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Cited by 236Cardiovascular and exercise physiologyMuscle metabolism and nutritionAdipose Tissue and Metabolism

Effect of endurance training on plasma free fatty acid turnover and oxidation during exercise

Martin, W. H., Dalsky, G. P., Hurley, B. F., Matthews, D. E., Bier, D. M., Hagberg, J. M., Rogers, M. A., King, D. S. +1 more·1993·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1993.265.5.e708
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Abstract

Plasma free fatty acid (FFA) levels tend to be lower and the plasma lipolytic hormone response to prolonged exercise of the same intensity is blunted after endurance exercise training. To determine whether training elicits a corresponding decrease in plasma FFA turnover and metabolism during prolonged exercise, we measured plasma [1-13C]palmitate kinetics and oxidation and respiratory gas exchange in 13 subjects during the latter portion of a 90- to 120-min bout of cycle ergometer work performed before and after 12 wk of alternate-day cycling and running. Training increased total fat oxidation during prolonged exercise by 41% (P < 0.005). However, for the final 30-60 min of the cycle ergometer protocol, the rate of 13CO2 production from [1-13C]palmitate oxidation was 27% lower (P < 0.05), the rate of palmitate turnover was 33% less (P < 0.05), and plasma FFA and glycerol concentrations were 32 and 20% lower (P < 0.05), respectively, than in the untrained state. Thus endurance exercise training results in decreased plasma FFA turnover and oxidation during a 90- to 120-min bout of submaximal exercise because of a slower rate of FFA release from adipose tissue.

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Crossref · 10.1152/ajpendo.1993.265.5.e708

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  • The use of IMTG during exercise, calculated indirectly with isotopic tracer methods, has been estimated to provide more than 50% of the total fat oxidized.

    “The use of IMTG during exercise, calculated indirectly with isotopic tracer methods, has been estimated to provide more than 50% of the total fat oxidized [145].”

    From Regulation of Energy Substrate Metabolism in Endurance Exercise (2021) · cites this paper as [145]

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Authors
Martin, W. H., Dalsky, G. P., Hurley, B. F., Matthews, D. E., Bier, D. M., Hagberg, J. M., Rogers, M. A., King, D. S., & Holloszy, J. O.
Affiliations
Washington University in St. Louis (US)
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1993-11-01
Volume
265
Issue
5
Pages
E708-E714
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1993.265.5.e708
OpenAlex
W1946501404
Cited by
236
References
27
Citations by year
2026: 2 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 10 · 2015: 9 · 2014: 6 · 2013: 5 · 2012: 11
FWCI
10.66
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p60am020579-08, 5p41rr000954-34)
  • National Center for Research Resources (RR 00954, RR.00036)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
endurance training, free fatty acid turnover, fatty acid oxidation, prolonged exercise, lipolysis, adipose tissue, glycerol, pulmonary gas exchange
MeSH terms
Adult, Carbon Dioxide, Carbon Isotopes, Fatty Acids, Nonesterified, Female, Glycerol, Humans, Lactates, Male, Oxidation-Reduction, Palmitic Acids, Physical Endurance, Respiration, Exercise, Palmitic Acid

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