Cited by 567MicroRNA in disease regulationRNA Research and SplicingPlant Molecular Biology Research

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The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

Guil, Sonia, Cáceres, Javier F·2007·Nature Structural & Molecular Biology

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Abstract

hnRNP A1 is an RNA-binding protein involved in various aspects of RNA processing. Use of an in vivo cross-linking and immunoprecipitation protocol to find hnRNP A1 RNA targets resulted in the identification of a microRNA (miRNA) precursor, pre-miR-18a. This microRNA is expressed as part of a cluster of intronic RNAs, including miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1 and miR-92, and potentially acts as an oncogene. Here we show that hnRNP A1 binds specifically to the primary RNA sequence pri-miR-18a before Drosha processing. HeLa cells depleted of hnRNP A1 have reduced in vitro processing activity with pri-miR-18a and also show reduced abundances of endogenous pre-miR-18a. Furthermore, we show that hnRNP A1 is required for miR-18a-mediated repression of a target reporter in vivo. These results underscore a previously uncharacterized role for general RNA-binding proteins as auxiliary factors that facilitate the processing of specific miRNAs.

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Authors: Guil, S., & Cáceres, J. F.
Affiliations: Western General Hospital (GB)
Corresponding author: Cáceres, Javier F
ORCID: Cáceres, Javier F
Venue: Nature Structural & Molecular Biology
Publisher: Springer Science and Business Media LLC
Published: 2007-06-10
Volume: 14
Issue: 7
Pages: 591-596
ISSN: 1545-9985 (ISSN-L)
1545-9993
DOI: 10.1038/nsmb1250
OpenAlex: W2079248832
Cited by: 567
References: 42
Citations by year: 2026: 7 · 2025: 11 · 2024: 10 · 2023: 12 · 2022: 16 · 2021: 36 · 2020: 27 · 2019: 20 · 2018: 26 · 2017: 35 · 2016: 18 · 2015: 40 · 2014: 40 · 2013: 44 · 2012: 41
FWCI: 15.27
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Structural & Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: hnRNP A1, miR-18a, microRNA processing, RNA-binding proteins, Drosha, microRNA precursors, miR-17-92 cluster, RNA target identification, gene repression, oncogenic microRNA
MeSH terms: Heterogeneous Nuclear Ribonucleoprotein A1, Gene Expression Regulation, HeLa Cells, Humans, RNA Precursors, RNA-Binding Proteins, Heterogeneous-Nuclear Ribonucleoprotein Group A-B, MicroRNAs, Ribonuclease III

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The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

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