cited by 176
Epigenome Maintenance in Response to DNA Damage
Dabin, J., Fortuny, A., & Polo, S. E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.006 · Cited by 161
LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2
Li, H., An, J., Wu, M., Zheng, Q., Gui, X., Li, T., Pu, H., & Lu, D. (2015) · Oncotarget · doi:10.18632/oncotarget.4443 · Cited by 160
DSBCapture: in situ capture and sequencing of DNA breaks
Lensing, S. V., Marsico, G., Hänsel‐Hertsch, R., Lam, E. Y. N., Tannahill, D., & Balasubramanian, S. (2016) · Nature Methods · doi:10.1038/nmeth.3960 · Cited by 155
PARP Inhibitors in Ovarian Cancer
Mittica, G., Ghisoni, E., Giannone, G., Genta, S., Aglietta, M., Sapino, A., & Valabrega, G. (2018) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892813666180305165256 · Cited by 158
Chakraborty, A., Tapryal, N., Venkova, T., Horikoshi, N., PANDITA, R. K., Sarker, A. H., Sarkar, P. S., Pandita, T. K., & Hazra, T. K. (2016) · Nature Communications · doi:10.1038/ncomms13049 · Cited by 166
Epigenetics, DNA damage, and aging
Soto-Palma, C., Niedernhofer, L. J., Faulk, C. D., & Dong, X. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158446 · Cited by 160
DEAD Box 1 Facilitates Removal of RNA and Homologous Recombination at DNA Double-Strand Breaks
Li, L., Germain, D. R., Poon, H.-Y., Hildebrandt, M. R., Monckton, E. A., McDonald, D., Hendzel, M. J., & Godbout, R. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00415-16 · Cited by 159
Studying DNA Double-Strand Break Repair: An Ever-Growing Toolbox
Vítor, A. C., Huertas, P., Legube, G., & de Almeida, S. F. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2020.00024 · Cited by 162
Self-citationSystematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
Nishi, R., Wijnhoven, P. W. G., le Sage, C., Tjeertes, J., Galanty, Y., Forment, J. V., Clague, M. J., Urbé, S., & Jackson, S. P. (2014) · Nature Cell Biology · doi:10.1038/ncb3028 · Cited by 153
Self-citationWei, L., Nakajima, S., Böhm, S., Bernstein, K. A., Shen, Z., Tsang, M., Levine, A. S., & Lan, L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507105112 · Cited by 147
SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia
Mar, B. G., Chu, S. H., Kahn, J. D., Krivtsov, A. V., Koche, R. P., Castellano, C. A., Kotlier, J. L., Zon, R. L., McConkey, M. E., Chabon, J. R., et al. (2017) · Blood · doi:10.1182/blood-2017-03-775569 · Cited by 143
Transcription-Coupled DNA Double-Strand Break Repair: Active Genes Need Special Care
Marnef, A., Cohen, S., & Legube, G. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.03.024 · Cited by 156
Self-citationPoly (ADP-Ribose) Polymerase Inhibitors: Talazoparib in Ovarian Cancer and Beyond
Boussios, S., Abson, C., Moschetta, M., Rassy, E., Karathanasi, A., Bhat, T., Ghumman, F. I. A., Sheriff, M., & Pavlidis, N. A. (2020) · Drugs in R&D · doi:10.1007/s40268-020-00301-8 · Cited by 142
Kim, J. J., Lee, S. Y., Gong, F., Battenhouse, A. M., Boutz, D. R., Bashyal, A., Refvik, S. T., Chiang, C., Xhemalçe, B., Paull, T. T., et al. (2019) · Genes & Development · doi:10.1101/gad.331231.119 · Cited by 138
Self-citationDNA-dependent protein kinase promotes DNA end processing by MRN and CtIP
Deshpande, R. A., Myler, L. R., Soniat, M. M., Makharashvili, N., Lee, L., Lees‐Miller, S. P., Finkelstein, I. J., & Paull, T. T. (2020) · Science Advances · doi:10.1126/sciadv.aay0922 · Cited by 141
DNA–RNA hybrids: the risks of DNA breakage during transcription
Aguilera, A., & Gómez‐González, B. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3395 · Cited by 137
Nuclear Actin and Actin-Binding Proteins in DNA Repair
Hurst, V., Shimada, K., & Gasser, S. M. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.02.010 · Cited by 133
Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance
Song, J., Yang, P. X., Chen, C., Ding, W., Tillement, O., Bai, H., & Zhang, S. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02266-z · Cited by 159
Iannelli, F., Galbiati, A., Capozzo, I., Nguyen, Q. H., Magnuson, B., Michelini, F., D’Alessandro, G., Cabrini, M., Roncador, M., Francia, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms15656 · Cited by 124
Replication Stress in Mammalian Cells and Its Consequences for Mitosis
Gelot, C., Magdalou, I., & López, B. S. (2015) · Genes · doi:10.3390/genes6020267 · Cited by 140
Meisenberg, C., Pinder, S. I., Hopkins, S. R., Wooller, S. K., Benstead-Hume, G., Pearl, F. M. G., Jeggo, P. A., & Downs, J. A. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.11.001 · Cited by 132
Jha, D. K., & Strahl, B. D. (2014) · Nature Communications · doi:10.1038/ncomms4965 · Cited by 123
53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination
Callén, E., Zong, D., Wu, W., Wong, N., Stanlie, A., Ishikawa, M., Pavani, R., Dumitrache, L. C., Byrum, A. K., Mendez‐Dorantes, C., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.09.024 · Cited by 126
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
Caron, P., Choudjaye, J., Clouaire, T., Bugler, B., Daburon, V., Aguirrebengoa, M., Mangeat, T., Iacovoni, J. S., Álvarez-Quilón, A., Cortés‐Ledesma, F., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.024 · Cited by 144
Self-citationBreaks in the 45S rDNA Lead to Recombination-Mediated Loss of Repeats
Warmerdam, D. O., van den Berg, J., & Medema, R. H. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.048 · Cited by 112
PRDM9, a driver of the genetic map
Grey, C., Baudat, F., & de Massy, B. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007479 · Cited by 124
Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks
Gürsoy-Yüzügüllü, Ö., House, N. C. M., & Price, B. D. (2015) · Journal of Molecular Biology · doi:10.1016/j.jmb.2015.11.021 · Cited by 118
A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis
Löbrich, M., & Jeggo, P. A. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.06.011 · Cited by 123
The tale of a tail: histone H4 acetylation and the repair of DNA breaks
Dhar, S., Gürsoy-Yüzügüllü, Ö., Parasuram, R., & Price, B. D. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0284 · Cited by 123
BRCA2 promotes DNA‐RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡
Sessa, G., Gómez‐González, B., Silva, S. D. R., Calero, C. P., Beaurepere, R., Barroso, S. I., Martineau, S., Martin, C. A., Ehlén, Å., Martínez, J. S., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020106018 · Cited by 118
Janssen, A., Breuer, G. A., Brinkman, E. K., van der Meulen, A. I., Borden, S. V., van Steensel, B., Bindra, R. S., LaRocque, J. R., & Karpen, G. H. (2016) · Genes & Development · doi:10.1101/gad.283028.116 · Cited by 118
A cohesin/HUSH- and LINC-dependent pathway controls ribosomal DNA double-strand break repairPreprint
Marnef, A., Finoux, A.-L., Arnould, C., Guillou, E., Daburon, V., Rocher, V., Mangeat, T., Mangeot, P. E., Ricci, E. P., & Legube, G. (2019) · Genes & Development · doi:10.1101/gad.324012.119 · Cited by 125
Self-citationLoss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness
Kari, V., Mansour, W. Y., Raul, S. K., Baumgart, S. J., Mund, A., Grade, M., Sirma, H., Simon, R., Will, H., Dobbelstein, M., et al. (2016) · EMBO Reports · doi:10.15252/embr.201642352 · Cited by 115
H3K36me3, message from chromatin to DNA damage repair
Sun, Z., Zhang, Y., Jia, J., Fang, Y., Tang, Y., Wu, H., & Fang, D. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-0374-z · Cited by 109
DNA double strand break repair pathway choice: a chromatin based decision?
Clouaire, T., & Legube, G. (2015) · Nucleus · doi:10.1080/19491034.2015.1010946 · Cited by 124
Self-citationA Snapshot on the Cis Chromatin Response to DNA Double-Strand Breaks
Clouaire, T., & Legube, G. (2019) · Trends in Genetics · doi:10.1016/j.tig.2019.02.003 · Cited by 117
Self-citationLife or Death after a Break: What Determines the Choice?
Krenning, L., van den Berg, J., & Medema, R. H. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.08.023 · Cited by 113
Human CDK12 and CDK13, multi-tasking CTD kinases for the new millenium
Greenleaf, A. L. (2018) · Transcription · doi:10.1080/21541264.2018.1535211 · Cited by 110
Korsholm, L. M., Gál, Z., Lin, L., Quevedo, O., Ahmad, D. A., Dulina, E., Luo, Y., Bártek, J., & Larsen, D. H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz518 · Cited by 102
Cell cycle-dependent control of homologous recombination
Zhao, X., Wei, C., Li, J., Xing, P., Li, J., Zheng, S., & Chen, X. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx055 · Cited by 113
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
Domingo‐Prim, J., Endara-Coll, M., Bonath, F., Jimeno, S., Prados‐Carvajal, R., Friedländer, M. R., Huertas, P., & Visa, N. (2019) · Nature Communications · doi:10.1038/s41467-019-10153-9 · Cited by 107
Ui, A., Chiba, N., & Yasui, A. (2020) · Cancer Science · doi:10.1111/cas.14404 · Cited by 104
Lu, H., Shamanna, R. A., de Freitas, J. K., Okur, M. N., Khadka, P., Kulikowicz, T., Holland, P. P., Tian, J. Y., Croteau, D. L., Davis, A. J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02146-3 · Cited by 104
The diverse roles of SPOP in prostate cancer and kidney cancer
Wang, Z. P., Song, Y., Ye, M., Dai, X., Zhu, X., & Wei, W. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-0314-z · Cited by 104
Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage
Burger, K., Schlackow, M., Potts, M., Hester, S., Mohammed, S., & Gullerová, M. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201612131 · Cited by 111
The multi-functionality of UHRF1: epigenome maintenance and preservation of genome integrity
Mancini, M., Magnani, E., Macchi, F., & Bonapace, I. M. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab293 · Cited by 97
Pazi, K., Chathoth, K. T., Taylor, G. C. A., Meynert, A. M., Ballinger, T. J., Kelder, M. J. E., Lalevée, S., Sanli, I., Feil, R., & Wood, A. J. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005595 · Cited by 99
Deciphering the BRCA1 Tumor Suppressor Network
Jiang, Q., & Greenberg, R. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.667931 · Cited by 96
The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin
Kalousi, A., Hoffbeck, A.-S., Selemenakis, P., Pinder, J. B., Savage, K. I., Khanna, K. K., Brino, L., Dellaire, G., Gorgoulis, V. G., & Soutoglou, E. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.005 · Cited by 100
RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks
Lu, H., Shamanna, R. A., Keijzers, G., Anand, R., Rasmussen, L. J., Ćejka, P., Croteau, D. L., & Bohr, V. A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.079 · Cited by 100
Myler, L. R., Gallardo, I. F., Zhou, Y., Gong, F., Yang, S.-H., Wold, M. S., Miller, K. M., Paull, T. T., & Finkelstein, I. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516674113 · Cited by 94
Self-citationPreserving genome integrity and function: the DNA damage response and histone modifications
Kim, J. J., Lee, S. Y., & Miller, K. M. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1620676 · Cited by 96
Self-citation
Metadata
- Authors
- Aymard, F., Bugler, B., Schmidt, C. K., Guillou, E., Caron, P., Briois, S., Iacovoni, J. S., Daburon, V., Miller, K. M., Jackson, S. P., & Legube, G.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- University of Cambridge (GB)
- Inserm (FR)
- Corresponding author
- Legube, Gaëlle
- ORCID
- Venue
- Nature Structural & Molecular Biology
- Published
- 2014-03-23
- Volume
- 21
- Issue
- 4
- Pages
- 366-374
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- PMC
- PMC4300393
- OpenAlex
- W2097027640
- Cited by
- 668
- References
- 52
- Citations by year
- 2026: 33 · 2025: 51 · 2024: 50 · 2023: 47 · 2022: 65 · 2021: 79 · 2020: 69 · 2019: 53 · 2018: 47 · 2017: 62 · 2016: 52 · 2015: 40 · 2014: 18
- FWCI
- 23.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (086861, 092096)
- European Molecular Biology Laboratory
- Broad Institute
- Cancer Research UK (C6/A11226, 11224, A11224)
- Agence Nationale de la Recherche (ANR-09-JCJC-0138)
- National Cancer Institute (F31CA260794)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- DNA double-strand breaks, homologous recombination, non-homologous end joining, RAD51, SETD2, transcriptionally active chromatin, DNA resection, transcription elongation, chromatin context
- MeSH terms
- Cell Line, Chromatin, DNA Repair, DNA-Binding Proteins, Histones, Humans, Neoplasm Proteins, Transcription, Genetic, Rad51 Recombinase, DNA Breaks, Double-Stranded, Homologous Recombination, DNA End-Joining Repair
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review